Motif ID: Tead1

Z-value: 0.615


Transcription factors associated with Tead1:

Gene SymbolEntrez IDGene Name
Tead1 ENSMUSG00000055320.10 Tead1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tead1mm10_v2_chr7_+_112679314_1126793250.302.7e-02Click!


Activity profile for motif Tead1.

activity profile for motif Tead1


Sorted Z-values histogram for motif Tead1

Sorted Z-values for motif Tead1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tead1

PNG image of the network

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Top targets:


Showing 1 to 20 of 89 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_54577578 6.000 ENSMUST00000054487.8
 Ajuba
ajuba LIM protein
chr10_-_87493651 4.849 ENSMUST00000020243.7
 Ascl1
achaete-scute complex homolog 1 (Drosophila)
chr2_+_91457501 4.447 ENSMUST00000028689.3
 Lrp4
low density lipoprotein receptor-related protein 4
chr9_-_8004585 4.413 ENSMUST00000086580.5
ENSMUST00000065353.6
 Yap1

yes-associated protein 1

chr2_+_20519776 4.406 ENSMUST00000114604.2
ENSMUST00000066509.3
 Etl4

enhancer trap locus 4

chr3_-_57575760 4.344 ENSMUST00000029380.7
 Wwtr1
WW domain containing transcription regulator 1
chr4_-_43558386 3.925 ENSMUST00000130353.1
 Tln1
talin 1
chr16_+_91225550 3.661 ENSMUST00000035608.8
 Olig2
oligodendrocyte transcription factor 2
chr19_-_4439388 3.379 ENSMUST00000117462.1
ENSMUST00000048197.3
 Rhod

ras homolog gene family, member D

chr6_+_17306335 3.329 ENSMUST00000007799.6
ENSMUST00000115456.1
ENSMUST00000115455.2
ENSMUST00000130505.1
 Cav1



caveolin 1, caveolae protein



chr11_-_32222233 3.317 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
 Rhbdf1


rhomboid family 1 (Drosophila)


chr10_+_24595623 3.027 ENSMUST00000176228.1
ENSMUST00000129142.1
 Ctgf

connective tissue growth factor

chr8_+_57511833 2.838 ENSMUST00000067925.6
 Hmgb2
high mobility group box 2
chr10_+_93641041 2.680 ENSMUST00000020204.4
 Ntn4
netrin 4
chr7_-_109616548 2.550 ENSMUST00000077909.1
ENSMUST00000084738.3
 St5

suppression of tumorigenicity 5

chr11_+_70700473 2.325 ENSMUST00000152618.2
ENSMUST00000102554.1
ENSMUST00000094499.4
ENSMUST00000072187.5
 Kif1c



kinesin family member 1C



chr10_+_24595434 2.288 ENSMUST00000020171.5
 Ctgf
connective tissue growth factor
chr2_+_156775409 2.125 ENSMUST00000088552.6
 Myl9
myosin, light polypeptide 9, regulatory
chr11_-_5381734 2.099 ENSMUST00000172492.1
 Znrf3
zinc and ring finger 3
chr11_+_70700606 1.896 ENSMUST00000137119.2
 Kif1c
kinesin family member 1C

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 8.8 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
2.8 8.5 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.9 6.6 GO:0035331 negative regulation of hippo signaling(GO:0035331)
1.3 6.4 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
1.3 5.3 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.1 4.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
1.5 4.4 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.0 4.2 GO:0048706 embryonic skeletal system development(GO:0048706)
0.5 3.9 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.2 3.4 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.1 3.4 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.0 2.9 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.4 2.8 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.7 2.7 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.1 2.4 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.4 2.1 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.0 2.1 GO:0070527 platelet aggregation(GO:0070527)
0.2 2.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 1.8 GO:0000187 activation of MAPK activity(GO:0000187)
0.3 1.7 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 16.1 GO:0005667 transcription factor complex(GO:0005667)
0.1 7.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.4 5.8 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 5.3 GO:0005801 cis-Golgi network(GO:0005801)
1.5 4.4 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.4 4.4 GO:0016600 flotillin complex(GO:0016600)
0.1 4.2 GO:0005871 kinesin complex(GO:0005871)
0.2 3.5 GO:0016460 myosin II complex(GO:0016460)
0.0 3.5 GO:0001726 ruffle(GO:0001726)
0.0 2.8 GO:0000793 condensed chromosome(GO:0000793)
0.0 2.7 GO:0005604 basement membrane(GO:0005604)
0.0 2.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.3 1.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 1.1 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.8 GO:0035869 ciliary transition zone(GO:0035869)
0.1 0.6 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.6 GO:0030478 actin cap(GO:0030478)
0.1 0.4 GO:0033269 internode region of axon(GO:0033269)
0.0 0.4 GO:0030126 COPI vesicle coat(GO:0030126)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 6.4 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.5 6.0 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 5.5 GO:0070888 E-box binding(GO:0070888)
0.2 5.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.2 4.4 GO:0070064 proline-rich region binding(GO:0070064)
0.1 4.4 GO:0003777 microtubule motor activity(GO:0003777)
0.4 3.9 GO:0030274 LIM domain binding(GO:0030274)
0.2 3.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 3.7 GO:0071837 HMG box domain binding(GO:0071837)
0.0 3.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 3.4 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 3.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.5 2.8 GO:0050786 RAGE receptor binding(GO:0050786)
0.3 2.7 GO:0043237 laminin-1 binding(GO:0043237)
0.1 2.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.5 2.4 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.2 2.1 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 2.1 GO:0005109 frizzled binding(GO:0005109)
0.2 2.0 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 1.7 GO:0016881 acid-amino acid ligase activity(GO:0016881)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.2 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.2 5.8 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 4.8 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 4.4 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 2.1 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.3 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.3 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 1.1 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.0 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.7 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.6 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 17.4 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 4.8 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.3 3.9 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.2 2.8 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 2.1 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 1.7 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 1.6 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.1 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 1.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.7 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.7 REACTOME_ELONGATION_ARREST_AND_RECOVERY Genes involved in Elongation arrest and recovery
0.0 0.7 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
0.1 0.6 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.4 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport