Motif ID: Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Z-value: 1.164

Transcription factors associated with Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2:

Gene SymbolEntrez IDGene Name
Bhlhe41 ENSMUSG00000030256.5 Bhlhe41
Srebf1 ENSMUSG00000020538.9 Srebf1
Srebf2 ENSMUSG00000022463.7 Srebf2
Tfeb ENSMUSG00000023990.12 Tfeb
Usf1 ENSMUSG00000026641.7 Usf1
Usf2 ENSMUSG00000058239.7 Usf2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Srebf1mm10_v2_chr11_-_60210410_602104650.384.6e-03Click!
Usf2mm10_v2_chr7_-_30956742_30956803-0.265.2e-02Click!
Usf1mm10_v2_chr1_+_171411305_1714113370.181.9e-01Click!
Tfebmm10_v2_chr17_+_47785720_477857390.162.5e-01Click!
Srebf2mm10_v2_chr15_+_82147238_821472750.152.7e-01Click!


Activity profile for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2.

activity profile for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2


Sorted Z-values histogram for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Sorted Z-values for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_148039035 13.528 ENSMUST00000097788.4
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr4_+_148039097 11.805 ENSMUST00000141283.1
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr10_+_41519493 9.049 ENSMUST00000019962.8
 Cd164
CD164 antigen
chr17_-_66077022 8.559 ENSMUST00000150766.1
ENSMUST00000038116.5
 Ankrd12

ankyrin repeat domain 12

chr15_-_3995708 8.478 ENSMUST00000046633.8
 AW549877
expressed sequence AW549877
chr9_-_87255536 8.363 ENSMUST00000093802.4
 4922501C03Rik
RIKEN cDNA 4922501C03 gene
chr15_-_10714612 8.090 ENSMUST00000169385.1
 Rai14
retinoic acid induced 14
chr15_+_66577536 7.883 ENSMUST00000048188.8
 Phf20l1
PHD finger protein 20-like 1
chr4_-_34882919 7.740 ENSMUST00000098163.2
ENSMUST00000047950.5
 Zfp292

zinc finger protein 292

chr7_-_46795661 7.487 ENSMUST00000123725.1
 Hps5
Hermansky-Pudlak syndrome 5 homolog (human)
chr4_+_127077374 7.407 ENSMUST00000046751.6
ENSMUST00000094713.3
 Zmym6

zinc finger, MYM-type 6

chr18_-_6135888 7.224 ENSMUST00000182383.1
ENSMUST00000062584.7
ENSMUST00000077128.6
ENSMUST00000182038.1
ENSMUST00000182213.1
 Arhgap12




Rho GTPase activating protein 12




chr3_-_89773221 6.978 ENSMUST00000038450.1
 4632404H12Rik
RIKEN cDNA 4632404H12 gene
chr2_-_79456750 6.928 ENSMUST00000041099.4
 Neurod1
neurogenic differentiation 1
chr11_+_49203465 6.567 ENSMUST00000150284.1
ENSMUST00000109197.1
ENSMUST00000151228.1
 Zfp62


zinc finger protein 62


chr10_+_111164794 6.538 ENSMUST00000105275.1
ENSMUST00000095310.1
 Osbpl8

oxysterol binding protein-like 8

chr7_-_46795881 6.468 ENSMUST00000107653.1
ENSMUST00000107654.1
ENSMUST00000014562.7
ENSMUST00000152759.1
 Hps5



Hermansky-Pudlak syndrome 5 homolog (human)



chr11_+_70000578 6.448 ENSMUST00000019362.8
 Dvl2
dishevelled 2, dsh homolog (Drosophila)
chr11_+_53350783 5.957 ENSMUST00000060945.5
 Aff4
AF4/FMR2 family, member 4
chr5_+_64803513 5.953 ENSMUST00000165536.1
 Klf3
Kruppel-like factor 3 (basic)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 403 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.3 25.3 GO:0070829 heterochromatin maintenance(GO:0070829)
0.4 17.2 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 16.6 GO:0008643 carbohydrate transport(GO:0008643)
0.2 15.4 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.5 13.3 GO:0097352 autophagosome maturation(GO:0097352)
3.6 10.9 GO:1904959 elastin biosynthetic process(GO:0051542) copper ion export(GO:0060003) regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
0.1 10.5 GO:0043473 pigmentation(GO:0043473)
2.6 10.4 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.2 9.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.2 9.1 GO:0007628 adult walking behavior(GO:0007628)
0.4 8.7 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.2 8.4 GO:0060612 adipose tissue development(GO:0060612)
0.1 8.4 GO:0002011 morphogenesis of an epithelial sheet(GO:0002011)
0.1 8.1 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.1 8.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 7.7 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
1.7 6.9 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.6 6.9 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
1.0 6.8 GO:0045346 regulation of MHC class II biosynthetic process(GO:0045346)
0.1 6.7 GO:0007492 endoderm development(GO:0007492)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 173 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 24.6 GO:0005773 vacuole(GO:0005773)
0.1 17.3 GO:0000139 Golgi membrane(GO:0000139)
0.0 16.1 GO:0045202 synapse(GO:0045202)
0.1 15.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
3.6 14.4 GO:0031084 BLOC-2 complex(GO:0031084)
0.4 13.5 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.6 10.4 GO:0043196 varicosity(GO:0043196)
1.4 9.7 GO:0033263 CORVET complex(GO:0033263)
0.1 8.9 GO:0005923 bicellular tight junction(GO:0005923)
0.8 8.2 GO:0071141 SMAD protein complex(GO:0071141)
0.1 7.8 GO:0030117 membrane coat(GO:0030117) coated membrane(GO:0048475)
1.8 7.2 GO:0019034 viral replication complex(GO:0019034)
0.1 7.2 GO:0016235 aggresome(GO:0016235)
0.8 7.1 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.4 6.8 GO:0010369 chromocenter(GO:0010369)
0.4 6.6 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.7 6.5 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.4 6.5 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.3 6.1 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.3 6.1 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 250 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 31.4 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 25.7 GO:0005096 GTPase activator activity(GO:0005096)
8.4 25.3 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 24.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.9 21.0 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.1 14.9 GO:0008565 protein transporter activity(GO:0008565)
0.8 12.8 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
3.6 10.9 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.5 10.8 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.2 10.3 GO:0017022 myosin binding(GO:0017022)
0.1 9.7 GO:0019905 syntaxin binding(GO:0019905)
0.2 9.6 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
1.2 8.5 GO:0033592 RNA strand annealing activity(GO:0033592)
1.1 8.0 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.2 7.3 GO:0005109 frizzled binding(GO:0005109)
0.4 7.1 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
2.3 6.9 GO:0035500 MH2 domain binding(GO:0035500)
0.1 6.8 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.2 6.6 GO:0070064 proline-rich region binding(GO:0070064)
1.1 6.5 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 10.5 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.1 10.2 PID_LKB1_PATHWAY LKB1 signaling events
0.1 9.5 PID_IL2_1PATHWAY IL2-mediated signaling events
0.1 7.9 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.1 4.9 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 3.4 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 3.3 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.2 3.2 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 3.0 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 2.9 PID_P73PATHWAY p73 transcription factor network
0.2 2.4 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.1 2.2 PID_ATM_PATHWAY ATM pathway
0.1 2.2 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.2 2.1 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 2.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 2.0 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 1.8 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 1.6 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 1.6 PID_CDC42_PATHWAY CDC42 signaling events
0.1 1.5 PID_AURORA_A_PATHWAY Aurora A signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 22.5 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.3 11.0 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.3 8.6 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.1 8.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.6 7.9 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.3 7.9 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.3 6.9 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 6.3 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.3 5.9 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.2 5.7 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.4 5.0 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.3 4.9 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 4.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 4.6 REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX_ Genes involved in Formation of RNA Pol II elongation complex
0.3 4.3 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.2 4.2 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.2 4.1 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 3.6 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 3.1 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 3.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase