Motif ID: Stat5a

Z-value: 1.040


Transcription factors associated with Stat5a:

Gene SymbolEntrez IDGene Name
Stat5a ENSMUSG00000004043.8 Stat5a



Activity profile for motif Stat5a.

activity profile for motif Stat5a


Sorted Z-values histogram for motif Stat5a

Sorted Z-values for motif Stat5a



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat5a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_55419898 4.461 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr10_-_42583628 4.021 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr8_+_94179089 3.891 ENSMUST00000034215.6
 Mt1
metallothionein 1
chr16_-_23890805 3.711 ENSMUST00000004480.3
 Sst
somatostatin
chr18_-_74961252 3.384 ENSMUST00000066532.4
 Lipg
lipase, endothelial
chr18_+_20665250 3.333 ENSMUST00000075312.3
 Ttr
transthyretin
chr9_+_44134562 3.036 ENSMUST00000034650.8
ENSMUST00000098852.2
 Mcam

melanoma cell adhesion molecule

chr10_+_84838143 2.983 ENSMUST00000095388.4
 Rfx4
regulatory factor X, 4 (influences HLA class II expression)
chr15_-_103366763 2.938 ENSMUST00000023128.6
 Itga5
integrin alpha 5 (fibronectin receptor alpha)
chr17_+_22689771 2.679 ENSMUST00000055305.8
 Gm9805
predicted gene 9805
chr2_-_80447625 2.667 ENSMUST00000028389.3
 Frzb
frizzled-related protein
chr4_-_136898803 2.656 ENSMUST00000046285.5
 C1qa
complement component 1, q subcomponent, alpha polypeptide
chr11_+_98412461 2.654 ENSMUST00000058295.5
 Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr7_+_88278085 2.647 ENSMUST00000032779.5
ENSMUST00000128791.1
 Ctsc

cathepsin C

chr9_-_77347816 2.386 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
 Mlip



muscular LMNA-interacting protein



chr4_-_64046925 2.306 ENSMUST00000107377.3
 Tnc
tenascin C
chr9_-_77347787 2.253 ENSMUST00000184848.1
ENSMUST00000184415.1
 Mlip

muscular LMNA-interacting protein

chr14_-_103843685 2.212 ENSMUST00000172237.1
 Ednrb
endothelin receptor type B
chr10_+_4710119 2.170 ENSMUST00000105588.1
ENSMUST00000105589.1
 Esr1

estrogen receptor 1 (alpha)

chr5_+_104435112 2.130 ENSMUST00000031243.8
ENSMUST00000086833.6
ENSMUST00000112748.1
ENSMUST00000112746.1
ENSMUST00000145084.1
ENSMUST00000132457.1
 Spp1





secreted phosphoprotein 1






Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 416 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.3 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.2 4.3 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.1 4.1 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.8 4.0 GO:0021764 amygdala development(GO:0021764)
0.2 4.0 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.6 3.8 GO:0071294 cellular response to zinc ion(GO:0071294)
1.2 3.7 GO:0060166 olfactory pit development(GO:0060166)
0.1 3.6 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.8 3.4 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.7 3.3 GO:0070327 thyroid hormone transport(GO:0070327)
0.1 3.3 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.3 2.9 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
2.7 2.7 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.9 2.7 GO:0070366 regulation of hepatocyte differentiation(GO:0070366)
0.5 2.7 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.5 2.7 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.6 2.5 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 2.5 GO:0032543 mitochondrial translation(GO:0032543)
0.6 2.3 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.2 2.3 GO:0047484 regulation of response to osmotic stress(GO:0047484)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 186 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 23.6 GO:0005615 extracellular space(GO:0005615)
0.1 10.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 7.7 GO:0044429 mitochondrial part(GO:0044429)
0.1 5.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 5.3 GO:0005581 collagen trimer(GO:0005581)
0.1 5.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
1.1 4.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.3 4.2 GO:0005614 interstitial matrix(GO:0005614)
0.1 4.1 GO:0015934 large ribosomal subunit(GO:0015934)
0.0 3.5 GO:0016605 PML body(GO:0016605)
0.6 3.2 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.3 3.2 GO:0005688 U6 snRNP(GO:0005688)
0.1 3.0 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 2.8 GO:0031965 nuclear membrane(GO:0031965)
0.7 2.7 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.4 2.7 GO:0042627 chylomicron(GO:0042627)
0.1 2.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 2.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 2.1 GO:0043219 lateral loop(GO:0043219)
0.6 1.9 GO:0034684 integrin alphav-beta5 complex(GO:0034684)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 290 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 7.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 4.8 GO:0005179 hormone activity(GO:0005179)
0.1 4.1 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 4.1 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.1 4.0 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.2 3.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 3.8 GO:0008565 protein transporter activity(GO:0008565)
0.0 3.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.8 3.4 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1 3.4 GO:0005507 copper ion binding(GO:0005507)
0.4 3.3 GO:0070324 thyroid hormone binding(GO:0070324)
0.8 3.2 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 3.1 GO:0008201 heparin binding(GO:0008201)
0.9 2.8 GO:0019958 C-X-C chemokine binding(GO:0019958)
0.3 2.7 GO:0031404 chloride ion binding(GO:0031404)
0.2 2.7 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.4 2.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 2.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 2.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 5.6 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.3 4.9 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.1 4.7 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.2 4.4 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 4.3 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.1 4.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 3.9 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 3.7 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 3.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.4 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 3.4 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.1 3.2 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 3.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 2.7 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 2.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.2 PID_IL27_PATHWAY IL27-mediated signaling events
0.1 2.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.8 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.7 NABA_MATRISOME_ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.4 REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION Genes involved in Antigen processing-Cross presentation
0.1 8.3 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 7.1 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 6.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 6.2 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 5.4 REACTOME_AMYLOIDS Genes involved in Amyloids
0.1 5.0 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 4.8 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 4.0 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 3.3 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 3.2 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 3.0 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 3.0 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.1 2.7 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 2.7 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 2.7 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.0 2.5 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.2 2.3 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.3 2.0 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 2.0 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling