Motif ID: Tfap2a
Z-value: 1.061
Transcription factors associated with Tfap2a:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Tfap2a | ENSMUSG00000021359.9 | Tfap2a |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tfap2a | mm10_v2_chr13_-_40730416_40730429 | 0.10 | 4.7e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 241 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 20.0 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.6 | 12.1 | GO:0050650 | chondroitin sulfate proteoglycan biosynthetic process(GO:0050650) |
| 0.3 | 10.9 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 2.0 | 8.2 | GO:0033024 | mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) |
| 1.9 | 7.8 | GO:0048686 | regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690) |
| 0.1 | 7.5 | GO:0099643 | neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643) |
| 0.2 | 7.4 | GO:0060716 | labyrinthine layer blood vessel development(GO:0060716) |
| 1.0 | 6.7 | GO:0033031 | positive regulation of neutrophil apoptotic process(GO:0033031) |
| 0.2 | 6.2 | GO:2000310 | regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310) |
| 1.5 | 6.1 | GO:0014012 | peripheral nervous system axon regeneration(GO:0014012) |
| 0.2 | 5.9 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 1.0 | 5.7 | GO:2000672 | negative regulation of motor neuron apoptotic process(GO:2000672) |
| 0.5 | 5.5 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 0.1 | 5.5 | GO:0017157 | regulation of exocytosis(GO:0017157) |
| 1.0 | 4.8 | GO:0051012 | microtubule sliding(GO:0051012) |
| 0.6 | 4.7 | GO:1903207 | neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208) |
| 0.1 | 4.6 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 0.5 | 4.5 | GO:0046959 | habituation(GO:0046959) |
| 0.1 | 4.4 | GO:0048821 | erythrocyte development(GO:0048821) |
| 0.5 | 4.3 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 131 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 23.1 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.1 | 9.9 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 9.9 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 8.6 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 2.6 | 7.8 | GO:0072534 | perineuronal net(GO:0072534) |
| 0.3 | 7.6 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 1.8 | 7.2 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 1.9 | 5.7 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 0.0 | 5.7 | GO:0030426 | growth cone(GO:0030426) |
| 0.5 | 5.5 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
| 0.1 | 5.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 5.1 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.1 | 4.9 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.1 | 4.8 | GO:0032420 | stereocilium(GO:0032420) |
| 0.9 | 4.7 | GO:1990037 | Lewy body core(GO:1990037) |
| 0.0 | 4.7 | GO:0031410 | cytoplasmic vesicle(GO:0031410) |
| 0.0 | 4.6 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.4 | 4.4 | GO:0042582 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.3 | 4.4 | GO:0043196 | varicosity(GO:0043196) |
| 0.1 | 4.4 | GO:0016459 | myosin complex(GO:0016459) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 169 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.8 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 2.0 | 12.1 | GO:0015018 | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018) |
| 0.7 | 11.4 | GO:0046625 | sphingolipid binding(GO:0046625) |
| 0.3 | 10.1 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 1.4 | 8.2 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
| 0.5 | 7.6 | GO:0031210 | phosphatidylcholine binding(GO:0031210) |
| 0.1 | 7.5 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 1.8 | 7.2 | GO:0031720 | haptoglobin binding(GO:0031720) |
| 0.0 | 7.0 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.8 | 6.7 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813) |
| 0.1 | 6.2 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.8 | 5.7 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.0 | 5.6 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.0 | 5.5 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.1 | 5.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.2 | 4.7 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.1 | 4.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.2 | 4.3 | GO:0031489 | myosin V binding(GO:0031489) |
| 1.3 | 3.9 | GO:0004517 | nitric-oxide synthase activity(GO:0004517) |
| 0.2 | 3.9 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 37 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.4 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 6.1 | PID_PDGFRB_PATHWAY | PDGFR-beta signaling pathway |
| 0.2 | 5.5 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 4.8 | PID_EPHB_FWD_PATHWAY | EPHB forward signaling |
| 0.1 | 4.6 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.0 | 3.7 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 3.5 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 3.4 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.1 | 3.4 | PID_INTEGRIN3_PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 3.0 | PID_IL2_1PATHWAY | IL2-mediated signaling events |
| 0.1 | 2.5 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.1 | 2.4 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.1 | 2.4 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 2.2 | PID_HDAC_CLASSII_PATHWAY | Signaling events mediated by HDAC Class II |
| 0.2 | 2.0 | PID_IL5_PATHWAY | IL5-mediated signaling events |
| 0.1 | 1.9 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.0 | 1.9 | PID_FOXO_PATHWAY | FoxO family signaling |
| 0.0 | 1.6 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
| 0.0 | 1.6 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.1 | 1.4 | PID_VEGFR1_2_PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 75 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 12.1 | REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.3 | 9.9 | REACTOME_IL_RECEPTOR_SHC_SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.5 | 7.9 | REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.1 | 7.5 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 6.6 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.2 | 5.3 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 4.7 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.2 | 4.6 | REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.3 | 4.3 | REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.1 | 4.3 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.3 | 3.9 | REACTOME_DSCAM_INTERACTIONS | Genes involved in DSCAM interactions |
| 0.1 | 3.9 | REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.1 | 3.8 | REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.1 | 3.8 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 3.6 | REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 3.6 | REACTOME_POTASSIUM_CHANNELS | Genes involved in Potassium Channels |
| 0.1 | 3.2 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.2 | 2.9 | REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.1 | 2.8 | REACTOME_IL_2_SIGNALING | Genes involved in Interleukin-2 signaling |
| 0.0 | 2.7 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
