Motif ID: Tbx19

Z-value: 0.696


Transcription factors associated with Tbx19:

Gene SymbolEntrez IDGene Name
Tbx19 ENSMUSG00000026572.5 Tbx19



Activity profile for motif Tbx19.

activity profile for motif Tbx19


Sorted Z-values histogram for motif Tbx19

Sorted Z-values for motif Tbx19



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx19

PNG image of the network

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Top targets:


Showing 1 to 20 of 110 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_101468164 4.688 ENSMUST00000001347.6
 Rnd2
Rho family GTPase 2
chr9_-_21760275 3.975 ENSMUST00000098942.4
 Spc24
SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr3_+_94693556 3.637 ENSMUST00000090848.3
ENSMUST00000173981.1
ENSMUST00000173849.1
ENSMUST00000174223.1
 Selenbp2



selenium binding protein 2



chr9_+_15520830 3.621 ENSMUST00000178999.1
 Smco4
single-pass membrane protein with coiled-coil domains 4
chr7_+_130936172 3.204 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chrY_+_897782 3.149 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr17_+_6978860 2.674 ENSMUST00000089119.5
ENSMUST00000179728.1
 Rnaset2b

ribonuclease T2B

chr18_-_82406777 2.599 ENSMUST00000065224.6
 Galr1
galanin receptor 1
chr2_-_113758638 2.481 ENSMUST00000099575.3
 Grem1
gremlin 1
chr19_+_5474681 2.472 ENSMUST00000165485.1
ENSMUST00000166253.1
ENSMUST00000167371.1
ENSMUST00000167855.1
ENSMUST00000070118.7
 Efemp2




epidermal growth factor-containing fibulin-like extracellular matrix protein 2




chr17_-_35027909 2.367 ENSMUST00000040151.2
 Sapcd1
suppressor APC domain containing 1
chr14_+_115042752 2.325 ENSMUST00000134140.2
 Mir17hg
Mir17 host gene 1 (non-protein coding)
chr10_+_20347788 2.261 ENSMUST00000169712.1
 Mtfr2
mitochondrial fission regulator 2
chr3_-_97610156 2.163 ENSMUST00000029730.4
 Chd1l
chromodomain helicase DNA binding protein 1-like
chr7_-_132776855 2.131 ENSMUST00000106168.1
 Fam53b
family with sequence similarity 53, member B
chr6_-_54593139 2.107 ENSMUST00000046520.6
 Fkbp14
FK506 binding protein 14
chr7_-_132786914 1.838 ENSMUST00000065371.7
ENSMUST00000106166.1
 Fam53b

family with sequence similarity 53, member B

chr6_+_90465287 1.821 ENSMUST00000113530.1
 Klf15
Kruppel-like factor 15
chr6_-_119467210 1.764 ENSMUST00000118120.1
 Wnt5b
wingless-related MMTV integration site 5B
chr1_-_93342734 1.623 ENSMUST00000027493.3
 Pask
PAS domain containing serine/threonine kinase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.7 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 4.0 GO:0035411 catenin import into nucleus(GO:0035411)
0.5 3.2 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.6 3.1 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.9 2.8 GO:0051464 positive regulation of cortisol secretion(GO:0051464)
0.8 2.5 GO:1901228 regulation of osteoclast proliferation(GO:0090289) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228) negative regulation of bone development(GO:1903011)
0.0 2.3 GO:0000266 mitochondrial fission(GO:0000266)
0.0 2.1 GO:0006338 chromatin remodeling(GO:0006338)
0.0 1.9 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.1 1.8 GO:0072112 renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 1.8 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.2 1.6 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.2 1.5 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.4 1.4 GO:1902990 leading strand elongation(GO:0006272) mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.2 1.4 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.4 1.3 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) olefin metabolic process(GO:1900673)
0.2 1.3 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
0.1 1.3 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.2 1.1 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.1 0.9 GO:0030150 protein import into mitochondrial matrix(GO:0030150)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.5 GO:0031012 extracellular matrix(GO:0031012)
0.0 4.5 GO:0005769 early endosome(GO:0005769)
0.7 4.0 GO:0031262 Ndc80 complex(GO:0031262)
0.0 3.6 GO:0001650 fibrillar center(GO:0001650)
0.0 3.3 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 2.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.6 GO:0070469 respiratory chain(GO:0070469)
0.1 1.5 GO:0045180 basal cortex(GO:0045180)
0.5 1.4 GO:0070557 PCNA-p21 complex(GO:0070557)
0.2 1.3 GO:0045179 apical cortex(GO:0045179)
0.0 1.3 GO:0031526 brush border membrane(GO:0031526)
0.0 1.0 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 0.6 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 0.6 GO:0033093 multivesicular body membrane(GO:0032585) Weibel-Palade body(GO:0033093)
0.1 0.6 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 0.5 GO:0005785 signal recognition particle receptor complex(GO:0005785) dense body(GO:0097433)
0.0 0.4 GO:0005787 signal peptidase complex(GO:0005787)
0.1 0.3 GO:0097361 CIA complex(GO:0097361)
0.0 0.2 GO:0060091 kinocilium(GO:0060091)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.6 GO:0008430 selenium binding(GO:0008430)
0.0 3.6 GO:0003924 GTPase activity(GO:0003924)
0.1 3.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.4 3.1 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.7 2.8 GO:0004966 galanin receptor activity(GO:0004966)
0.0 2.7 GO:0004540 ribonuclease activity(GO:0004540)
0.3 2.5 GO:0036122 BMP binding(GO:0036122)
0.1 2.2 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 2.2 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 1.9 GO:0003954 NADH dehydrogenase activity(GO:0003954)
0.0 1.8 GO:0005109 frizzled binding(GO:0005109)
0.0 1.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.5 1.4 GO:0032139 DNA polymerase processivity factor activity(GO:0030337) dinucleotide insertion or deletion binding(GO:0032139)
0.3 1.3 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.2 1.3 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.1 1.1 GO:0070403 NAD+ binding(GO:0070403)
0.0 1.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 0.8 GO:0070991 medium-chain-acyl-CoA dehydrogenase activity(GO:0070991)
0.1 0.6 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.6 GO:0031489 myosin V binding(GO:0031489)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.0 PID_PLK1_PATHWAY PLK1 signaling events
0.0 2.5 PID_BMP_PATHWAY BMP receptor signaling
0.0 2.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.8 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.4 PID_BARD1_PATHWAY BARD1 signaling events
0.0 1.1 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 1.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.2 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 2.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 2.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.6 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 1.4 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 1.3 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 1.0 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.8 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.8 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.7 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 0.6 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.6 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 0.4 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 0.4 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.4 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.2 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion