Motif ID: Tfap2d

Z-value: 0.707


Transcription factors associated with Tfap2d:

Gene SymbolEntrez IDGene Name
Tfap2d ENSMUSG00000042596.7 Tfap2d

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2dmm10_v2_chr1_+_19103022_191030430.265.2e-02Click!


Activity profile for motif Tfap2d.

activity profile for motif Tfap2d


Sorted Z-values histogram for motif Tfap2d

Sorted Z-values for motif Tfap2d



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2d

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_32222233 4.252 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
 Rhbdf1


rhomboid family 1 (Drosophila)


chr12_+_84009481 3.526 ENSMUST00000168120.1
 Acot1
acyl-CoA thioesterase 1
chr8_-_105637350 3.203 ENSMUST00000182863.1
 Gm5914
predicted gene 5914
chr18_+_64340225 2.351 ENSMUST00000175965.2
ENSMUST00000115145.3
 Onecut2

one cut domain, family member 2

chr2_+_26586607 2.242 ENSMUST00000174211.1
ENSMUST00000145575.2
ENSMUST00000173920.1
 Egfl7


EGF-like domain 7


chr4_-_154636831 2.108 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
 Prdm16






PR domain containing 16






chr12_+_83987854 2.072 ENSMUST00000021649.7
 Acot2
acyl-CoA thioesterase 2
chr7_+_130936172 2.004 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr9_-_79718631 1.958 ENSMUST00000180083.1
 Col12a1
collagen, type XII, alpha 1
chr7_-_4789541 1.939 ENSMUST00000168578.1
 Tmem238
transmembrane protein 238
chr4_+_152008803 1.910 ENSMUST00000097773.3
 Klhl21
kelch-like 21
chr8_-_105637403 1.862 ENSMUST00000182046.1
 Gm5914
predicted gene 5914
chr13_-_92131494 1.825 ENSMUST00000099326.3
ENSMUST00000146492.1
 Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chr5_-_71095765 1.818 ENSMUST00000000572.5
 Gabra2
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2
chr9_-_79718518 1.739 ENSMUST00000071750.6
 Col12a1
collagen, type XII, alpha 1
chr9_-_79718720 1.643 ENSMUST00000121227.1
 Col12a1
collagen, type XII, alpha 1
chr11_-_31370066 1.522 ENSMUST00000020546.2
 Stc2
stanniocalcin 2
chr19_+_8929628 1.482 ENSMUST00000096241.4
 Eml3
echinoderm microtubule associated protein like 3
chr2_+_25180737 1.477 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr3_+_33799791 1.464 ENSMUST00000099153.3
 Ttc14
tetratricopeptide repeat domain 14

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 138 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.1 3.5 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.5 3.0 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.1 2.9 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 2.8 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.2 2.4 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.4 2.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.3 2.1 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.2 2.1 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.1 1.9 GO:0034629 cellular protein complex localization(GO:0034629)
0.0 1.7 GO:0006414 translational elongation(GO:0006414)
0.2 1.5 GO:0014807 regulation of somitogenesis(GO:0014807)
0.1 1.5 GO:0006817 phosphate ion transport(GO:0006817)
0.5 1.4 GO:1904580 regulation of intracellular mRNA localization(GO:1904580)
0.2 1.4 GO:0089700 protein kinase D signaling(GO:0089700)
0.1 1.4 GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.3 1.3 GO:0001920 negative regulation of receptor recycling(GO:0001920) positive regulation of low-density lipoprotein particle receptor catabolic process(GO:0032805)
0.3 1.3 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1 1.3 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.1 1.3 GO:0010457 centriole-centriole cohesion(GO:0010457)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.0 GO:0031012 extracellular matrix(GO:0031012)
1.8 5.3 GO:0030934 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.0 4.0 GO:0000139 Golgi membrane(GO:0000139)
0.0 2.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.3 GO:0031901 early endosome membrane(GO:0031901)
0.0 2.1 GO:0016235 aggresome(GO:0016235)
0.3 1.9 GO:0005827 polar microtubule(GO:0005827)
0.1 1.9 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 1.9 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.4 1.3 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 1.3 GO:0005814 centriole(GO:0005814)
0.0 1.2 GO:0005884 actin filament(GO:0005884)
0.4 1.1 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.1 1.1 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 1.0 GO:0046930 pore complex(GO:0046930)
0.0 1.0 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 1.0 GO:0000421 autophagosome membrane(GO:0000421)
0.0 1.0 GO:0035869 ciliary transition zone(GO:0035869)
0.1 0.9 GO:0042555 MCM complex(GO:0042555)
0.0 0.9 GO:0005865 striated muscle thin filament(GO:0005865)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.1 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 4.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.8 GO:0005112 Notch binding(GO:0005112)
0.0 2.3 GO:0020037 heme binding(GO:0020037)
0.1 2.2 GO:0050699 WW domain binding(GO:0050699)
0.0 2.1 GO:0046332 SMAD binding(GO:0046332)
0.1 2.0 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 2.0 GO:0005109 frizzled binding(GO:0005109)
0.3 1.8 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.0 1.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 1.5 GO:0043495 protein anchor(GO:0043495)
0.1 1.4 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 1.4 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 1.4 GO:0071889 14-3-3 protein binding(GO:0071889)
0.4 1.3 GO:0034190 very-low-density lipoprotein particle binding(GO:0034189) apolipoprotein receptor binding(GO:0034190)
0.2 1.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 1.3 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 1.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.4 1.2 GO:0004686 elongation factor-2 kinase activity(GO:0004686)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.3 NABA_COLLAGENS Genes encoding collagen proteins
0.0 3.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.3 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 2.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.2 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 1.5 PID_IGF1_PATHWAY IGF1 pathway
0.2 1.2 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.1 1.2 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.2 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.2 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.2 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 1.1 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.1 PID_TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 1.0 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.0 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 0.9 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.8 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.8 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 0.7 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 2.4 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.1 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 1.9 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 1.6 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 1.5 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.1 1.2 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 1.2 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 1.1 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.1 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 1.1 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 1.0 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.1 1.0 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.0 1.0 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 0.9 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.7 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 0.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 0.6 REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION Genes involved in Extracellular matrix organization
0.0 0.6 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.6 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle