Motif ID: Thra

Z-value: 0.590


Transcription factors associated with Thra:

Gene SymbolEntrez IDGene Name
Thra ENSMUSG00000058756.7 Thra

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Thramm10_v2_chr11_+_98741805_98741816-0.671.7e-08Click!


Activity profile for motif Thra.

activity profile for motif Thra


Sorted Z-values histogram for motif Thra

Sorted Z-values for motif Thra



Network of associatons between targets according to the STRING database.



First level regulatory network of Thra

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_44300876 5.814 ENSMUST00000045607.5
 Melk
maternal embryonic leucine zipper kinase
chr18_+_57142782 4.470 ENSMUST00000139892.1
 Megf10
multiple EGF-like-domains 10
chr14_-_118052235 4.253 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr10_+_93641041 3.576 ENSMUST00000020204.4
 Ntn4
netrin 4
chr7_-_141214080 3.540 ENSMUST00000026573.5
ENSMUST00000170841.1
 1600016N20Rik

RIKEN cDNA 1600016N20 gene

chr1_+_84839833 3.254 ENSMUST00000097672.3
 Fbxo36
F-box protein 36
chr6_+_113531675 3.209 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr10_-_92162753 2.818 ENSMUST00000182197.1
 Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr11_-_40733373 2.496 ENSMUST00000020579.8
 Hmmr
hyaluronan mediated motility receptor (RHAMM)
chr10_-_88146867 2.416 ENSMUST00000164121.1
ENSMUST00000164803.1
ENSMUST00000168163.1
ENSMUST00000048518.9
 Parpbp



PARP1 binding protein



chr1_-_84839304 2.397 ENSMUST00000027421.6
 Trip12
thyroid hormone receptor interactor 12
chr17_+_85620816 2.384 ENSMUST00000175898.2
 Six3
sine oculis-related homeobox 3
chr4_-_135272798 2.335 ENSMUST00000037099.8
 Clic4
chloride intracellular channel 4 (mitochondrial)
chr13_+_44729794 2.304 ENSMUST00000172830.1
 Jarid2
jumonji, AT rich interactive domain 2
chr12_-_111672290 2.175 ENSMUST00000001304.7
 Ckb
creatine kinase, brain
chr3_-_52104891 2.121 ENSMUST00000121440.1
 Maml3
mastermind like 3 (Drosophila)
chr5_+_110839973 2.116 ENSMUST00000066160.1
 Chek2
checkpoint kinase 2
chr1_-_170306332 2.105 ENSMUST00000179801.1
 Gm7694
predicted gene 7694
chr13_+_94875600 2.079 ENSMUST00000022195.10
 Otp
orthopedia homolog (Drosophila)
chr4_-_137766474 2.071 ENSMUST00000139951.1
 Alpl
alkaline phosphatase, liver/bone/kidney

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.3 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.7 4.5 GO:0043654 skeletal muscle satellite cell activation(GO:0014719) recognition of apoptotic cell(GO:0043654)
0.7 4.3 GO:0006570 tyrosine metabolic process(GO:0006570)
0.3 3.7 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.7 3.6 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.5 3.2 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.0 3.0 GO:0006457 protein folding(GO:0006457)
0.4 2.9 GO:0007296 vitellogenesis(GO:0007296)
0.8 2.4 GO:1902915 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.8 2.4 GO:0097402 neuroblast migration(GO:0097402)
0.2 2.4 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.2 2.3 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.4 2.2 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.2 2.2 GO:0001675 acrosome assembly(GO:0001675)
0.1 2.2 GO:0006337 nucleosome disassembly(GO:0006337)
0.5 2.1 GO:1903463 regulation of mitotic cell cycle DNA replication(GO:1903463)
0.3 2.1 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.2 2.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.2 2.1 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.1 2.1 GO:0046677 response to antibiotic(GO:0046677)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.5 GO:0016607 nuclear speck(GO:0016607)
0.2 4.5 GO:0001891 phagocytic cup(GO:0001891)
0.2 4.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 3.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 3.7 GO:0000776 kinetochore(GO:0000776)
0.0 3.2 GO:0000793 condensed chromosome(GO:0000793)
0.1 2.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 2.2 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 2.2 GO:0016514 SWI/SNF complex(GO:0016514)
0.1 2.2 GO:0002080 acrosomal membrane(GO:0002080)
0.1 2.1 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 2.1 GO:0016605 PML body(GO:0016605)
0.0 2.1 GO:0005604 basement membrane(GO:0005604)
0.0 1.8 GO:0000922 spindle pole(GO:0000922)
0.3 1.7 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 1.6 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 1.6 GO:0043194 axon initial segment(GO:0043194)
0.0 1.5 GO:0043198 dendritic shaft(GO:0043198)
0.5 1.4 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 1.4 GO:0034707 chloride channel complex(GO:0034707)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.6 4.5 GO:0001849 complement component C1q binding(GO:0001849)
0.0 4.4 GO:0051082 unfolded protein binding(GO:0051082)
0.3 4.3 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 3.7 GO:0032452 histone demethylase activity(GO:0032452)
0.4 3.6 GO:0043237 laminin-1 binding(GO:0043237)
0.1 3.2 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 2.7 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 2.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 2.4 GO:0001222 transcription corepressor binding(GO:0001222)
0.5 2.2 GO:0004111 creatine kinase activity(GO:0004111)
0.5 2.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.4 2.0 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.2 2.0 GO:0015245 fatty acid transporter activity(GO:0015245)
0.0 1.9 GO:0005109 frizzled binding(GO:0005109)
0.0 1.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 1.7 GO:0043495 protein anchor(GO:0043495)
0.0 1.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.3 1.6 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.2 1.6 GO:0030274 LIM domain binding(GO:0030274)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.3 PID_ATM_PATHWAY ATM pathway
0.0 5.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 3.6 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 2.9 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 2.6 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 2.0 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.2 1.8 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.4 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.3 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 1.1 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 1.0 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.0 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.9 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.6 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.6 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.4 3.5 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.4 3.5 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.2 3.4 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 3.2 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 3.1 REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.1 2.5 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 2.1 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.8 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 1.6 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 1.5 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.1 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.0 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.9 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 0.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.7 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.6 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.6 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis