Motif ID: Tfap2c

Z-value: 0.925


Transcription factors associated with Tfap2c:

Gene SymbolEntrez IDGene Name
Tfap2c ENSMUSG00000028640.5 Tfap2c

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2cmm10_v2_chr2_+_172550761_172550782-0.711.3e-09Click!


Activity profile for motif Tfap2c.

activity profile for motif Tfap2c


Sorted Z-values histogram for motif Tfap2c

Sorted Z-values for motif Tfap2c



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2c

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_70493156 9.103 ENSMUST00000008032.7
 Crlf1
cytokine receptor-like factor 1
chr14_+_119138415 8.129 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr6_+_4505493 6.043 ENSMUST00000031668.8
 Col1a2
collagen, type I, alpha 2
chr9_-_29412204 5.076 ENSMUST00000115237.1
 Ntm
neurotrimin
chr18_-_61911783 5.019 ENSMUST00000049378.8
ENSMUST00000166783.1
 Ablim3

actin binding LIM protein family, member 3

chr4_+_152338887 5.011 ENSMUST00000005175.4
 Chd5
chromodomain helicase DNA binding protein 5
chr9_-_29411736 4.891 ENSMUST00000115236.1
 Ntm
neurotrimin
chr2_+_76406529 4.724 ENSMUST00000111929.1
ENSMUST00000077972.4
ENSMUST00000111930.2
 Osbpl6


oxysterol binding protein-like 6


chr4_+_152338619 4.462 ENSMUST00000030775.5
ENSMUST00000164662.1
 Chd5

chromodomain helicase DNA binding protein 5

chr9_+_89909775 4.295 ENSMUST00000034912.4
ENSMUST00000034909.4
 Rasgrf1

RAS protein-specific guanine nucleotide-releasing factor 1

chr11_+_67455339 4.255 ENSMUST00000108681.1
 Gas7
growth arrest specific 7
chr6_+_38663061 3.925 ENSMUST00000114874.3
 Clec2l
C-type lectin domain family 2, member L
chr1_-_75264195 3.825 ENSMUST00000027404.5
 Ptprn
protein tyrosine phosphatase, receptor type, N
chr10_+_13966268 3.605 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr12_-_76709997 3.593 ENSMUST00000166101.1
 Sptb
spectrin beta, erythrocytic
chr6_+_4504814 3.575 ENSMUST00000141483.1
 Col1a2
collagen, type I, alpha 2
chr7_-_31126945 3.443 ENSMUST00000098548.4
 Scn1b
sodium channel, voltage-gated, type I, beta
chr4_+_104367549 3.437 ENSMUST00000106830.2
 Dab1
disabled 1
chr11_-_106715251 3.382 ENSMUST00000080853.4
ENSMUST00000183610.1
ENSMUST00000103069.3
ENSMUST00000106796.2
 Pecam1



platelet/endothelial cell adhesion molecule 1



chr11_-_120047070 3.279 ENSMUST00000064307.3
 Aatk
apoptosis-associated tyrosine kinase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 10.2 GO:0043589 skin morphogenesis(GO:0043589)
1.4 9.5 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
1.5 9.1 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
1.4 8.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 7.6 GO:0010977 negative regulation of neuron projection development(GO:0010977)
1.0 5.0 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 5.0 GO:0030032 lamellipodium assembly(GO:0030032)
0.2 4.4 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 4.3 GO:0051017 actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572)
0.8 4.0 GO:0051012 microtubule sliding(GO:0051012)
1.3 3.9 GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465)
0.3 3.8 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.1 3.7 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.1 3.6 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
1.1 3.4 GO:0086047 membrane depolarization during Purkinje myocyte cell action potential(GO:0086047)
0.9 3.4 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812) lateral motor column neuron migration(GO:0097477)
0.8 3.4 GO:0050904 diapedesis(GO:0050904)
0.3 3.3 GO:0032482 Rab protein signal transduction(GO:0032482)
0.2 3.2 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.5 3.1 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393) follicle-stimulating hormone signaling pathway(GO:0042699)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.3 GO:0031225 anchored component of membrane(GO:0031225)
3.2 9.6 GO:0005584 collagen type I trimer(GO:0005584)
0.4 9.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
3.0 9.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 5.3 GO:0030027 lamellipodium(GO:0030027)
0.7 5.0 GO:0005638 lamin filament(GO:0005638)
0.2 4.7 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 4.7 GO:0005884 actin filament(GO:0005884)
0.0 4.6 GO:0005903 brush border(GO:0005903)
0.2 4.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 4.1 GO:0043197 dendritic spine(GO:0043197)
0.1 4.0 GO:0072686 mitotic spindle(GO:0072686)
0.0 3.8 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.6 3.6 GO:0008091 spectrin(GO:0008091)
0.0 3.5 GO:0045211 postsynaptic membrane(GO:0045211)
0.7 3.4 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.2 3.4 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 3.3 GO:0044295 axonal growth cone(GO:0044295)
0.0 3.3 GO:0000139 Golgi membrane(GO:0000139)
0.3 3.2 GO:0032426 stereocilium tip(GO:0032426)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.6 GO:0003779 actin binding(GO:0003779)
0.6 9.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
2.4 9.5 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
1.3 9.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
2.0 8.1 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.2 5.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 4.6 GO:0019902 phosphatase binding(GO:0019902)
0.0 4.6 GO:0005096 GTPase activator activity(GO:0005096)
0.1 4.3 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.4 3.9 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 3.8 GO:0030507 spectrin binding(GO:0030507)
0.2 3.6 GO:0030506 ankyrin binding(GO:0030506)
0.5 3.4 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 3.4 GO:0042169 SH2 domain binding(GO:0042169)
0.1 3.2 GO:0071837 HMG box domain binding(GO:0071837)
1.0 3.1 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.1 3.1 GO:0070888 E-box binding(GO:0070888)
0.3 3.0 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.0 3.0 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.5 2.9 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.6 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 8.2 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 5.9 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.3 5.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 4.8 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 4.4 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 3.6 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 3.4 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 3.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 2.7 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 2.7 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 2.2 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 2.0 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 1.2 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 1.2 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.2 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 1.1 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.0 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.9 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 10.1 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.2 8.1 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 7.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 6.8 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 5.3 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 5.2 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 4.1 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 4.1 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.4 3.9 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.2 3.8 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.3 3.4 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.1 3.3 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 3.0 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.2 2.9 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 2.9 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.2 2.7 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.4 2.6 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 2.5 REACTOME_DAG_AND_IP3_SIGNALING Genes involved in DAG and IP3 signaling
0.2 2.2 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 2.0 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis