Motif ID: Tbx4
Z-value: 1.103
Transcription factors associated with Tbx4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Tbx4 | ENSMUSG00000000094.6 | Tbx4 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 16.3 | GO:0035262 | gonad morphogenesis(GO:0035262) |
| 2.7 | 8.2 | GO:0035934 | corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852) |
| 2.7 | 10.7 | GO:0030091 | protein repair(GO:0030091) |
| 2.5 | 7.4 | GO:0032474 | otolith morphogenesis(GO:0032474) |
| 2.5 | 29.6 | GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269) |
| 2.3 | 11.5 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 1.8 | 5.5 | GO:0001951 | intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896) |
| 1.4 | 12.6 | GO:0071493 | cellular response to UV-B(GO:0071493) |
| 1.3 | 11.4 | GO:0090527 | actin filament reorganization(GO:0090527) |
| 1.1 | 15.9 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) |
| 1.1 | 4.5 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 1.0 | 12.4 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
| 1.0 | 2.9 | GO:0045014 | detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594) |
| 0.8 | 6.8 | GO:0044027 | hypermethylation of CpG island(GO:0044027) |
| 0.8 | 8.8 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
| 0.8 | 6.8 | GO:0010587 | miRNA catabolic process(GO:0010587) |
| 0.7 | 6.1 | GO:0048752 | semicircular canal morphogenesis(GO:0048752) |
| 0.6 | 2.5 | GO:0060032 | notochord regression(GO:0060032) |
| 0.6 | 8.3 | GO:0060059 | embryonic retina morphogenesis in camera-type eye(GO:0060059) |
| 0.6 | 1.7 | GO:0044333 | Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041) |
| 0.6 | 1.7 | GO:0051866 | general adaptation syndrome(GO:0051866) |
| 0.5 | 9.5 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
| 0.4 | 2.8 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.4 | 2.8 | GO:0006297 | nucleotide-excision repair, DNA gap filling(GO:0006297) |
| 0.4 | 1.5 | GO:0007412 | axon target recognition(GO:0007412) |
| 0.3 | 11.8 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.3 | 2.0 | GO:0051189 | molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189) |
| 0.3 | 0.6 | GO:1902202 | regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) |
| 0.3 | 2.2 | GO:0045213 | neurotransmitter receptor metabolic process(GO:0045213) |
| 0.3 | 2.4 | GO:0048625 | myoblast fate commitment(GO:0048625) |
| 0.3 | 10.9 | GO:0007129 | synapsis(GO:0007129) |
| 0.3 | 7.5 | GO:0007340 | acrosome reaction(GO:0007340) |
| 0.3 | 0.8 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 0.3 | 2.9 | GO:0071318 | cellular response to ATP(GO:0071318) |
| 0.3 | 5.9 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 0.3 | 2.1 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.3 | 0.8 | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
| 0.2 | 0.6 | GO:0006546 | glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464) |
| 0.2 | 2.0 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.2 | 2.3 | GO:0097067 | cellular response to thyroid hormone stimulus(GO:0097067) |
| 0.2 | 3.4 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 0.2 | 5.9 | GO:0042149 | cellular response to glucose starvation(GO:0042149) |
| 0.1 | 2.0 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
| 0.1 | 10.1 | GO:0008543 | fibroblast growth factor receptor signaling pathway(GO:0008543) |
| 0.1 | 0.4 | GO:0035521 | monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522) |
| 0.1 | 0.3 | GO:0048633 | positive regulation of skeletal muscle tissue growth(GO:0048633) |
| 0.1 | 16.1 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
| 0.1 | 0.6 | GO:0019348 | dolichol metabolic process(GO:0019348) |
| 0.1 | 0.3 | GO:0071638 | negative regulation of monocyte chemotactic protein-1 production(GO:0071638) |
| 0.1 | 4.1 | GO:0043666 | regulation of phosphoprotein phosphatase activity(GO:0043666) |
| 0.1 | 3.3 | GO:0035019 | somatic stem cell population maintenance(GO:0035019) |
| 0.1 | 0.8 | GO:0001675 | acrosome assembly(GO:0001675) |
| 0.1 | 1.0 | GO:0006465 | signal peptide processing(GO:0006465) |
| 0.0 | 1.4 | GO:0071385 | cellular response to glucocorticoid stimulus(GO:0071385) |
| 0.0 | 1.9 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.0 | 2.0 | GO:0030500 | regulation of bone mineralization(GO:0030500) |
| 0.0 | 0.4 | GO:0007202 | activation of phospholipase C activity(GO:0007202) |
| 0.0 | 1.1 | GO:0006493 | protein O-linked glycosylation(GO:0006493) |
| 0.0 | 0.6 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.0 | 1.5 | GO:2000177 | regulation of neural precursor cell proliferation(GO:2000177) |
| 0.0 | 0.3 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.0 | 1.3 | GO:0043473 | pigmentation(GO:0043473) |
| 0.0 | 1.2 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.0 | 2.3 | GO:0060348 | bone development(GO:0060348) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 12.6 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 3.7 | 11.0 | GO:0097135 | cyclin E2-CDK2 complex(GO:0097135) |
| 1.1 | 5.5 | GO:1990357 | terminal web(GO:1990357) |
| 1.0 | 5.9 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.4 | 15.9 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.4 | 2.8 | GO:0031415 | NatA complex(GO:0031415) |
| 0.3 | 1.3 | GO:0031084 | BLOC-2 complex(GO:0031084) |
| 0.3 | 2.4 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.3 | 6.8 | GO:0001741 | XY body(GO:0001741) |
| 0.2 | 2.9 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.2 | 2.5 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.2 | 9.5 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.2 | 28.1 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.1 | 2.0 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.1 | 1.7 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.1 | 1.0 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.1 | 1.6 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.1 | 6.8 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 7.5 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.1 | 1.1 | GO:0005922 | connexon complex(GO:0005922) |
| 0.1 | 5.5 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 11.4 | GO:0005884 | actin filament(GO:0005884) |
| 0.1 | 2.2 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 2.0 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 2.8 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.0 | 0.6 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.0 | 16.8 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 1.7 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 0.7 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.0 | 1.5 | GO:0035097 | histone methyltransferase complex(GO:0035097) |
| 0.0 | 1.4 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 4.7 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 1.9 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 1.0 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 7.5 | GO:0009986 | cell surface(GO:0009986) |
| 0.0 | 2.8 | GO:0031965 | nuclear membrane(GO:0031965) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 12.6 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
| 3.5 | 17.4 | GO:0019828 | aspartic-type endopeptidase inhibitor activity(GO:0019828) |
| 3.4 | 10.1 | GO:0005105 | type 1 fibroblast growth factor receptor binding(GO:0005105) |
| 1.8 | 10.7 | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity(GO:0033743) |
| 1.4 | 11.4 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 0.9 | 4.5 | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) |
| 0.8 | 6.8 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.8 | 5.9 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.8 | 11.8 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.6 | 6.8 | GO:0002151 | G-quadruplex RNA binding(GO:0002151) |
| 0.4 | 6.6 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.4 | 1.6 | GO:0086038 | calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038) |
| 0.4 | 12.9 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.4 | 15.9 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.4 | 2.9 | GO:0046790 | virion binding(GO:0046790) |
| 0.3 | 11.5 | GO:0005112 | Notch binding(GO:0005112) |
| 0.2 | 4.0 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.2 | 0.6 | GO:0005171 | hepatocyte growth factor receptor binding(GO:0005171) |
| 0.2 | 2.8 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.2 | 8.4 | GO:0070888 | E-box binding(GO:0070888) |
| 0.2 | 36.7 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.2 | 0.6 | GO:0003976 | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976) |
| 0.2 | 2.0 | GO:0016783 | sulfurtransferase activity(GO:0016783) |
| 0.1 | 2.2 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.1 | 20.8 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 1.5 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.1 | 2.8 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.1 | 7.9 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.1 | 1.1 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.1 | 0.3 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
| 0.1 | 1.7 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 3.4 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.1 | 1.1 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.1 | 1.5 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.4 | GO:0016004 | phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229) |
| 0.0 | 1.4 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 0.7 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.0 | 0.6 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.0 | 5.5 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 2.5 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 5.9 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.0 | 1.0 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 2.0 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.0 | 1.2 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.0 | 1.5 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.0 | 8.9 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.0 | 2.8 | GO:0008022 | protein C-terminus binding(GO:0008022) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 12.6 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.8 | 11.0 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.3 | 2.0 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.2 | 7.3 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.2 | 9.5 | PID_RHOA_PATHWAY | RhoA signaling pathway |
| 0.2 | 9.6 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
| 0.1 | 4.0 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.1 | 8.6 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.1 | 11.5 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.1 | 6.1 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 6.8 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 5.1 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.1 | 2.9 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.0 | 2.1 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.0 | 1.5 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 2.4 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 0.6 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.6 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.3 | PID_IL2_PI3K_PATHWAY | IL2 signaling events mediated by PI3K |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 10.1 | REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 1.1 | 4.5 | REACTOME_ETHANOL_OXIDATION | Genes involved in Ethanol oxidation |
| 0.5 | 12.6 | REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.4 | 11.0 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.3 | 2.9 | REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.3 | 4.0 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
| 0.2 | 2.2 | REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.2 | 8.2 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.2 | 7.3 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 2.9 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 15.9 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
| 0.1 | 1.0 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 | Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) |
| 0.1 | 1.1 | REACTOME_GAP_JUNCTION_ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 0.6 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.0 | 2.1 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 6.7 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 1.1 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 1.7 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.6 | REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 0.3 | REACTOME_MTORC1_MEDIATED_SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 0.7 | REACTOME_MRNA_3_END_PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.0 | 1.5 | REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
