Motif ID: Tbx15

Z-value: 0.711


Transcription factors associated with Tbx15:

Gene SymbolEntrez IDGene Name
Tbx15 ENSMUSG00000027868.5 Tbx15



Activity profile for motif Tbx15.

activity profile for motif Tbx15


Sorted Z-values histogram for motif Tbx15

Sorted Z-values for motif Tbx15



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx15

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_48045144 10.654 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr6_+_108213086 7.055 ENSMUST00000032192.6
 Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr19_-_10304867 5.553 ENSMUST00000039327.4
 Dagla
diacylglycerol lipase, alpha
chr17_-_81649607 5.484 ENSMUST00000163680.2
ENSMUST00000086538.3
ENSMUST00000163123.1
 Slc8a1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr16_-_23988852 5.147 ENSMUST00000023151.5
 Bcl6
B cell leukemia/lymphoma 6
chr5_+_32136458 4.907 ENSMUST00000031017.9
 Fosl2
fos-like antigen 2
chr10_+_123264076 4.741 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr4_-_129121889 4.529 ENSMUST00000139450.1
ENSMUST00000125931.1
ENSMUST00000116444.2
 Hpca


hippocalcin


chr12_-_78980758 4.372 ENSMUST00000174072.1
 Tmem229b
transmembrane protein 229B
chr4_+_125490688 4.365 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr3_-_82074639 4.353 ENSMUST00000029635.8
 Gucy1b3
guanylate cyclase 1, soluble, beta 3
chr16_-_43979050 3.939 ENSMUST00000165648.1
ENSMUST00000036321.7
 Zdhhc23

zinc finger, DHHC domain containing 23

chrX_+_159840463 3.674 ENSMUST00000112451.1
ENSMUST00000112453.2
 Sh3kbp1

SH3-domain kinase binding protein 1

chr3_+_96181151 3.625 ENSMUST00000035371.8
 Sv2a
synaptic vesicle glycoprotein 2 a
chr19_-_37207293 3.601 ENSMUST00000132580.1
ENSMUST00000079754.4
ENSMUST00000136286.1
ENSMUST00000126188.1
ENSMUST00000126781.1
 Cpeb3




cytoplasmic polyadenylation element binding protein 3




chr7_+_79810727 3.572 ENSMUST00000107394.1
 Mesp2
mesoderm posterior 2
chr9_-_49798905 3.516 ENSMUST00000114476.2
 Ncam1
neural cell adhesion molecule 1
chr6_-_28831747 3.466 ENSMUST00000062304.5
 Lrrc4
leucine rich repeat containing 4
chr6_+_114131229 3.440 ENSMUST00000032451.7
 Slc6a11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr17_-_29237759 3.417 ENSMUST00000137727.1
ENSMUST00000024805.7
 Cpne5

copine V


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 178 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.6 10.7 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
1.2 7.1 GO:0042045 epithelial fluid transport(GO:0042045)
2.2 6.5 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.9 6.3 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
2.0 6.1 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.7 5.9 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
1.9 5.6 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
1.9 5.6 GO:0046340 diacylglycerol catabolic process(GO:0046340)
1.8 5.5 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.2 5.4 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.2 5.3 GO:0018345 protein palmitoylation(GO:0018345)
2.6 5.1 GO:0032763 regulation of mast cell cytokine production(GO:0032763)
0.3 4.9 GO:0003334 keratinocyte development(GO:0003334)
1.6 4.8 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
0.2 4.6 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.1 4.5 GO:0001919 regulation of receptor recycling(GO:0001919)
1.5 4.4 GO:0099548 trans-synaptic signaling by nitric oxide(GO:0099548)
0.4 4.4 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
1.2 3.6 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.9 3.6 GO:0008078 mesodermal cell migration(GO:0008078)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 9.0 GO:0030426 growth cone(GO:0030426)
0.3 8.4 GO:0032839 dendrite cytoplasm(GO:0032839)
2.4 7.1 GO:0031088 platelet dense granule membrane(GO:0031088)
0.2 7.1 GO:0030673 axolemma(GO:0030673)
0.0 6.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.4 6.8 GO:0043196 varicosity(GO:0043196)
0.1 6.3 GO:0030131 clathrin adaptor complex(GO:0030131)
0.5 6.1 GO:0044327 dendritic spine head(GO:0044327)
0.0 5.6 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.3 4.8 GO:0043083 synaptic cleft(GO:0043083)
0.3 4.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 4.7 GO:0030014 CCR4-NOT complex(GO:0030014)
0.7 4.6 GO:0071203 WASH complex(GO:0071203)
0.5 3.9 GO:0042629 mast cell granule(GO:0042629)
0.0 3.9 GO:0001650 fibrillar center(GO:0001650)
0.4 3.6 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.2 3.6 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 3.4 GO:0043235 receptor complex(GO:0043235)
0.6 3.2 GO:0030314 junctional membrane complex(GO:0030314)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 120 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.9 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.5 9.9 GO:0030275 LRR domain binding(GO:0030275)
2.4 7.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
1.0 7.1 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 5.9 GO:0030276 clathrin binding(GO:0030276)
1.1 5.6 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.2 5.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.4 5.2 GO:0044213 intronic transcription regulatory region DNA binding(GO:0044213)
0.4 5.1 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
1.2 5.0 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
1.6 4.8 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
0.1 4.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.9 4.4 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.4 4.4 GO:0004016 adenylate cyclase activity(GO:0004016)
0.1 4.2 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.5 3.6 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
1.1 3.4 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.4 3.3 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.1 3.2 GO:0019213 deacetylase activity(GO:0019213)
0.8 3.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 12.8 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 6.6 PID_FGF_PATHWAY FGF signaling pathway
0.2 6.5 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 5.1 PID_SHP2_PATHWAY SHP2 signaling
0.0 4.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 3.8 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 3.8 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 3.3 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 3.2 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1 3.1 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 3.1 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 3.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.9 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.1 2.6 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 2.2 PID_INSULIN_PATHWAY Insulin Pathway
0.1 2.1 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 2.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.8 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 1.6 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.6 WNT_SIGNALING Genes related to Wnt-mediated signal transduction

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 13.0 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 12.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 6.8 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 5.6 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.4 5.5 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.2 5.0 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.5 4.8 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 4.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 4.1 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 3.9 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 3.7 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 3.2 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.3 3.1 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.2 3.1 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 2.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.8 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.1 2.5 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 2.5 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.2 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.1 2.0 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism