Motif ID: Trp53

Z-value: 1.257


Transcription factors associated with Trp53:

Gene SymbolEntrez IDGene Name
Trp53 ENSMUSG00000059552.7 Trp53

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Trp53mm10_v2_chr11_+_69580392_695804190.412.1e-03Click!


Activity profile for motif Trp53.

activity profile for motif Trp53


Sorted Z-values histogram for motif Trp53

Sorted Z-values for motif Trp53



Network of associatons between targets according to the STRING database.



First level regulatory network of Trp53

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_69206146 21.804 ENSMUST00000127243.1
ENSMUST00000149643.1
ENSMUST00000167875.2
ENSMUST00000005365.8
Spc25



SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)



chr17_-_33890584 18.434 ENSMUST00000114361.2
ENSMUST00000173492.1
Kifc1

kinesin family member C1

chr2_-_69206133 17.535 ENSMUST00000112320.1
Spc25
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr17_-_33890539 16.672 ENSMUST00000173386.1
Kifc1
kinesin family member C1
chr15_-_98004695 16.277 ENSMUST00000023123.8
Col2a1
collagen, type II, alpha 1
chr15_-_98004634 16.054 ENSMUST00000131560.1
ENSMUST00000088355.5
Col2a1

collagen, type II, alpha 1

chr1_+_6487231 15.070 ENSMUST00000140079.1
ENSMUST00000131494.1
St18

suppression of tumorigenicity 18

chr8_-_22185758 13.629 ENSMUST00000046916.7
Ckap2
cytoskeleton associated protein 2
chr17_+_29090969 12.479 ENSMUST00000119901.1
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr8_+_94977101 12.134 ENSMUST00000179619.1
Gpr56
G protein-coupled receptor 56
chr15_+_85859689 11.017 ENSMUST00000170629.1
Gtse1
G two S phase expressed protein 1
chr11_-_102925086 10.678 ENSMUST00000021311.9
Kif18b
kinesin family member 18B
chr14_+_73237891 10.079 ENSMUST00000044405.6
Lpar6
lysophosphatidic acid receptor 6
chr3_-_75956888 8.820 ENSMUST00000038563.7
ENSMUST00000167078.1
ENSMUST00000117242.1
Golim4


golgi integral membrane protein 4


chr14_+_13454010 8.670 ENSMUST00000112656.2
Synpr
synaptoporin
chr10_+_93641041 7.845 ENSMUST00000020204.4
Ntn4
netrin 4
chr11_-_3527916 7.385 ENSMUST00000020718.4
Smtn
smoothelin
chr5_-_30073554 7.263 ENSMUST00000026846.6
Tyms
thymidylate synthase
chr14_-_54926784 6.990 ENSMUST00000022813.6
Efs
embryonal Fyn-associated substrate
chr9_-_106158109 6.656 ENSMUST00000159809.1
ENSMUST00000162562.1
ENSMUST00000036382.6
ENSMUST00000112543.2
Glyctk



glycerate kinase



chr9_+_72438534 6.571 ENSMUST00000034746.8
Mns1
meiosis-specific nuclear structural protein 1
chr9_+_72438519 6.373 ENSMUST00000184604.1
Mns1
meiosis-specific nuclear structural protein 1
chr14_-_34374617 6.307 ENSMUST00000023826.4
Sncg
synuclein, gamma
chr14_+_13453937 6.279 ENSMUST00000153954.1
Synpr
synaptoporin
chr17_+_26917091 6.059 ENSMUST00000078961.4
Kifc5b
kinesin family member C5B
chr14_+_47001336 5.958 ENSMUST00000125113.1
Samd4
sterile alpha motif domain containing 4
chr2_+_59612034 5.809 ENSMUST00000112568.1
ENSMUST00000037526.4
Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr10_-_81350389 5.693 ENSMUST00000020454.4
ENSMUST00000105324.2
ENSMUST00000154609.2
ENSMUST00000105323.1
Hmg20b



high mobility group 20B



chr2_+_72285637 5.674 ENSMUST00000090824.5
ENSMUST00000135469.1
Zak

sterile alpha motif and leucine zipper containing kinase AZK

chr10_-_81350191 5.403 ENSMUST00000122993.1
Hmg20b
high mobility group 20B
chr9_+_66946057 5.247 ENSMUST00000040917.7
ENSMUST00000127896.1
Rps27l

ribosomal protein S27-like

chr10_+_56377300 5.032 ENSMUST00000068581.7
Gja1
gap junction protein, alpha 1
chr10_-_81350305 4.843 ENSMUST00000167481.1
Hmg20b
high mobility group 20B
chr9_-_100486788 4.842 ENSMUST00000098458.3
Il20rb
interleukin 20 receptor beta
chr9_+_45138437 4.789 ENSMUST00000060125.5
Scn4b
sodium channel, type IV, beta
chr1_+_82339049 4.588 ENSMUST00000140020.1
Rhbdd1
rhomboid domain containing 1
chrX_-_142306170 4.391 ENSMUST00000134825.2
Kcne1l
potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene
chr13_+_113317084 4.282 ENSMUST00000136755.2
BC067074
cDNA sequence BC067074
chr5_+_114707760 4.217 ENSMUST00000094441.4
Tchp
trichoplein, keratin filament binding
chr1_-_79858627 4.214 ENSMUST00000027467.4
Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr4_-_135573623 4.147 ENSMUST00000105855.1
Grhl3
grainyhead-like 3 (Drosophila)
chr7_+_75455534 3.969 ENSMUST00000147005.1
ENSMUST00000166315.1
Akap13

A kinase (PRKA) anchor protein 13

chr4_+_116596672 3.719 ENSMUST00000051869.7
Ccdc17
coiled-coil domain containing 17
chr5_-_116422858 3.710 ENSMUST00000036991.4
Hspb8
heat shock protein 8
chr15_-_102350692 3.522 ENSMUST00000041208.7
Aaas
achalasia, adrenocortical insufficiency, alacrimia
chr14_-_103843685 3.455 ENSMUST00000172237.1
Ednrb
endothelin receptor type B
chr9_+_107576915 3.294 ENSMUST00000112387.2
ENSMUST00000123005.1
ENSMUST00000010195.7
ENSMUST00000144392.1
Hyal1



hyaluronoglucosaminidase 1



chr17_+_35821675 3.267 ENSMUST00000003635.6
Ier3
immediate early response 3
chr13_+_21754067 3.005 ENSMUST00000091709.2
Hist1h2bn
histone cluster 1, H2bn
chr14_-_70653081 2.943 ENSMUST00000062629.4
Npm2
nucleophosmin/nucleoplasmin 2
chr12_+_59129720 2.926 ENSMUST00000175912.1
ENSMUST00000176892.1
Ctage5

CTAGE family, member 5

chr12_+_59129757 2.901 ENSMUST00000069430.8
ENSMUST00000177370.1
Ctage5

CTAGE family, member 5

chr4_-_96591555 2.797 ENSMUST00000055693.8
Cyp2j9
cytochrome P450, family 2, subfamily j, polypeptide 9
chr17_+_87282880 2.685 ENSMUST00000041110.5
ENSMUST00000125875.1
Ttc7

tetratricopeptide repeat domain 7

chr6_+_128438757 2.682 ENSMUST00000144745.1
Gm10069
predicted gene 10069
chr4_-_43030440 2.665 ENSMUST00000135660.1
Stoml2
stomatin (Epb7.2)-like 2
chr2_-_155592567 2.619 ENSMUST00000155347.1
ENSMUST00000130881.1
ENSMUST00000079691.6
Gss


glutathione synthetase


chr11_+_17211912 2.618 ENSMUST00000046955.6
Wdr92
WD repeat domain 92
chr2_-_155074447 2.502 ENSMUST00000137242.1
ENSMUST00000054607.9
Ahcy

S-adenosylhomocysteine hydrolase

chr9_-_72985344 2.467 ENSMUST00000124565.2
Gm5918
predicted gene 5918
chr10_+_110745433 2.396 ENSMUST00000174857.1
ENSMUST00000073781.5
ENSMUST00000173471.1
ENSMUST00000173634.1
E2f7



E2F transcription factor 7



chr16_+_20651652 2.385 ENSMUST00000007212.8
Psmd2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr9_-_114982739 2.322 ENSMUST00000053150.5
Gm9846
predicted gene 9846
chr2_+_29890063 2.312 ENSMUST00000028128.6
Odf2
outer dense fiber of sperm tails 2
chr4_-_129641060 2.273 ENSMUST00000046425.9
ENSMUST00000133803.1
Txlna

taxilin alpha

chr4_+_132351768 2.236 ENSMUST00000172202.1
Gm17300
predicted gene, 17300
chr2_+_29889217 2.230 ENSMUST00000123335.1
Odf2
outer dense fiber of sperm tails 2
chr4_-_83285141 2.165 ENSMUST00000150522.1
Ttc39b
tetratricopeptide repeat domain 39B
chr14_-_20496780 2.163 ENSMUST00000022353.3
Mss51
MSS51 mitochondrial translational activator
chr5_+_34989473 1.973 ENSMUST00000114284.1
ENSMUST00000114285.1
Rgs12

regulator of G-protein signaling 12

chr6_-_38837224 1.941 ENSMUST00000160962.1
Hipk2
homeodomain interacting protein kinase 2
chr14_+_74735641 1.901 ENSMUST00000177283.1
Esd
esterase D/formylglutathione hydrolase
chr3_-_28765364 1.899 ENSMUST00000094335.3
Gm6505
predicted pseudogene 6505
chr9_+_38719024 1.898 ENSMUST00000129598.1
Vwa5a
von Willebrand factor A domain containing 5A
chr13_+_22035821 1.870 ENSMUST00000110455.2
Hist1h2bk
histone cluster 1, H2bk
chr16_-_59632520 1.859 ENSMUST00000118438.1
Arl6
ADP-ribosylation factor-like 6
chr4_-_129640959 1.858 ENSMUST00000132217.1
ENSMUST00000130017.1
ENSMUST00000154105.1
Txlna


taxilin alpha


chr7_-_114927726 1.856 ENSMUST00000059737.2
Gm6816
predicted gene 6816
chr7_-_98309471 1.796 ENSMUST00000033020.7
Acer3
alkaline ceramidase 3
chr8_-_84893887 1.781 ENSMUST00000003907.7
ENSMUST00000182458.1
ENSMUST00000109745.1
ENSMUST00000142748.1
Gcdh



glutaryl-Coenzyme A dehydrogenase



chr18_+_61639542 1.634 ENSMUST00000183083.1
ENSMUST00000183087.1
Gm20748

predicted gene, 20748

chr10_+_94550852 1.628 ENSMUST00000148910.1
ENSMUST00000117460.1
Tmcc3

transmembrane and coiled coil domains 3

chr4_+_115057410 1.618 ENSMUST00000136946.1
Tal1
T cell acute lymphocytic leukemia 1
chr7_+_64392645 1.606 ENSMUST00000037205.8
Mcee
methylmalonyl CoA epimerase
chr1_+_161969179 1.489 ENSMUST00000111594.2
ENSMUST00000028021.6
Pigc

phosphatidylinositol glycan anchor biosynthesis, class C

chr15_+_83100281 1.441 ENSMUST00000167389.1
ENSMUST00000166427.1
Serhl

serine hydrolase-like

chrX_+_74254782 1.383 ENSMUST00000119197.1
ENSMUST00000088313.4
Emd

emerin

chr11_+_88204396 1.357 ENSMUST00000118784.1
ENSMUST00000139170.1
ENSMUST00000107915.3
ENSMUST00000144070.1
Mrps23



mitochondrial ribosomal protein S23



chr6_+_134981998 1.356 ENSMUST00000167323.1
Apold1
apolipoprotein L domain containing 1
chr17_-_24696147 1.337 ENSMUST00000046839.8
Gfer
growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)
chr13_-_22035589 1.325 ENSMUST00000091742.4
Hist1h2ah
histone cluster 1, H2ah
chr5_-_138272733 1.324 ENSMUST00000161665.1
ENSMUST00000100530.1
Gal3st4

galactose-3-O-sulfotransferase 4

chr12_-_74316394 1.300 ENSMUST00000110441.1
Gm11042
predicted gene 11042
chr14_-_55944536 1.245 ENSMUST00000022834.6
Cma1
chymase 1, mast cell
chr10_+_80622677 1.226 ENSMUST00000079773.6
Csnk1g2
casein kinase 1, gamma 2
chr16_+_20717665 1.221 ENSMUST00000021405.7
Polr2h
polymerase (RNA) II (DNA directed) polypeptide H
chr3_-_19265007 1.191 ENSMUST00000091314.4
Pde7a
phosphodiesterase 7A
chr5_-_115194283 1.179 ENSMUST00000112113.1
Cabp1
calcium binding protein 1
chr4_-_9643638 1.143 ENSMUST00000108333.1
ENSMUST00000108334.1
ENSMUST00000108335.1
ENSMUST00000152526.1
ENSMUST00000103004.3
Asph




aspartate-beta-hydroxylase




chr15_-_77927728 1.127 ENSMUST00000174468.1
ENSMUST00000174529.1
ENSMUST00000173631.1
Txn2


thioredoxin 2


chr4_+_115057683 1.124 ENSMUST00000161601.1
Tal1
T cell acute lymphocytic leukemia 1
chr11_-_17211504 1.108 ENSMUST00000020317.7
Pno1
partner of NOB1 homolog (S. cerevisiae)
chrX_-_38635066 1.107 ENSMUST00000058265.7
C1galt1c1
C1GALT1-specific chaperone 1
chr8_-_22694061 1.057 ENSMUST00000131767.1
Ikbkb
inhibitor of kappaB kinase beta
chr7_+_97332311 1.038 ENSMUST00000054107.5
Kctd21
potassium channel tetramerisation domain containing 21
chr5_-_138272786 0.890 ENSMUST00000161279.1
ENSMUST00000161647.1
Gal3st4

galactose-3-O-sulfotransferase 4

chr7_+_24884809 0.861 ENSMUST00000156372.1
ENSMUST00000124035.1
Rps19

ribosomal protein S19

chr6_-_118562226 0.830 ENSMUST00000112830.1
Ankrd26
ankyrin repeat domain 26
chr3_-_19264959 0.821 ENSMUST00000121951.1
Pde7a
phosphodiesterase 7A
chr3_+_96172327 0.797 ENSMUST00000076372.4
Sf3b4
splicing factor 3b, subunit 4
chr11_-_93968293 0.789 ENSMUST00000170303.1
Gm20390
predicted gene 20390
chr5_+_34999046 0.779 ENSMUST00000114281.1
Rgs12
regulator of G-protein signaling 12
chr11_-_93968242 0.777 ENSMUST00000107844.2
Nme1
NME/NM23 nucleoside diphosphate kinase 1
chr1_-_191907527 0.775 ENSMUST00000069573.5
1700034H15Rik
RIKEN cDNA 1700034H15 gene
chr15_+_100154379 0.768 ENSMUST00000023768.6
ENSMUST00000108971.2
Dip2b

DIP2 disco-interacting protein 2 homolog B (Drosophila)

chr1_+_161969284 0.731 ENSMUST00000160881.1
ENSMUST00000159648.1
Pigc

phosphatidylinositol glycan anchor biosynthesis, class C

chr15_+_83100201 0.728 ENSMUST00000078218.4
Serhl
serine hydrolase-like
chr2_-_130664565 0.612 ENSMUST00000089559.4
Ddrgk1
DDRGK domain containing 1
chrX_-_37191160 0.597 ENSMUST00000016571.7
Ndufa1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1
chr16_-_11909398 0.559 ENSMUST00000127972.1
ENSMUST00000121750.1
ENSMUST00000096272.4
ENSMUST00000073371.6
Cpped1



calcineurin-like phosphoesterase domain containing 1



chr17_+_32506446 0.493 ENSMUST00000165999.1
Cyp4f17
cytochrome P450, family 4, subfamily f, polypeptide 17
chr17_-_34862473 0.442 ENSMUST00000025229.4
ENSMUST00000176203.2
ENSMUST00000128767.1
Cfb


complement factor B


chr9_-_26999491 0.440 ENSMUST00000060513.7
ENSMUST00000120367.1
Acad8

acyl-Coenzyme A dehydrogenase family, member 8

chr19_-_43524462 0.393 ENSMUST00000026196.7
Got1
glutamate oxaloacetate transaminase 1, soluble
chr5_+_34999070 0.382 ENSMUST00000114280.1
Rgs12
regulator of G-protein signaling 12
chr19_+_4097392 0.377 ENSMUST00000174514.1
ENSMUST00000174149.1
Cdk2ap2

CDK2-associated protein 2

chr7_-_64872993 0.353 ENSMUST00000094331.2
Ndnl2
necdin-like 2
chr2_-_164857542 0.349 ENSMUST00000109316.1
ENSMUST00000156255.1
ENSMUST00000128110.1
ENSMUST00000109317.3
Pltp



phospholipid transfer protein



chr13_-_27582168 0.327 ENSMUST00000006664.1
ENSMUST00000095926.1
Prl8a1

prolactin family 8, subfamily a, member 1

chr2_-_17731035 0.318 ENSMUST00000028080.5
Nebl
nebulette
chr11_-_102469839 0.219 ENSMUST00000103086.3
Itga2b
integrin alpha 2b
chr19_-_4793851 0.213 ENSMUST00000178615.1
ENSMUST00000179189.1
ENSMUST00000164376.2
ENSMUST00000164209.2
ENSMUST00000180248.1
Rbm4




RNA binding motif protein 4




chr7_-_103741322 0.206 ENSMUST00000051346.2
Olfr629
olfactory receptor 629
chr13_+_23574381 0.179 ENSMUST00000090776.4
Hist1h2ad
histone cluster 1, H2ad
chr14_-_59365410 0.168 ENSMUST00000161031.1
ENSMUST00000160425.1
Phf11d

PHD finger protein 11D

chr2_+_10372426 0.161 ENSMUST00000114864.2
ENSMUST00000116594.2
ENSMUST00000041105.6
Sfmbt2


Scm-like with four mbt domains 2


chr9_-_21963568 0.156 ENSMUST00000006397.5
Epor
erythropoietin receptor
chr12_-_81532840 0.119 ENSMUST00000166664.1
ENSMUST00000164386.1
ENSMUST00000169158.1
ENSMUST00000164431.1
ENSMUST00000163402.1
Gm20498

Synj2bp


predicted gene 20498

synaptojanin 2 binding protein


chr11_-_98438941 0.107 ENSMUST00000002655.7
Mien1
migration and invasion enhancer 1
chr7_-_28962265 0.078 ENSMUST00000068045.7
Actn4
actinin alpha 4
chr5_+_34999111 0.072 ENSMUST00000114283.1
Rgs12
regulator of G-protein signaling 12
chr2_+_180078623 0.071 ENSMUST00000087563.6
Mtg2
mitochondrial ribosome associated GTPase 2
chr11_+_52360824 0.066 ENSMUST00000102758.1
Vdac1
voltage-dependent anion channel 1
chr2_+_152962485 0.054 ENSMUST00000099197.2
ENSMUST00000103155.3
Ttll9

tubulin tyrosine ligase-like family, member 9

chr2_-_127521358 0.039 ENSMUST00000028850.8
ENSMUST00000103215.4
Kcnip3

Kv channel interacting protein 3, calsenilin


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
11.7 35.1 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)
3.0 35.6 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
1.8 7.3 GO:0046073 dTMP biosynthetic process(GO:0006231) dTMP metabolic process(GO:0046073)
1.7 5.0 GO:0003104 positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643)
1.6 4.8 GO:0002865 immune response-inhibiting signal transduction(GO:0002765) negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865)
1.6 7.8 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
1.6 12.5 GO:0071493 cellular response to UV-B(GO:0071493)
1.5 4.6 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
1.3 15.1 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
1.2 3.5 GO:0014826 vein smooth muscle contraction(GO:0014826)
1.1 15.9 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
1.1 4.2 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.9 2.7 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.9 2.7 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.8 12.9 GO:0070986 left/right axis specification(GO:0070986)
0.8 2.4 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.7 4.0 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.6 3.2 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.6 4.4 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.6 4.2 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.5 1.9 GO:0046294 formaldehyde catabolic process(GO:0046294)
0.5 3.3 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.5 1.9 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.5 10.1 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.4 1.1 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.4 4.8 GO:0099623 regulation of ventricular cardiac muscle cell membrane repolarization(GO:0060307) regulation of cardiac muscle cell membrane repolarization(GO:0099623)
0.4 24.3 GO:0007019 microtubule depolymerization(GO:0007019)
0.4 39.3 GO:0007052 mitotic spindle organization(GO:0007052)
0.3 4.1 GO:0061436 establishment of skin barrier(GO:0061436)
0.3 2.5 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.3 7.2 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978)
0.3 2.9 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.2 6.0 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.2 5.8 GO:0097062 dendritic spine maintenance(GO:0097062)
0.2 1.1 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.2 6.3 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.2 3.4 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
0.2 1.1 GO:0016266 O-glycan processing(GO:0016266)
0.2 1.8 GO:0046512 sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520)
0.1 1.7 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 1.3 GO:0097421 liver regeneration(GO:0097421)
0.1 0.4 GO:0006106 fumarate metabolic process(GO:0006106) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)
0.1 1.8 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.1 0.6 GO:1990564 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721) protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 0.4 GO:0060265 positive regulation of respiratory burst involved in inflammatory response(GO:0060265)
0.1 0.3 GO:0042360 vitamin E metabolic process(GO:0042360)
0.1 1.1 GO:0006662 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.1 0.4 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.8 GO:0006228 UTP biosynthetic process(GO:0006228)
0.1 1.4 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.1 4.5 GO:1902017 regulation of cilium assembly(GO:1902017)
0.1 2.7 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 2.2 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.2 GO:0097167 circadian regulation of translation(GO:0097167)
0.0 0.8 GO:0060259 regulation of feeding behavior(GO:0060259)
0.0 0.8 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 3.5 GO:0009566 fertilization(GO:0009566)
0.0 0.4 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.0 0.4 GO:2000035 regulation of stem cell division(GO:2000035)
0.0 1.2 GO:0032611 interleukin-1 beta production(GO:0032611)
0.0 3.2 GO:0042113 B cell activation(GO:0042113)
0.0 1.5 GO:0006342 chromatin silencing(GO:0006342)
0.0 0.2 GO:0061032 visceral serous pericardium development(GO:0061032)
0.0 1.6 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.6 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.1 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 2.5 GO:0007018 microtubule-based movement(GO:0007018)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
6.6 39.3 GO:0031262 Ndc80 complex(GO:0031262)
4.2 12.5 GO:0070557 PCNA-p21 complex(GO:0070557)
4.0 15.9 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
2.7 32.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
2.1 10.7 GO:0000235 astral microtubule(GO:0000235)
1.8 36.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.9 2.7 GO:0033193 Lsd1/2 complex(GO:0033193)
0.7 4.2 GO:0045179 apical cortex(GO:0045179)
0.6 14.9 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.5 5.0 GO:0005916 fascia adherens(GO:0005916)
0.4 24.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.4 4.2 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.4 4.6 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.3 4.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.2 1.1 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.2 2.4 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540) cytosolic proteasome complex(GO:0031597)
0.2 11.2 GO:0005882 intermediate filament(GO:0005882)
0.2 2.7 GO:0042101 T cell receptor complex(GO:0042101)
0.2 2.4 GO:0097539 ciliary transition fiber(GO:0097539)
0.1 2.2 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 5.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 6.1 GO:0005871 kinesin complex(GO:0005871)
0.1 17.7 GO:0032993 protein-DNA complex(GO:0032993)
0.1 1.1 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 3.2 GO:0097440 apical dendrite(GO:0097440)
0.1 11.7 GO:0043679 axon terminus(GO:0043679)
0.1 4.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 6.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 4.8 GO:0005604 basement membrane(GO:0005604)
0.0 1.4 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 1.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 7.1 GO:0031965 nuclear membrane(GO:0031965)
0.0 9.1 GO:0019866 mitochondrial inner membrane(GO:0005743) organelle inner membrane(GO:0019866)
0.0 1.3 GO:0016605 PML body(GO:0016605)
0.0 1.9 GO:0005884 actin filament(GO:0005884)
0.0 0.2 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 14.1 GO:0005794 Golgi apparatus(GO:0005794)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
6.5 32.3 GO:0042289 MHC class II protein binding(GO:0042289)
4.2 12.5 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
2.5 35.1 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
1.4 10.1 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
1.3 5.0 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
1.2 3.5 GO:0004962 endothelin receptor activity(GO:0004962)
1.1 3.3 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.9 5.2 GO:0008494 translation activator activity(GO:0008494)
0.7 6.6 GO:0043237 laminin-1 binding(GO:0043237)
0.7 15.9 GO:0000400 four-way junction DNA binding(GO:0000400)
0.7 4.8 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.6 1.9 GO:0018738 S-formylglutathione hydrolase activity(GO:0018738)
0.5 4.4 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.5 7.3 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.4 4.0 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.4 2.7 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.4 1.1 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.4 2.2 GO:0050694 galactose 3-O-sulfotransferase activity(GO:0050694)
0.4 2.5 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.4 1.1 GO:0008384 IkappaB kinase activity(GO:0008384)
0.3 2.1 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.3 1.3 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.3 1.8 GO:0017040 ceramidase activity(GO:0017040)
0.2 1.9 GO:0046790 virion binding(GO:0046790)
0.2 16.7 GO:0003777 microtubule motor activity(GO:0003777)
0.2 6.0 GO:0030371 translation repressor activity(GO:0030371)
0.2 2.2 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.2 6.3 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 2.6 GO:0016594 glycine binding(GO:0016594)
0.1 0.4 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.1 2.2 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.1 1.2 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 1.1 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.1 3.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 4.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 20.2 GO:0001047 core promoter binding(GO:0001047)
0.1 1.6 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 1.6 GO:0016854 racemase and epimerase activity(GO:0016854)
0.1 5.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 4.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.2 GO:0070051 fibrinogen binding(GO:0070051)
0.0 3.7 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 4.1 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.2 GO:0035198 miRNA binding(GO:0035198)
0.0 0.7 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 1.1 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 2.2 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.4 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.2 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 12.5 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.7 32.3 NABA_COLLAGENS Genes encoding collagen proteins
0.3 6.4 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.3 5.7 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 5.0 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 9.7 PID_E2F_PATHWAY E2F transcription factor network
0.1 4.5 PID_PLK1_PATHWAY PLK1 signaling events
0.1 4.0 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.1 3.5 PID_ENDOTHELIN_PATHWAY Endothelins
0.0 2.3 PID_FOXO_PATHWAY FoxO family signaling
0.0 0.8 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 1.9 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.2 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 35.1 REACTOME_KINESINS Genes involved in Kinesins
1.1 10.1 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.7 32.3 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.5 12.5 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.4 5.0 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.4 38.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.4 7.3 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.3 3.3 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.2 15.9 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 3.5 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1 7.8 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 4.9 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 2.6 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 2.9 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.1 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 1.6 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 0.4 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.1 1.2 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 2.2 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 3.0 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.2 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 4.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 2.4 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.8 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.1 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.4 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.3 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.8 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 3.2 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 0.4 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.2 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins