Motif ID: Tfap2b

Z-value: 0.778


Transcription factors associated with Tfap2b:

Gene SymbolEntrez IDGene Name
Tfap2b ENSMUSG00000025927.7 Tfap2b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2bmm10_v2_chr1_+_19212054_19212106-0.366.9e-03Click!


Activity profile for motif Tfap2b.

activity profile for motif Tfap2b


Sorted Z-values histogram for motif Tfap2b

Sorted Z-values for motif Tfap2b



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_5740885 6.350 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr2_+_158610731 5.620 ENSMUST00000045738.4
 Slc32a1
solute carrier family 32 (GABA vesicular transporter), member 1
chr2_+_91945703 5.342 ENSMUST00000178895.1
 Gm9821
predicted gene 9821
chr2_-_93957040 5.269 ENSMUST00000148314.2
 Gm13889
predicted gene 13889
chr19_+_38055002 4.983 ENSMUST00000096096.4
ENSMUST00000116506.1
ENSMUST00000169673.1
 Cep55


centrosomal protein 55


chr2_-_36105271 4.710 ENSMUST00000112960.1
ENSMUST00000112967.5
ENSMUST00000112963.1
 Lhx6


LIM homeobox protein 6


chr1_-_14310198 4.048 ENSMUST00000168081.2
ENSMUST00000027066.6
 Eya1

eyes absent 1 homolog (Drosophila)

chr17_+_86963279 3.989 ENSMUST00000139344.1
 Rhoq
ras homolog gene family, member Q
chr4_+_8690399 3.345 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7
chr2_+_59612034 3.309 ENSMUST00000112568.1
ENSMUST00000037526.4
 Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr17_-_70849644 3.152 ENSMUST00000134654.1
ENSMUST00000172229.1
ENSMUST00000127719.1
 Tgif1


TGFB-induced factor homeobox 1


chr17_+_83215271 2.955 ENSMUST00000170794.1
 Pkdcc
protein kinase domain containing, cytoplasmic
chr4_+_46450892 2.934 ENSMUST00000102926.4
 Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr17_+_86963077 2.818 ENSMUST00000024956.8
 Rhoq
ras homolog gene family, member Q
chr4_+_109978004 2.800 ENSMUST00000061187.3
 Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr14_-_67715585 2.685 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
 Cdca2


cell division cycle associated 2


chr5_-_137314175 2.666 ENSMUST00000024119.9
 Trip6
thyroid hormone receptor interactor 6
chr12_+_70825492 2.650 ENSMUST00000057859.7
 Frmd6
FERM domain containing 6
chr18_+_64340225 2.628 ENSMUST00000175965.2
ENSMUST00000115145.3
 Onecut2

one cut domain, family member 2

chr3_-_137981523 2.595 ENSMUST00000136613.1
ENSMUST00000029806.6
 Dapp1

dual adaptor for phosphotyrosine and 3-phosphoinositides 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.9 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.3 6.8 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
2.1 6.3 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.6 5.6 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.3 5.0 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.8 4.6 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 4.3 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.3 4.1 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.7 4.0 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.1 3.6 GO:0097062 dendritic spine maintenance(GO:0097062)
0.3 3.4 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
1.1 3.3 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.2 3.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.5 3.0 GO:0090005 negative regulation of Golgi to plasma membrane protein transport(GO:0042997) negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.1 2.8 GO:0060033 anatomical structure regression(GO:0060033)
0.7 2.7 GO:2000256 endomitotic cell cycle(GO:0007113) thrombopoietin-mediated signaling pathway(GO:0038163) positive regulation of male germ cell proliferation(GO:2000256)
0.4 2.7 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.4 2.7 GO:0097473 cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.4 2.6 GO:0003383 apical constriction(GO:0003383)
0.2 2.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.3 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.5 5.0 GO:0090543 Flemming body(GO:0090543)
0.0 4.8 GO:0032993 protein-DNA complex(GO:0032993)
0.9 4.7 GO:0044316 cone cell pedicle(GO:0044316)
0.0 4.3 GO:0043296 apical junction complex(GO:0043296)
0.0 3.0 GO:0005884 actin filament(GO:0005884)
0.2 2.7 GO:0032433 filopodium tip(GO:0032433)
0.2 2.7 GO:0032593 insulin-responsive compartment(GO:0032593)
0.5 2.0 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.0 1.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.5 1.6 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.2 1.6 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.1 1.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.5 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.5 GO:0030667 secretory granule membrane(GO:0030667)
0.1 1.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 1.4 GO:0031901 early endosome membrane(GO:0031901)
0.1 1.3 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 1.2 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 1.2 GO:0043235 receptor complex(GO:0043235)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 9.1 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.5 5.9 GO:0005522 profilin binding(GO:0005522)
1.9 5.6 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.1 4.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 4.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 3.3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 3.2 GO:0070410 co-SMAD binding(GO:0070410)
0.0 3.0 GO:0042393 histone binding(GO:0042393)
0.5 2.7 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.2 2.7 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 2.3 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.2 2.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 2.1 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 2.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 2.0 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 2.0 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 2.0 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 2.0 GO:0005080 protein kinase C binding(GO:0005080)
0.5 1.9 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.2 1.9 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.5 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 8.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 4.8 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 3.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 3.3 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 2.3 NABA_COLLAGENS Genes encoding collagen proteins
0.0 2.1 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.7 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 1.7 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.6 PID_EPO_PATHWAY EPO signaling pathway
0.0 1.5 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.3 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.3 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.0 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 0.9 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 0.9 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 0.8 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.8 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.7 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.6 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.6 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 5.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 3.5 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 3.4 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.2 2.7 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 2.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 1.7 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 1.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.6 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 1.6 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.0 1.3 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.0 1.1 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 0.9 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.1 0.9 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.1 0.8 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.8 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.8 REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER Genes involved in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
0.0 0.7 REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.0 0.7 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 0.6 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions