Motif ID: Taf1

Z-value: 2.830


Transcription factors associated with Taf1:

Gene SymbolEntrez IDGene Name
Taf1 ENSMUSG00000031314.11 Taf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Taf1mm10_v2_chrX_+_101532734_1015327770.731.7e-10Click!


Activity profile for motif Taf1.

activity profile for motif Taf1


Sorted Z-values histogram for motif Taf1

Sorted Z-values for motif Taf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Taf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_79854618 11.125 ENSMUST00000165704.1
 Ptbp1
polypyrimidine tract binding protein 1
chr10_+_79854658 10.393 ENSMUST00000171599.1
ENSMUST00000095457.4
 Ptbp1

polypyrimidine tract binding protein 1

chr2_+_119047116 10.240 ENSMUST00000152380.1
ENSMUST00000099542.2
 Casc5

cancer susceptibility candidate 5

chr7_+_59228743 10.162 ENSMUST00000107537.1
 Ube3a
ubiquitin protein ligase E3A
chr3_-_84220853 9.669 ENSMUST00000154152.1
ENSMUST00000107693.2
ENSMUST00000107695.2
 Trim2


tripartite motif-containing 2


chr5_-_123749393 9.632 ENSMUST00000057795.5
ENSMUST00000111515.1
ENSMUST00000182309.1
 Rsrc2


arginine/serine-rich coiled-coil 2


chr2_+_119047129 9.419 ENSMUST00000153300.1
ENSMUST00000028799.5
 Casc5

cancer susceptibility candidate 5

chr5_-_123749371 8.931 ENSMUST00000182955.1
ENSMUST00000182489.1
ENSMUST00000050827.7
 Rsrc2


arginine/serine-rich coiled-coil 2


chr5_+_23434435 8.719 ENSMUST00000094962.2
ENSMUST00000115128.1
 Kmt2e

lysine (K)-specific methyltransferase 2E

chr6_+_38433913 8.407 ENSMUST00000160583.1
 Ubn2
ubinuclein 2
chr3_+_69004969 7.577 ENSMUST00000136502.1
ENSMUST00000107803.1
 Smc4

structural maintenance of chromosomes 4

chr4_+_148039035 7.042 ENSMUST00000097788.4
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr3_+_69004711 6.822 ENSMUST00000042901.8
 Smc4
structural maintenance of chromosomes 4
chr8_-_111259192 6.716 ENSMUST00000169020.1
ENSMUST00000003404.8
 Glg1

golgi apparatus protein 1

chr15_-_86033777 6.715 ENSMUST00000016172.7
 Celsr1
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
chr4_-_62208426 6.409 ENSMUST00000068822.3
 Zfp37
zinc finger protein 37
chr18_-_6241470 6.362 ENSMUST00000163210.1
 Kif5b
kinesin family member 5B
chr1_-_166002613 6.358 ENSMUST00000177358.1
ENSMUST00000160908.1
ENSMUST00000027850.8
ENSMUST00000160260.2
 Pou2f1



POU domain, class 2, transcription factor 1



chr7_+_123123870 6.105 ENSMUST00000094053.5
 Tnrc6a
trinucleotide repeat containing 6a
chrX_-_73966329 6.089 ENSMUST00000114372.2
ENSMUST00000033761.6
 Hcfc1

host cell factor C1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 470 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 22.9 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
1.3 14.7 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
1.8 14.4 GO:0010032 meiotic chromosome condensation(GO:0010032)
3.6 14.3 GO:0070829 heterochromatin maintenance(GO:0070829)
2.8 13.9 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
1.0 13.5 GO:0060009 Sertoli cell development(GO:0060009)
0.1 13.3 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
3.0 12.2 GO:0097393 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
1.7 11.8 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
1.4 11.1 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
1.0 10.2 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.7 10.2 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.1 9.3 GO:0006635 fatty acid beta-oxidation(GO:0006635)
2.2 9.0 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
1.1 9.0 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.1 8.8 GO:0045638 negative regulation of myeloid cell differentiation(GO:0045638)
2.9 8.7 GO:0035621 ER to Golgi ceramide transport(GO:0035621) ceramide transport(GO:0035627)
1.4 8.7 GO:0034773 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
0.5 8.7 GO:0042119 neutrophil activation(GO:0042119)
1.2 8.6 GO:0090234 regulation of kinetochore assembly(GO:0090234)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 207 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 50.0 GO:0005654 nucleoplasm(GO:0005654)
0.1 28.1 GO:0000785 chromatin(GO:0000785)
0.1 17.9 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 16.3 GO:0005768 endosome(GO:0005768)
0.5 14.5 GO:0030992 intraciliary transport particle B(GO:0030992)
1.4 14.4 GO:0000796 condensin complex(GO:0000796)
0.6 13.2 GO:0035253 ciliary rootlet(GO:0035253)
3.0 12.2 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.2 11.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 11.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.3 10.8 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.5 10.3 GO:0016580 Sin3 complex(GO:0016580)
0.6 9.9 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 9.9 GO:0005815 microtubule organizing center(GO:0005815)
0.1 9.3 GO:0017053 transcriptional repressor complex(GO:0017053)
3.0 8.9 GO:0036125 mitochondrial fatty acid beta-oxidation multienzyme complex(GO:0016507) fatty acid beta-oxidation multienzyme complex(GO:0036125)
1.0 8.3 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 8.2 GO:0000922 spindle pole(GO:0000922)
0.1 8.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 8.0 GO:0044306 neuron projection terminus(GO:0044306)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 251 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 40.0 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.1 35.1 GO:0061659 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.1 34.2 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 30.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
3.8 22.6 GO:0001069 regulatory region RNA binding(GO:0001069)
2.1 14.8 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.3 14.3 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.3 14.3 GO:0061733 peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.3 14.2 GO:0070063 RNA polymerase binding(GO:0070063)
0.1 13.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.6 12.8 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
4.2 12.6 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.3 12.6 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 12.6 GO:0008270 zinc ion binding(GO:0008270)
1.7 12.2 GO:0015616 DNA translocase activity(GO:0015616)
0.1 12.1 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.4 11.7 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 11.7 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
1.6 11.1 GO:0099609 microtubule lateral binding(GO:0099609)
0.6 10.7 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 23.7 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.4 21.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 15.6 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.3 13.6 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.3 13.5 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.3 12.9 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.4 12.0 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.3 11.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 11.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.4 9.5 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.2 8.7 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.6 7.7 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.3 7.0 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.3 6.9 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.2 6.5 PID_ATM_PATHWAY ATM pathway
0.3 6.2 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.2 4.2 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.3 4.1 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.6 3.6 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1 3.5 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 23.9 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS Genes involved in CREB phosphorylation through the activation of Ras
0.4 22.5 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.7 18.0 REACTOME_KINESINS Genes involved in Kinesins
0.6 18.0 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.4 17.0 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.3 15.0 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.8 13.0 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.4 12.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 12.6 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.2 9.3 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.2 8.5 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.4 8.2 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 8.1 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA Genes involved in Processing of Capped Intron-Containing Pre-mRNA
0.2 7.9 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 7.6 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
0.2 7.3 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.2 6.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 6.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.4 6.0 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.2 5.4 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions