Motif ID: Tlx2

Z-value: 0.951


Transcription factors associated with Tlx2:

Gene SymbolEntrez IDGene Name
Tlx2 ENSMUSG00000068327.3 Tlx2



Activity profile for motif Tlx2.

activity profile for motif Tlx2


Sorted Z-values histogram for motif Tlx2

Sorted Z-values for motif Tlx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tlx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_21111452 4.346 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr9_-_21037775 4.277 ENSMUST00000180870.1
 Gm26592
predicted gene, 26592
chr3_-_82074639 4.208 ENSMUST00000029635.8
 Gucy1b3
guanylate cyclase 1, soluble, beta 3
chr15_+_54745702 4.186 ENSMUST00000050027.8
 Nov
nephroblastoma overexpressed gene
chr9_+_111311674 3.681 ENSMUST00000078626.3
 Trank1
tetratricopeptide repeat and ankyrin repeat containing 1
chr8_+_94772009 3.262 ENSMUST00000034230.5
 Cx3cl1
chemokine (C-X3-C motif) ligand 1
chr19_+_6401675 3.216 ENSMUST00000113471.1
ENSMUST00000113469.2
 Rasgrp2

RAS, guanyl releasing protein 2

chrX_-_162565514 3.181 ENSMUST00000154424.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chr3_+_8509477 2.972 ENSMUST00000029002.7
 Stmn2
stathmin-like 2
chr9_+_87015537 2.895 ENSMUST00000058846.4
 Ripply2
ripply2 homolog (zebrafish)
chr14_+_66344369 2.854 ENSMUST00000118426.1
ENSMUST00000121955.1
ENSMUST00000120229.1
ENSMUST00000134440.1
 Stmn4



stathmin-like 4



chr14_+_66344296 2.837 ENSMUST00000152093.1
ENSMUST00000074523.6
 Stmn4

stathmin-like 4

chr17_+_68837062 2.750 ENSMUST00000178545.1
 Tmem200c
transmembrane protein 200C
chr9_-_107710475 2.709 ENSMUST00000080560.3
 Sema3f
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr13_+_13784278 2.662 ENSMUST00000021734.7
 Gng4
guanine nucleotide binding protein (G protein), gamma 4
chr11_-_51650813 2.652 ENSMUST00000142721.1
ENSMUST00000156835.1
ENSMUST00000001080.9
 N4bp3


NEDD4 binding protein 3


chr14_-_66280949 2.606 ENSMUST00000111121.1
ENSMUST00000022622.7
ENSMUST00000089250.2
 Ptk2b


PTK2 protein tyrosine kinase 2 beta


chr1_-_45925570 2.539 ENSMUST00000027137.4
 Slc40a1
solute carrier family 40 (iron-regulated transporter), member 1
chr6_-_12749193 2.526 ENSMUST00000046121.6
ENSMUST00000172356.1
 Thsd7a

thrombospondin, type I, domain containing 7A

chr19_-_24031006 2.525 ENSMUST00000096164.4
 Fam189a2
family with sequence similarity 189, member A2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 223 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.7 GO:0009648 photoperiodism(GO:0009648)
0.1 4.5 GO:0034605 cellular response to heat(GO:0034605)
0.6 4.3 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.1 4.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.4 4.2 GO:0099548 trans-synaptic signaling by nitric oxide(GO:0099548)
1.4 4.2 GO:1990523 bone regeneration(GO:1990523)
0.0 4.2 GO:0016052 carbohydrate catabolic process(GO:0016052)
0.4 3.6 GO:0015838 proline transport(GO:0015824) amino-acid betaine transport(GO:0015838)
0.0 3.4 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.8 3.3 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.1 3.3 GO:0032543 mitochondrial translation(GO:0032543)
0.1 3.2 GO:0071277 cellular response to calcium ion(GO:0071277)
0.2 3.1 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
1.0 3.0 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
1.0 3.0 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.4 2.9 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.4 2.9 GO:0046645 positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) positive regulation of uterine smooth muscle contraction(GO:0070474)
0.2 2.9 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 2.9 GO:0002181 cytoplasmic translation(GO:0002181)
0.5 2.7 GO:0034436 glycoprotein transport(GO:0034436)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 116 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 6.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 4.1 GO:0005802 trans-Golgi network(GO:0005802)
0.1 3.6 GO:0000242 pericentriolar material(GO:0000242)
0.3 3.4 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.2 3.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 2.9 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 2.9 GO:0005921 gap junction(GO:0005921)
0.1 2.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.7 GO:0031225 anchored component of membrane(GO:0031225)
0.2 2.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 2.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 2.5 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 2.5 GO:0043209 myelin sheath(GO:0043209)
0.2 2.4 GO:0070852 cell body fiber(GO:0070852)
0.1 2.2 GO:0097449 astrocyte projection(GO:0097449)
0.1 2.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 2.2 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 2.2 GO:0005923 bicellular tight junction(GO:0005923)
0.2 2.1 GO:0005642 annulate lamellae(GO:0005642)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 157 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.1 GO:0005509 calcium ion binding(GO:0005509)
0.1 8.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.5 6.4 GO:0004016 adenylate cyclase activity(GO:0004016)
0.2 5.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 4.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 4.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
1.4 4.2 GO:0016160 alpha-amylase activity(GO:0004556) amylase activity(GO:0016160)
0.7 4.0 GO:0043426 MRF binding(GO:0043426)
0.0 3.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.5 3.6 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.1 3.3 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.5 3.0 GO:0016936 galactoside binding(GO:0016936)
0.0 3.0 GO:0030165 PDZ domain binding(GO:0030165)
0.6 2.9 GO:0042610 CD8 receptor binding(GO:0042610)
0.4 2.9 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 2.9 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.2 2.7 GO:0045499 chemorepellent activity(GO:0045499)
0.0 2.7 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.3 2.6 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.2 2.5 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 7.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 5.7 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.2 5.2 PID_ARF_3PATHWAY Arf1 pathway
0.0 4.9 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.2 4.0 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 3.8 PID_RAS_PATHWAY Regulation of Ras family activation
0.2 3.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 2.9 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.1 2.4 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 2.3 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.1 2.3 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 2.1 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 2.0 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 1.9 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.1 1.7 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 1.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 0.9 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.9 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.3 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.2 5.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 5.8 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.2 5.3 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 4.3 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 3.9 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 3.5 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.1 3.1 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.5 2.9 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 2.9 REACTOME_REGULATION_OF_SIGNALING_BY_CBL Genes involved in Regulation of signaling by CBL
0.1 2.7 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.2 2.6 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.2 2.5 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 2.5 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 2.5 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.8 2.4 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.1 2.1 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 2.1 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 2.1 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 2.0 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN