Motif ID: Tead3_Tead4
Z-value: 2.408
Transcription factors associated with Tead3_Tead4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Tead3 | ENSMUSG00000002249.11 | Tead3 |
| Tead4 | ENSMUSG00000030353.9 | Tead4 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tead3 | mm10_v2_chr17_-_28350600_28350681 | 0.71 | 1.5e-09 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.6 | 58.4 | GO:0070318 | positive regulation of G0 to G1 transition(GO:0070318) |
| 12.5 | 25.1 | GO:0072190 | ureter urothelium development(GO:0072190) ureter morphogenesis(GO:0072197) |
| 9.8 | 29.4 | GO:1904580 | regulation of intracellular mRNA localization(GO:1904580) |
| 8.8 | 26.4 | GO:0033088 | negative regulation of immature T cell proliferation in thymus(GO:0033088) |
| 7.4 | 22.3 | GO:0071918 | urea transmembrane transport(GO:0071918) |
| 5.4 | 37.5 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 5.3 | 21.2 | GO:0003278 | apoptotic process involved in heart morphogenesis(GO:0003278) |
| 5.2 | 36.3 | GO:0072257 | metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307) |
| 5.0 | 29.7 | GO:0007253 | cytoplasmic sequestering of NF-kappaB(GO:0007253) |
| 4.7 | 23.3 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 4.2 | 21.1 | GO:0052428 | modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428) |
| 4.1 | 32.7 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
| 4.0 | 16.1 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
| 3.9 | 11.8 | GO:1904395 | positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) |
| 3.8 | 45.9 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 3.7 | 18.4 | GO:1903609 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
| 3.4 | 10.1 | GO:0060745 | mammary gland branching involved in pregnancy(GO:0060745) |
| 2.6 | 7.9 | GO:0048687 | positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) |
| 2.6 | 7.7 | GO:2000065 | negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065) |
| 2.1 | 4.3 | GO:0045168 | cell-cell signaling involved in cell fate commitment(GO:0045168) |
| 2.0 | 13.8 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 1.8 | 3.7 | GO:0072095 | regulation of branch elongation involved in ureteric bud branching(GO:0072095) |
| 1.8 | 8.8 | GO:0032298 | positive regulation of DNA-dependent DNA replication initiation(GO:0032298) |
| 1.7 | 6.8 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
| 1.7 | 8.5 | GO:0036151 | phosphatidylcholine acyl-chain remodeling(GO:0036151) |
| 1.6 | 8.2 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
| 1.5 | 7.7 | GO:0038018 | Wnt receptor catabolic process(GO:0038018) |
| 1.5 | 4.4 | GO:1905000 | regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000) |
| 1.4 | 9.9 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
| 1.4 | 5.6 | GO:0060372 | regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372) |
| 1.4 | 5.6 | GO:0007228 | positive regulation of hh target transcription factor activity(GO:0007228) pancreas morphogenesis(GO:0061113) metanephric renal vesicle formation(GO:0072093) |
| 1.3 | 6.3 | GO:0032347 | regulation of aldosterone biosynthetic process(GO:0032347) |
| 1.2 | 3.5 | GO:0060558 | regulation of calcidiol 1-monooxygenase activity(GO:0060558) |
| 1.1 | 4.6 | GO:1902724 | positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728) |
| 1.1 | 4.5 | GO:1900220 | semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220) |
| 1.1 | 7.6 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
| 1.1 | 5.3 | GO:0042891 | antibiotic transport(GO:0042891) dipeptide transport(GO:0042938) |
| 1.0 | 19.8 | GO:0071803 | keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803) |
| 1.0 | 3.1 | GO:0001827 | inner cell mass cell fate commitment(GO:0001827) |
| 1.0 | 4.0 | GO:2001045 | closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045) |
| 1.0 | 9.9 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 1.0 | 2.9 | GO:0001951 | intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896) |
| 1.0 | 7.6 | GO:0070314 | G1 to G0 transition(GO:0070314) |
| 0.9 | 2.7 | GO:0070309 | notochord formation(GO:0014028) lens fiber cell morphogenesis(GO:0070309) negative regulation of lymphangiogenesis(GO:1901491) |
| 0.9 | 12.3 | GO:0055059 | asymmetric neuroblast division(GO:0055059) |
| 0.9 | 2.6 | GO:1903002 | regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002) |
| 0.7 | 4.2 | GO:0070094 | positive regulation of glucagon secretion(GO:0070094) |
| 0.7 | 5.4 | GO:0060662 | tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662) |
| 0.7 | 5.4 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.7 | 9.3 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 0.7 | 10.6 | GO:0045723 | positive regulation of fatty acid biosynthetic process(GO:0045723) |
| 0.6 | 7.8 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 0.6 | 8.0 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
| 0.6 | 1.8 | GO:0048162 | preantral ovarian follicle growth(GO:0001546) multi-layer follicle stage(GO:0048162) |
| 0.6 | 3.0 | GO:0006189 | 'de novo' IMP biosynthetic process(GO:0006189) |
| 0.6 | 4.1 | GO:1990504 | dense core granule exocytosis(GO:1990504) |
| 0.6 | 1.7 | GO:0007161 | calcium-independent cell-matrix adhesion(GO:0007161) |
| 0.6 | 4.6 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.5 | 2.6 | GO:1902732 | positive regulation of chondrocyte proliferation(GO:1902732) |
| 0.5 | 3.6 | GO:0007343 | egg activation(GO:0007343) |
| 0.5 | 2.1 | GO:0006166 | purine ribonucleoside salvage(GO:0006166) |
| 0.5 | 1.5 | GO:0008065 | establishment of blood-nerve barrier(GO:0008065) regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.5 | 2.0 | GO:0046947 | hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947) |
| 0.5 | 4.0 | GO:0045023 | G0 to G1 transition(GO:0045023) regulation of G0 to G1 transition(GO:0070316) |
| 0.5 | 5.3 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 0.5 | 1.9 | GO:2000319 | negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320) |
| 0.5 | 1.9 | GO:0051387 | negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387) |
| 0.5 | 12.4 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.5 | 9.0 | GO:1903672 | positive regulation of sprouting angiogenesis(GO:1903672) |
| 0.5 | 1.8 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.5 | 4.1 | GO:0070423 | nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423) nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070431) |
| 0.4 | 1.8 | GO:0042360 | vitamin E metabolic process(GO:0042360) |
| 0.4 | 7.9 | GO:0097201 | negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201) |
| 0.4 | 1.8 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
| 0.4 | 20.7 | GO:0032611 | interleukin-1 beta production(GO:0032611) |
| 0.4 | 1.2 | GO:1902396 | protein localization to bicellular tight junction(GO:1902396) |
| 0.4 | 1.2 | GO:0045668 | negative regulation of osteoblast differentiation(GO:0045668) |
| 0.4 | 1.6 | GO:0002667 | lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) |
| 0.4 | 7.1 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.4 | 2.0 | GO:0001658 | branching involved in ureteric bud morphogenesis(GO:0001658) |
| 0.4 | 4.6 | GO:0051451 | myoblast migration(GO:0051451) |
| 0.4 | 2.7 | GO:0007406 | negative regulation of neuroblast proliferation(GO:0007406) |
| 0.4 | 3.0 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
| 0.4 | 5.1 | GO:0002467 | germinal center formation(GO:0002467) |
| 0.3 | 15.6 | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle(GO:2000134) |
| 0.3 | 11.9 | GO:0035411 | catenin import into nucleus(GO:0035411) |
| 0.3 | 1.8 | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) |
| 0.3 | 1.8 | GO:0001547 | antral ovarian follicle growth(GO:0001547) |
| 0.3 | 4.5 | GO:0038092 | nodal signaling pathway(GO:0038092) |
| 0.3 | 12.4 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.3 | 1.9 | GO:0035745 | T-helper 2 cell cytokine production(GO:0035745) |
| 0.3 | 7.2 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.3 | 1.1 | GO:0021986 | epithalamus development(GO:0021538) habenula development(GO:0021986) |
| 0.2 | 10.5 | GO:0006826 | iron ion transport(GO:0006826) |
| 0.2 | 1.4 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
| 0.2 | 0.7 | GO:2000987 | positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987) |
| 0.2 | 4.2 | GO:0010592 | positive regulation of lamellipodium assembly(GO:0010592) |
| 0.2 | 2.1 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
| 0.2 | 7.6 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.2 | 24.6 | GO:0048706 | embryonic skeletal system development(GO:0048706) |
| 0.2 | 0.4 | GO:1904685 | positive regulation of metalloendopeptidase activity(GO:1904685) |
| 0.2 | 1.0 | GO:0044828 | negative regulation by host of viral process(GO:0044793) negative regulation by host of viral genome replication(GO:0044828) |
| 0.2 | 0.2 | GO:0048850 | hypophysis morphogenesis(GO:0048850) |
| 0.2 | 2.3 | GO:0045199 | maintenance of epithelial cell apical/basal polarity(GO:0045199) |
| 0.2 | 2.7 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.2 | 1.9 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
| 0.2 | 2.8 | GO:1904293 | negative regulation of ERAD pathway(GO:1904293) |
| 0.2 | 0.9 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
| 0.2 | 0.6 | GO:2000832 | cortisol secretion(GO:0043400) regulation of cortisol secretion(GO:0051462) negative regulation of steroid hormone secretion(GO:2000832) negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850) |
| 0.2 | 5.9 | GO:2000249 | regulation of actin cytoskeleton reorganization(GO:2000249) |
| 0.2 | 1.5 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 0.2 | 15.3 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.2 | 8.4 | GO:0042058 | regulation of epidermal growth factor receptor signaling pathway(GO:0042058) |
| 0.2 | 1.0 | GO:0098734 | protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734) |
| 0.2 | 0.8 | GO:0045163 | clustering of voltage-gated potassium channels(GO:0045163) |
| 0.2 | 7.8 | GO:0048747 | muscle fiber development(GO:0048747) |
| 0.2 | 1.1 | GO:0031642 | negative regulation of myelination(GO:0031642) |
| 0.2 | 0.3 | GO:0070103 | regulation of interleukin-6-mediated signaling pathway(GO:0070103) negative regulation of interleukin-6-mediated signaling pathway(GO:0070104) |
| 0.1 | 3.1 | GO:2001273 | regulation of glucose import in response to insulin stimulus(GO:2001273) |
| 0.1 | 0.9 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.1 | 6.3 | GO:0006940 | regulation of smooth muscle contraction(GO:0006940) |
| 0.1 | 1.1 | GO:0030035 | microspike assembly(GO:0030035) |
| 0.1 | 0.6 | GO:1901301 | regulation of cargo loading into COPII-coated vesicle(GO:1901301) |
| 0.1 | 0.4 | GO:0016095 | polyprenol catabolic process(GO:0016095) |
| 0.1 | 0.8 | GO:0072189 | ureter development(GO:0072189) |
| 0.1 | 0.5 | GO:0000415 | negative regulation of histone H3-K36 methylation(GO:0000415) |
| 0.1 | 2.1 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
| 0.1 | 0.7 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.1 | 0.8 | GO:0035562 | negative regulation of chromatin binding(GO:0035562) |
| 0.1 | 0.4 | GO:0019244 | lactate biosynthetic process from pyruvate(GO:0019244) |
| 0.1 | 2.0 | GO:0010801 | negative regulation of peptidyl-threonine phosphorylation(GO:0010801) |
| 0.1 | 0.2 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
| 0.1 | 14.5 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.1 | 1.4 | GO:0003215 | cardiac right ventricle morphogenesis(GO:0003215) |
| 0.1 | 7.3 | GO:0000187 | activation of MAPK activity(GO:0000187) |
| 0.1 | 0.3 | GO:0033580 | protein glycosylation at cell surface(GO:0033575) protein galactosylation at cell surface(GO:0033580) protein galactosylation(GO:0042125) |
| 0.1 | 5.2 | GO:0050728 | negative regulation of inflammatory response(GO:0050728) |
| 0.1 | 1.3 | GO:0046825 | regulation of protein export from nucleus(GO:0046825) |
| 0.1 | 0.5 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
| 0.1 | 3.1 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 0.1 | 2.0 | GO:0051496 | positive regulation of stress fiber assembly(GO:0051496) |
| 0.1 | 0.8 | GO:0048642 | negative regulation of skeletal muscle tissue development(GO:0048642) |
| 0.1 | 0.9 | GO:0034315 | regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315) |
| 0.1 | 0.5 | GO:0061470 | T follicular helper cell differentiation(GO:0061470) |
| 0.0 | 0.3 | GO:1903275 | positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278) |
| 0.0 | 1.7 | GO:0045494 | photoreceptor cell maintenance(GO:0045494) |
| 0.0 | 1.0 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.0 | 1.7 | GO:0017145 | stem cell division(GO:0017145) |
| 0.0 | 1.2 | GO:0010569 | regulation of double-strand break repair via homologous recombination(GO:0010569) |
| 0.0 | 0.3 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148) |
| 0.0 | 3.6 | GO:0007519 | skeletal muscle tissue development(GO:0007519) |
| 0.0 | 3.2 | GO:0006261 | DNA-dependent DNA replication(GO:0006261) |
| 0.0 | 1.6 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.0 | 0.2 | GO:0019433 | triglyceride catabolic process(GO:0019433) |
| 0.0 | 2.1 | GO:0051453 | regulation of intracellular pH(GO:0051453) |
| 0.0 | 0.3 | GO:0006654 | phosphatidic acid biosynthetic process(GO:0006654) |
| 0.0 | 0.1 | GO:0019074 | viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074) |
| 0.0 | 0.7 | GO:0016572 | histone phosphorylation(GO:0016572) |
| 0.0 | 2.2 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
| 0.0 | 0.3 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 0.9 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
| 0.0 | 0.2 | GO:0060441 | epithelial tube branching involved in lung morphogenesis(GO:0060441) |
| 0.0 | 0.8 | GO:0006914 | autophagy(GO:0006914) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.0 | 21.1 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
| 3.2 | 12.7 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 2.9 | 8.8 | GO:0097135 | cyclin E2-CDK2 complex(GO:0097135) |
| 2.6 | 7.9 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 2.0 | 26.4 | GO:0043219 | lateral loop(GO:0043219) |
| 1.9 | 5.7 | GO:0030934 | collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934) |
| 1.6 | 6.3 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 1.4 | 10.1 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 1.4 | 4.2 | GO:0005899 | insulin receptor complex(GO:0005899) |
| 1.3 | 17.2 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 1.2 | 17.3 | GO:0005614 | interstitial matrix(GO:0005614) |
| 1.2 | 8.5 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 1.2 | 11.8 | GO:0016600 | flotillin complex(GO:0016600) |
| 1.1 | 23.3 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 1.0 | 53.5 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.9 | 4.4 | GO:0031523 | Myb complex(GO:0031523) |
| 0.9 | 2.6 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.8 | 7.4 | GO:0030478 | actin cap(GO:0030478) |
| 0.8 | 3.2 | GO:0008623 | CHRAC(GO:0008623) |
| 0.7 | 81.1 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.7 | 5.3 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.6 | 2.9 | GO:1990357 | terminal web(GO:1990357) |
| 0.6 | 1.7 | GO:0034679 | integrin alpha2-beta1 complex(GO:0034666) integrin alpha3-beta1 complex(GO:0034667) integrin alpha9-beta1 complex(GO:0034679) |
| 0.5 | 8.6 | GO:0008305 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.5 | 5.6 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.5 | 31.5 | GO:0016459 | myosin complex(GO:0016459) |
| 0.5 | 1.4 | GO:0031074 | nucleocytoplasmic shuttling complex(GO:0031074) |
| 0.5 | 19.8 | GO:0002102 | podosome(GO:0002102) |
| 0.3 | 4.2 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.3 | 1.0 | GO:0002944 | cyclin K-CDK12 complex(GO:0002944) |
| 0.3 | 8.0 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.3 | 2.8 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.3 | 15.8 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.3 | 2.0 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.3 | 4.7 | GO:0010369 | chromocenter(GO:0010369) |
| 0.3 | 4.7 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.2 | 13.5 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.2 | 4.9 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.2 | 47.1 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.2 | 12.3 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.2 | 88.3 | GO:0030055 | cell-substrate junction(GO:0030055) |
| 0.2 | 16.1 | GO:0005604 | basement membrane(GO:0005604) |
| 0.2 | 78.4 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.2 | 0.7 | GO:0032280 | symmetric synapse(GO:0032280) |
| 0.1 | 1.0 | GO:0034518 | mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518) |
| 0.1 | 0.4 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.1 | 12.2 | GO:0000922 | spindle pole(GO:0000922) |
| 0.1 | 0.3 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.1 | 0.3 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.1 | 0.5 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
| 0.1 | 0.8 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.1 | 0.6 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.1 | 1.9 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.1 | 4.3 | GO:0005912 | adherens junction(GO:0005912) |
| 0.1 | 6.9 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.0 | 8.9 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 4.1 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 1.9 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 0.9 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 3.1 | GO:0022626 | cytosolic ribosome(GO:0022626) |
| 0.0 | 12.0 | GO:0005874 | microtubule(GO:0005874) |
| 0.0 | 0.7 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 0.0 | 0.7 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 2.7 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 0.9 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 0.3 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.0 | 1.8 | GO:0000502 | proteasome complex(GO:0000502) |
| 0.0 | 8.1 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 0.3 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.0 | 0.2 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.0 | 2.4 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 0.2 | GO:0031045 | dense core granule(GO:0031045) |
| 0.0 | 0.3 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.0 | 9.1 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 0.5 | GO:0005882 | intermediate filament(GO:0005882) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.8 | 26.4 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 5.3 | 21.1 | GO:0004859 | phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834) |
| 5.1 | 45.9 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 4.3 | 94.3 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 3.7 | 22.3 | GO:0015204 | urea transmembrane transporter activity(GO:0015204) |
| 3.7 | 18.4 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 3.5 | 31.6 | GO:0030274 | LIM domain binding(GO:0030274) |
| 3.4 | 10.1 | GO:0031798 | type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
| 3.1 | 40.5 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 2.8 | 8.5 | GO:0030156 | benzodiazepine receptor binding(GO:0030156) |
| 2.3 | 29.7 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 2.3 | 25.1 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) |
| 2.1 | 29.4 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 1.8 | 16.1 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 1.8 | 5.3 | GO:0042936 | dipeptide transporter activity(GO:0042936) |
| 1.7 | 15.6 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 1.4 | 5.6 | GO:0005113 | patched binding(GO:0005113) |
| 1.2 | 8.2 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 1.1 | 4.4 | GO:0034988 | Fc-gamma receptor I complex binding(GO:0034988) |
| 1.0 | 4.0 | GO:0072542 | protein phosphatase activator activity(GO:0072542) |
| 1.0 | 13.8 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
| 0.9 | 5.6 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.9 | 7.9 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.9 | 2.6 | GO:0046911 | hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.8 | 4.1 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.7 | 17.4 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.7 | 5.6 | GO:0086008 | voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008) |
| 0.7 | 2.1 | GO:0004731 | purine-nucleoside phosphorylase activity(GO:0004731) |
| 0.6 | 8.8 | GO:0035173 | histone kinase activity(GO:0035173) |
| 0.6 | 12.4 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.6 | 5.3 | GO:0071253 | connexin binding(GO:0071253) |
| 0.6 | 1.7 | GO:0019960 | C-X3-C chemokine binding(GO:0019960) |
| 0.6 | 6.3 | GO:0015093 | ferrous iron transmembrane transporter activity(GO:0015093) |
| 0.6 | 3.4 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.5 | 4.6 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.5 | 19.8 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.5 | 2.0 | GO:0008475 | procollagen-lysine 5-dioxygenase activity(GO:0008475) |
| 0.5 | 5.4 | GO:0009922 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.5 | 6.3 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.5 | 1.9 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 0.5 | 11.6 | GO:0034185 | apolipoprotein binding(GO:0034185) |
| 0.4 | 0.9 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.4 | 4.2 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.4 | 10.5 | GO:0030371 | translation repressor activity(GO:0030371) |
| 0.4 | 8.1 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.4 | 4.2 | GO:0015271 | outward rectifier potassium channel activity(GO:0015271) |
| 0.3 | 3.4 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.3 | 3.6 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.3 | 4.5 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.3 | 1.3 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
| 0.3 | 4.3 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.3 | 5.2 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.3 | 6.8 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.3 | 7.2 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.3 | 0.8 | GO:0070139 | ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139) |
| 0.3 | 1.8 | GO:0000340 | RNA 7-methylguanosine cap binding(GO:0000340) |
| 0.3 | 8.6 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.2 | 9.3 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.2 | 32.1 | GO:0003774 | motor activity(GO:0003774) |
| 0.2 | 9.9 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.2 | 9.2 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.2 | 2.0 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.2 | 1.5 | GO:0070739 | protein-glutamic acid ligase activity(GO:0070739) |
| 0.2 | 6.7 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.2 | 8.0 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.2 | 1.1 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.2 | 3.0 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.1 | 0.9 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.1 | 2.7 | GO:0005003 | ephrin receptor activity(GO:0005003) |
| 0.1 | 4.6 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.1 | 26.7 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 0.4 | GO:0047751 | 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) enone reductase activity(GO:0035671) cholestenone 5-alpha-reductase activity(GO:0047751) |
| 0.1 | 2.1 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.1 | 0.4 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.1 | 15.0 | GO:0005539 | glycosaminoglycan binding(GO:0005539) |
| 0.1 | 3.6 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 0.5 | GO:0047134 | protein-disulfide reductase activity(GO:0047134) |
| 0.1 | 7.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 8.6 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.1 | 12.0 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.1 | 2.9 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.1 | 1.9 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.1 | 7.3 | GO:0035254 | glutamate receptor binding(GO:0035254) |
| 0.1 | 0.6 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.1 | 0.5 | GO:0003923 | GPI-anchor transamidase activity(GO:0003923) |
| 0.1 | 1.0 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
| 0.1 | 3.8 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.1 | 1.6 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.1 | 0.3 | GO:0047276 | N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276) |
| 0.1 | 0.4 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.1 | 2.5 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 0.7 | GO:0001104 | RNA polymerase II transcription cofactor activity(GO:0001104) |
| 0.0 | 4.9 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.2 | GO:0034711 | inhibin binding(GO:0034711) |
| 0.0 | 9.7 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.0 | 0.7 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 1.7 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 4.6 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 0.8 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 5.0 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 0.9 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.0 | 0.2 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.0 | 2.2 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.0 | 0.2 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
| 0.0 | 0.3 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 0.9 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 0.8 | GO:0002020 | protease binding(GO:0002020) |
| 0.0 | 0.2 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.0 | 3.1 | GO:0045296 | cadherin binding(GO:0045296) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 21.2 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
| 2.0 | 93.5 | PID_AMB2_NEUTROPHILS_PATHWAY | amb2 Integrin signaling |
| 1.2 | 16.4 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.7 | 57.7 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.7 | 15.6 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.6 | 18.2 | PID_WNT_CANONICAL_PATHWAY | Canonical Wnt signaling pathway |
| 0.6 | 39.3 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.6 | 15.5 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.5 | 8.6 | PID_INTEGRIN_CS_PATHWAY | Integrin family cell surface interactions |
| 0.3 | 9.9 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.3 | 13.4 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.3 | 43.5 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 4.9 | PID_IL27_PATHWAY | IL27-mediated signaling events |
| 0.3 | 2.7 | PID_EPHA2_FWD_PATHWAY | EPHA2 forward signaling |
| 0.3 | 8.8 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.3 | 9.2 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.2 | 4.2 | PID_S1P_S1P2_PATHWAY | S1P2 pathway |
| 0.2 | 9.5 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.2 | 3.3 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.2 | 1.8 | PID_ALK2_PATHWAY | ALK2 signaling events |
| 0.2 | 5.1 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
| 0.1 | 5.1 | PID_FCER1_PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.1 | 8.5 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 4.3 | PID_PS1_PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.1 | 6.3 | PID_TGFBR_PATHWAY | TGF-beta receptor signaling |
| 0.1 | 7.3 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 6.3 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.1 | 3.2 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 8.5 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 1.5 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.1 | 8.7 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.1 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.0 | 0.8 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.1 | ST_INTEGRIN_SIGNALING_PATHWAY | Integrin Signaling Pathway |
| 0.0 | 0.9 | PID_ERBB2_ERBB3_PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 1.9 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 3.0 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 2.1 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
| 0.0 | 1.1 | PID_P53_REGULATION_PATHWAY | p53 pathway |
| 0.0 | 0.9 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 107.1 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 2.3 | 31.6 | REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 1.8 | 1.8 | REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 1.7 | 27.3 | REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 1.5 | 12.0 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 1.5 | 29.4 | REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
| 1.1 | 22.3 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.9 | 14.7 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.8 | 5.3 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.7 | 19.4 | REACTOME_ENOS_ACTIVATION_AND_REGULATION | Genes involved in eNOS activation and regulation |
| 0.6 | 16.4 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.5 | 1.6 | REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.5 | 9.9 | REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.5 | 7.6 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.4 | 9.5 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.4 | 13.3 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.4 | 4.9 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.4 | 10.3 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.4 | 4.2 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.3 | 4.3 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.3 | 10.1 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.3 | 9.3 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.3 | 9.9 | REACTOME_PI3K_AKT_ACTIVATION | Genes involved in PI3K/AKT activation |
| 0.3 | 4.3 | REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.2 | 1.9 | REACTOME_EGFR_DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.2 | 3.0 | REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.2 | 5.4 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.2 | 4.5 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.2 | 9.0 | REACTOME_SIGNAL_TRANSDUCTION_BY_L1 | Genes involved in Signal transduction by L1 |
| 0.2 | 4.5 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.2 | 1.8 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.1 | 24.7 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 2.0 | REACTOME_MTORC1_MEDIATED_SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.1 | 3.4 | REACTOME_METAL_ION_SLC_TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.1 | 2.1 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 6.5 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 5.3 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 1.1 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.1 | 1.9 | REACTOME_DEADENYLATION_OF_MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 5.2 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.1 | 0.4 | REACTOME_ANDROGEN_BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.1 | 1.2 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.1 | 5.6 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 1.9 | REACTOME_MRNA_3_END_PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.0 | 1.0 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 1.9 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 0.9 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 1.0 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
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