Motif ID: Tfcp2

Z-value: 1.796


Transcription factors associated with Tfcp2:

Gene SymbolEntrez IDGene Name
Tfcp2 ENSMUSG00000009733.8 Tfcp2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfcp2mm10_v2_chr15_-_100551959_1005520100.525.3e-05Click!


Activity profile for motif Tfcp2.

activity profile for motif Tfcp2


Sorted Z-values histogram for motif Tfcp2

Sorted Z-values for motif Tfcp2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfcp2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_57511833 33.137 ENSMUST00000067925.6
 Hmgb2
high mobility group box 2
chr11_+_69045640 22.602 ENSMUST00000108666.1
ENSMUST00000021277.5
 Aurkb

aurora kinase B

chr11_-_22001605 18.271 ENSMUST00000006071.7
 Otx1
orthodenticle homolog 1 (Drosophila)
chr10_-_42583628 17.340 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr13_-_100786402 16.316 ENSMUST00000174038.1
ENSMUST00000091295.7
ENSMUST00000072119.8
 Ccnb1


cyclin B1


chr2_-_5012716 14.924 ENSMUST00000027980.7
 Mcm10
minichromosome maintenance deficient 10 (S. cerevisiae)
chr5_+_92809372 13.863 ENSMUST00000113054.2
 Shroom3
shroom family member 3
chr12_+_24708984 13.361 ENSMUST00000154588.1
 Rrm2
ribonucleotide reductase M2
chr14_-_21989475 13.159 ENSMUST00000043409.7
 Zfp503
zinc finger protein 503
chr1_+_184034381 12.420 ENSMUST00000048655.7
 Dusp10
dual specificity phosphatase 10
chr2_+_163225363 12.198 ENSMUST00000099110.3
ENSMUST00000165937.1
 Tox2

TOX high mobility group box family member 2

chr8_+_94172618 12.105 ENSMUST00000034214.6
 Mt2
metallothionein 2
chr6_+_56017489 11.827 ENSMUST00000052827.4
 Ppp1r17
protein phosphatase 1, regulatory subunit 17
chr1_+_44551483 11.764 ENSMUST00000074525.3
 Gulp1
GULP, engulfment adaptor PTB domain containing 1
chr16_-_26989974 11.404 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr18_+_11633276 11.217 ENSMUST00000115861.2
 Rbbp8
retinoblastoma binding protein 8
chr1_+_107511489 11.069 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_107511416 10.919 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_-_131097535 10.873 ENSMUST00000016672.4
 Mapkapk2
MAP kinase-activated protein kinase 2
chr12_-_91779129 10.864 ENSMUST00000170077.1
 Ston2
stonin 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 124 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.7 33.1 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.6 25.3 GO:0006270 DNA replication initiation(GO:0006270)
1.3 22.9 GO:0030953 astral microtubule organization(GO:0030953)
7.5 22.6 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.1 21.2 GO:0010466 negative regulation of peptidase activity(GO:0010466)
2.3 18.3 GO:0048852 diencephalon morphogenesis(GO:0048852)
3.5 17.3 GO:0021764 amygdala development(GO:0021764)
5.4 16.3 GO:0043987 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) histone H3-S10 phosphorylation(GO:0043987)
1.2 15.8 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
3.8 15.3 GO:1902724 positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.6 14.9 GO:0040034 regulation of development, heterochronic(GO:0040034)
3.6 14.5 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.2 13.9 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.3 13.8 GO:0006911 phagocytosis, engulfment(GO:0006911)
4.4 13.2 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
2.5 12.4 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
1.7 12.1 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
2.2 11.2 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.1 11.2 GO:0010921 regulation of phosphatase activity(GO:0010921)
0.1 11.1 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 59.9 GO:0005634 nucleus(GO:0005634)
0.2 33.1 GO:0000793 condensed chromosome(GO:0000793)
0.0 29.5 GO:0005615 extracellular space(GO:0005615)
4.5 22.6 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 18.8 GO:0005813 centrosome(GO:0005813)
0.2 16.7 GO:0017053 transcriptional repressor complex(GO:0017053)
4.1 16.3 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 16.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
5.3 15.8 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.1 15.8 GO:0030027 lamellipodium(GO:0030027)
2.1 14.9 GO:0031298 replication fork protection complex(GO:0031298)
0.1 13.7 GO:0043296 apical junction complex(GO:0043296)
0.1 10.9 GO:0030136 clathrin-coated vesicle(GO:0030136)
2.1 10.7 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
2.0 10.1 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.3 8.0 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 7.5 GO:0015629 actin cytoskeleton(GO:0015629)
0.8 7.3 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.7 6.8 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
2.2 6.5 GO:0034684 integrin alphav-beta5 complex(GO:0034684)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.3 32.0 GO:0050786 RAGE receptor binding(GO:0050786)
0.1 29.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
2.2 26.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
1.7 25.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
4.5 22.6 GO:0035174 histone serine kinase activity(GO:0035174)
0.5 22.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 17.3 GO:0003707 steroid hormone receptor activity(GO:0003707)
4.1 16.3 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
1.7 15.3 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 15.2 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
1.1 14.9 GO:0003688 DNA replication origin binding(GO:0003688)
2.9 14.5 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.2 13.2 GO:0048487 beta-tubulin binding(GO:0048487)
0.8 11.2 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 11.1 GO:0051015 actin filament binding(GO:0051015)
0.2 10.9 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 10.8 GO:0019955 cytokine binding(GO:0019955)
2.1 10.7 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.6 10.5 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 10.0 GO:0003682 chromatin binding(GO:0003682)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 43.3 PID_AURORA_A_PATHWAY Aurora A signaling
0.4 29.4 PID_E2F_PATHWAY E2F transcription factor network
0.2 29.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4 20.3 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.4 18.3 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.4 16.8 PID_ARF6_PATHWAY Arf6 signaling events
0.7 15.8 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.8 15.3 ST_STAT3_PATHWAY STAT3 Pathway
0.1 9.7 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.2 9.2 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.2 7.7 PID_BMP_PATHWAY BMP receptor signaling
0.4 6.5 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.1 6.2 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 6.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 5.7 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.2 5.5 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 4.2 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.3 3.6 PID_TNF_PATHWAY TNF receptor signaling pathway
0.1 3.2 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 2.9 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 33.1 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.3 23.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 22.6 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
1.9 18.5 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.9 16.6 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.6 15.8 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
1.3 15.3 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 14.3 REACTOME_HEMOSTASIS Genes involved in Hemostasis
0.5 13.9 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.2 13.0 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.7 12.5 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.1 9.5 REACTOME_TRANSLATION Genes involved in Translation
0.3 7.7 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.2 7.6 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.4 6.5 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.2 6.5 REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.4 6.4 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.4 6.2 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 5.7 REACTOME_DNA_REPAIR Genes involved in DNA Repair
0.1 5.5 REACTOME_MYOGENESIS Genes involved in Myogenesis