Motif ID: Tfap2e

Z-value: 0.703


Transcription factors associated with Tfap2e:

Gene SymbolEntrez IDGene Name
Tfap2e ENSMUSG00000042477.7 Tfap2e

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2emm10_v2_chr4_-_126736236_126736245-0.256.7e-02Click!


Activity profile for motif Tfap2e.

activity profile for motif Tfap2e


Sorted Z-values histogram for motif Tfap2e

Sorted Z-values for motif Tfap2e



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2e

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 67 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_91945703 11.021 ENSMUST00000178895.1
 Gm9821
predicted gene 9821
chr11_-_102897123 8.897 ENSMUST00000067444.3
 Gfap
glial fibrillary acidic protein
chr11_-_102897146 5.496 ENSMUST00000077902.4
 Gfap
glial fibrillary acidic protein
chr6_+_108213086 4.616 ENSMUST00000032192.6
 Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr15_-_102524615 2.805 ENSMUST00000023814.7
 Npff
neuropeptide FF-amide peptide precursor
chr13_-_101768154 2.599 ENSMUST00000055518.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr1_+_159737510 2.248 ENSMUST00000111669.3
 Tnr
tenascin R
chr5_-_34187670 1.861 ENSMUST00000042701.6
ENSMUST00000119171.1
 Mxd4

Max dimerization protein 4

chr8_+_41239718 1.715 ENSMUST00000045218.7
 Pcm1
pericentriolar material 1
chr3_-_113630068 1.697 ENSMUST00000092154.3
ENSMUST00000106536.1
ENSMUST00000106535.1
 Rnpc3


RNA-binding region (RNP1, RRM) containing 3


chr6_-_97617536 1.666 ENSMUST00000113355.2
 Frmd4b
FERM domain containing 4B
chr7_-_19629355 1.609 ENSMUST00000049912.8
ENSMUST00000094762.3
ENSMUST00000098754.4
 Relb


avian reticuloendotheliosis viral (v-rel) oncogene related B


chr2_-_38287174 1.592 ENSMUST00000130472.1
 Dennd1a
DENN/MADD domain containing 1A
chr4_-_149774238 1.577 ENSMUST00000105686.2
 Slc25a33
solute carrier family 25, member 33
chr13_+_54949388 1.547 ENSMUST00000026994.7
ENSMUST00000109994.2
 Unc5a

unc-5 homolog A (C. elegans)

chr15_-_58214882 1.483 ENSMUST00000022986.6
 Fbxo32
F-box protein 32
chr9_-_97111117 1.411 ENSMUST00000085206.4
 Slc25a36
solute carrier family 25, member 36
chr2_+_102658640 1.353 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr16_+_93832121 1.325 ENSMUST00000044068.6
 Morc3
microrchidia 3
chr6_-_39725448 1.252 ENSMUST00000002487.8
 Braf
Braf transforming gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 14.4 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.5 5.4 GO:0010459 negative regulation of heart rate(GO:0010459)
0.8 4.6 GO:0042045 epithelial fluid transport(GO:0042045)
0.7 3.0 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.1 2.3 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.6 2.2 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.7 2.1 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.3 2.1 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.1 1.8 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.2 1.7 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 1.7 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.3 1.6 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 1.6 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.5 1.5 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.2 1.5 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.2 1.4 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1 1.3 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.3 1.2 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.2 1.2 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
0.4 1.1 GO:0097212 lysosomal membrane organization(GO:0097212)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.6 14.4 GO:0097450 astrocyte end-foot(GO:0097450)
1.5 4.6 GO:0031088 platelet dense granule membrane(GO:0031088)
0.2 3.6 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 2.9 GO:0032589 neuron projection membrane(GO:0032589)
0.0 2.5 GO:0043204 perikaryon(GO:0043204)
0.7 2.2 GO:0072534 perineuronal net(GO:0072534)
0.1 2.1 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 1.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 1.8 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 1.7 GO:0000242 pericentriolar material(GO:0000242)
0.1 1.7 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.2 1.6 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 1.6 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 1.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 1.2 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 1.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 1.2 GO:0016605 PML body(GO:0016605)
0.1 1.0 GO:0034706 sodium channel complex(GO:0034706)
0.0 0.9 GO:0005776 autophagosome(GO:0005776)
0.1 0.7 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 14.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
1.5 4.6 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 3.4 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 3.0 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.1 2.8 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.6 2.6 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 2.2 GO:0046625 sphingolipid binding(GO:0046625)
0.4 2.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 2.1 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.2 1.7 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.3 1.5 GO:0005042 netrin receptor activity(GO:0005042)
0.2 1.4 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 1.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 1.2 GO:0035591 signaling adaptor activity(GO:0035591)
0.1 1.0 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 1.0 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.3 0.9 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.9 GO:0004697 protein kinase C activity(GO:0004697)
0.1 0.7 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.6 GO:0004622 lysophospholipase activity(GO:0004622) acylglycerol lipase activity(GO:0047372)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.0 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 2.6 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 2.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.1 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.9 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.6 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 1.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.5 PID_FOXO_PATHWAY FoxO family signaling
0.0 1.2 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.0 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 14.4 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 3.0 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 2.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.3 2.6 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 2.1 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 2.1 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 1.7 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.5 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 1.4 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 1.2 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.0 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.5 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.3 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.3 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways