Motif ID: Tfcp2l1

Z-value: 0.784


Transcription factors associated with Tfcp2l1:

Gene SymbolEntrez IDGene Name
Tfcp2l1 ENSMUSG00000026380.9 Tfcp2l1



Activity profile for motif Tfcp2l1.

activity profile for motif Tfcp2l1


Sorted Z-values histogram for motif Tfcp2l1

Sorted Z-values for motif Tfcp2l1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfcp2l1

PNG image of the network

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Top targets:


Showing 1 to 20 of 87 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_98004634 16.053 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr15_-_98004695 15.766 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr2_+_172549581 11.757 ENSMUST00000030391.2
 Tfap2c
transcription factor AP-2, gamma
chr16_-_22161450 7.371 ENSMUST00000115379.1
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr5_+_114568016 5.832 ENSMUST00000043650.7
 Fam222a
family with sequence similarity 222, member A
chr1_+_184034381 3.694 ENSMUST00000048655.7
 Dusp10
dual specificity phosphatase 10
chr8_+_57511833 3.446 ENSMUST00000067925.6
 Hmgb2
high mobility group box 2
chr5_+_30105161 2.758 ENSMUST00000058045.4
 Gareml
GRB2 associated, regulator of MAPK1-like
chr6_-_90810118 2.669 ENSMUST00000101151.3
 Iqsec1
IQ motif and Sec7 domain 1
chr3_-_101836223 2.491 ENSMUST00000061831.4
 Mab21l3
mab-21-like 3 (C. elegans)
chr2_-_26122769 2.368 ENSMUST00000140993.1
ENSMUST00000028300.5
 Nacc2

nucleus accumbens associated 2, BEN and BTB (POZ) domain containing

chr14_+_11553523 2.325 ENSMUST00000022264.6
 Ptprg
protein tyrosine phosphatase, receptor type, G
chr7_-_38107490 2.315 ENSMUST00000108023.3
 Ccne1
cyclin E1
chr2_-_91931696 1.921 ENSMUST00000090602.5
 Mdk
midkine
chr17_+_35059035 1.789 ENSMUST00000007255.6
ENSMUST00000174493.1
 Ddah2

dimethylarginine dimethylaminohydrolase 2

chr2_-_91931774 1.601 ENSMUST00000069423.6
 Mdk
midkine
chr4_-_135573623 1.497 ENSMUST00000105855.1
 Grhl3
grainyhead-like 3 (Drosophila)
chr1_-_184033998 1.359 ENSMUST00000050306.5
 1700056E22Rik
RIKEN cDNA 1700056E22 gene
chr4_-_147936713 1.289 ENSMUST00000105712.1
ENSMUST00000019199.7
 Plod1

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1

chr16_-_76403673 1.222 ENSMUST00000052867.7
 Gm9843
predicted gene 9843

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 31.8 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
3.9 11.8 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.1 7.4 GO:0051028 mRNA transport(GO:0051028)
0.7 3.7 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
1.2 3.5 GO:0030421 defecation(GO:0030421)
0.5 3.4 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.1 2.7 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.2 2.4 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.1 2.3 GO:0007129 synapsis(GO:0007129)
0.0 2.3 GO:1901998 toxin transport(GO:1901998)
0.7 2.2 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.1 1.9 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.2 1.8 GO:0006527 arginine catabolic process(GO:0006527)
0.1 1.8 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.1 1.5 GO:0061436 establishment of skin barrier(GO:0061436)
0.3 1.3 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.0 1.2 GO:1902476 chloride transmembrane transport(GO:1902476)
0.4 1.1 GO:0009446 putrescine biosynthetic process(GO:0009446)
0.2 1.0 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.3 0.9 GO:0098528 terpenoid catabolic process(GO:0016115) skeletal muscle fiber differentiation(GO:0098528)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 31.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 2.5 GO:0000793 condensed chromosome(GO:0000793)
0.1 2.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 2.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 2.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 1.8 GO:0005801 cis-Golgi network(GO:0005801)
0.0 1.0 GO:0002102 podosome(GO:0002102)
0.0 0.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.3 0.8 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
0.1 0.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 0.6 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.1 0.5 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 0.5 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.4 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.3 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.3 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 0.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.4 31.8 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 10.0 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.3 7.4 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.2 3.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 3.5 GO:0008083 growth factor activity(GO:0008083)
0.6 3.4 GO:0050786 RAGE receptor binding(GO:0050786)
0.1 3.3 GO:0004407 histone deacetylase activity(GO:0004407)
0.1 2.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 2.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 2.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 2.2 GO:0001786 phosphatidylserine binding(GO:0001786) calcium-dependent phospholipid binding(GO:0005544)
0.3 1.8 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 1.6 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 1.5 GO:0031490 chromatin DNA binding(GO:0031490)
0.3 1.3 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.1 1.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 1.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 1.0 GO:0071253 connexin binding(GO:0071253)
0.1 0.9 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.1 0.9 GO:0001972 retinoic acid binding(GO:0001972)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 31.8 NABA_COLLAGENS Genes encoding collagen proteins
0.2 12.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 4.7 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.1 3.5 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 2.7 PID_ARF6_PATHWAY Arf6 signaling events
0.2 2.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.9 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 0.8 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.2 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.1 PID_ALK2_PATHWAY ALK2 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 31.8 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 6.2 REACTOME_DIABETES_PATHWAYS Genes involved in Diabetes pathways
0.2 3.4 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 2.3 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 1.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 1.1 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 1.0 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 0.9 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 0.9 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 0.9 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.5 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.4 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 0.3 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.2 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.2 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling