Motif ID: Tcf21_Msc
Z-value: 1.116
Transcription factors associated with Tcf21_Msc:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Msc | ENSMUSG00000025930.5 | Msc |
| Tcf21 | ENSMUSG00000045680.7 | Tcf21 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 5.5 | GO:0031660 | regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) |
| 1.5 | 6.1 | GO:0010273 | detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169) |
| 1.4 | 14.9 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 1.3 | 6.3 | GO:0003105 | negative regulation of glomerular filtration(GO:0003105) positive regulation of NAD(P)H oxidase activity(GO:0033864) positive regulation of toll-like receptor 2 signaling pathway(GO:0034137) |
| 1.2 | 7.4 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 1.0 | 3.1 | GO:1990523 | bone regeneration(GO:1990523) |
| 1.0 | 3.0 | GO:0035622 | intrahepatic bile duct development(GO:0035622) renal vesicle induction(GO:0072034) |
| 0.8 | 3.8 | GO:0035405 | histone-threonine phosphorylation(GO:0035405) |
| 0.8 | 4.5 | GO:0046598 | positive regulation of viral entry into host cell(GO:0046598) |
| 0.7 | 2.2 | GO:1903070 | negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070) |
| 0.7 | 2.1 | GO:0036292 | DNA rewinding(GO:0036292) |
| 0.7 | 2.8 | GO:0002337 | B-1a B cell differentiation(GO:0002337) |
| 0.7 | 2.0 | GO:1904760 | myofibroblast differentiation(GO:0036446) regulation of myofibroblast differentiation(GO:1904760) |
| 0.6 | 4.0 | GO:0042574 | retinal metabolic process(GO:0042574) |
| 0.6 | 2.9 | GO:0061511 | centriole elongation(GO:0061511) |
| 0.6 | 5.1 | GO:0030035 | microspike assembly(GO:0030035) |
| 0.5 | 1.6 | GO:2000564 | CD8-positive, alpha-beta T cell proliferation(GO:0035740) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) |
| 0.5 | 6.4 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
| 0.5 | 1.5 | GO:0003032 | detection of oxygen(GO:0003032) |
| 0.5 | 1.4 | GO:0046381 | CMP-N-acetylneuraminate metabolic process(GO:0046381) |
| 0.5 | 1.4 | GO:0002586 | positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588) |
| 0.5 | 1.4 | GO:0032650 | regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913) |
| 0.4 | 1.3 | GO:1901420 | negative regulation of response to alcohol(GO:1901420) |
| 0.4 | 1.3 | GO:0006553 | lysine metabolic process(GO:0006553) |
| 0.4 | 4.7 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.4 | 2.1 | GO:1902732 | positive regulation of chondrocyte proliferation(GO:1902732) |
| 0.4 | 1.2 | GO:1901052 | sarcosine metabolic process(GO:1901052) sarcosine catabolic process(GO:1901053) |
| 0.4 | 2.0 | GO:1900109 | regulation of histone H3-K9 dimethylation(GO:1900109) |
| 0.4 | 4.3 | GO:0030432 | peristalsis(GO:0030432) |
| 0.4 | 2.6 | GO:0060372 | regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372) |
| 0.4 | 4.1 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.4 | 1.5 | GO:0046210 | nitrate catabolic process(GO:0043602) nitric oxide catabolic process(GO:0046210) cellular organohalogen metabolic process(GO:0090345) cellular organofluorine metabolic process(GO:0090346) |
| 0.4 | 1.1 | GO:0098968 | neurotransmitter receptor transport postsynaptic membrane to endosome(GO:0098968) |
| 0.4 | 1.8 | GO:0006564 | L-serine biosynthetic process(GO:0006564) |
| 0.4 | 1.8 | GO:0046601 | positive regulation of centriole replication(GO:0046601) |
| 0.4 | 3.5 | GO:0090527 | actin filament reorganization(GO:0090527) |
| 0.3 | 1.7 | GO:0010668 | ectodermal cell differentiation(GO:0010668) |
| 0.3 | 1.7 | GO:0000454 | snoRNA guided rRNA pseudouridine synthesis(GO:0000454) |
| 0.3 | 1.3 | GO:0072272 | proximal/distal pattern formation involved in metanephric nephron development(GO:0072272) |
| 0.3 | 1.3 | GO:1904451 | regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453) |
| 0.3 | 0.9 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.3 | 3.1 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
| 0.3 | 1.5 | GO:0032224 | positive regulation of synaptic transmission, cholinergic(GO:0032224) |
| 0.3 | 2.9 | GO:0042095 | interferon-gamma biosynthetic process(GO:0042095) |
| 0.3 | 3.7 | GO:0001675 | acrosome assembly(GO:0001675) |
| 0.3 | 1.1 | GO:0010891 | negative regulation of sequestering of triglyceride(GO:0010891) positive regulation of triglyceride catabolic process(GO:0010898) |
| 0.3 | 3.4 | GO:0014842 | regulation of skeletal muscle satellite cell proliferation(GO:0014842) |
| 0.3 | 2.5 | GO:0098700 | neurotransmitter loading into synaptic vesicle(GO:0098700) |
| 0.3 | 0.8 | GO:0044339 | canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339) |
| 0.3 | 1.9 | GO:0043383 | negative T cell selection(GO:0043383) negative thymic T cell selection(GO:0045060) |
| 0.3 | 2.7 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 0.3 | 2.6 | GO:0042473 | outer ear morphogenesis(GO:0042473) |
| 0.2 | 2.7 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.2 | 3.4 | GO:2000096 | segment specification(GO:0007379) positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.2 | 4.8 | GO:0048368 | lateral mesoderm development(GO:0048368) |
| 0.2 | 2.1 | GO:0006013 | mannose metabolic process(GO:0006013) |
| 0.2 | 0.7 | GO:0036091 | positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) |
| 0.2 | 0.9 | GO:0090472 | dibasic protein processing(GO:0090472) |
| 0.2 | 2.5 | GO:0046643 | regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643) |
| 0.2 | 0.9 | GO:1905076 | regulation of interleukin-17 secretion(GO:1905076) positive regulation of T-helper 17 type immune response(GO:2000318) |
| 0.2 | 2.7 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.2 | 1.7 | GO:0043951 | negative regulation of cAMP-mediated signaling(GO:0043951) |
| 0.2 | 0.6 | GO:0006030 | chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032) |
| 0.2 | 3.5 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) |
| 0.2 | 2.3 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
| 0.2 | 0.6 | GO:0016332 | establishment or maintenance of polarity of embryonic epithelium(GO:0016332) |
| 0.2 | 2.7 | GO:0048199 | vesicle targeting, to, from or within Golgi(GO:0048199) |
| 0.2 | 0.8 | GO:1900220 | semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220) |
| 0.2 | 1.5 | GO:0015074 | DNA integration(GO:0015074) |
| 0.2 | 0.2 | GO:0021593 | rhombomere morphogenesis(GO:0021593) |
| 0.2 | 0.5 | GO:0010757 | negative regulation of plasminogen activation(GO:0010757) |
| 0.2 | 1.1 | GO:0003383 | apical constriction(GO:0003383) |
| 0.2 | 1.1 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
| 0.2 | 0.7 | GO:0071105 | response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105) |
| 0.2 | 1.0 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.2 | 2.5 | GO:1902004 | positive regulation of beta-amyloid formation(GO:1902004) |
| 0.2 | 0.5 | GO:0032286 | central nervous system myelin maintenance(GO:0032286) |
| 0.2 | 0.8 | GO:0046864 | retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143) |
| 0.2 | 0.6 | GO:0006547 | histidine metabolic process(GO:0006547) |
| 0.2 | 1.8 | GO:0032000 | positive regulation of fatty acid beta-oxidation(GO:0032000) |
| 0.1 | 0.4 | GO:0019074 | viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074) |
| 0.1 | 0.9 | GO:2000095 | regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095) |
| 0.1 | 3.0 | GO:0040034 | regulation of development, heterochronic(GO:0040034) |
| 0.1 | 0.7 | GO:0050912 | detection of chemical stimulus involved in sensory perception(GO:0050907) detection of chemical stimulus involved in sensory perception of taste(GO:0050912) |
| 0.1 | 0.4 | GO:0061365 | positive regulation of triglyceride lipase activity(GO:0061365) |
| 0.1 | 1.7 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
| 0.1 | 1.0 | GO:0048625 | embryonic hindgut morphogenesis(GO:0048619) myoblast fate commitment(GO:0048625) |
| 0.1 | 1.3 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.1 | 0.9 | GO:0014043 | negative regulation of neuron maturation(GO:0014043) |
| 0.1 | 0.7 | GO:0010888 | negative regulation of lipid storage(GO:0010888) |
| 0.1 | 1.9 | GO:0006721 | terpenoid metabolic process(GO:0006721) |
| 0.1 | 1.4 | GO:0035994 | response to muscle stretch(GO:0035994) |
| 0.1 | 0.5 | GO:0072365 | regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365) |
| 0.1 | 1.5 | GO:0032695 | negative regulation of interleukin-12 production(GO:0032695) |
| 0.1 | 1.0 | GO:0090205 | positive regulation of cholesterol biosynthetic process(GO:0045542) positive regulation of cholesterol metabolic process(GO:0090205) |
| 0.1 | 0.8 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 0.1 | 0.7 | GO:1900113 | negative regulation of histone H3-K9 trimethylation(GO:1900113) |
| 0.1 | 2.1 | GO:0048240 | sperm capacitation(GO:0048240) |
| 0.1 | 4.1 | GO:0007520 | myoblast fusion(GO:0007520) |
| 0.1 | 1.3 | GO:1901629 | regulation of presynaptic membrane organization(GO:1901629) |
| 0.1 | 0.6 | GO:0051790 | short-chain fatty acid biosynthetic process(GO:0051790) |
| 0.1 | 2.9 | GO:0001937 | negative regulation of endothelial cell proliferation(GO:0001937) |
| 0.1 | 3.3 | GO:0035458 | cellular response to interferon-beta(GO:0035458) |
| 0.1 | 0.6 | GO:0003406 | retinal pigment epithelium development(GO:0003406) |
| 0.1 | 1.6 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.1 | 3.1 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.1 | 2.1 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
| 0.1 | 3.0 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.1 | 3.0 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.1 | 10.2 | GO:0051592 | response to calcium ion(GO:0051592) |
| 0.1 | 0.2 | GO:0035106 | operant conditioning(GO:0035106) |
| 0.1 | 1.6 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 0.1 | 0.7 | GO:0042487 | regulation of odontogenesis of dentin-containing tooth(GO:0042487) |
| 0.1 | 0.9 | GO:0046498 | S-adenosylhomocysteine metabolic process(GO:0046498) |
| 0.1 | 2.2 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 0.1 | 0.3 | GO:0035519 | protein K29-linked ubiquitination(GO:0035519) |
| 0.1 | 4.1 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
| 0.1 | 0.2 | GO:0010730 | negative regulation of hydrogen peroxide metabolic process(GO:0010727) negative regulation of hydrogen peroxide biosynthetic process(GO:0010730) |
| 0.1 | 0.3 | GO:0016340 | calcium-dependent cell-matrix adhesion(GO:0016340) |
| 0.1 | 0.2 | GO:0044313 | protein K6-linked deubiquitination(GO:0044313) |
| 0.1 | 0.7 | GO:2000194 | regulation of female gonad development(GO:2000194) |
| 0.1 | 0.6 | GO:0007342 | fusion of sperm to egg plasma membrane(GO:0007342) |
| 0.1 | 0.4 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.1 | 0.4 | GO:0002326 | B cell lineage commitment(GO:0002326) |
| 0.1 | 0.6 | GO:0048102 | autophagic cell death(GO:0048102) |
| 0.1 | 0.4 | GO:0019433 | triglyceride catabolic process(GO:0019433) |
| 0.1 | 1.8 | GO:0051973 | positive regulation of telomerase activity(GO:0051973) |
| 0.1 | 0.8 | GO:1902895 | positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895) |
| 0.1 | 4.0 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
| 0.1 | 0.8 | GO:0097084 | vascular smooth muscle cell development(GO:0097084) |
| 0.1 | 0.9 | GO:0097320 | membrane tubulation(GO:0097320) |
| 0.1 | 0.5 | GO:0015791 | polyol transport(GO:0015791) |
| 0.1 | 0.6 | GO:0043619 | regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619) |
| 0.1 | 0.2 | GO:1901072 | glucosamine-containing compound catabolic process(GO:1901072) |
| 0.1 | 0.8 | GO:0010592 | positive regulation of lamellipodium assembly(GO:0010592) |
| 0.1 | 0.1 | GO:0009106 | lipoate metabolic process(GO:0009106) |
| 0.1 | 0.2 | GO:2000659 | regulation of interleukin-1-mediated signaling pathway(GO:2000659) |
| 0.1 | 0.5 | GO:0050957 | equilibrioception(GO:0050957) |
| 0.1 | 0.4 | GO:0006741 | NADP biosynthetic process(GO:0006741) |
| 0.1 | 1.5 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.1 | 0.2 | GO:0006546 | glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464) |
| 0.1 | 1.0 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.1 | 0.2 | GO:0006269 | DNA replication, synthesis of RNA primer(GO:0006269) |
| 0.1 | 0.2 | GO:0021852 | pyramidal neuron migration(GO:0021852) |
| 0.1 | 0.2 | GO:0046416 | D-amino acid metabolic process(GO:0046416) |
| 0.1 | 0.6 | GO:0048194 | Golgi vesicle budding(GO:0048194) |
| 0.1 | 0.2 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
| 0.1 | 0.6 | GO:0071447 | cellular response to hydroperoxide(GO:0071447) |
| 0.1 | 0.7 | GO:0050965 | detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965) |
| 0.1 | 1.6 | GO:0032611 | interleukin-1 beta production(GO:0032611) |
| 0.1 | 0.1 | GO:1903847 | regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849) |
| 0.1 | 0.1 | GO:0001954 | positive regulation of cell-matrix adhesion(GO:0001954) |
| 0.0 | 1.4 | GO:0060008 | Sertoli cell differentiation(GO:0060008) |
| 0.0 | 0.8 | GO:0001573 | ganglioside metabolic process(GO:0001573) |
| 0.0 | 0.4 | GO:0002347 | response to tumor cell(GO:0002347) |
| 0.0 | 3.3 | GO:0007569 | cell aging(GO:0007569) |
| 0.0 | 0.6 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.0 | 0.5 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.0 | 1.0 | GO:0007064 | mitotic sister chromatid cohesion(GO:0007064) |
| 0.0 | 1.7 | GO:0045214 | sarcomere organization(GO:0045214) |
| 0.0 | 0.3 | GO:0032429 | lysosomal lumen acidification(GO:0007042) regulation of phospholipase A2 activity(GO:0032429) |
| 0.0 | 0.2 | GO:0072429 | response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423) response to intra-S DNA damage checkpoint signaling(GO:0072429) |
| 0.0 | 0.1 | GO:1900377 | negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377) |
| 0.0 | 0.5 | GO:0090003 | regulation of Golgi to plasma membrane protein transport(GO:0042996) regulation of establishment of protein localization to plasma membrane(GO:0090003) |
| 0.0 | 0.4 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.0 | 2.6 | GO:0048663 | neuron fate commitment(GO:0048663) |
| 0.0 | 0.1 | GO:0033566 | gamma-tubulin complex localization(GO:0033566) |
| 0.0 | 0.1 | GO:2000642 | negative regulation of early endosome to late endosome transport(GO:2000642) |
| 0.0 | 0.6 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
| 0.0 | 1.3 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 0.0 | 0.5 | GO:0007602 | phototransduction(GO:0007602) |
| 0.0 | 0.5 | GO:0048642 | negative regulation of skeletal muscle tissue development(GO:0048642) |
| 0.0 | 0.7 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
| 0.0 | 0.2 | GO:0032298 | positive regulation of DNA-dependent DNA replication initiation(GO:0032298) |
| 0.0 | 0.4 | GO:0070493 | thrombin receptor signaling pathway(GO:0070493) |
| 0.0 | 0.2 | GO:0032049 | cardiolipin biosynthetic process(GO:0032049) |
| 0.0 | 0.6 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.0 | 1.2 | GO:0006940 | regulation of smooth muscle contraction(GO:0006940) |
| 0.0 | 1.3 | GO:1901264 | carbohydrate derivative transport(GO:1901264) |
| 0.0 | 0.6 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) |
| 0.0 | 2.9 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
| 0.0 | 2.2 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.0 | 0.6 | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502) |
| 0.0 | 1.1 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.0 | 0.6 | GO:0044030 | regulation of DNA methylation(GO:0044030) |
| 0.0 | 0.1 | GO:0090070 | positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234) |
| 0.0 | 0.0 | GO:0006083 | acetate metabolic process(GO:0006083) |
| 0.0 | 0.3 | GO:0032933 | response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501) |
| 0.0 | 0.3 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.0 | 0.2 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.0 | 0.2 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
| 0.0 | 1.8 | GO:0007093 | mitotic cell cycle checkpoint(GO:0007093) |
| 0.0 | 0.2 | GO:0033004 | negative regulation of mast cell activation(GO:0033004) |
| 0.0 | 0.4 | GO:0006298 | mismatch repair(GO:0006298) |
| 0.0 | 0.2 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.0 | 0.7 | GO:0000266 | mitochondrial fission(GO:0000266) |
| 0.0 | 0.2 | GO:0051085 | chaperone mediated protein folding requiring cofactor(GO:0051085) |
| 0.0 | 1.1 | GO:0015992 | proton transport(GO:0015992) |
| 0.0 | 0.5 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.0 | 0.0 | GO:0042117 | monocyte activation(GO:0042117) |
| 0.0 | 2.1 | GO:0090132 | epithelial cell migration(GO:0010631) tissue migration(GO:0090130) epithelium migration(GO:0090132) |
| 0.0 | 0.0 | GO:0006049 | UDP-N-acetylglucosamine catabolic process(GO:0006049) |
| 0.0 | 0.1 | GO:0002053 | positive regulation of mesenchymal cell proliferation(GO:0002053) |
| 0.0 | 0.1 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.0 | 0.4 | GO:0016925 | protein sumoylation(GO:0016925) |
| 0.0 | 0.1 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.0 | 0.2 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 4.8 | GO:0071149 | TEAD-2-YAP complex(GO:0071149) |
| 1.4 | 5.5 | GO:0000942 | condensed nuclear chromosome outer kinetochore(GO:0000942) |
| 1.3 | 6.3 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.7 | 2.0 | GO:1990423 | RZZ complex(GO:1990423) |
| 0.6 | 2.5 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.5 | 2.4 | GO:0005587 | collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651) |
| 0.4 | 1.7 | GO:0001651 | dense fibrillar component(GO:0001651) |
| 0.4 | 1.4 | GO:0061702 | inflammasome complex(GO:0061702) |
| 0.3 | 1.3 | GO:0097574 | lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795) |
| 0.3 | 1.8 | GO:0098536 | deuterosome(GO:0098536) |
| 0.3 | 2.3 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.2 | 1.7 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.2 | 2.1 | GO:0030018 | Z disc(GO:0030018) |
| 0.2 | 0.8 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.2 | 4.1 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.2 | 0.8 | GO:0008623 | CHRAC(GO:0008623) |
| 0.2 | 0.6 | GO:0071438 | integrin alpha3-beta1 complex(GO:0034667) invadopodium membrane(GO:0071438) |
| 0.2 | 2.5 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.2 | 0.3 | GO:0016011 | dystroglycan complex(GO:0016011) |
| 0.2 | 3.1 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.1 | 2.2 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
| 0.1 | 1.0 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.1 | 1.1 | GO:0034750 | Scrib-APC-beta-catenin complex(GO:0034750) |
| 0.1 | 1.1 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.1 | 1.2 | GO:0043034 | costamere(GO:0043034) |
| 0.1 | 1.2 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 2.3 | GO:0008305 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.1 | 2.7 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.1 | 1.0 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.1 | 5.5 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.1 | 0.8 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.1 | 0.6 | GO:0097504 | Gemini of coiled bodies(GO:0097504) |
| 0.1 | 1.4 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.1 | 0.5 | GO:0031021 | interphase microtubule organizing center(GO:0031021) |
| 0.1 | 8.1 | GO:0030175 | filopodium(GO:0030175) |
| 0.1 | 4.9 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.1 | 0.8 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.1 | 2.7 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.1 | 2.6 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 0.4 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.1 | 1.5 | GO:0005605 | basal lamina(GO:0005605) |
| 0.1 | 0.4 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.1 | 0.3 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.1 | 0.4 | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) |
| 0.1 | 4.1 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.1 | 8.3 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.1 | 4.0 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.1 | 1.1 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 0.4 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.1 | 1.4 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.0 | 2.0 | GO:0043596 | nuclear replication fork(GO:0043596) |
| 0.0 | 1.7 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.0 | 4.8 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
| 0.0 | 0.2 | GO:0048476 | Holliday junction resolvase complex(GO:0048476) |
| 0.0 | 2.9 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 1.3 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.0 | 0.7 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 3.0 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 1.0 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.0 | 1.6 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 0.2 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
| 0.0 | 0.9 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 0.4 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 0.5 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 0.1 | GO:0045098 | type III intermediate filament(GO:0045098) |
| 0.0 | 0.2 | GO:0044305 | calyx of Held(GO:0044305) |
| 0.0 | 3.3 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.0 | 0.7 | GO:0035869 | ciliary transition zone(GO:0035869) |
| 0.0 | 0.1 | GO:0005940 | septin ring(GO:0005940) |
| 0.0 | 0.3 | GO:0043218 | compact myelin(GO:0043218) |
| 0.0 | 1.6 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.7 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.0 | 0.4 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.0 | 6.2 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 1.0 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 0.2 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 0.1 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.0 | 8.1 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 0.5 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.0 | 14.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 1.1 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 1.7 | GO:0005923 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.0 | 1.0 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 0.5 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 1.9 | GO:0005770 | late endosome(GO:0005770) |
| 0.0 | 0.2 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 0.0 | 0.1 | GO:0030914 | STAGA complex(GO:0030914) |
| 0.0 | 0.3 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.0 | 0.9 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 0.1 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.0 | 14.6 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 14.9 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 1.6 | 6.3 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 1.4 | 5.5 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 1.3 | 4.0 | GO:0000253 | 3-keto sterol reductase activity(GO:0000253) |
| 1.2 | 7.1 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 1.0 | 2.9 | GO:0016715 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715) |
| 0.7 | 3.7 | GO:0005534 | galactose binding(GO:0005534) |
| 0.7 | 2.1 | GO:0004994 | somatostatin receptor activity(GO:0004994) |
| 0.6 | 3.8 | GO:0035184 | histone threonine kinase activity(GO:0035184) |
| 0.5 | 1.6 | GO:0017099 | very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099) |
| 0.5 | 1.4 | GO:0016716 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716) |
| 0.5 | 3.7 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 0.4 | 1.2 | GO:0046997 | sarcosine dehydrogenase activity(GO:0008480) oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997) |
| 0.4 | 1.5 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.4 | 1.8 | GO:0004095 | carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416) |
| 0.4 | 1.5 | GO:0016708 | nitric oxide dioxygenase activity(GO:0008941) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor(GO:0016708) iron-cytochrome-c reductase activity(GO:0047726) |
| 0.4 | 4.2 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.3 | 2.6 | GO:0086008 | voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008) |
| 0.3 | 3.0 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) |
| 0.3 | 2.3 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
| 0.3 | 0.8 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 0.3 | 1.0 | GO:0004103 | choline kinase activity(GO:0004103) |
| 0.3 | 4.8 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
| 0.2 | 1.7 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 0.2 | 0.7 | GO:0008502 | melatonin receptor activity(GO:0008502) |
| 0.2 | 1.2 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.2 | 3.4 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.2 | 0.7 | GO:0008527 | taste receptor activity(GO:0008527) |
| 0.2 | 0.6 | GO:0004487 | methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) |
| 0.2 | 0.6 | GO:0004568 | chitinase activity(GO:0004568) |
| 0.2 | 1.4 | GO:0031432 | titin binding(GO:0031432) |
| 0.2 | 1.4 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.2 | 0.9 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
| 0.2 | 2.1 | GO:0036310 | annealing helicase activity(GO:0036310) |
| 0.2 | 2.0 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.2 | 1.0 | GO:0019841 | retinal binding(GO:0016918) retinol binding(GO:0019841) |
| 0.2 | 1.6 | GO:0016004 | phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229) |
| 0.2 | 1.1 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
| 0.2 | 0.6 | GO:0004315 | 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315) |
| 0.2 | 3.5 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.2 | 0.6 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.1 | 3.6 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.1 | 1.9 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.1 | 0.4 | GO:0046969 | histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969) |
| 0.1 | 2.3 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 1.1 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.1 | 0.7 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.1 | 0.4 | GO:0000033 | alpha-1,3-mannosyltransferase activity(GO:0000033) |
| 0.1 | 1.3 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.1 | 0.6 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.1 | 1.0 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.1 | 0.4 | GO:0008802 | betaine-aldehyde dehydrogenase activity(GO:0008802) |
| 0.1 | 0.8 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.1 | 1.2 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.1 | 1.0 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
| 0.1 | 2.6 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.1 | 0.9 | GO:0050308 | sugar-phosphatase activity(GO:0050308) |
| 0.1 | 0.7 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.1 | 0.3 | GO:0008732 | threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 0.1 | 1.1 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 1.8 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.1 | 0.7 | GO:0050693 | LBD domain binding(GO:0050693) |
| 0.1 | 3.5 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.1 | 1.3 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.1 | 0.9 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.1 | 1.2 | GO:0004559 | alpha-mannosidase activity(GO:0004559) |
| 0.1 | 0.4 | GO:0009374 | biotin binding(GO:0009374) |
| 0.1 | 13.3 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 1.4 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.1 | 1.1 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.1 | 1.6 | GO:0043028 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028) |
| 0.1 | 0.7 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.1 | 2.8 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.1 | 1.4 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 1.9 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.1 | 1.2 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.1 | 0.4 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 0.2 | GO:0000099 | sulfur amino acid transmembrane transporter activity(GO:0000099) |
| 0.1 | 0.2 | GO:0004677 | DNA-dependent protein kinase activity(GO:0004677) |
| 0.1 | 0.8 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.1 | 0.9 | GO:0005313 | L-glutamate transmembrane transporter activity(GO:0005313) |
| 0.1 | 3.0 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.1 | 1.3 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.1 | 0.3 | GO:0004645 | phosphorylase activity(GO:0004645) |
| 0.0 | 0.9 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 4.1 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 0.2 | GO:0045322 | unmethylated CpG binding(GO:0045322) |
| 0.0 | 1.9 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 1.3 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.5 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.0 | 0.7 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.0 | 0.3 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.0 | 0.3 | GO:0019788 | NEDD8 transferase activity(GO:0019788) |
| 0.0 | 0.1 | GO:0016979 | lipoate-protein ligase activity(GO:0016979) |
| 0.0 | 1.3 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 2.3 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 0.8 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.0 | 0.6 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.0 | 3.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 1.3 | GO:0050661 | NADP binding(GO:0050661) |
| 0.0 | 0.9 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
| 0.0 | 0.6 | GO:0004659 | prenyltransferase activity(GO:0004659) |
| 0.0 | 1.5 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 1.5 | GO:1901505 | carbohydrate derivative transporter activity(GO:1901505) |
| 0.0 | 0.1 | GO:0042954 | lipoprotein transporter activity(GO:0042954) |
| 0.0 | 0.4 | GO:0098505 | G-rich strand telomeric DNA binding(GO:0098505) |
| 0.0 | 1.1 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 0.2 | GO:0048256 | flap endonuclease activity(GO:0048256) |
| 0.0 | 0.6 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.0 | 1.8 | GO:0043621 | protein self-association(GO:0043621) |
| 0.0 | 1.3 | GO:0016504 | peptidase activator activity(GO:0016504) |
| 0.0 | 0.8 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 0.4 | GO:0016646 | oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646) |
| 0.0 | 1.2 | GO:0015175 | neutral amino acid transmembrane transporter activity(GO:0015175) |
| 0.0 | 2.4 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.0 | 0.3 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.0 | 0.2 | GO:0017169 | CDP-alcohol phosphatidyltransferase activity(GO:0017169) |
| 0.0 | 0.7 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.0 | 0.5 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.0 | 0.8 | GO:0051183 | vitamin transporter activity(GO:0051183) |
| 0.0 | 1.2 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 0.4 | GO:0003951 | NAD+ kinase activity(GO:0003951) |
| 0.0 | 1.3 | GO:0016209 | antioxidant activity(GO:0016209) |
| 0.0 | 0.4 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.0 | 4.4 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 0.7 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 0.3 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 0.4 | GO:0032183 | SUMO binding(GO:0032183) |
| 0.0 | 10.9 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 1.1 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.0 | 0.5 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 0.5 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 2.3 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 0.6 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.0 | 0.8 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 1.1 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.0 | 3.1 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 1.1 | GO:0008094 | DNA-dependent ATPase activity(GO:0008094) |
| 0.0 | 2.0 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.0 | 0.2 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 0.2 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.0 | 0.1 | GO:0019215 | intermediate filament binding(GO:0019215) |
| 0.0 | 0.2 | GO:0016641 | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641) |
| 0.0 | 0.0 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.0 | 1.2 | GO:0004519 | endonuclease activity(GO:0004519) |
| 0.0 | 0.6 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 0.2 | GO:0003746 | translation elongation factor activity(GO:0003746) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.8 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.2 | 13.0 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 1.5 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.2 | 4.5 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.1 | 2.3 | PID_INTEGRIN_CS_PATHWAY | Integrin family cell surface interactions |
| 0.1 | 4.9 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.1 | 7.0 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.1 | 2.3 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 3.2 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.1 | 2.4 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 1.3 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.1 | 2.9 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.1 | 0.3 | ST_PAC1_RECEPTOR_PATHWAY | PAC1 Receptor Pathway |
| 0.1 | 1.1 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 1.5 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.1 | 1.5 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 2.1 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.0 | 1.3 | PID_A6B1_A6B4_INTEGRIN_PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.0 | 2.1 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.1 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 1.0 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 1.3 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.4 | PID_THROMBIN_PAR4_PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 0.3 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
| 0.0 | 4.5 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.2 | PID_FANCONI_PATHWAY | Fanconi anemia pathway |
| 0.0 | 1.9 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 4.4 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.4 | PID_BARD1_PATHWAY | BARD1 signaling events |
| 0.0 | 0.4 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.0 | 1.9 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
| 0.0 | 2.1 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.5 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.9 | PID_ERBB1_DOWNSTREAM_PATHWAY | ErbB1 downstream signaling |
| 0.0 | 1.5 | NABA_MATRISOME_ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.0 | 0.7 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 0.5 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.0 | 0.3 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.0 | 0.3 | PID_FCER1_PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 0.4 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 5.5 | REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.4 | 2.7 | REACTOME_ENDOGENOUS_STEROLS | Genes involved in Endogenous sterols |
| 0.3 | 1.8 | REACTOME_THE_NLRP3_INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.2 | 2.4 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.2 | 6.3 | REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.2 | 5.8 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.2 | 1.1 | REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.2 | 3.0 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.2 | 1.3 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.1 | 1.8 | REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in RORA Activates Circadian Expression |
| 0.1 | 0.7 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.1 | 1.4 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.1 | 8.0 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 5.3 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 0.5 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 7.9 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 1.2 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.1 | 3.5 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 2.5 | REACTOME_MUSCLE_CONTRACTION | Genes involved in Muscle contraction |
| 0.1 | 0.9 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 2.7 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 0.7 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.1 | 7.3 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 0.5 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 1.0 | REACTOME_SYNTHESIS_OF_PC | Genes involved in Synthesis of PC |
| 0.0 | 2.9 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 0.8 | REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 1.0 | REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.0 | 0.7 | REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN | Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen |
| 0.0 | 0.6 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 0.8 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 0.6 | REACTOME_FANCONI_ANEMIA_PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.0 | 0.3 | REACTOME_ELONGATION_ARREST_AND_RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.0 | 2.7 | REACTOME_G_ALPHA1213_SIGNALLING_EVENTS | Genes involved in G alpha (12/13) signalling events |
| 0.0 | 0.4 | REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.0 | 0.4 | REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.0 | 0.8 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 1.9 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.2 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.0 | 0.9 | REACTOME_GLUCOSE_TRANSPORT | Genes involved in Glucose transport |
| 0.0 | 0.7 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.7 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.3 | REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.0 | 0.4 | REACTOME_DOUBLE_STRAND_BREAK_REPAIR | Genes involved in Double-Strand Break Repair |
| 0.0 | 0.5 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 1.6 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 0.6 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 1.7 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 0.6 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 0.5 | REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.0 | 0.2 | REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.0 | 0.2 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
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