Motif ID: Tcf7l1

Z-value: 0.842


Transcription factors associated with Tcf7l1:

Gene SymbolEntrez IDGene Name
Tcf7l1 ENSMUSG00000055799.7 Tcf7l1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf7l1mm10_v2_chr6_-_72788952_727890610.447.9e-04Click!


Activity profile for motif Tcf7l1.

activity profile for motif Tcf7l1


Sorted Z-values histogram for motif Tcf7l1

Sorted Z-values for motif Tcf7l1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf7l1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_108920800 4.851 ENSMUST00000140821.1
 Axin2
axin2
chr11_+_108921648 4.691 ENSMUST00000144511.1
 Axin2
axin2
chr3_+_131110350 4.380 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
 Lef1


lymphoid enhancer binding factor 1


chr7_+_45216671 4.050 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr14_-_98169542 3.794 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr14_+_27039001 3.749 ENSMUST00000035336.3
 Il17rd
interleukin 17 receptor D
chr7_-_115824699 3.718 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr17_-_70851189 3.690 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr9_+_85842852 3.342 ENSMUST00000098500.3
 Tpbg
trophoblast glycoprotein
chr2_+_153031852 3.199 ENSMUST00000037235.6
 Xkr7
X Kell blood group precursor related family member 7 homolog
chr3_-_57575760 3.031 ENSMUST00000029380.7
 Wwtr1
WW domain containing transcription regulator 1
chr18_-_62756275 2.979 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr1_-_183147461 2.933 ENSMUST00000171366.1
 Disp1
dispatched homolog 1 (Drosophila)
chr15_+_34238026 2.746 ENSMUST00000022867.3
 Laptm4b
lysosomal-associated protein transmembrane 4B
chr18_+_82914632 2.639 ENSMUST00000071233.6
 Zfp516
zinc finger protein 516
chr4_+_62583568 2.611 ENSMUST00000098031.3
 Rgs3
regulator of G-protein signaling 3
chr2_+_152081529 2.596 ENSMUST00000064061.3
 Scrt2
scratch homolog 2, zinc finger protein (Drosophila)
chr2_+_70474923 2.561 ENSMUST00000100043.2
 Sp5
trans-acting transcription factor 5
chr9_+_35423582 2.538 ENSMUST00000154652.1
 Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr2_+_173021902 2.401 ENSMUST00000029014.9
 Rbm38
RNA binding motif protein 38

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 11.1 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.3 5.1 GO:0048617 embryonic foregut morphogenesis(GO:0048617)
0.7 4.9 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.4 4.6 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
1.5 4.4 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.3 4.1 GO:0048368 lateral mesoderm development(GO:0048368)
1.3 3.8 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.6 3.7 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.3 3.7 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.3 3.7 GO:0038092 nodal signaling pathway(GO:0038092)
0.1 3.0 GO:2001222 regulation of neuron migration(GO:2001222)
0.3 2.9 GO:0060539 diaphragm development(GO:0060539)
0.0 2.8 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 2.6 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.1 2.6 GO:0009409 response to cold(GO:0009409)
0.3 2.5 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 2.3 GO:0006338 chromatin remodeling(GO:0006338)
0.0 2.2 GO:0030336 negative regulation of cell migration(GO:0030336)
0.7 2.1 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.3 2.1 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 16.4 GO:0005667 transcription factor complex(GO:0005667)
0.0 5.1 GO:0005813 centrosome(GO:0005813)
0.4 4.7 GO:1990907 beta-catenin-TCF complex(GO:1990907)
1.4 4.1 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.2 4.1 GO:0071564 npBAF complex(GO:0071564)
0.2 2.3 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.1 2.3 GO:0016580 Sin3 complex(GO:0016580)
0.5 2.2 GO:0008623 CHRAC(GO:0008623)
0.2 2.1 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 2.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 1.9 GO:0044294 dendritic growth cone(GO:0044294)
0.1 1.9 GO:0051233 spindle midzone(GO:0051233)
0.6 1.8 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.0 1.8 GO:0000922 spindle pole(GO:0000922)
0.1 1.6 GO:0036038 MKS complex(GO:0036038)
0.0 1.6 GO:0001772 immunological synapse(GO:0001772)
0.1 1.3 GO:0031105 septin complex(GO:0031105)
0.2 1.2 GO:0001533 cornified envelope(GO:0001533)
0.1 1.1 GO:0001739 sex chromatin(GO:0001739)
0.1 1.1 GO:0031597 cytosolic proteasome complex(GO:0031597)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 11.1 GO:0070411 I-SMAD binding(GO:0070411)
0.1 9.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 4.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 4.7 GO:0003682 chromatin binding(GO:0003682)
0.1 4.6 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.7 4.4 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 3.9 GO:0005096 GTPase activator activity(GO:0005096)
0.5 3.8 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
1.2 3.7 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.2 3.7 GO:0070410 co-SMAD binding(GO:0070410)
0.2 3.4 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 3.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.2 2.9 GO:0015197 peptide transporter activity(GO:0015197)
0.1 2.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.6 2.5 GO:0050436 microfibril binding(GO:0050436)
0.0 2.5 GO:0033613 activating transcription factor binding(GO:0033613)
0.2 2.2 GO:0034711 inhibin binding(GO:0034711)
0.1 2.1 GO:0070064 proline-rich region binding(GO:0070064)
0.0 2.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.5 2.0 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.2 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.1 8.9 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 5.2 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 4.3 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 3.2 PID_FGF_PATHWAY FGF signaling pathway
0.1 2.6 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 2.2 PID_ALK1_PATHWAY ALK1 signaling events
0.1 2.1 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 2.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.0 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 1.9 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 1.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.6 PID_MYC_PATHWAY C-MYC pathway
0.0 1.3 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 1.2 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 1.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.1 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.0 1.1 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 1.1 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.0 PID_RAS_PATHWAY Regulation of Ras family activation

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 4.2 REACTOME_SIGNALING_BY_FGFR Genes involved in Signaling by FGFR
0.1 3.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 3.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 3.2 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 3.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.2 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 2.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 2.0 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 1.5 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 1.4 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.0 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.9 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.9 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 0.8 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 0.8 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.1 0.7 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.7 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.5 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions