Motif ID: Thrb

Z-value: 0.426


Transcription factors associated with Thrb:

Gene SymbolEntrez IDGene Name
Thrb ENSMUSG00000021779.10 Thrb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Thrbmm10_v2_chr14_+_17660956_176609630.066.6e-01Click!


Activity profile for motif Thrb.

activity profile for motif Thrb


Sorted Z-values histogram for motif Thrb

Sorted Z-values for motif Thrb



Network of associatons between targets according to the STRING database.



First level regulatory network of Thrb

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_25470031 2.622 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr2_-_25469742 2.239 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr9_-_107668967 2.239 ENSMUST00000177567.1
 Slc38a3
solute carrier family 38, member 3
chr12_+_108334341 1.808 ENSMUST00000021684.4
 Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr12_+_112620030 1.763 ENSMUST00000180015.1
ENSMUST00000021726.6
 Adssl1

adenylosuccinate synthetase like 1

chr2_-_105399286 1.722 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr5_-_111761697 1.385 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
 E130006D01Rik


RIKEN cDNA E130006D01 gene


chr3_+_14863495 1.269 ENSMUST00000029076.4
 Car3
carbonic anhydrase 3
chr11_-_115612491 1.267 ENSMUST00000106507.2
 Mif4gd
MIF4G domain containing
chr5_-_92278155 1.091 ENSMUST00000159345.1
ENSMUST00000113102.3
 Naaa

N-acylethanolamine acid amidase

chr3_-_36475688 1.064 ENSMUST00000029266.8
 Anxa5
annexin A5
chr3_-_79842662 1.006 ENSMUST00000029568.1
 Tmem144
transmembrane protein 144
chr16_+_36934976 0.898 ENSMUST00000023531.8
 Hcls1
hematopoietic cell specific Lyn substrate 1
chr11_+_109485606 0.879 ENSMUST00000106697.1
 Arsg
arylsulfatase G
chr3_+_67374091 0.702 ENSMUST00000077916.5
 Mlf1
myeloid leukemia factor 1
chr3_+_67374116 0.664 ENSMUST00000061322.8
 Mlf1
myeloid leukemia factor 1
chr1_-_137969213 0.658 ENSMUST00000182680.1
ENSMUST00000182424.1
 Gm26936

predicted gene, 26936

chr16_+_32419696 0.571 ENSMUST00000014220.8
ENSMUST00000080316.7
 Tctex1d2

Tctex1 domain containing 2

chr11_-_103344651 0.423 ENSMUST00000041385.7
 Arhgap27
Rho GTPase activating protein 27
chr9_+_102626278 0.410 ENSMUST00000038673.7
 Anapc13
anaphase promoting complex subunit 13
chr4_+_20042046 0.380 ENSMUST00000098242.3
 Ggh
gamma-glutamyl hydrolase
chrX_+_112311334 0.364 ENSMUST00000026599.3
ENSMUST00000113415.1
 Apool

apolipoprotein O-like

chr15_-_103251465 0.346 ENSMUST00000133600.1
ENSMUST00000134554.1
ENSMUST00000156927.1
ENSMUST00000149111.1
ENSMUST00000132836.1
 Nfe2




nuclear factor, erythroid derived 2




chrX_-_78583882 0.333 ENSMUST00000114025.1
ENSMUST00000134602.1
ENSMUST00000114024.2
 Prrg1


proline rich Gla (G-carboxyglutamic acid) 1


chr15_-_100669496 0.298 ENSMUST00000182814.1
ENSMUST00000182068.1
 Bin2

bridging integrator 2

chr9_-_102626509 0.269 ENSMUST00000161645.1
ENSMUST00000162297.1
ENSMUST00000162655.1
 Cep63


centrosomal protein 63


chrX_-_78583782 0.254 ENSMUST00000177904.1
 Prrg1
proline rich Gla (G-carboxyglutamic acid) 1
chr9_-_102626095 0.239 ENSMUST00000093791.3
 Cep63
centrosomal protein 63
chr16_+_37916440 0.173 ENSMUST00000061274.7
 Gpr156
G protein-coupled receptor 156
chr4_-_148444744 0.129 ENSMUST00000051633.2
 Ubiad1
UbiA prenyltransferase domain containing 1
chr14_-_61360395 0.125 ENSMUST00000022494.8
 Ebpl
emopamil binding protein-like
chr2_+_152962485 0.104 ENSMUST00000099197.2
ENSMUST00000103155.3
 Ttll9

tubulin tyrosine ligase-like family, member 9

chr9_+_95857597 0.096 ENSMUST00000034980.7
 Atr
ataxia telangiectasia and Rad3 related
chr7_+_101896817 0.083 ENSMUST00000143835.1
 Anapc15
anaphase prompoting complex C subunit 15
chr2_+_32363192 0.075 ENSMUST00000048964.7
ENSMUST00000113332.1
 Ciz1

CDKN1A interacting zinc finger protein 1

chr3_-_116712198 0.046 ENSMUST00000120120.1
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr14_+_54476100 0.015 ENSMUST00000164766.1
ENSMUST00000164697.1
 Rem2

rad and gem related GTP binding protein 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.9 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.6 1.8 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.4 2.2 GO:0015817 glutamine transport(GO:0006868) histidine transport(GO:0015817) cellular response to potassium ion starvation(GO:0051365)
0.3 1.1 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.2 1.8 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.2 1.4 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.1 0.9 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 0.4 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.1 1.0 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.1 0.5 GO:0098535 de novo centriole assembly(GO:0098535)
0.0 0.3 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.0 1.3 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.1 GO:0042373 vitamin K metabolic process(GO:0042373)
0.0 0.1 GO:1904884 telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.0 0.4 GO:0042407 cristae formation(GO:0042407)
0.0 0.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.1 4.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.4 GO:0061617 MICOS complex(GO:0061617)
0.0 1.4 GO:0097546 ciliary base(GO:0097546)
0.0 0.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 1.1 GO:0014704 intercalated disc(GO:0014704)
0.0 0.3 GO:0001891 phagocytic cup(GO:0001891)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.9 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.7 2.2 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
0.1 1.3 GO:0016151 nickel cation binding(GO:0016151)
0.1 1.8 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 1.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.9 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.1 0.4 GO:0008242 omega peptidase activity(GO:0008242)
0.0 0.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 1.8 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.0 0.6 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 1.1 GO:0015144 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.0 0.1 GO:0032405 MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.8 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 1.8 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 0.9 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 2.2 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane