Motif ID: Tgif1_Meis3

Z-value: 2.943

Transcription factors associated with Tgif1_Meis3:

Gene SymbolEntrez IDGene Name
Meis3 ENSMUSG00000041420.12 Meis3
Tgif1 ENSMUSG00000047407.11 Tgif1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tgif1mm10_v2_chr17_-_70853482_70853546-0.873.2e-18Click!
Meis3mm10_v2_chr7_+_16175085_161751390.446.7e-04Click!


Activity profile for motif Tgif1_Meis3.

activity profile for motif Tgif1_Meis3


Sorted Z-values histogram for motif Tgif1_Meis3

Sorted Z-values for motif Tgif1_Meis3



Network of associatons between targets according to the STRING database.



First level regulatory network of Tgif1_Meis3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_49246131 47.446 ENSMUST00000064395.6
 Nav2
neuron navigator 2
chr15_-_66831625 39.126 ENSMUST00000164163.1
 Sla
src-like adaptor
chr15_-_66801577 31.504 ENSMUST00000168589.1
 Sla
src-like adaptor
chr8_+_70501116 22.410 ENSMUST00000127983.1
 Crlf1
cytokine receptor-like factor 1
chr7_+_49246812 21.882 ENSMUST00000184945.1
 Nav2
neuron navigator 2
chr15_+_18818895 21.133 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr1_-_132542934 20.904 ENSMUST00000086521.4
 Cntn2
contactin 2
chr3_+_26331150 20.122 ENSMUST00000099182.2
 A830092H15Rik
RIKEN cDNA A830092H15 gene
chr7_+_112225856 18.823 ENSMUST00000050149.5
ENSMUST00000106647.1
ENSMUST00000106648.1
 Mical2


microtubule associated monooxygenase, calponin and LIM domain containing 2


chr4_+_102254993 18.250 ENSMUST00000106908.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr19_+_23758819 17.059 ENSMUST00000025830.7
 Apba1
amyloid beta (A4) precursor protein binding, family A, member 1
chr11_+_105589970 16.663 ENSMUST00000168598.1
ENSMUST00000100330.3
 Tanc2

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2

chr1_+_159737510 16.454 ENSMUST00000111669.3
 Tnr
tenascin R
chr4_+_102254739 15.762 ENSMUST00000106907.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr1_-_162478004 15.642 ENSMUST00000086074.5
ENSMUST00000070330.7
 Dnm3

dynamin 3

chr4_-_155345696 15.495 ENSMUST00000103178.4
 Prkcz
protein kinase C, zeta
chr9_-_29963112 15.486 ENSMUST00000075069.4
 Ntm
neurotrimin
chr6_-_53068562 14.932 ENSMUST00000074541.5
 Jazf1
JAZF zinc finger 1
chr18_-_66291770 14.686 ENSMUST00000130300.1
 Ccbe1
collagen and calcium binding EGF domains 1
chr17_-_24205514 14.287 ENSMUST00000097376.3
ENSMUST00000168410.2
ENSMUST00000167791.2
ENSMUST00000040474.7
 Tbc1d24



TBC1 domain family, member 24




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 642 entries
Log-likelihood per target Total log-likelihoodTermDescription
17.3 69.3 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
3.9 50.8 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.7 46.0 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
11.2 44.8 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
1.3 40.3 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.8 31.2 GO:0006376 mRNA splice site selection(GO:0006376)
0.4 29.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.7 27.1 GO:0034605 cellular response to heat(GO:0034605)
1.4 25.8 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
1.8 24.5 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
2.7 24.2 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
1.0 24.1 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
3.9 23.5 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
5.8 23.1 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
4.5 22.3 GO:0043987 histone H3-S10 phosphorylation(GO:0043987)
0.2 22.3 GO:0071805 potassium ion transmembrane transport(GO:0071805)
1.8 22.0 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
3.1 21.8 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.3 21.5 GO:0031338 regulation of vesicle fusion(GO:0031338)
4.3 21.4 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 245 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 251.4 GO:0016021 integral component of membrane(GO:0016021)
0.6 83.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
4.6 73.9 GO:0005614 interstitial matrix(GO:0005614)
0.3 66.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 60.1 GO:0030427 site of polarized growth(GO:0030427)
1.6 49.3 GO:0033268 node of Ranvier(GO:0033268)
2.0 48.9 GO:0071565 nBAF complex(GO:0071565)
0.7 46.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
1.6 42.8 GO:0000930 gamma-tubulin complex(GO:0000930)
1.6 39.1 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.1 31.5 GO:0000139 Golgi membrane(GO:0000139)
0.2 29.1 GO:0001650 fibrillar center(GO:0001650)
1.8 25.4 GO:0016342 catenin complex(GO:0016342)
0.3 22.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.7 20.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 20.3 GO:0016605 PML body(GO:0016605)
4.0 20.2 GO:0044316 cone cell pedicle(GO:0044316)
0.2 18.8 GO:0070382 exocytic vesicle(GO:0070382)
6.2 18.7 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 18.7 GO:0005802 trans-Golgi network(GO:0005802)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 382 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 85.7 GO:0030552 cAMP binding(GO:0030552)
1.9 72.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.4 49.2 GO:0008201 heparin binding(GO:0008201)
0.3 45.4 GO:0017137 Rab GTPase binding(GO:0017137)
1.4 35.9 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.6 35.7 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.6 31.2 GO:0036002 pre-mRNA binding(GO:0036002)
1.3 30.9 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
1.4 30.6 GO:0071949 FAD binding(GO:0071949)
0.1 29.5 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
5.8 29.2 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.1 26.2 GO:0008017 microtubule binding(GO:0008017)
0.4 24.7 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 24.5 GO:0003714 transcription corepressor activity(GO:0003714)
2.0 23.8 GO:0032050 clathrin heavy chain binding(GO:0032050)
3.3 22.9 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.4 22.1 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
1.3 21.9 GO:0048018 receptor agonist activity(GO:0048018)
0.9 21.8 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.5 21.7 GO:0048365 Rac GTPase binding(GO:0048365)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 57.6 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.4 47.9 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.3 46.9 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.4 42.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.7 35.1 PID_REELIN_PATHWAY Reelin signaling pathway
0.7 30.4 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.8 22.9 PID_ARF_3PATHWAY Arf1 pathway
0.5 22.9 SIG_CHEMOTAXIS Genes related to chemotaxis
0.5 18.9 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.6 18.6 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.4 18.1 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.2 15.9 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.5 13.3 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.5 13.2 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.4 12.1 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.3 10.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.4 9.6 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.4 9.3 PID_BCR_5PATHWAY BCR signaling pathway
0.6 9.2 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.4 8.0 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 144 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 68.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.6 55.1 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
1.2 41.0 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
1.1 41.0 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.9 37.2 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.9 34.2 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
1.0 28.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.7 23.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.6 22.2 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.7 21.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.3 21.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 19.9 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
1.0 19.5 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.8 18.7 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.8 17.2 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.4 16.8 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
1.1 15.9 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.7 15.9 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.6 15.1 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.9 14.1 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation