Motif ID: Tbr1

Z-value: 0.922


Transcription factors associated with Tbr1:

Gene SymbolEntrez IDGene Name
Tbr1 ENSMUSG00000035033.9 Tbr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbr1mm10_v2_chr2_+_61804453_61804538-0.341.2e-02Click!


Activity profile for motif Tbr1.

activity profile for motif Tbr1


Sorted Z-values histogram for motif Tbr1

Sorted Z-values for motif Tbr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_120899067 7.676 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr10_+_57784859 5.441 ENSMUST00000020024.5
 Fabp7
fatty acid binding protein 7, brain
chr2_+_71528657 5.213 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr2_+_164562579 3.676 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr2_-_71546745 3.651 ENSMUST00000024159.6
 Dlx2
distal-less homeobox 2
chr2_+_71529085 3.627 ENSMUST00000152711.1
 Dlx1
distal-less homeobox 1
chr5_+_111733924 3.539 ENSMUST00000180627.1
 Gm26897
predicted gene, 26897
chr9_-_21760275 3.459 ENSMUST00000098942.4
 Spc24
SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr10_+_57784914 3.455 ENSMUST00000165013.1
 Fabp7
fatty acid binding protein 7, brain
chr3_-_115715031 3.361 ENSMUST00000055676.2
 S1pr1
sphingosine-1-phosphate receptor 1
chr9_-_43239816 3.339 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr4_-_109665249 3.284 ENSMUST00000063531.4
 Cdkn2c
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chrX_+_100625737 3.098 ENSMUST00000048962.3
 Kif4
kinesin family member 4
chr1_-_138847579 3.042 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr11_-_32222233 2.783 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
 Rhbdf1


rhomboid family 1 (Drosophila)


chr1_-_189688074 2.766 ENSMUST00000171929.1
ENSMUST00000165962.1
 Cenpf

centromere protein F

chr3_-_145649970 2.731 ENSMUST00000029846.3
 Cyr61
cysteine rich protein 61
chr17_+_87635974 2.656 ENSMUST00000053577.8
 Epcam
epithelial cell adhesion molecule
chr14_+_62292475 2.618 ENSMUST00000166879.1
 Rnaseh2b
ribonuclease H2, subunit B
chr3_+_135212557 2.543 ENSMUST00000062893.7
 Cenpe
centromere protein E

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 312 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.2 12.5 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.4 7.8 GO:0060134 prepulse inhibition(GO:0060134)
1.9 7.7 GO:0030091 protein repair(GO:0030091)
2.3 6.9 GO:0030421 defecation(GO:0030421)
0.2 5.7 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
1.1 5.4 GO:0035262 gonad morphogenesis(GO:0035262)
0.9 5.3 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.1 4.1 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.7 4.0 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.9 3.8 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
1.2 3.7 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344)
0.1 3.7 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.6 3.5 GO:0045218 zonula adherens maintenance(GO:0045218)
1.1 3.4 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.3 3.4 GO:0051255 spindle midzone assembly(GO:0051255)
0.0 3.4 GO:0051297 centrosome cycle(GO:0007098) centrosome organization(GO:0051297)
0.4 3.2 GO:0015670 carbon dioxide transport(GO:0015670)
0.5 3.1 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.1 3.0 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 2.9 GO:0035411 catenin import into nucleus(GO:0035411)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 134 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.2 GO:0005667 transcription factor complex(GO:0005667)
0.0 6.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.5 6.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 5.7 GO:0030027 lamellipodium(GO:0030027)
0.4 5.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 5.3 GO:0045171 intercellular bridge(GO:0045171)
0.1 5.3 GO:0005604 basement membrane(GO:0005604)
0.4 3.6 GO:0070652 HAUS complex(GO:0070652)
0.0 3.6 GO:0016324 apical plasma membrane(GO:0016324)
0.6 3.5 GO:0031262 Ndc80 complex(GO:0031262)
0.3 3.5 GO:0005915 zonula adherens(GO:0005915)
0.0 3.5 GO:0005814 centriole(GO:0005814)
0.3 3.1 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 3.1 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 3.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.5 2.6 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.4 2.6 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 2.6 GO:0015934 large ribosomal subunit(GO:0015934)
0.6 2.5 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.1 2.4 GO:0030992 intraciliary transport particle B(GO:0030992)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 204 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.6 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.2 9.4 GO:0005504 fatty acid binding(GO:0005504)
1.3 7.7 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.1 7.7 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 5.8 GO:0008083 growth factor activity(GO:0008083)
0.4 5.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 4.8 GO:0003727 single-stranded RNA binding(GO:0003727)
0.2 4.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 4.3 GO:0048487 beta-tubulin binding(GO:0048487)
0.4 4.2 GO:0008430 selenium binding(GO:0008430)
1.0 4.0 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.3 4.0 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.7 3.7 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.3 3.5 GO:0070097 delta-catenin binding(GO:0070097)
0.3 3.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 3.3 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.4 3.2 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.4 3.2 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.6 3.1 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.2 3.0 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.1 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 8.0 PID_PLK1_PATHWAY PLK1 signaling events
0.2 6.9 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 6.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.3 3.8 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 3.4 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 3.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 3.2 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 3.1 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.3 2.5 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 2.4 PID_E2F_PATHWAY E2F transcription factor network
0.1 2.1 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 2.1 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 1.9 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.8 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.8 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.6 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.5 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 1.4 PID_FANCONI_PATHWAY Fanconi anemia pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.3 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 3.7 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.3 3.1 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 3.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 2.9 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.8 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 2.6 REACTOME_DNA_REPAIR Genes involved in DNA Repair
0.1 2.5 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.2 2.4 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.3 2.3 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 2.3 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 2.3 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.3 2.2 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 2.1 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 2.0 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.9 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 1.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 1.8 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0 1.7 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 1.7 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes