Motif ID: Tbp

Z-value: 2.507


Transcription factors associated with Tbp:

Gene SymbolEntrez IDGene Name
Tbp ENSMUSG00000014767.10 Tbp

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbpmm10_v2_chr17_+_15499888_15499960-0.524.4e-05Click!


Activity profile for motif Tbp.

activity profile for motif Tbp


Sorted Z-values histogram for motif Tbp

Sorted Z-values for motif Tbp



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbp

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_87948666 31.504 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr7_-_103853199 23.981 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr3_-_145649970 21.823 ENSMUST00000029846.3
 Cyr61
cysteine rich protein 61
chr8_+_94179089 21.477 ENSMUST00000034215.6
 Mt1
metallothionein 1
chr13_+_21717626 20.088 ENSMUST00000091754.2
 Hist1h3h
histone cluster 1, H3h
chr13_+_23581563 16.643 ENSMUST00000102968.1
 Hist1h4d
histone cluster 1, H4d
chr13_+_51846673 16.169 ENSMUST00000021903.2
 Gadd45g
growth arrest and DNA-damage-inducible 45 gamma
chr2_+_13573927 15.665 ENSMUST00000141365.1
ENSMUST00000028062.2
 Vim

vimentin

chr11_-_99024179 15.576 ENSMUST00000068031.7
 Top2a
topoisomerase (DNA) II alpha
chr1_-_138842429 15.469 ENSMUST00000112026.2
ENSMUST00000019374.7
 Lhx9

LIM homeobox protein 9

chrX_-_162159717 15.281 ENSMUST00000087085.3
 Nhs
Nance-Horan syndrome (human)
chr2_-_93957040 14.479 ENSMUST00000148314.2
 Gm13889
predicted gene 13889
chr2_+_119618717 13.779 ENSMUST00000028771.7
 Nusap1
nucleolar and spindle associated protein 1
chr13_+_23575753 13.762 ENSMUST00000105105.1
 Hist1h3d
histone cluster 1, H3d
chr16_+_91225550 13.703 ENSMUST00000035608.8
 Olig2
oligodendrocyte transcription factor 2
chr5_-_77115145 13.544 ENSMUST00000081964.5
 Hopx
HOP homeobox
chr7_-_142899985 13.391 ENSMUST00000000219.3
 Th
tyrosine hydroxylase
chr13_+_23752267 13.180 ENSMUST00000091703.2
 Hist1h3b
histone cluster 1, H3b
chr4_+_136143497 13.158 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr17_-_24251382 13.066 ENSMUST00000115390.3
 Ccnf
cyclin F

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 140 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.9 121.2 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.6 46.6 GO:0006334 nucleosome assembly(GO:0006334)
2.4 31.5 GO:0042573 retinoic acid metabolic process(GO:0042573)
1.7 31.5 GO:0019430 removal of superoxide radicals(GO:0019430)
5.8 29.1 GO:0015671 oxygen transport(GO:0015671)
0.3 28.3 GO:0006342 chromatin silencing(GO:0006342)
4.4 21.8 GO:0060591 chondroblast differentiation(GO:0060591)
4.3 21.5 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
1.1 20.5 GO:0000920 cell separation after cytokinesis(GO:0000920)
1.6 19.0 GO:0002227 innate immune response in mucosa(GO:0002227)
0.8 18.7 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
1.6 16.2 GO:0042095 interferon-gamma biosynthetic process(GO:0042095)
3.1 15.7 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
3.9 15.6 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
3.1 15.5 GO:0035262 gonad morphogenesis(GO:0035262)
0.2 15.3 GO:0002088 lens development in camera-type eye(GO:0002088)
1.0 13.8 GO:0007076 mitotic chromosome condensation(GO:0007076)
4.6 13.7 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
2.3 13.5 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
3.3 13.4 GO:0042414 epinephrine metabolic process(GO:0042414)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 120.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 90.1 GO:0005634 nucleus(GO:0005634)
0.0 53.0 GO:0005654 nucleoplasm(GO:0005654)
1.3 50.7 GO:0000786 nucleosome(GO:0000786)
0.6 29.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 24.0 GO:0000793 condensed chromosome(GO:0000793)
0.1 22.7 GO:0005667 transcription factor complex(GO:0005667)
0.3 20.5 GO:0005871 kinesin complex(GO:0005871)
0.1 19.2 GO:0000790 nuclear chromatin(GO:0000790)
0.7 18.6 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 17.8 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
3.9 15.7 GO:0045098 type III intermediate filament(GO:0045098)
0.3 15.1 GO:0005876 spindle microtubule(GO:0005876)
0.1 14.8 GO:0043209 myelin sheath(GO:0043209)
0.2 14.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.6 14.3 GO:0005680 anaphase-promoting complex(GO:0005680)
4.5 13.4 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
1.9 13.2 GO:0097452 GAIT complex(GO:0097452)
0.5 10.0 GO:0010369 chromocenter(GO:0010369)
1.6 9.6 GO:0032299 ribonuclease H2 complex(GO:0032299)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 104.8 GO:0003677 DNA binding(GO:0003677)
1.9 93.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.3 60.5 GO:0042393 histone binding(GO:0042393)
5.3 31.5 GO:0019841 retinol binding(GO:0019841)
5.8 29.1 GO:0005344 oxygen transporter activity(GO:0005344)
2.8 28.5 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 26.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.5 21.5 GO:0005507 copper ion binding(GO:0005507)
0.2 20.5 GO:0003777 microtubule motor activity(GO:0003777)
1.4 18.7 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 16.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
2.0 16.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.5 15.8 GO:0071837 HMG box domain binding(GO:0071837)
3.9 15.7 GO:1990254 keratin filament binding(GO:1990254)
3.9 15.6 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.7 14.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
2.7 13.4 GO:0035240 dopamine binding(GO:0035240)
4.4 13.2 GO:0035605 peptidyl-cysteine S-nitrosylase activity(GO:0035605)
0.5 11.5 GO:0070628 proteasome binding(GO:0070628)
0.3 11.3 GO:0005504 fatty acid binding(GO:0005504)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 42.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.3 28.0 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
1.5 21.5 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.4 20.8 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.6 19.8 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.5 18.7 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.4 15.6 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 13.2 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.4 11.5 PID_IL3_PATHWAY IL3-mediated signaling events
0.3 10.1 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.5 9.9 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 9.0 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.2 8.1 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2 6.5 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 6.5 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 5.7 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.2 4.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.2 4.4 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.2 3.9 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.2 3.7 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.1 160.4 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
2.1 33.0 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.5 29.6 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.9 22.8 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.8 20.5 REACTOME_KINESINS Genes involved in Kinesins
0.6 15.9 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 13.7 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
1.2 13.4 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.3 13.3 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 12.7 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.4 12.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 12.3 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
1.2 10.8 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 10.0 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
2.0 9.9 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 9.6 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
0.1 8.5 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
2.6 7.9 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.4 7.0 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.5 6.6 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport