Motif ID: Stat6

Z-value: 0.977


Transcription factors associated with Stat6:

Gene SymbolEntrez IDGene Name
Stat6 ENSMUSG00000002147.12 Stat6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat6mm10_v2_chr10_+_127642975_127643034-0.265.4e-02Click!


Activity profile for motif Stat6.

activity profile for motif Stat6


Sorted Z-values histogram for motif Stat6

Sorted Z-values for motif Stat6



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat6

PNG image of the network

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Top targets:


Showing 1 to 20 of 138 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_70421533 10.627 ENSMUST00000034742.6
 Ccnb2
cyclin B2
chr14_-_21989475 9.995 ENSMUST00000043409.7
 Zfp503
zinc finger protein 503
chr16_-_23890805 8.593 ENSMUST00000004480.3
 Sst
somatostatin
chr18_+_50053282 8.320 ENSMUST00000148159.2
 Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr11_-_102579461 7.970 ENSMUST00000107081.1
 Gm11627
predicted gene 11627
chr2_-_113848655 7.892 ENSMUST00000102545.1
ENSMUST00000110948.1
 Arhgap11a

Rho GTPase activating protein 11A

chr15_-_82244716 7.555 ENSMUST00000089155.4
ENSMUST00000089157.3
 Cenpm

centromere protein M

chr4_+_116708467 7.293 ENSMUST00000030452.6
 Ccdc163
coiled-coil domain containing 163
chr2_-_113848601 7.114 ENSMUST00000110949.2
 Arhgap11a
Rho GTPase activating protein 11A
chr17_-_89910449 6.392 ENSMUST00000086423.4
 Gm10184
predicted pseudogene 10184
chr2_+_70562854 6.079 ENSMUST00000130998.1
 Gad1
glutamate decarboxylase 1
chr1_-_120121030 5.997 ENSMUST00000027634.6
 Dbi
diazepam binding inhibitor
chr10_-_78591945 5.950 ENSMUST00000040580.6
 Syde1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr2_+_70563435 5.918 ENSMUST00000123330.1
 Gad1
glutamate decarboxylase 1
chr4_+_116708571 5.915 ENSMUST00000106462.2
ENSMUST00000138305.1
ENSMUST00000125671.1
ENSMUST00000130828.1
 Ccdc163



coiled-coil domain containing 163



chr5_+_139543889 5.846 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr2_+_163225363 5.532 ENSMUST00000099110.3
ENSMUST00000165937.1
 Tox2

TOX high mobility group box family member 2

chr4_+_116708687 5.213 ENSMUST00000135499.1
 Ccdc163
coiled-coil domain containing 163
chr4_+_136143497 5.023 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr4_+_116708624 4.999 ENSMUST00000106463.1
 Ccdc163
coiled-coil domain containing 163

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 12.0 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
3.3 10.0 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.2 10.0 GO:0043029 T cell homeostasis(GO:0043029)
0.1 8.3 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
1.2 6.0 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.6 6.0 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.7 5.8 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
1.1 5.7 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.2 5.0 GO:0030903 notochord development(GO:0030903)
0.1 4.9 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.2 4.5 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.1 4.4 GO:0051489 regulation of filopodium assembly(GO:0051489)
1.3 4.0 GO:1902524 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.5 3.8 GO:0003062 regulation of heart rate by chemical signal(GO:0003062)
0.4 3.8 GO:0071493 cellular response to UV-B(GO:0071493)
0.0 3.4 GO:0010631 epithelial cell migration(GO:0010631)
0.1 3.1 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.5 3.0 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.1 3.0 GO:0007032 endosome organization(GO:0007032)
0.1 2.7 GO:0071300 cellular response to retinoic acid(GO:0071300)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.7 GO:0005813 centrosome(GO:0005813)
0.2 9.3 GO:0060077 inhibitory synapse(GO:0060077)
0.0 7.6 GO:0000776 kinetochore(GO:0000776)
0.4 6.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 6.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.3 5.9 GO:0044300 cerebellar mossy fiber(GO:0044300)
1.2 4.9 GO:0031092 platelet alpha granule membrane(GO:0031092)
1.3 3.8 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 2.7 GO:0005884 actin filament(GO:0005884)
0.1 2.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 2.2 GO:0005801 cis-Golgi network(GO:0005801)
0.0 2.2 GO:0016459 myosin complex(GO:0016459)
0.0 2.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 2.0 GO:0045298 tubulin complex(GO:0045298)
0.0 1.5 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.3 1.4 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 1.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.4 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.0 1.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.2 GO:0005096 GTPase activator activity(GO:0005096)
0.0 12.3 GO:0045296 cadherin binding(GO:0045296)
1.7 12.0 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.2 10.0 GO:0005179 hormone activity(GO:0005179)
0.2 8.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
2.0 6.0 GO:0030156 benzodiazepine receptor binding(GO:0030156)
1.0 6.0 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 5.5 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 5.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 5.0 GO:0003712 transcription cofactor activity(GO:0003712)
0.1 4.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 4.1 GO:0004697 protein kinase C activity(GO:0004697)
1.3 3.8 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 3.8 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 3.4 GO:0030507 spectrin binding(GO:0030507)
0.7 3.0 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
0.0 2.6 GO:0017124 SH3 domain binding(GO:0017124)
0.2 2.4 GO:0042301 phosphate ion binding(GO:0042301)
0.1 2.3 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.3 2.2 GO:0031419 cobalamin binding(GO:0031419)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.6 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 6.0 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.4 3.8 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 3.8 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 3.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.6 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 2.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 2.2 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 2.0 PID_PLK1_PATHWAY PLK1 signaling events
0.1 1.7 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 1.7 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.0 1.4 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.0 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 0.6 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 20.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.5 12.0 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.6 10.6 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 9.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 7.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 6.0 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 4.9 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 3.8 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 3.8 REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in RORA Activates Circadian Expression
0.1 3.4 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.3 3.0 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 2.5 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 2.4 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 2.4 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 2.1 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 1.7 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 1.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.2 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 1.1 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 1.0 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation