Motif ID: Tbx4

Z-value: 1.103


Transcription factors associated with Tbx4:

Gene SymbolEntrez IDGene Name
Tbx4 ENSMUSG00000000094.6 Tbx4



Activity profile for motif Tbx4.

activity profile for motif Tbx4


Sorted Z-values histogram for motif Tbx4

Sorted Z-values for motif Tbx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 116 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 22.057 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr1_+_6730051 19.479 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr2_+_164562579 17.378 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr1_-_138847579 16.289 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr17_+_29093763 12.636 ENSMUST00000023829.6
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr9_-_43239816 12.546 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr6_+_15196949 12.435 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
 Foxp2



forkhead box P2



chr7_-_28302238 11.468 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr10_-_120899067 10.652 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr1_+_6730135 10.090 ENSMUST00000155921.1
 St18
suppression of tumorigenicity 18
chr14_-_70642268 10.070 ENSMUST00000022697.5
 Fgf17
fibroblast growth factor 17
chr5_+_115908644 9.460 ENSMUST00000141101.1
 Cit
citron
chr7_-_115824699 8.813 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr6_+_7555053 8.194 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chrX_-_53269020 7.774 ENSMUST00000114838.1
 Fam122b
family with sequence similarity 122, member B
chr11_-_115813621 7.653 ENSMUST00000041684.4
ENSMUST00000156812.1
 Caskin2

CASK-interacting protein 2

chr6_-_94700137 7.428 ENSMUST00000101126.2
ENSMUST00000032105.4
 Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr9_+_35421541 7.265 ENSMUST00000119129.2
 Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr4_+_11191726 7.174 ENSMUST00000029866.9
ENSMUST00000108324.3
 Ccne2

cyclin E2

chr4_-_134018829 6.839 ENSMUST00000051674.2
 Lin28a
lin-28 homolog A (C. elegans)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 29.6 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
3.3 16.3 GO:0035262 gonad morphogenesis(GO:0035262)
0.1 16.1 GO:0010466 negative regulation of peptidase activity(GO:0010466)
1.1 15.9 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
1.4 12.6 GO:0071493 cellular response to UV-B(GO:0071493)
1.0 12.4 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.3 11.8 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
2.3 11.5 GO:0007386 compartment pattern specification(GO:0007386)
1.3 11.4 GO:0090527 actin filament reorganization(GO:0090527)
0.3 10.9 GO:0007129 synapsis(GO:0007129)
2.7 10.7 GO:0030091 protein repair(GO:0030091)
0.1 10.1 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.5 9.5 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.8 8.8 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.6 8.3 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
2.7 8.2 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.3 7.5 GO:0007340 acrosome reaction(GO:0007340)
2.5 7.4 GO:0032474 otolith morphogenesis(GO:0032474)
0.8 6.8 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.8 6.8 GO:0010587 miRNA catabolic process(GO:0010587)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 28.1 GO:0032993 protein-DNA complex(GO:0032993)
0.0 16.8 GO:0005667 transcription factor complex(GO:0005667)
0.4 15.9 GO:0032809 neuronal cell body membrane(GO:0032809)
4.2 12.6 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 11.4 GO:0005884 actin filament(GO:0005884)
3.7 11.0 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.2 9.5 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 7.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 7.5 GO:0009986 cell surface(GO:0009986)
0.3 6.8 GO:0001741 XY body(GO:0001741)
0.1 6.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
1.0 5.9 GO:0032299 ribonuclease H2 complex(GO:0032299)
1.1 5.5 GO:1990357 terminal web(GO:1990357)
0.1 5.5 GO:0005581 collagen trimer(GO:0005581)
0.0 4.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.2 2.9 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.4 2.8 GO:0031415 NatA complex(GO:0031415)
0.0 2.8 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 2.8 GO:0031965 nuclear membrane(GO:0031965)
0.2 2.5 GO:0097542 ciliary tip(GO:0097542)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 36.7 GO:0001047 core promoter binding(GO:0001047)
0.1 20.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
3.5 17.4 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.4 15.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.4 12.9 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
4.2 12.6 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.8 11.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.3 11.5 GO:0005112 Notch binding(GO:0005112)
1.4 11.4 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
1.8 10.7 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
3.4 10.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 8.9 GO:0008270 zinc ion binding(GO:0008270)
0.2 8.4 GO:0070888 E-box binding(GO:0070888)
0.1 7.9 GO:0097110 scaffold protein binding(GO:0097110)
0.8 6.8 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.6 6.8 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.4 6.6 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.8 5.9 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 5.9 GO:0000287 magnesium ion binding(GO:0000287)
0.0 5.5 GO:0051015 actin filament binding(GO:0051015)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 12.6 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 11.5 PID_NOTCH_PATHWAY Notch signaling pathway
0.8 11.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 9.6 PID_ERBB4_PATHWAY ErbB4 signaling events
0.2 9.5 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 8.6 PID_FGF_PATHWAY FGF signaling pathway
0.2 7.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 6.8 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 6.1 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 5.1 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 4.0 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 2.9 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 2.4 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.1 PID_PLK1_PATHWAY PLK1 signaling events
0.3 2.0 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.5 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.3 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.9 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.5 12.6 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.4 11.0 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
1.3 10.1 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.2 8.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 7.3 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 6.7 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.1 4.5 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.3 4.0 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.3 2.9 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.2 2.9 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.2 2.2 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 2.1 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.7 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.5 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.1 1.1 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 1.1 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 1.0 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.7 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.6 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling