Motif ID: Tfap4

Z-value: 1.051


Transcription factors associated with Tfap4:

Gene SymbolEntrez IDGene Name
Tfap4 ENSMUSG00000005718.7 Tfap4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap4mm10_v2_chr16_-_4559720_4559747-0.162.3e-01Click!


Activity profile for motif Tfap4.

activity profile for motif Tfap4


Sorted Z-values histogram for motif Tfap4

Sorted Z-values for motif Tfap4



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_40346290 12.313 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr7_-_120202104 9.075 ENSMUST00000033198.5
 Crym
crystallin, mu
chr4_+_119814495 8.861 ENSMUST00000106307.2
 Hivep3
human immunodeficiency virus type I enhancer binding protein 3
chr8_+_66386292 8.101 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr6_-_136171722 7.008 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr4_+_48045144 6.941 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr16_+_91269759 6.747 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr16_+_43510267 6.611 ENSMUST00000114695.2
 Zbtb20
zinc finger and BTB domain containing 20
chr15_-_66812593 6.545 ENSMUST00000100572.3
 Sla
src-like adaptor
chr13_+_29014399 5.597 ENSMUST00000146336.1
ENSMUST00000130109.1
 A330102I10Rik

RIKEN cDNA A330102I10 gene

chr2_+_170731807 5.510 ENSMUST00000029075.4
 Dok5
docking protein 5
chr10_-_102490418 4.688 ENSMUST00000020040.3
 Nts
neurotensin
chr2_+_37516618 4.669 ENSMUST00000065441.6
 Gpr21
G protein-coupled receptor 21
chr7_-_97417730 4.655 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr15_+_80287234 4.439 ENSMUST00000160424.1
 Cacna1i
calcium channel, voltage-dependent, alpha 1I subunit
chr2_-_5063996 4.371 ENSMUST00000114996.1
 Optn
optineurin
chr14_-_45219364 4.256 ENSMUST00000022377.4
ENSMUST00000143609.1
ENSMUST00000139526.1
 Txndc16


thioredoxin domain containing 16


chr9_+_45370185 4.217 ENSMUST00000085939.6
 Fxyd6
FXYD domain-containing ion transport regulator 6
chr5_+_90772435 4.148 ENSMUST00000031320.6
 Pf4
platelet factor 4
chr8_+_12984246 4.074 ENSMUST00000110873.3
ENSMUST00000173006.1
ENSMUST00000145067.1
 Mcf2l


mcf.2 transforming sequence-like



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 137 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 9.1 GO:0070327 thyroid hormone transport(GO:0070327)
0.5 8.1 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
2.0 8.0 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.1 7.7 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
1.8 7.0 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
2.3 6.9 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.2 6.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 6.5 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.2 5.6 GO:0071625 vocalization behavior(GO:0071625)
0.3 5.5 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.1 5.1 GO:0051592 response to calcium ion(GO:0051592)
0.2 4.7 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.1 4.7 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627)
0.1 4.5 GO:0008542 visual learning(GO:0008542)
0.2 4.4 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.1 4.3 GO:0045454 cell redox homeostasis(GO:0045454)
0.8 4.1 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347) negative regulation of cytolysis(GO:0045918)
0.2 4.1 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.1 4.0 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.4 3.8 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.5 GO:0005802 trans-Golgi network(GO:0005802)
0.1 11.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.3 8.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 7.4 GO:0043679 axon terminus(GO:0043679)
0.5 7.0 GO:0043083 synaptic cleft(GO:0043083)
0.0 6.8 GO:0005770 late endosome(GO:0005770)
0.1 4.6 GO:0005637 nuclear inner membrane(GO:0005637)
0.4 4.3 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.1 4.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.4 3.8 GO:0005883 neurofilament(GO:0005883)
0.2 3.8 GO:1990635 proximal dendrite(GO:1990635)
0.2 3.8 GO:0071564 npBAF complex(GO:0071564)
0.1 3.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 3.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 3.5 GO:0030425 dendrite(GO:0030425)
0.5 3.2 GO:0097512 cardiac myofibril(GO:0097512)
0.2 3.0 GO:0042405 nuclear inclusion body(GO:0042405)
0.2 3.0 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.7 2.8 GO:0097574 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.0 2.7 GO:0043197 dendritic spine(GO:0043197)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 9.1 GO:0070324 thyroid hormone binding(GO:0070324)
0.3 8.1 GO:0042287 MHC protein binding(GO:0042287)
0.9 8.0 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.9 7.0 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.2 6.9 GO:0005158 insulin receptor binding(GO:0005158)
0.3 6.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.2 6.5 GO:0001223 transcription coactivator binding(GO:0001223)
0.2 6.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 4.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
1.2 4.7 GO:0004952 dopamine neurotransmitter receptor activity(GO:0004952)
0.3 4.6 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
1.1 4.4 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 4.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 4.3 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.8 4.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 4.0 GO:0017080 sodium channel regulator activity(GO:0017080)
0.2 3.8 GO:0070064 proline-rich region binding(GO:0070064)
0.1 3.8 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 3.8 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.6 3.7 GO:0005042 netrin receptor activity(GO:0005042)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.0 PID_REELIN_PATHWAY Reelin signaling pathway
0.2 6.9 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 6.3 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 5.9 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 5.5 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 5.4 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 4.1 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.0 3.7 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 3.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.2 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.2 2.8 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 2.8 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.0 2.6 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 2.5 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 2.4 NABA_MATRISOME_ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.2 2.2 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 2.2 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.2 2.1 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 2.0 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 1.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.0 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 5.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 4.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 4.4 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.7 4.1 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.3 3.7 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 2.8 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 2.6 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 2.4 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.1 2.4 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.3 2.3 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 2.3 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.2 2.2 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 2.1 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.1 2.0 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.9 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 1.9 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 1.8 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 1.7 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 1.6 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism