Motif ID: Stat6
Z-value: 0.977
Transcription factors associated with Stat6:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Stat6 | ENSMUSG00000002147.12 | Stat6 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Stat6 | mm10_v2_chr10_+_127642975_127643034 | -0.26 | 5.4e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.3 | 10.0 | GO:0070315 | G1 to G0 transition involved in cell differentiation(GO:0070315) |
1.7 | 12.0 | GO:0009449 | gamma-aminobutyric acid biosynthetic process(GO:0009449) |
1.3 | 4.0 | GO:1902524 | interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524) |
1.2 | 6.0 | GO:0036151 | phosphatidylcholine acyl-chain remodeling(GO:0036151) |
1.1 | 5.7 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
0.7 | 5.8 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
0.6 | 6.0 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
0.5 | 2.0 | GO:2000383 | regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384) |
0.5 | 3.0 | GO:0015842 | aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) |
0.5 | 3.8 | GO:0003062 | regulation of heart rate by chemical signal(GO:0003062) |
0.4 | 2.2 | GO:0042364 | water-soluble vitamin biosynthetic process(GO:0042364) |
0.4 | 2.2 | GO:0060849 | regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849) |
0.4 | 3.8 | GO:0071493 | cellular response to UV-B(GO:0071493) |
0.4 | 1.7 | GO:0006526 | arginine biosynthetic process(GO:0006526) |
0.4 | 1.2 | GO:0086053 | renin secretion into blood stream(GO:0002001) cell communication by chemical coupling(GO:0010643) AV node cell to bundle of His cell communication by electrical coupling(GO:0086053) regulation of renin secretion into blood stream(GO:1900133) |
0.3 | 1.4 | GO:0006776 | vitamin A metabolic process(GO:0006776) positive regulation of skeletal muscle tissue regeneration(GO:0043415) |
0.3 | 0.9 | GO:0045658 | regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659) |
0.3 | 0.6 | GO:2000484 | positive regulation of interleukin-8 secretion(GO:2000484) |
0.3 | 0.9 | GO:0070682 | proteasome regulatory particle assembly(GO:0070682) |
0.3 | 0.8 | GO:0060423 | limb joint morphogenesis(GO:0036022) embryonic skeletal limb joint morphogenesis(GO:0036023) negative regulation of mitotic cell cycle, embryonic(GO:0045976) foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492) positive regulation of epithelial cell proliferation involved in prostate gland development(GO:0060769) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of histone demethylase activity (H3-K4 specific)(GO:1904173) |
0.2 | 0.7 | GO:0001757 | somite specification(GO:0001757) |
0.2 | 0.6 | GO:0006106 | fumarate metabolic process(GO:0006106) |
0.2 | 2.1 | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) |
0.2 | 5.0 | GO:0030903 | notochord development(GO:0030903) |
0.2 | 10.0 | GO:0043029 | T cell homeostasis(GO:0043029) |
0.2 | 0.9 | GO:0070966 | nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) |
0.2 | 0.9 | GO:0006384 | transcription initiation from RNA polymerase III promoter(GO:0006384) |
0.2 | 1.4 | GO:0043201 | response to leucine(GO:0043201) cellular response to leucine(GO:0071233) |
0.2 | 2.2 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
0.2 | 0.8 | GO:0018242 | protein O-linked glycosylation via serine(GO:0018242) |
0.2 | 2.1 | GO:0090435 | protein localization to nuclear envelope(GO:0090435) |
0.2 | 0.5 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) |
0.2 | 4.5 | GO:0007617 | mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705) |
0.2 | 2.3 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
0.1 | 4.9 | GO:0001937 | negative regulation of endothelial cell proliferation(GO:0001937) |
0.1 | 8.3 | GO:0050830 | defense response to Gram-positive bacterium(GO:0050830) |
0.1 | 3.1 | GO:0010172 | embryonic body morphogenesis(GO:0010172) |
0.1 | 0.5 | GO:1905077 | negative regulation of interleukin-17 secretion(GO:1905077) |
0.1 | 1.7 | GO:0021891 | olfactory bulb interneuron development(GO:0021891) |
0.1 | 0.7 | GO:0006561 | proline biosynthetic process(GO:0006561) |
0.1 | 2.1 | GO:0007271 | synaptic transmission, cholinergic(GO:0007271) |
0.1 | 2.6 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
0.1 | 4.4 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
0.1 | 2.7 | GO:0071300 | cellular response to retinoic acid(GO:0071300) |
0.1 | 3.0 | GO:0007032 | endosome organization(GO:0007032) |
0.1 | 0.8 | GO:0048642 | negative regulation of skeletal muscle tissue development(GO:0048642) |
0.0 | 0.1 | GO:1903490 | regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490) |
0.0 | 0.6 | GO:1990403 | embryonic brain development(GO:1990403) |
0.0 | 2.0 | GO:0097120 | receptor localization to synapse(GO:0097120) |
0.0 | 1.2 | GO:0018345 | protein palmitoylation(GO:0018345) |
0.0 | 0.2 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
0.0 | 0.6 | GO:0045722 | positive regulation of gluconeogenesis(GO:0045722) |
0.0 | 1.4 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
0.0 | 1.2 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
0.0 | 1.4 | GO:0033119 | negative regulation of RNA splicing(GO:0033119) |
0.0 | 1.5 | GO:0045744 | negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744) |
0.0 | 0.3 | GO:0043248 | proteasome assembly(GO:0043248) |
0.0 | 1.0 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
0.0 | 0.7 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
0.0 | 0.4 | GO:0000338 | protein deneddylation(GO:0000338) |
0.0 | 0.9 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
0.0 | 3.4 | GO:0010631 | epithelial cell migration(GO:0010631) |
0.0 | 0.1 | GO:0052428 | modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428) |
0.0 | 1.4 | GO:0006664 | glycolipid metabolic process(GO:0006664) liposaccharide metabolic process(GO:1903509) |
0.0 | 0.8 | GO:0032543 | mitochondrial translation(GO:0032543) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.3 | 3.8 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
1.2 | 4.9 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
0.4 | 6.0 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
0.3 | 5.9 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
0.3 | 1.4 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
0.2 | 9.3 | GO:0060077 | inhibitory synapse(GO:0060077) |
0.2 | 6.0 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
0.2 | 2.0 | GO:0045298 | tubulin complex(GO:0045298) |
0.1 | 0.8 | GO:0034750 | Scrib-APC-beta-catenin complex(GO:0034750) |
0.1 | 0.6 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
0.1 | 1.2 | GO:0005922 | connexon complex(GO:0005922) |
0.1 | 0.9 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
0.1 | 2.4 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
0.0 | 7.6 | GO:0000776 | kinetochore(GO:0000776) |
0.0 | 1.5 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
0.0 | 2.4 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
0.0 | 2.2 | GO:0005801 | cis-Golgi network(GO:0005801) |
0.0 | 0.6 | GO:0045239 | tricarboxylic acid cycle enzyme complex(GO:0045239) |
0.0 | 0.9 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
0.0 | 0.8 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
0.0 | 2.2 | GO:0016459 | myosin complex(GO:0016459) |
0.0 | 0.3 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
0.0 | 1.4 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
0.0 | 0.1 | GO:0034657 | GID complex(GO:0034657) |
0.0 | 1.4 | GO:0000313 | organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761) |
0.0 | 2.1 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
0.0 | 0.6 | GO:0005637 | nuclear inner membrane(GO:0005637) |
0.0 | 2.7 | GO:0005884 | actin filament(GO:0005884) |
0.0 | 0.1 | GO:0044613 | nuclear pore central transport channel(GO:0044613) |
0.0 | 1.3 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
0.0 | 9.7 | GO:0005813 | centrosome(GO:0005813) |
0.0 | 0.2 | GO:0031932 | TORC2 complex(GO:0031932) |
0.0 | 0.4 | GO:0008180 | COP9 signalosome(GO:0008180) |
0.0 | 0.7 | GO:0005811 | lipid particle(GO:0005811) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.0 | 6.0 | GO:0030156 | benzodiazepine receptor binding(GO:0030156) |
1.7 | 12.0 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
1.3 | 3.8 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
1.0 | 6.0 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
0.7 | 3.0 | GO:0036468 | aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468) |
0.5 | 1.4 | GO:0016501 | prostacyclin receptor activity(GO:0016501) |
0.4 | 1.7 | GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812) |
0.4 | 1.2 | GO:0086077 | gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling(GO:0086077) |
0.3 | 2.2 | GO:0031419 | cobalamin binding(GO:0031419) |
0.2 | 2.4 | GO:0042301 | phosphate ion binding(GO:0042301) |
0.2 | 2.1 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
0.2 | 0.6 | GO:0071723 | lipopeptide binding(GO:0071723) |
0.2 | 2.1 | GO:0000340 | RNA 7-methylguanosine cap binding(GO:0000340) |
0.2 | 8.3 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
0.2 | 0.7 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
0.2 | 4.1 | GO:0004697 | protein kinase C activity(GO:0004697) |
0.2 | 2.2 | GO:0001972 | retinoic acid binding(GO:0001972) |
0.2 | 10.0 | GO:0005179 | hormone activity(GO:0005179) |
0.1 | 2.3 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
0.1 | 1.2 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
0.1 | 0.2 | GO:0043426 | MRF binding(GO:0043426) |
0.1 | 1.4 | GO:0046527 | glucosyltransferase activity(GO:0046527) |
0.1 | 5.4 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
0.1 | 3.8 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
0.1 | 4.2 | GO:0050840 | extracellular matrix binding(GO:0050840) |
0.1 | 0.5 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
0.1 | 3.4 | GO:0030507 | spectrin binding(GO:0030507) |
0.1 | 0.7 | GO:0004622 | lysophospholipase activity(GO:0004622) |
0.1 | 0.9 | GO:0055106 | ubiquitin-protein transferase regulator activity(GO:0055106) |
0.1 | 2.1 | GO:0001671 | ATPase activator activity(GO:0001671) |
0.1 | 5.5 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
0.0 | 0.8 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
0.0 | 0.9 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
0.0 | 13.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
0.0 | 1.2 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
0.0 | 0.5 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
0.0 | 0.1 | GO:0051425 | PTB domain binding(GO:0051425) |
0.0 | 12.3 | GO:0045296 | cadherin binding(GO:0045296) |
0.0 | 1.1 | GO:0005504 | fatty acid binding(GO:0005504) |
0.0 | 0.2 | GO:0070180 | large ribosomal subunit rRNA binding(GO:0070180) |
0.0 | 1.2 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
0.0 | 0.6 | GO:0070717 | poly-purine tract binding(GO:0070717) |
0.0 | 1.4 | GO:0019003 | GDP binding(GO:0019003) |
0.0 | 2.2 | GO:0019905 | syntaxin binding(GO:0019905) |
0.0 | 0.8 | GO:0030332 | cyclin binding(GO:0030332) |
0.0 | 2.6 | GO:0017124 | SH3 domain binding(GO:0017124) |
0.0 | 1.3 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
0.0 | 0.6 | GO:0016836 | hydro-lyase activity(GO:0016836) |
0.0 | 0.8 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
0.0 | 0.6 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
0.0 | 1.7 | GO:0031072 | heat shock protein binding(GO:0031072) |
0.0 | 0.9 | GO:0043022 | ribosome binding(GO:0043022) |
0.0 | 1.8 | GO:0051015 | actin filament binding(GO:0051015) |
0.0 | 5.0 | GO:0003712 | transcription cofactor activity(GO:0003712) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 3.8 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
0.2 | 10.6 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
0.2 | 3.8 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
0.1 | 6.0 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
0.1 | 1.7 | PID_PRL_SIGNALING_EVENTS_PATHWAY | Signaling events mediated by PRL |
0.1 | 2.2 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
0.0 | 2.2 | PID_PS1_PATHWAY | Presenilin action in Notch and Wnt signaling |
0.0 | 1.0 | PID_SYNDECAN_2_PATHWAY | Syndecan-2-mediated signaling events |
0.0 | 2.0 | PID_PLK1_PATHWAY | PLK1 signaling events |
0.0 | 2.6 | PID_FCER1_PATHWAY | Fc-epsilon receptor I signaling in mast cells |
0.0 | 0.6 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
0.0 | 1.7 | ST_FAS_SIGNALING_PATHWAY | Fas Signaling Pathway |
0.0 | 3.0 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.0 | 1.4 | PID_MTOR_4PATHWAY | mTOR signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 10.6 | REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
0.5 | 12.0 | REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
0.3 | 3.0 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
0.2 | 2.1 | REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
0.1 | 6.0 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
0.1 | 3.8 | REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
0.1 | 3.8 | REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in RORA Activates Circadian Expression |
0.1 | 0.8 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
0.1 | 20.6 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
0.1 | 9.0 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
0.1 | 1.2 | REACTOME_GAP_JUNCTION_ASSEMBLY | Genes involved in Gap junction assembly |
0.1 | 2.4 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
0.1 | 1.7 | REACTOME_PYRIMIDINE_METABOLISM | Genes involved in Pyrimidine metabolism |
0.1 | 7.6 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
0.1 | 0.6 | REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
0.1 | 3.4 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
0.1 | 4.9 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
0.0 | 2.4 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
0.0 | 1.0 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
0.0 | 2.5 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
0.0 | 0.9 | REACTOME_RNA_POL_III_CHAIN_ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
0.0 | 0.5 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
0.0 | 1.4 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
0.0 | 1.1 | REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
0.0 | 0.8 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |