Motif ID: Tbx5

Z-value: 0.671


Transcription factors associated with Tbx5:

Gene SymbolEntrez IDGene Name
Tbx5 ENSMUSG00000018263.8 Tbx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbx5mm10_v2_chr5_+_119834663_119834663-0.066.7e-01Click!


Activity profile for motif Tbx5.

activity profile for motif Tbx5


Sorted Z-values histogram for motif Tbx5

Sorted Z-values for motif Tbx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 6.983 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr1_-_138848576 5.676 ENSMUST00000112030.2
 Lhx9
LIM homeobox protein 9
chr14_+_122475397 4.790 ENSMUST00000075888.5
 Zic2
zinc finger protein of the cerebellum 2
chr7_-_28302238 3.633 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr5_-_5514730 3.381 ENSMUST00000115445.1
ENSMUST00000179804.1
ENSMUST00000125110.1
ENSMUST00000115446.1
 Cldn12



claudin 12



chr9_-_43239816 3.365 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr10_+_93641041 3.334 ENSMUST00000020204.4
 Ntn4
netrin 4
chr15_-_98004634 3.181 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr15_-_98004695 3.157 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr3_+_108383829 3.009 ENSMUST00000090561.3
ENSMUST00000102629.1
ENSMUST00000128089.1
 Psrc1


proline/serine-rich coiled-coil 1


chr5_-_5514873 2.965 ENSMUST00000060947.7
 Cldn12
claudin 12
chr3_+_126596951 2.803 ENSMUST00000106402.1
 Camk2d
calcium/calmodulin-dependent protein kinase II, delta
chr10_-_120899067 2.788 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr3_+_126596993 2.709 ENSMUST00000163226.1
ENSMUST00000066466.6
ENSMUST00000169051.1
 Camk2d


calcium/calmodulin-dependent protein kinase II, delta


chrX_+_100625737 2.620 ENSMUST00000048962.3
 Kif4
kinesin family member 4
chr4_-_134018829 2.612 ENSMUST00000051674.2
 Lin28a
lin-28 homolog A (C. elegans)
chr7_-_79594924 2.578 ENSMUST00000172788.1
 Rhcg
Rhesus blood group-associated C glycoprotein
chr4_-_41517326 2.544 ENSMUST00000030152.6
ENSMUST00000095126.4
 1110017D15Rik

RIKEN cDNA 1110017D15 gene

chr17_-_70851189 2.396 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr4_+_128883549 2.312 ENSMUST00000035667.8
 Trim62
tripartite motif-containing 62

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 150 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 7.3 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
0.5 6.3 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
1.1 5.7 GO:0035262 gonad morphogenesis(GO:0035262)
1.2 4.8 GO:1900224 positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.4 3.9 GO:0010587 miRNA catabolic process(GO:0010587)
0.7 3.6 GO:0007386 compartment pattern specification(GO:0007386)
0.4 3.6 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.5 3.4 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.7 3.3 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.2 3.1 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.1 3.0 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.7 2.8 GO:0030091 protein repair(GO:0030091)
0.9 2.6 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.1 2.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 2.3 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 2.3 GO:0010719 negative regulation of epithelial to mesenchymal transition(GO:0010719)
0.0 2.1 GO:0051028 mRNA transport(GO:0051028)
0.0 2.1 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 1.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 1.8 GO:0090527 actin filament reorganization(GO:0090527)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.4 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 6.3 GO:0016604 nuclear body(GO:0016604)
0.2 6.2 GO:0043194 axon initial segment(GO:0043194)
0.5 5.9 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 4.7 GO:0005667 transcription factor complex(GO:0005667)
0.0 4.0 GO:0005604 basement membrane(GO:0005604)
0.4 3.4 GO:0002177 manchette(GO:0002177)
0.1 2.8 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 2.6 GO:0045171 intercellular bridge(GO:0045171)
0.0 2.5 GO:0009925 basal plasma membrane(GO:0009925)
0.0 2.4 GO:0005681 spliceosomal complex(GO:0005681)
0.0 2.3 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 2.1 GO:0005876 spindle microtubule(GO:0005876)
0.0 1.9 GO:0005884 actin filament(GO:0005884)
0.0 1.7 GO:0005719 nuclear euchromatin(GO:0005719)
0.3 1.6 GO:1990357 terminal web(GO:1990357)
0.5 1.4 GO:0035061 interchromatin granule(GO:0035061)
0.1 1.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 1.4 GO:0016589 NURF complex(GO:0016589)
0.0 1.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.6 GO:0005198 structural molecule activity(GO:0005198)
0.9 7.3 GO:0031432 titin binding(GO:0031432)
1.3 6.3 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 5.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 4.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 3.7 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 3.6 GO:0005112 Notch binding(GO:0005112)
0.0 3.5 GO:0004386 helicase activity(GO:0004386)
0.4 3.3 GO:0043237 laminin-1 binding(GO:0043237)
0.1 3.1 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.5 2.8 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.3 2.8 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.0 2.8 GO:0051015 actin filament binding(GO:0051015)
0.1 2.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 2.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 2.4 GO:0070410 co-SMAD binding(GO:0070410)
0.6 1.9 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.2 1.8 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.2 1.8 GO:0008420 CTD phosphatase activity(GO:0008420)
0.2 1.7 GO:0003680 AT DNA binding(GO:0003680)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.9 NABA_COLLAGENS Genes encoding collagen proteins
0.1 5.0 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 4.9 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 3.3 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 3.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 2.9 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 2.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.7 PID_FGF_PATHWAY FGF signaling pathway
0.0 1.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.5 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 1.3 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 1.2 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 1.1 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.0 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.9 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.8 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 0.8 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.7 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 0.7 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.7 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.9 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 6.9 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 5.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 4.9 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 3.4 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 2.4 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 2.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 1.9 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 1.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.8 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 1.7 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.4 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 1.3 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 1.2 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.2 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 1.2 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 1.1 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 1.0 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 1.0 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 1.0 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells