Motif ID: Tcf3

Z-value: 0.633


Transcription factors associated with Tcf3:

Gene SymbolEntrez IDGene Name
Tcf3 ENSMUSG00000020167.8 Tcf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf3mm10_v2_chr10_-_80433615_804336550.541.9e-05Click!


Activity profile for motif Tcf3.

activity profile for motif Tcf3


Sorted Z-values histogram for motif Tcf3

Sorted Z-values for motif Tcf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_28302238 7.511 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr14_-_20181773 4.209 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr12_+_109459843 4.080 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr15_+_34238026 4.008 ENSMUST00000022867.3
 Laptm4b
lysosomal-associated protein transmembrane 4B
chr6_-_72235559 3.980 ENSMUST00000042646.7
 Atoh8
atonal homolog 8 (Drosophila)
chr8_-_122699066 3.858 ENSMUST00000127984.1
 Cbfa2t3
core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)
chr1_+_74791516 3.731 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr15_-_78773452 3.511 ENSMUST00000018313.5
 Mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr13_-_60177357 3.338 ENSMUST00000065086.4
 Gas1
growth arrest specific 1
chr17_-_35703971 3.319 ENSMUST00000148065.1
 Ddr1
discoidin domain receptor family, member 1
chr17_-_35704000 3.199 ENSMUST00000097333.3
ENSMUST00000003628.6
 Ddr1

discoidin domain receptor family, member 1

chr7_+_19094594 2.978 ENSMUST00000049454.5
 Six5
sine oculis-related homeobox 5
chr7_+_45216671 2.978 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr13_-_116309639 2.968 ENSMUST00000036060.6
 Isl1
ISL1 transcription factor, LIM/homeodomain
chr2_+_131186942 2.962 ENSMUST00000028804.8
ENSMUST00000079857.8
 Cdc25b

cell division cycle 25B

chr1_-_119053339 2.916 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chr5_-_98566762 2.860 ENSMUST00000086912.4
 1700010H22Rik
RIKEN cDNA 1700010H22 gene
chr19_-_45560508 2.676 ENSMUST00000026239.6
 Poll
polymerase (DNA directed), lambda
chr14_+_27039001 2.656 ENSMUST00000035336.3
 Il17rd
interleukin 17 receptor D
chr19_+_25610533 2.642 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 213 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 7.5 GO:0007386 compartment pattern specification(GO:0007386)
0.6 7.4 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.6 6.4 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.2 5.6 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.5 5.3 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
1.3 5.1 GO:0060032 notochord regression(GO:0060032)
0.3 4.6 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1 4.6 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.7 4.2 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.2 4.1 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.2 4.1 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.3 4.0 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.6 3.9 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.4 3.8 GO:0030322 stabilization of membrane potential(GO:0030322)
0.4 3.2 GO:0002315 marginal zone B cell differentiation(GO:0002315)
1.0 3.0 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913)
0.4 3.0 GO:0007144 female meiosis I(GO:0007144)
0.2 3.0 GO:0014841 skeletal muscle satellite cell proliferation(GO:0014841)
0.2 3.0 GO:0030903 notochord development(GO:0030903)
0.6 2.9 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.4 5.8 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 5.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.4 5.1 GO:0097542 ciliary tip(GO:0097542)
1.7 5.0 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.4 4.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.9 4.6 GO:0097149 centralspindlin complex(GO:0097149)
0.0 3.9 GO:0000922 spindle pole(GO:0000922)
0.1 3.7 GO:0001891 phagocytic cup(GO:0001891)
0.1 3.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 3.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
1.0 3.0 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.2 2.9 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 2.7 GO:0060077 inhibitory synapse(GO:0060077)
0.0 2.5 GO:0005923 bicellular tight junction(GO:0005923)
0.6 2.3 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.2 2.2 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 2.2 GO:0031528 microvillus membrane(GO:0031528)
0.1 2.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 2.1 GO:0002102 podosome(GO:0002102)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 8.9 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.2 8.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 7.9 GO:0005112 Notch binding(GO:0005112)
0.2 7.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 6.3 GO:0070888 E-box binding(GO:0070888)
1.3 5.4 GO:0050436 microfibril binding(GO:0050436)
0.1 5.1 GO:0002039 p53 binding(GO:0002039)
1.0 5.0 GO:0042289 MHC class II protein binding(GO:0042289)
0.2 4.8 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.2 4.2 GO:0051861 glycolipid binding(GO:0051861)
0.1 4.2 GO:0005109 frizzled binding(GO:0005109)
0.3 3.8 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 3.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.5 3.7 GO:0001849 complement component C1q binding(GO:0001849)
0.0 3.7 GO:0003714 transcription corepressor activity(GO:0003714)
1.2 3.5 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 3.4 GO:0017048 Rho GTPase binding(GO:0017048)
0.2 3.0 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.6 2.9 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.0 2.9 GO:0003774 motor activity(GO:0003774)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.6 PID_NOTCH_PATHWAY Notch signaling pathway
0.3 9.9 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 4.6 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 4.6 PID_PLK1_PATHWAY PLK1 signaling events
0.0 4.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 3.8 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 3.4 NABA_COLLAGENS Genes encoding collagen proteins
0.0 3.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 3.0 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 2.7 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.2 2.5 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 2.4 PID_BARD1_PATHWAY BARD1 signaling events
0.1 2.0 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 2.0 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.2 1.9 PID_CONE_PATHWAY Visual signal transduction: Cones
0.1 1.9 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 1.9 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 1.7 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.7 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 1.5 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 5.4 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 5.4 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.1 5.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 5.0 REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION Genes involved in Incretin Synthesis, Secretion, and Inactivation
0.1 4.1 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 3.9 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.2 3.5 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.2 3.0 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 2.7 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 2.6 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 2.3 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.1 2.2 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 2.2 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 2.0 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.9 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.1 1.8 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.2 1.7 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.6 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 1.5 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions