Motif ID: Tfdp1_Wt1_Egr2

Z-value: 1.975

Transcription factors associated with Tfdp1_Wt1_Egr2:

Gene SymbolEntrez IDGene Name
Egr2 ENSMUSG00000037868.9 Egr2
Tfdp1 ENSMUSG00000038482.10 Tfdp1
Wt1 ENSMUSG00000016458.7 Wt1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfdp1mm10_v2_chr8_+_13339656_133396740.681.4e-08Click!
Egr2mm10_v2_chr10_+_67537861_67537930-0.238.8e-02Click!


Activity profile for motif Tfdp1_Wt1_Egr2.

activity profile for motif Tfdp1_Wt1_Egr2


Sorted Z-values histogram for motif Tfdp1_Wt1_Egr2

Sorted Z-values for motif Tfdp1_Wt1_Egr2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfdp1_Wt1_Egr2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_125490688 26.315 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr16_-_22163299 17.642 ENSMUST00000100052.4
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr11_-_12037391 16.493 ENSMUST00000093321.5
 Grb10
growth factor receptor bound protein 10
chr13_+_48261427 16.199 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr13_-_56252163 15.332 ENSMUST00000058475.4
 Neurog1
neurogenin 1
chr3_-_8667033 15.262 ENSMUST00000042412.3
 Hey1
hairy/enhancer-of-split related with YRPW motif 1
chr2_-_156839790 11.903 ENSMUST00000134838.1
ENSMUST00000137463.1
ENSMUST00000149275.2
 Gm14230


predicted gene 14230


chr19_+_38481057 11.274 ENSMUST00000182481.1
 Plce1
phospholipase C, epsilon 1
chr9_-_119578981 10.895 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr4_-_41695935 10.764 ENSMUST00000145379.1
 Cntfr
ciliary neurotrophic factor receptor
chrX_-_52165252 10.709 ENSMUST00000033450.2
 Gpc4
glypican 4
chr10_-_120476469 10.692 ENSMUST00000072777.7
ENSMUST00000159699.1
 Hmga2

high mobility group AT-hook 2

chr2_+_168081004 10.471 ENSMUST00000052125.6
 Pard6b
par-6 (partitioning defective 6) homolog beta (C. elegans)
chr6_-_91411341 10.439 ENSMUST00000032180.6
 Wnt7a
wingless-related MMTV integration site 7A
chr9_-_8004585 10.338 ENSMUST00000086580.5
ENSMUST00000065353.6
 Yap1

yes-associated protein 1

chr5_+_33721724 10.031 ENSMUST00000067150.7
ENSMUST00000169212.2
ENSMUST00000114411.2
ENSMUST00000164207.3
 Fgfr3



fibroblast growth factor receptor 3



chr12_+_112146187 9.934 ENSMUST00000128402.2
 Kif26a
kinesin family member 26A
chr4_+_154960915 9.795 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr7_-_34812677 9.764 ENSMUST00000078686.6
 Chst8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr2_-_102186322 9.748 ENSMUST00000111222.1
ENSMUST00000058790.5
 Ldlrad3

low density lipoprotein receptor class A domain containing 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,225 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.6 32.1 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.3 32.0 GO:0051028 mRNA transport(GO:0051028)
1.8 30.8 GO:0038092 nodal signaling pathway(GO:0038092)
4.6 27.8 GO:0072049 comma-shaped body morphogenesis(GO:0072049)
2.5 27.3 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
5.6 22.5 GO:0003360 brainstem development(GO:0003360)
2.1 21.5 GO:0008063 Toll signaling pathway(GO:0008063)
0.6 20.7 GO:0006270 DNA replication initiation(GO:0006270)
0.9 19.7 GO:0051764 actin crosslink formation(GO:0051764)
0.6 18.7 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
2.0 18.1 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
3.6 18.0 GO:0007386 compartment pattern specification(GO:0007386)
0.5 17.9 GO:0006284 base-excision repair(GO:0006284)
5.8 17.3 GO:1904274 tricellular tight junction assembly(GO:1904274)
2.2 17.3 GO:0044027 hypermethylation of CpG island(GO:0044027)
1.4 17.2 GO:0030903 notochord development(GO:0030903)
2.1 17.0 GO:0001842 neural fold formation(GO:0001842)
4.1 16.4 GO:0007354 zygotic determination of anterior/posterior axis, embryo(GO:0007354)
3.9 15.7 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
3.1 15.7 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 394 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 293.4 GO:0005634 nucleus(GO:0005634)
0.4 58.3 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.4 29.4 GO:0005643 nuclear pore(GO:0005643)
1.2 29.2 GO:0001741 XY body(GO:0001741)
0.4 25.9 GO:0031519 PcG protein complex(GO:0031519)
0.1 25.4 GO:0016607 nuclear speck(GO:0016607)
0.1 23.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.5 22.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.3 22.4 GO:0005844 polysome(GO:0005844)
0.5 22.1 GO:0002102 podosome(GO:0002102)
7.1 21.3 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.2 21.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.6 20.2 GO:0032839 dendrite cytoplasm(GO:0032839)
1.3 19.0 GO:0035631 CD40 receptor complex(GO:0035631)
0.5 19.0 GO:0016592 mediator complex(GO:0016592)
2.9 17.7 GO:0061689 tricellular tight junction(GO:0061689)
0.2 17.6 GO:0000922 spindle pole(GO:0000922)
0.9 16.7 GO:0097470 ribbon synapse(GO:0097470)
1.4 16.6 GO:0016600 flotillin complex(GO:0016600)
0.1 16.2 GO:0005925 focal adhesion(GO:0005925)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 652 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 80.2 GO:0003682 chromatin binding(GO:0003682)
0.4 79.7 GO:0001047 core promoter binding(GO:0001047)
0.2 40.3 GO:0042393 histone binding(GO:0042393)
1.0 40.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.5 34.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
2.2 28.5 GO:0001972 retinoic acid binding(GO:0001972)
0.6 28.3 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.8 27.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
1.6 26.1 GO:0003680 AT DNA binding(GO:0003680)
2.8 25.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
4.9 24.5 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.1 24.3 GO:0045296 cadherin binding(GO:0045296)
0.9 23.8 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.3 23.2 GO:0003777 microtubule motor activity(GO:0003777)
3.9 23.1 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.8 22.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.7 22.1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.4 21.7 GO:0033613 activating transcription factor binding(GO:0033613)
1.3 21.6 GO:0017166 vinculin binding(GO:0017166)
2.6 20.7 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 59.9 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.8 58.2 PID_E2F_PATHWAY E2F transcription factor network
1.7 52.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.9 41.6 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.8 40.6 PID_IGF1_PATHWAY IGF1 pathway
0.5 33.7 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.6 32.7 PID_PLK1_PATHWAY PLK1 signaling events
0.6 31.7 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.5 31.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.7 30.3 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
1.2 28.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.7 28.5 PID_ERBB4_PATHWAY ErbB4 signaling events
0.6 27.9 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.5 27.7 PID_CMYB_PATHWAY C-MYB transcription factor network
1.9 26.6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.5 24.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.6 20.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.5 19.7 PID_BMP_PATHWAY BMP receptor signaling
0.6 18.9 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.7 17.9 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 179 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 60.6 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
1.4 36.8 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
1.7 36.2 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
1.0 32.7 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.2 30.8 REACTOME_DIABETES_PATHWAYS Genes involved in Diabetes pathways
1.5 29.8 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
1.0 29.0 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.5 26.1 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.9 24.2 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
1.3 22.8 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
1.3 22.1 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.9 20.8 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.5 19.9 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
1.3 18.7 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.3 18.6 REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.7 17.6 REACTOME_KINESINS Genes involved in Kinesins
0.2 17.4 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
1.9 17.0 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.5 16.5 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.4 16.5 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis