Motif ID: Tcf4_Mesp1

Z-value: 2.643

Transcription factors associated with Tcf4_Mesp1:

Gene SymbolEntrez IDGene Name
Mesp1 ENSMUSG00000030544.5 Mesp1
Tcf4 ENSMUSG00000053477.9 Tcf4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf4mm10_v2_chr18_+_69346143_693462030.162.4e-01Click!


Activity profile for motif Tcf4_Mesp1.

activity profile for motif Tcf4_Mesp1


Sorted Z-values histogram for motif Tcf4_Mesp1

Sorted Z-values for motif Tcf4_Mesp1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf4_Mesp1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66831625 59.690 ENSMUST00000164163.1
 Sla
src-like adaptor
chr13_-_57907587 46.258 ENSMUST00000172326.1
 Spock1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
chr11_-_67922136 45.951 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr13_+_83504032 40.998 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr12_+_82616885 29.354 ENSMUST00000161801.1
 Rgs6
regulator of G-protein signaling 6
chr15_+_54571358 28.148 ENSMUST00000025356.2
 Mal2
mal, T cell differentiation protein 2
chr9_-_29411736 27.208 ENSMUST00000115236.1
 Ntm
neurotrimin
chr10_+_123264076 26.358 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr5_+_37028329 26.314 ENSMUST00000173836.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr5_-_139130159 25.712 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr17_-_26201328 22.724 ENSMUST00000025019.2
 Arhgdig
Rho GDP dissociation inhibitor (GDI) gamma
chr11_+_42419729 22.214 ENSMUST00000007797.4
 Gabrb2
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
chr14_-_121797670 21.554 ENSMUST00000100299.3
 Dock9
dedicator of cytokinesis 9
chr2_-_163918683 20.863 ENSMUST00000044734.2
 Rims4
regulating synaptic membrane exocytosis 4
chr14_+_101729907 20.430 ENSMUST00000100337.3
 Lmo7
LIM domain only 7
chr7_+_123982799 20.258 ENSMUST00000106437.1
 Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr11_+_103171081 20.138 ENSMUST00000042286.5
 Fmnl1
formin-like 1
chr14_-_39472825 19.778 ENSMUST00000168810.2
ENSMUST00000173780.1
ENSMUST00000166968.2
 Nrg3


neuregulin 3


chr19_-_57314896 19.728 ENSMUST00000111524.1
 Ablim1
actin-binding LIM protein 1
chr6_-_8778106 19.522 ENSMUST00000151758.1
ENSMUST00000115519.1
ENSMUST00000153390.1
 Ica1


islet cell autoantigen 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 623 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 94.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.8 53.4 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
13.7 41.2 GO:0007521 muscle cell fate determination(GO:0007521)
0.3 38.7 GO:0016579 protein deubiquitination(GO:0016579)
0.7 37.4 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
0.8 37.3 GO:0045022 early endosome to late endosome transport(GO:0045022)
1.4 35.9 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
0.4 35.9 GO:1903749 positive regulation of establishment of protein localization to mitochondrion(GO:1903749)
3.2 32.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.6 31.7 GO:0034605 cellular response to heat(GO:0034605)
7.7 30.9 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
3.2 29.2 GO:0071420 cellular response to histamine(GO:0071420)
4.0 28.3 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
2.2 26.7 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.9 26.1 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
1.5 25.6 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.2 25.4 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
2.5 25.0 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.6 25.0 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
1.9 24.7 GO:0016191 synaptic vesicle uncoating(GO:0016191)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 236 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 145.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.4 108.8 GO:0097060 synaptic membrane(GO:0097060)
0.5 96.3 GO:0005802 trans-Golgi network(GO:0005802)
0.4 72.8 GO:0060076 excitatory synapse(GO:0060076)
2.0 57.7 GO:0033268 node of Ranvier(GO:0033268)
0.7 46.9 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 44.6 GO:0016021 integral component of membrane(GO:0016021)
0.3 38.1 GO:0030016 myofibril(GO:0030016)
1.1 37.8 GO:0032809 neuronal cell body membrane(GO:0032809)
0.7 37.0 GO:0031901 early endosome membrane(GO:0031901)
0.1 35.5 GO:0005887 integral component of plasma membrane(GO:0005887)
1.6 33.2 GO:0032279 asymmetric synapse(GO:0032279)
2.2 33.0 GO:1902711 GABA-A receptor complex(GO:1902711)
1.1 28.6 GO:0000930 gamma-tubulin complex(GO:0000930)
2.2 28.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.5 25.3 GO:0045335 phagocytic vesicle(GO:0045335)
1.3 24.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
1.6 24.5 GO:0043196 varicosity(GO:0043196)
0.2 23.8 GO:0001650 fibrillar center(GO:0001650)
1.0 22.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 379 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 92.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.3 54.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
1.4 52.0 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.7 51.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.5 51.0 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
1.3 44.2 GO:0030552 cAMP binding(GO:0030552)
1.7 43.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
6.0 41.7 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
2.2 39.0 GO:0050811 GABA receptor binding(GO:0050811)
3.3 36.7 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
2.3 36.7 GO:0003680 AT DNA binding(GO:0003680)
0.2 36.3 GO:0003779 actin binding(GO:0003779)
2.8 33.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.7 31.1 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
2.5 30.4 GO:0004016 adenylate cyclase activity(GO:0004016)
0.7 29.0 GO:0030507 spectrin binding(GO:0030507)
1.6 26.9 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
1.1 26.0 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.6 25.8 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 25.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 79.0 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
1.0 62.4 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
1.1 52.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.9 45.9 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
1.1 45.7 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
1.3 42.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.7 39.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.5 25.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.7 23.0 PID_RAS_PATHWAY Regulation of Ras family activation
0.7 22.4 PID_PI3KCI_PATHWAY Class I PI3K signaling events
1.4 21.1 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.4 20.9 PID_LKB1_PATHWAY LKB1 signaling events
0.8 20.0 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.7 19.3 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.7 18.0 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.6 17.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.5 16.9 PID_RHOA_PATHWAY RhoA signaling pathway
0.8 15.2 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.3 14.9 PID_P73PATHWAY p73 transcription factor network
0.1 13.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 135 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 59.8 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
1.4 51.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
1.4 46.1 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
1.8 41.6 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
1.4 33.8 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
2.1 33.0 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.8 29.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
1.1 29.2 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
1.8 26.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
1.6 25.5 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
1.5 24.5 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
1.9 24.3 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.9 23.1 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.7 22.4 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
1.7 22.2 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
5.3 21.2 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
1.0 20.9 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.9 20.5 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.8 19.4 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
1.0 19.0 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling