Motif ID: Tgif2_Tgif2lx1_Tgif2lx2

Z-value: 0.852

Transcription factors associated with Tgif2_Tgif2lx1_Tgif2lx2:

Gene SymbolEntrez IDGene Name
Tgif2 ENSMUSG00000062175.7 Tgif2
Tgif2lx1 ENSMUSG00000061283.4 Tgif2lx1
Tgif2lx2 ENSMUSG00000063242.6 Tgif2lx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tgif2mm10_v2_chr2_+_156840966_1568410170.384.8e-03Click!


Activity profile for motif Tgif2_Tgif2lx1_Tgif2lx2.

activity profile for motif Tgif2_Tgif2lx1_Tgif2lx2


Sorted Z-values histogram for motif Tgif2_Tgif2lx1_Tgif2lx2

Sorted Z-values for motif Tgif2_Tgif2lx1_Tgif2lx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tgif2_Tgif2lx1_Tgif2lx2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 167 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_105675478 6.652 ENSMUST00000167211.2
ENSMUST00000111083.3
 Pax6

paired box gene 6

chr2_+_105675429 6.326 ENSMUST00000111085.1
 Pax6
paired box gene 6
chr1_+_19103022 6.320 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr3_+_102010138 5.913 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr5_-_115119277 5.400 ENSMUST00000031524.7
 Acads
acyl-Coenzyme A dehydrogenase, short chain
chr7_+_51621830 5.385 ENSMUST00000032710.5
 Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr11_+_115154139 3.309 ENSMUST00000021076.5
 Rab37
RAB37, member of RAS oncogene family
chr6_+_112273758 3.308 ENSMUST00000032376.5
 Lmcd1
LIM and cysteine-rich domains 1
chr7_-_44670820 2.594 ENSMUST00000048102.7
 Myh14
myosin, heavy polypeptide 14
chr15_+_85510812 2.491 ENSMUST00000079690.2
 Gm4825
predicted pseudogene 4825
chr10_-_92165159 2.478 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr4_-_133967235 2.396 ENSMUST00000123234.1
 Hmgn2
high mobility group nucleosomal binding domain 2
chr13_+_108316332 2.381 ENSMUST00000051594.5
 Depdc1b
DEP domain containing 1B
chr10_-_81430966 2.347 ENSMUST00000117966.1
 Nfic
nuclear factor I/C
chr11_-_87108656 2.293 ENSMUST00000051395.8
 Prr11
proline rich 11
chr2_-_129297205 2.177 ENSMUST00000052708.6
 Ckap2l
cytoskeleton associated protein 2-like
chr5_-_124095749 2.163 ENSMUST00000031354.4
 Abcb9
ATP-binding cassette, sub-family B (MDR/TAP), member 9
chr1_+_36307745 1.895 ENSMUST00000142319.1
ENSMUST00000097778.2
ENSMUST00000115031.1
ENSMUST00000115032.1
ENSMUST00000137906.1
ENSMUST00000115029.1
 Arid5a





AT rich interactive domain 5A (MRF1-like)





chr13_+_108316395 1.858 ENSMUST00000171178.1
 Depdc1b
DEP domain containing 1B
chr17_-_36989504 1.794 ENSMUST00000169189.1
 H2-M5
histocompatibility 2, M region locus 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 13.0 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.1 6.3 GO:0030901 midbrain development(GO:0030901)
0.6 5.4 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.6 5.4 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0 4.3 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
0.1 3.6 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.2 3.5 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.3 3.3 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 3.3 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 2.6 GO:0071625 vocalization behavior(GO:0071625)
0.1 2.4 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.0 2.3 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.0 2.3 GO:0007050 cell cycle arrest(GO:0007050)
0.5 1.9 GO:2000318 positive regulation of T-helper 17 type immune response(GO:2000318)
0.0 1.8 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 1.7 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.3 1.6 GO:1903181 regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181)
0.1 1.6 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 1.6 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.5 1.5 GO:1901052 sarcosine metabolic process(GO:1901052) sarcosine catabolic process(GO:1901053)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 23.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 6.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 5.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 3.3 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.4 2.6 GO:0097513 myosin II filament(GO:0097513)
0.0 2.3 GO:0001650 fibrillar center(GO:0001650)
0.0 2.2 GO:0072686 mitotic spindle(GO:0072686)
0.3 1.7 GO:0031262 Ndc80 complex(GO:0031262)
0.0 1.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 1.2 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 1.2 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 1.1 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 0.9 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.9 GO:0097546 ciliary base(GO:0097546)
0.0 0.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.6 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.5 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 0.5 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.5 GO:0030061 mitochondrial crista(GO:0030061)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 13.0 GO:0003680 AT DNA binding(GO:0003680)
0.0 7.5 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.3 6.0 GO:0015172 acidic amino acid transmembrane transporter activity(GO:0015172)
0.1 5.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.3 5.4 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 4.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 3.3 GO:0005096 GTPase activator activity(GO:0005096)
0.2 2.6 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.4 2.2 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
0.1 1.9 GO:0046965 retinoid X receptor binding(GO:0046965)
0.1 1.8 GO:0042605 peptide antigen binding(GO:0042605)
0.1 1.6 GO:0050897 cobalt ion binding(GO:0050897)
0.1 1.6 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.5 1.5 GO:0046997 sarcosine dehydrogenase activity(GO:0008480) oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.0 1.5 GO:0008276 protein methyltransferase activity(GO:0008276)
0.2 1.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 1.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 1.2 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 1.2 GO:0048406 nerve growth factor binding(GO:0048406)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.1 PID_CDC42_PATHWAY CDC42 signaling events
0.0 2.3 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.6 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.2 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.6 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 0.6 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.6 PID_BCR_5PATHWAY BCR signaling pathway
0.0 0.3 PID_RAC1_PATHWAY RAC1 signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 13.0 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.3 5.4 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 5.1 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 2.6 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.6 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 1.4 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.1 1.2 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 1.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 0.7 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 0.6 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.4 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.3 REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.0 0.2 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.1 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.1 REACTOME_ADP_SIGNALLING_THROUGH_P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1