Motif ID: Trp53

Z-value: 1.257


Transcription factors associated with Trp53:

Gene SymbolEntrez IDGene Name
Trp53 ENSMUSG00000059552.7 Trp53

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Trp53mm10_v2_chr11_+_69580392_695804190.412.1e-03Click!


Activity profile for motif Trp53.

activity profile for motif Trp53


Sorted Z-values histogram for motif Trp53

Sorted Z-values for motif Trp53



Network of associatons between targets according to the STRING database.



First level regulatory network of Trp53

PNG image of the network

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Top targets:


Showing 1 to 20 of 145 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_69206146 21.804 ENSMUST00000127243.1
ENSMUST00000149643.1
ENSMUST00000167875.2
ENSMUST00000005365.8
 Spc25



SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)



chr17_-_33890584 18.434 ENSMUST00000114361.2
ENSMUST00000173492.1
 Kifc1

kinesin family member C1

chr2_-_69206133 17.535 ENSMUST00000112320.1
 Spc25
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr17_-_33890539 16.672 ENSMUST00000173386.1
 Kifc1
kinesin family member C1
chr15_-_98004695 16.277 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr15_-_98004634 16.054 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr1_+_6487231 15.070 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr8_-_22185758 13.629 ENSMUST00000046916.7
 Ckap2
cytoskeleton associated protein 2
chr17_+_29090969 12.479 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr8_+_94977101 12.134 ENSMUST00000179619.1
 Gpr56
G protein-coupled receptor 56
chr15_+_85859689 11.017 ENSMUST00000170629.1
 Gtse1
G two S phase expressed protein 1
chr11_-_102925086 10.678 ENSMUST00000021311.9
 Kif18b
kinesin family member 18B
chr14_+_73237891 10.079 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr3_-_75956888 8.820 ENSMUST00000038563.7
ENSMUST00000167078.1
ENSMUST00000117242.1
 Golim4


golgi integral membrane protein 4


chr14_+_13454010 8.670 ENSMUST00000112656.2
 Synpr
synaptoporin
chr10_+_93641041 7.845 ENSMUST00000020204.4
 Ntn4
netrin 4
chr11_-_3527916 7.385 ENSMUST00000020718.4
 Smtn
smoothelin
chr5_-_30073554 7.263 ENSMUST00000026846.6
 Tyms
thymidylate synthase
chr14_-_54926784 6.990 ENSMUST00000022813.6
 Efs
embryonal Fyn-associated substrate
chr9_-_106158109 6.656 ENSMUST00000159809.1
ENSMUST00000162562.1
ENSMUST00000036382.6
ENSMUST00000112543.2
 Glyctk



glycerate kinase




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 39.3 GO:0007052 mitotic spindle organization(GO:0007052)
3.0 35.6 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
11.7 35.1 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)
0.4 24.3 GO:0007019 microtubule depolymerization(GO:0007019)
1.1 15.9 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
1.3 15.1 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.8 12.9 GO:0070986 left/right axis specification(GO:0070986)
1.6 12.5 GO:0071493 cellular response to UV-B(GO:0071493)
0.5 10.1 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
1.6 7.8 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
1.8 7.3 GO:0046073 dTMP biosynthetic process(GO:0006231) dTMP metabolic process(GO:0046073)
0.3 7.2 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978)
0.2 6.3 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.2 6.0 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.2 5.8 GO:0097062 dendritic spine maintenance(GO:0097062)
1.7 5.0 GO:0003104 positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643)
1.6 4.8 GO:0002865 immune response-inhibiting signal transduction(GO:0002765) negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865)
0.4 4.8 GO:0099623 regulation of ventricular cardiac muscle cell membrane repolarization(GO:0060307) regulation of cardiac muscle cell membrane repolarization(GO:0099623)
1.5 4.6 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1 4.5 GO:1902017 regulation of cilium assembly(GO:1902017)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.6 39.3 GO:0031262 Ndc80 complex(GO:0031262)
1.8 36.5 GO:0031616 spindle pole centrosome(GO:0031616)
2.7 32.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.4 24.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 17.7 GO:0032993 protein-DNA complex(GO:0032993)
4.0 15.9 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.6 14.9 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 14.1 GO:0005794 Golgi apparatus(GO:0005794)
4.2 12.5 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 11.7 GO:0043679 axon terminus(GO:0043679)
0.2 11.2 GO:0005882 intermediate filament(GO:0005882)
2.1 10.7 GO:0000235 astral microtubule(GO:0000235)
0.0 9.1 GO:0019866 mitochondrial inner membrane(GO:0005743) organelle inner membrane(GO:0019866)
0.0 7.1 GO:0031965 nuclear membrane(GO:0031965)
0.1 6.1 GO:0005871 kinesin complex(GO:0005871)
0.1 6.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 5.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.5 5.0 GO:0005916 fascia adherens(GO:0005916)
0.3 4.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 4.8 GO:0005604 basement membrane(GO:0005604)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 35.1 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
6.5 32.3 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 20.2 GO:0001047 core promoter binding(GO:0001047)
0.2 16.7 GO:0003777 microtubule motor activity(GO:0003777)
0.7 15.9 GO:0000400 four-way junction DNA binding(GO:0000400)
4.2 12.5 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
1.4 10.1 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.5 7.3 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.7 6.6 GO:0043237 laminin-1 binding(GO:0043237)
0.2 6.3 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 6.0 GO:0030371 translation repressor activity(GO:0030371)
0.1 5.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.9 5.2 GO:0008494 translation activator activity(GO:0008494)
1.3 5.0 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.7 4.8 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 4.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.5 4.4 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.1 4.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 4.1 GO:0019905 syntaxin binding(GO:0019905)
0.4 4.0 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 32.3 NABA_COLLAGENS Genes encoding collagen proteins
1.4 12.5 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 9.7 PID_E2F_PATHWAY E2F transcription factor network
0.3 6.4 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.3 5.7 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 5.0 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 4.5 PID_PLK1_PATHWAY PLK1 signaling events
0.1 4.0 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.1 3.5 PID_ENDOTHELIN_PATHWAY Endothelins
0.0 2.3 PID_FOXO_PATHWAY FoxO family signaling
0.0 1.9 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.8 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.2 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 38.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
1.3 35.1 REACTOME_KINESINS Genes involved in Kinesins
0.7 32.3 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 15.9 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.5 12.5 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
1.1 10.1 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 7.8 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.4 7.3 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.4 5.0 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 4.9 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 4.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 3.5 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.3 3.3 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 3.2 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 3.0 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 2.9 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 2.6 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 2.4 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 2.2 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 1.6 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation