Motif ID: Tbx21
Z-value: 1.091
Transcription factors associated with Tbx21:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Tbx21 | ENSMUSG00000001444.2 | Tbx21 |
Top targets:
Showing 1 to 20 of 137 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 74 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 27.3 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.5 | 27.0 | GO:0034605 | cellular response to heat(GO:0034605) |
| 2.0 | 12.0 | GO:0009405 | pathogenesis(GO:0009405) |
| 0.1 | 10.0 | GO:0010977 | negative regulation of neuron projection development(GO:0010977) |
| 0.1 | 9.4 | GO:0060113 | inner ear receptor cell differentiation(GO:0060113) |
| 0.1 | 6.9 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 1.5 | 6.1 | GO:0010040 | response to iron(II) ion(GO:0010040) positive regulation of hydrogen peroxide metabolic process(GO:0010726) negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) regulation of peroxidase activity(GO:2000468) |
| 0.1 | 5.4 | GO:0046847 | filopodium assembly(GO:0046847) |
| 0.5 | 4.9 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.1 | 4.6 | GO:0014047 | glutamate secretion(GO:0014047) |
| 0.5 | 4.4 | GO:0051014 | actin filament severing(GO:0051014) |
| 0.1 | 4.3 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 1.0 | 4.2 | GO:1903860 | negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) |
| 0.4 | 4.2 | GO:0045217 | cell-cell junction maintenance(GO:0045217) |
| 0.0 | 4.0 | GO:0008202 | steroid metabolic process(GO:0008202) |
| 1.3 | 3.8 | GO:2001206 | positive regulation of osteoclast development(GO:2001206) |
| 0.6 | 3.7 | GO:0032796 | uropod organization(GO:0032796) |
| 1.2 | 3.6 | GO:0043379 | rRNA export from nucleus(GO:0006407) memory T cell differentiation(GO:0043379) response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650) |
| 0.1 | 3.6 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
| 0.0 | 3.6 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 50 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 27.3 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.2 | 9.6 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 8.0 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 1.5 | 6.1 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.2 | 4.9 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 4.8 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.1 | 4.6 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 4.2 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.1 | 3.9 | GO:0016592 | mediator complex(GO:0016592) |
| 0.4 | 3.8 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.3 | 3.7 | GO:0032426 | stereocilium tip(GO:0032426) |
| 1.2 | 3.6 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
| 0.1 | 3.5 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.7 | 3.4 | GO:0048476 | Holliday junction resolvase complex(GO:0048476) |
| 0.1 | 3.3 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 3.3 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.2 | 3.0 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 3.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.4 | 2.9 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 0.2 | 2.9 | GO:0031209 | SCAR complex(GO:0031209) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 61 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 26.2 | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) |
| 0.1 | 24.3 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 10.6 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.4 | 9.6 | GO:0031683 | G-protein beta/gamma-subunit complex binding(GO:0031683) |
| 0.4 | 8.0 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.0 | 7.6 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.0 | 6.9 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.3 | 6.7 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 1.0 | 6.1 | GO:0050544 | arachidonic acid binding(GO:0050544) |
| 0.1 | 5.9 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.1 | 5.5 | GO:0019003 | GDP binding(GO:0019003) |
| 0.2 | 5.4 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.1 | 4.9 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.9 | 4.6 | GO:0001640 | adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) |
| 0.0 | 3.9 | GO:0001104 | RNA polymerase II transcription cofactor activity(GO:0001104) |
| 0.3 | 3.7 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.2 | 3.6 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.1 | 3.6 | GO:0008276 | protein methyltransferase activity(GO:0008276) |
| 0.1 | 3.5 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.7 | 3.4 | GO:0017108 | 5'-flap endonuclease activity(GO:0017108) |
Gene overrepresentation in C2:CP category:
Showing 1 to 15 of 15 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 9.6 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.1 | 6.2 | PID_MET_PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.1 | 6.1 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.1 | 4.3 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.0 | 4.3 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 3.6 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.1 | 3.3 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.0 | 3.2 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.1 | 3.0 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.1 | 1.6 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 1.3 | PID_PI3KCI_PATHWAY | Class I PI3K signaling events |
| 0.1 | 1.1 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 1.1 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.0 | 1.0 | PID_P53_REGULATION_PATHWAY | p53 pathway |
| 0.0 | 0.5 | PID_BCR_5PATHWAY | BCR signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 27 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.0 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 1.9 | 9.6 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 8.2 | REACTOME_AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 5.4 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.4 | 4.6 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.0 | 4.2 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.6 | 4.0 | REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 3.9 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.3 | 3.6 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.1 | 3.5 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 2.9 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
| 0.1 | 2.8 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.1 | 2.5 | REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.1 | 2.0 | REACTOME_HYALURONAN_METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.0 | 1.7 | REACTOME_MRNA_3_END_PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.1 | 1.6 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 1.6 | REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION | Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription |
| 0.3 | 1.5 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 1.4 | REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.0 | 1.3 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
