Motif ID: Tead3_Tead4

Z-value: 2.408

Transcription factors associated with Tead3_Tead4:

Gene SymbolEntrez IDGene Name
Tead3 ENSMUSG00000002249.11 Tead3
Tead4 ENSMUSG00000030353.9 Tead4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tead3mm10_v2_chr17_-_28350600_283506810.711.5e-09Click!


Activity profile for motif Tead3_Tead4.

activity profile for motif Tead3_Tead4


Sorted Z-values histogram for motif Tead3_Tead4

Sorted Z-values for motif Tead3_Tead4



Network of associatons between targets according to the STRING database.



First level regulatory network of Tead3_Tead4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_54577578 40.477 ENSMUST00000054487.8
 Ajuba
ajuba LIM protein
chr10_+_24595623 32.335 ENSMUST00000176228.1
ENSMUST00000129142.1
 Ctgf

connective tissue growth factor

chr4_-_43558386 31.628 ENSMUST00000130353.1
 Tln1
talin 1
chr5_-_137314175 29.730 ENSMUST00000024119.9
 Trip6
thyroid hormone receptor interactor 6
chr12_-_80112998 29.427 ENSMUST00000165114.1
ENSMUST00000021552.1
 Zfp36l1

zinc finger protein 36, C3H type-like 1

chr11_+_98412461 26.442 ENSMUST00000058295.5
 Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr10_+_24595434 26.041 ENSMUST00000020171.5
 Ctgf
connective tissue growth factor
chr11_+_112782182 25.075 ENSMUST00000000579.2
 Sox9
SRY-box containing gene 9
chr2_+_20519776 24.540 ENSMUST00000114604.2
ENSMUST00000066509.3
 Etl4

enhancer trap locus 4

chr10_-_78591945 23.335 ENSMUST00000040580.6
 Syde1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr3_-_57575760 22.436 ENSMUST00000029380.7
 Wwtr1
WW domain containing transcription regulator 1
chr18_-_78206408 22.250 ENSMUST00000163367.1
 Slc14a2
solute carrier family 14 (urea transporter), member 2
chr3_-_145649970 21.192 ENSMUST00000029846.3
 Cyr61
cysteine rich protein 61
chr8_-_61760067 19.761 ENSMUST00000121493.1
 Palld
palladin, cytoskeletal associated protein
chr13_-_113046357 17.377 ENSMUST00000022282.3
 Gpx8
glutathione peroxidase 8 (putative)
chr17_+_78508063 16.634 ENSMUST00000024880.9
 Vit
vitrin
chr10_+_93641041 16.084 ENSMUST00000020204.4
 Ntn4
netrin 4
chr17_-_35702040 14.765 ENSMUST00000166980.2
ENSMUST00000145900.1
 Ddr1

discoidin domain receptor family, member 1

chr17_-_35701937 14.193 ENSMUST00000155628.1
 Ddr1
discoidin domain receptor family, member 1
chr11_-_115813621 14.030 ENSMUST00000041684.4
ENSMUST00000156812.1
 Caskin2

CASK-interacting protein 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 163 entries
Log-likelihood per target Total log-likelihoodTermDescription
14.6 58.4 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
3.8 45.9 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
5.4 37.5 GO:0035331 negative regulation of hippo signaling(GO:0035331)
5.2 36.3 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
4.1 32.7 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
5.0 29.7 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
9.8 29.4 GO:1904580 regulation of intracellular mRNA localization(GO:1904580)
8.8 26.4 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
12.5 25.1 GO:0072190 ureter urothelium development(GO:0072190) ureter morphogenesis(GO:0072197)
0.2 24.6 GO:0048706 embryonic skeletal system development(GO:0048706)
4.7 23.3 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
7.4 22.3 GO:0071918 urea transmembrane transport(GO:0071918)
5.3 21.2 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
4.2 21.1 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.4 20.7 GO:0032611 interleukin-1 beta production(GO:0032611)
1.0 19.8 GO:0071803 keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803)
3.7 18.4 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
4.0 16.1 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.3 15.6 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.2 15.3 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 88.3 GO:0030055 cell-substrate junction(GO:0030055)
0.7 81.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 78.4 GO:0005667 transcription factor complex(GO:0005667)
1.0 53.5 GO:0005801 cis-Golgi network(GO:0005801)
0.2 47.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.5 31.5 GO:0016459 myosin complex(GO:0016459)
2.0 26.4 GO:0043219 lateral loop(GO:0043219)
1.1 23.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
7.0 21.1 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.5 19.8 GO:0002102 podosome(GO:0002102)
1.2 17.3 GO:0005614 interstitial matrix(GO:0005614)
1.3 17.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.2 16.1 GO:0005604 basement membrane(GO:0005604)
0.3 15.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 13.5 GO:0005871 kinesin complex(GO:0005871)
3.2 12.7 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.2 12.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 12.2 GO:0000922 spindle pole(GO:0000922)
0.0 12.0 GO:0005874 microtubule(GO:0005874)
1.2 11.8 GO:0016600 flotillin complex(GO:0016600)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.3 94.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
5.1 45.9 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
3.1 40.5 GO:0045294 alpha-catenin binding(GO:0045294)
0.2 32.1 GO:0003774 motor activity(GO:0003774)
3.5 31.6 GO:0030274 LIM domain binding(GO:0030274)
2.3 29.7 GO:0005149 interleukin-1 receptor binding(GO:0005149)
2.1 29.4 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 26.7 GO:0003714 transcription corepressor activity(GO:0003714)
8.8 26.4 GO:0001042 RNA polymerase I core binding(GO:0001042)
2.3 25.1 GO:0097157 pre-mRNA intronic binding(GO:0097157)
3.7 22.3 GO:0015204 urea transmembrane transporter activity(GO:0015204)
5.3 21.1 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
0.5 19.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
3.7 18.4 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.7 17.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
1.8 16.1 GO:0043237 laminin-1 binding(GO:0043237)
1.7 15.6 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 15.0 GO:0005539 glycosaminoglycan binding(GO:0005539)
1.0 13.8 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.6 12.4 GO:0017049 GTP-Rho binding(GO:0017049)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 93.5 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.7 57.7 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.3 43.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.6 39.3 PID_AP1_PATHWAY AP-1 transcription factor network
2.6 21.2 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.6 18.2 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
1.2 16.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.7 15.6 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.6 15.5 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.3 13.4 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.3 9.9 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.2 9.5 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.3 9.2 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.3 8.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 8.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.5 8.6 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.1 8.5 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 8.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 7.3 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 6.3 PID_TGFBR_PATHWAY TGF-beta receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.5 107.1 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
2.3 31.6 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
1.5 29.4 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
1.7 27.3 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 24.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
1.1 22.3 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.7 19.4 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.6 16.4 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.9 14.7 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.4 13.3 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
1.5 12.0 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.4 10.3 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.3 10.1 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.5 9.9 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.3 9.9 REACTOME_PI3K_AKT_ACTIVATION Genes involved in PI3K/AKT activation
0.4 9.5 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.3 9.3 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 9.0 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 Genes involved in Signal transduction by L1
0.5 7.6 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 6.5 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)