Motif ID: Tal1

Z-value: 0.795


Transcription factors associated with Tal1:

Gene SymbolEntrez IDGene Name
Tal1 ENSMUSG00000028717.6 Tal1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tal1mm10_v2_chr4_+_115059507_1150595530.104.6e-01Click!


Activity profile for motif Tal1.

activity profile for motif Tal1


Sorted Z-values histogram for motif Tal1

Sorted Z-values for motif Tal1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tal1

PNG image of the network

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Top targets:


Showing 1 to 20 of 171 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_103853199 7.780 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr11_+_32276400 4.374 ENSMUST00000020531.2
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr11_+_32276893 4.248 ENSMUST00000145569.1
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr8_-_125898291 2.850 ENSMUST00000047239.6
 Pcnxl2
pecanex-like 2 (Drosophila)
chr2_+_180499893 2.657 ENSMUST00000029084.2
 Ntsr1
neurotensin receptor 1
chr16_-_18621366 2.597 ENSMUST00000051160.2
 Gp1bb
glycoprotein Ib, beta polypeptide
chr19_+_42247544 2.310 ENSMUST00000122375.1
 Golga7b
golgi autoantigen, golgin subfamily a, 7B
chr9_+_57998036 2.309 ENSMUST00000181289.1
 Gm17322
predicted gene, 17322
chr10_+_116177351 2.299 ENSMUST00000155606.1
ENSMUST00000128399.1
 Ptprr

protein tyrosine phosphatase, receptor type, R

chr10_+_97565436 2.297 ENSMUST00000038160.4
 Lum
lumican
chr7_+_119900099 2.219 ENSMUST00000106516.1
 Lyrm1
LYR motif containing 1
chr10_-_11082287 2.208 ENSMUST00000105561.2
ENSMUST00000044306.6
 Grm1

glutamate receptor, metabotropic 1

chr8_-_71511762 1.854 ENSMUST00000048452.4
 Plvap
plasmalemma vesicle associated protein
chr7_+_97842917 1.842 ENSMUST00000033040.5
 Pak1
p21 protein (Cdc42/Rac)-activated kinase 1
chr17_-_29237759 1.794 ENSMUST00000137727.1
ENSMUST00000024805.7
 Cpne5

copine V

chr6_+_86078070 1.780 ENSMUST00000032069.5
 Add2
adducin 2 (beta)
chr2_-_79908428 1.746 ENSMUST00000102652.3
ENSMUST00000102651.3
 Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr5_-_107972864 1.733 ENSMUST00000153172.1
 Fam69a
family with sequence similarity 69, member A
chr15_+_89568322 1.714 ENSMUST00000023295.2
 Acr
acrosin prepropeptide
chr12_+_95692212 1.679 ENSMUST00000057324.3
 Flrt2
fibronectin leucine rich transmembrane protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 16.4 GO:0015671 oxygen transport(GO:0015671)
0.2 3.3 GO:0034390 smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391)
0.7 2.7 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238)
0.6 2.3 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.6 2.3 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.2 2.3 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 2.3 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.6 2.2 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 1.9 GO:0002693 positive regulation of cellular extravasation(GO:0002693)
0.6 1.8 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.1 1.8 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 1.8 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 1.8 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.6 1.7 GO:0007341 penetration of zona pellucida(GO:0007341)
0.6 1.7 GO:0050975 sensory perception of touch(GO:0050975)
0.2 1.7 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.2 1.6 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 1.6 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.5 1.5 GO:0060382 regulation of DNA strand elongation(GO:0060382)
0.2 1.5 GO:0042866 pyruvate biosynthetic process(GO:0042866)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 16.4 GO:0005833 hemoglobin complex(GO:0005833)
0.7 2.7 GO:0032280 symmetric synapse(GO:0032280)
0.3 2.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.2 2.3 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.2 2.2 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0 2.2 GO:0030496 midbody(GO:0030496)
0.2 2.0 GO:0071437 invadopodium(GO:0071437)
0.1 1.9 GO:0005901 caveola(GO:0005901)
0.2 1.8 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 1.7 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 1.7 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.5 1.6 GO:1990075 kinesin II complex(GO:0016939) periciliary membrane compartment(GO:1990075)
0.1 1.6 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.5 1.5 GO:0005584 collagen type I trimer(GO:0005584)
0.4 1.5 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.2 1.5 GO:0070187 telosome(GO:0070187)
0.0 1.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 1.3 GO:0097228 sperm principal piece(GO:0097228)
0.0 1.3 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.1 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 16.4 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 4.1 GO:0005518 collagen binding(GO:0005518)
0.4 3.0 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 2.7 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 2.3 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 2.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.6 2.2 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.1 1.7 GO:0005537 mannose binding(GO:0005537)
0.1 1.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.7 GO:0045499 chemorepellent activity(GO:0045499)
0.0 1.6 GO:0019894 kinesin binding(GO:0019894)
0.5 1.5 GO:1990955 G-rich single-stranded DNA binding(GO:1990955)
0.5 1.5 GO:0004743 pyruvate kinase activity(GO:0004743)
0.3 1.5 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 1.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 1.5 GO:0036002 pre-mRNA binding(GO:0036002)
0.3 1.3 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 1.3 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 1.3 GO:0017166 vinculin binding(GO:0017166)
0.2 1.2 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.1 2.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.5 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 1.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.3 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.0 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.9 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.7 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.7 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.6 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.5 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.5 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.3 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.2 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.2 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.2 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 3.3 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 3.0 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 2.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 2.3 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.2 2.2 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.8 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 1.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.7 REACTOME_REGULATION_OF_APOPTOSIS Genes involved in Regulation of Apoptosis
0.1 1.6 REACTOME_KINESINS Genes involved in Kinesins
0.1 1.5 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.4 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 1.3 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 1.3 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.3 1.2 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 1.1 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.2 1.0 REACTOME_PD1_SIGNALING Genes involved in PD-1 signaling
0.1 0.9 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 0.8 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism