Motif ID: Tcf21_Msc

Z-value: 1.116

Transcription factors associated with Tcf21_Msc:

Gene SymbolEntrez IDGene Name
Msc ENSMUSG00000025930.5 Msc
Tcf21 ENSMUSG00000045680.7 Tcf21



Activity profile for motif Tcf21_Msc.

activity profile for motif Tcf21_Msc


Sorted Z-values histogram for motif Tcf21_Msc

Sorted Z-values for motif Tcf21_Msc



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf21_Msc

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_90537242 7.346 ENSMUST00000098911.3
 S100a16
S100 calcium binding protein A16
chr4_+_144893077 7.062 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr1_-_14310198 6.371 ENSMUST00000168081.2
ENSMUST00000027066.6
 Eya1

eyes absent 1 homolog (Drosophila)

chr8_-_122432924 6.342 ENSMUST00000017604.8
 Cyba
cytochrome b-245, alpha polypeptide
chr3_+_90537306 6.296 ENSMUST00000107335.1
 S100a16
S100 calcium binding protein A16
chr5_-_28210022 6.170 ENSMUST00000118882.1
 Cnpy1
canopy 1 homolog (zebrafish)
chr8_+_94172618 6.122 ENSMUST00000034214.6
 Mt2
metallothionein 2
chr2_-_105399286 6.004 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr13_-_100786402 5.530 ENSMUST00000174038.1
ENSMUST00000091295.7
ENSMUST00000072119.8
 Ccnb1


cyclin B1


chr11_+_99864476 5.005 ENSMUST00000092694.3
 Gm11559
predicted gene 11559
chr7_+_45216671 4.808 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr5_-_140389188 4.749 ENSMUST00000031539.7
 Snx8
sorting nexin 8
chr15_+_78926720 4.537 ENSMUST00000089377.5
 Lgals1
lectin, galactose binding, soluble 1
chr14_-_20181773 4.521 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr4_+_144892813 4.424 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr11_+_113619318 4.348 ENSMUST00000146390.2
ENSMUST00000106630.1
 Sstr2

somatostatin receptor 2

chr12_-_91779129 4.096 ENSMUST00000170077.1
 Ston2
stonin 2
chr6_+_29398920 4.082 ENSMUST00000181464.1
ENSMUST00000180829.1
 Ccdc136

coiled-coil domain containing 136

chr14_+_55478753 4.049 ENSMUST00000022821.6
 Dhrs4
dehydrogenase/reductase (SDR family) member 4
chr2_-_170131156 4.009 ENSMUST00000063710.6
 Zfp217
zinc finger protein 217

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 207 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 14.9 GO:0042572 retinol metabolic process(GO:0042572)
0.1 10.2 GO:0051592 response to calcium ion(GO:0051592)
1.2 7.4 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.5 6.4 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
1.3 6.3 GO:0003105 negative regulation of glomerular filtration(GO:0003105) positive regulation of NAD(P)H oxidase activity(GO:0033864) positive regulation of toll-like receptor 2 signaling pathway(GO:0034137)
1.5 6.1 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
1.8 5.5 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
0.6 5.1 GO:0030035 microspike assembly(GO:0030035)
0.2 4.8 GO:0048368 lateral mesoderm development(GO:0048368)
0.4 4.7 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.8 4.5 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.4 4.3 GO:0030432 peristalsis(GO:0030432)
0.4 4.1 GO:0009404 toxin metabolic process(GO:0009404)
0.1 4.1 GO:0007520 myoblast fusion(GO:0007520)
0.1 4.1 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.6 4.0 GO:0042574 retinal metabolic process(GO:0042574)
0.1 4.0 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.8 3.8 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.3 3.7 GO:0001675 acrosome assembly(GO:0001675)
0.4 3.5 GO:0090527 actin filament reorganization(GO:0090527)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 14.6 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 14.4 GO:0005615 extracellular space(GO:0005615)
0.1 8.3 GO:0032993 protein-DNA complex(GO:0032993)
0.1 8.1 GO:0030175 filopodium(GO:0030175)
0.0 8.1 GO:0005667 transcription factor complex(GO:0005667)
1.3 6.3 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 6.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
1.4 5.5 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 5.5 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 4.9 GO:0031901 early endosome membrane(GO:0031901)
1.6 4.8 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 4.8 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.2 4.1 GO:0002080 acrosomal membrane(GO:0002080)
0.1 4.1 GO:0031526 brush border membrane(GO:0031526)
0.1 4.0 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 3.3 GO:0036064 ciliary basal body(GO:0036064)
0.2 3.1 GO:0031527 filopodium membrane(GO:0031527)
0.0 3.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 2.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 147 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 14.9 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 13.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 10.9 GO:0005509 calcium ion binding(GO:0005509)
1.2 7.1 GO:0001069 regulatory region RNA binding(GO:0001069)
1.6 6.3 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
1.4 5.5 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.3 4.8 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 4.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.4 4.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 4.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
1.3 4.0 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.6 3.8 GO:0035184 histone threonine kinase activity(GO:0035184)
0.7 3.7 GO:0005534 galactose binding(GO:0005534)
0.5 3.7 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 3.6 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.2 3.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 3.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 3.4 GO:0016805 dipeptidase activity(GO:0016805)
0.0 3.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 3.1 GO:0042393 histone binding(GO:0042393)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 7.0 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 4.9 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.2 4.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 4.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 4.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 3.8 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 3.2 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 2.9 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 2.4 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 2.3 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.1 2.3 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 2.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 2.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 2.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.9 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.9 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.2 1.5 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 1.5 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 1.5 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.0 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 7.9 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 7.3 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.2 6.3 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.2 5.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.6 5.5 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1 5.3 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 3.5 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.2 3.0 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 2.9 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.4 2.7 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 2.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 2.7 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events
0.1 2.5 REACTOME_MUSCLE_CONTRACTION Genes involved in Muscle contraction
0.2 2.4 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.3 1.8 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 1.8 REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in RORA Activates Circadian Expression
0.0 1.7 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase