Motif ID: Tbx1_Eomes

Z-value: 0.912

Transcription factors associated with Tbx1_Eomes:

Gene SymbolEntrez IDGene Name
Eomes ENSMUSG00000032446.8 Eomes
Tbx1 ENSMUSG00000009097.9 Tbx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Eomesmm10_v2_chr9_+_118478344_1184784510.551.5e-05Click!


Activity profile for motif Tbx1_Eomes.

activity profile for motif Tbx1_Eomes


Sorted Z-values histogram for motif Tbx1_Eomes

Sorted Z-values for motif Tbx1_Eomes



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx1_Eomes

PNG image of the network

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Top targets:


Showing 1 to 20 of 162 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 20.767 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr1_+_6730051 16.320 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr1_-_138847579 13.050 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr4_+_125490688 11.012 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr2_-_13011747 10.263 ENSMUST00000061545.5
 C1ql3
C1q-like 3
chr1_+_6730135 9.741 ENSMUST00000155921.1
 St18
suppression of tumorigenicity 18
chr7_-_28302238 8.968 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr9_-_43239816 8.840 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr6_+_15196949 8.531 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
 Foxp2



forkhead box P2



chr17_+_29093763 7.104 ENSMUST00000023829.6
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr1_+_132316112 6.691 ENSMUST00000082125.5
ENSMUST00000072177.7
 Nuak2

NUAK family, SNF1-like kinase, 2

chr2_+_164562579 6.680 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr2_-_57114970 6.609 ENSMUST00000028166.2
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr6_-_94700137 6.479 ENSMUST00000101126.2
ENSMUST00000032105.4
 Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr11_-_84068357 6.427 ENSMUST00000100705.4
 Dusp14
dual specificity phosphatase 14
chr11_-_84068766 5.627 ENSMUST00000018792.5
 Dusp14
dual specificity phosphatase 14
chr1_+_153665274 5.396 ENSMUST00000152114.1
ENSMUST00000111812.1
 Rgs8

regulator of G-protein signaling 8

chr10_-_92162753 5.363 ENSMUST00000182197.1
 Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr12_+_3891728 4.828 ENSMUST00000172689.1
ENSMUST00000111186.1
 Dnmt3a

DNA methyltransferase 3A

chr18_-_46212595 4.550 ENSMUST00000037011.4
 Trim36
tripartite motif-containing 36

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 26.1 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
1.2 16.7 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
2.6 13.1 GO:0035262 gonad morphogenesis(GO:0035262)
0.1 13.1 GO:0050807 regulation of synapse organization(GO:0050807)
1.0 11.0 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.3 10.5 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
1.8 9.0 GO:0007386 compartment pattern specification(GO:0007386)
0.7 8.5 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.8 7.1 GO:0071493 cellular response to UV-B(GO:0071493)
0.8 7.0 GO:0090527 actin filament reorganization(GO:0090527)
0.2 6.7 GO:0042149 cellular response to glucose starvation(GO:0042149)
1.7 6.6 GO:0051866 general adaptation syndrome(GO:0051866)
2.2 6.5 GO:0032474 otolith morphogenesis(GO:0032474)
0.0 6.4 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.6 4.8 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.2 4.5 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.2 4.5 GO:0007340 acrosome reaction(GO:0007340)
1.1 4.2 GO:0030091 protein repair(GO:0030091)
1.9 3.7 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.2 3.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 25.3 GO:0032993 protein-DNA complex(GO:0032993)
0.4 16.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.4 11.0 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 10.5 GO:0005581 collagen trimer(GO:0005581)
2.4 7.1 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 7.0 GO:0005884 actin filament(GO:0005884)
0.0 6.3 GO:0016607 nuclear speck(GO:0016607)
0.2 4.8 GO:0001741 XY body(GO:0001741)
0.8 4.5 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 4.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.5 3.5 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 3.1 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 3.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.3 2.9 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 2.6 GO:0031965 nuclear membrane(GO:0031965)
0.2 2.5 GO:0005916 fascia adherens(GO:0005916)
0.5 2.4 GO:1990357 terminal web(GO:1990357)
0.6 1.7 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.1 1.7 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 1.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 20.4 GO:0001047 core promoter binding(GO:0001047)
0.4 16.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
2.2 11.0 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.7 10.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 9.0 GO:0005112 Notch binding(GO:0005112)
2.4 7.1 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.9 7.0 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
1.3 6.7 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.0 6.1 GO:0000287 magnesium ion binding(GO:0000287)
0.6 4.8 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.6 4.5 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.7 4.2 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.1 3.7 GO:0008432 JUN kinase binding(GO:0008432)
1.2 3.5 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 3.5 GO:0051015 actin filament binding(GO:0051015)
0.0 3.1 GO:0017048 Rho GTPase binding(GO:0017048)
0.3 3.0 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.5 2.9 GO:0070728 leucine binding(GO:0070728)
0.2 2.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 2.4 GO:0005540 hyaluronic acid binding(GO:0005540)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 9.4 PID_NOTCH_PATHWAY Notch signaling pathway
0.8 7.1 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 6.5 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 4.3 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 3.9 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.5 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 3.1 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 2.7 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.2 2.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 2.4 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 2.1 PID_E2F_PATHWAY E2F transcription factor network
0.0 2.1 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.7 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.3 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.2 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 1.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.0 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.1 0.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.7 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.6 11.0 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.3 7.1 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.2 6.5 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 4.4 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 3.7 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.9 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 2.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 2.4 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.2 2.4 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 2.2 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 2.1 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 1.9 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 1.7 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.7 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 1.5 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.3 1.3 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 1.2 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 1.2 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL Genes involved in Cell surface interactions at the vascular wall
0.1 1.0 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells