Motif ID: Trp63

Z-value: 0.777


Transcription factors associated with Trp63:

Gene SymbolEntrez IDGene Name
Trp63 ENSMUSG00000022510.8 Trp63



Activity profile for motif Trp63.

activity profile for motif Trp63


Sorted Z-values histogram for motif Trp63

Sorted Z-values for motif Trp63



Network of associatons between targets according to the STRING database.



First level regulatory network of Trp63

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_116038734 11.599 ENSMUST00000166877.1
Sox6
SRY-box containing gene 6
chr17_+_29090969 6.717 ENSMUST00000119901.1
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr1_-_9700209 5.875 ENSMUST00000088658.4
Mybl1
myeloblastosis oncogene-like 1
chr6_+_34709442 4.720 ENSMUST00000115021.1
Cald1
caldesmon 1
chr6_+_34709610 4.706 ENSMUST00000031775.6
Cald1
caldesmon 1
chr7_-_141443314 4.571 ENSMUST00000106005.2
Lrdd
leucine-rich and death domain containing
chr11_-_101466222 4.328 ENSMUST00000040430.7
Vat1
vesicle amine transport protein 1 homolog (T californica)
chr12_-_108003414 3.906 ENSMUST00000109887.1
ENSMUST00000109891.2
Bcl11b

B cell leukemia/lymphoma 11B

chr12_-_108003594 3.898 ENSMUST00000066060.4
Bcl11b
B cell leukemia/lymphoma 11B
chr19_-_5875268 3.764 ENSMUST00000025728.6
Frmd8
FERM domain containing 8
chr19_-_5875210 3.763 ENSMUST00000155227.1
Frmd8
FERM domain containing 8
chr8_-_87959560 3.672 ENSMUST00000109655.2
Zfp423
zinc finger protein 423
chr7_-_37772868 3.633 ENSMUST00000176205.1
Zfp536
zinc finger protein 536
chr11_-_69948145 3.625 ENSMUST00000179298.1
ENSMUST00000018710.6
ENSMUST00000135437.1
ENSMUST00000141837.2
ENSMUST00000142500.1
Slc2a4




solute carrier family 2 (facilitated glucose transporter), member 4




chr2_+_59612034 3.154 ENSMUST00000112568.1
ENSMUST00000037526.4
Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr8_-_31918203 3.016 ENSMUST00000073884.4
Nrg1
neuregulin 1
chr4_-_96591555 2.707 ENSMUST00000055693.8
Cyp2j9
cytochrome P450, family 2, subfamily j, polypeptide 9
chr5_-_5265224 2.240 ENSMUST00000115450.1
Cdk14
cyclin-dependent kinase 14
chr2_-_170427828 2.215 ENSMUST00000013667.2
ENSMUST00000109152.2
ENSMUST00000068137.4
Bcas1


breast carcinoma amplified sequence 1


chr19_+_53140430 2.047 ENSMUST00000111741.2
Add3
adducin 3 (gamma)
chr11_-_106487796 2.011 ENSMUST00000001059.2
ENSMUST00000106799.1
ENSMUST00000106800.1
Ern1


endoplasmic reticulum (ER) to nucleus signalling 1


chr14_-_122451109 1.738 ENSMUST00000081580.2
Gm5089
predicted gene 5089
chr10_-_80671976 1.731 ENSMUST00000003433.6
Mknk2
MAP kinase-interacting serine/threonine kinase 2
chr11_-_106487833 1.709 ENSMUST00000106801.1
Ern1
endoplasmic reticulum (ER) to nucleus signalling 1
chr7_-_65370908 1.694 ENSMUST00000032729.6
Tjp1
tight junction protein 1
chr15_+_76696725 1.588 ENSMUST00000023203.4
Gpt
glutamic pyruvic transaminase, soluble
chr3_-_108402589 1.552 ENSMUST00000147565.1
Celsr2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
chr5_-_5266038 1.321 ENSMUST00000115451.1
ENSMUST00000115452.1
ENSMUST00000131392.1
Cdk14


cyclin-dependent kinase 14


chr7_-_65371210 1.188 ENSMUST00000102592.3
Tjp1
tight junction protein 1
chr8_-_47352348 1.081 ENSMUST00000110367.2
Stox2
storkhead box 2
chr4_-_134018829 1.020 ENSMUST00000051674.2
Lin28a
lin-28 homolog A (C. elegans)
chrX_+_159255919 0.905 ENSMUST00000112492.1
Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr11_+_98863610 0.893 ENSMUST00000142414.1
ENSMUST00000037480.8
Wipf2

WAS/WASL interacting protein family, member 2

chrX_+_159255782 0.613 ENSMUST00000126686.1
ENSMUST00000033671.6
Rps6ka3

ribosomal protein S6 kinase polypeptide 3

chr7_-_126160992 0.563 ENSMUST00000164741.1
Xpo6
exportin 6
chr10_-_61452658 0.551 ENSMUST00000167087.1
ENSMUST00000020288.7
Eif4ebp2

eukaryotic translation initiation factor 4E binding protein 2

chr13_-_103334429 0.531 ENSMUST00000167058.1
ENSMUST00000164111.1
Mast4

microtubule associated serine/threonine kinase family member 4

chr16_+_37868383 0.341 ENSMUST00000078717.6
Lrrc58
leucine rich repeat containing 58
chr8_+_84686300 0.124 ENSMUST00000177531.1
Trmt1
tRNA methyltransferase 1
chr5_+_142401484 0.107 ENSMUST00000072837.5
Foxk1
forkhead box K1
chr19_-_6080311 0.084 ENSMUST00000159832.1
Vps51
vacuolar protein sorting 51 homolog (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 7.8 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
1.1 11.6 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.9 4.3 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.7 6.7 GO:0071493 cellular response to UV-B(GO:0071493)
0.7 3.7 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.4 3.0 GO:0045213 neurotransmitter receptor metabolic process(GO:0045213)
0.4 1.6 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.2 2.9 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.2 3.6 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 9.4 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.1 3.6 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
0.1 1.0 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 1.7 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.1 3.2 GO:0097062 dendritic spine maintenance(GO:0097062)
0.1 3.7 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.1 GO:0002940 tRNA N2-guanine methylation(GO:0002940)
0.0 0.6 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 3.6 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086)
0.0 1.5 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.7 GO:0070557 PCNA-p21 complex(GO:0070557)
1.0 9.4 GO:0030478 actin cap(GO:0030478)
0.7 3.7 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.7 3.6 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.4 2.9 GO:0046581 intercellular canaliculus(GO:0046581)
0.2 3.6 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 3.0 GO:0030673 axolemma(GO:0030673)
0.0 11.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 4.3 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 2.0 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 0.1 GO:1990745 EARP complex(GO:1990745)
0.0 3.2 GO:0043679 axon terminus(GO:0043679)
0.0 1.0 GO:0010494 cytoplasmic stress granule(GO:0010494)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.7 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.9 3.6 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.7 5.9 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.3 2.9 GO:0071253 connexin binding(GO:0071253)
0.2 3.6 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.2 3.7 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.2 3.0 GO:0045499 chemorepellent activity(GO:0045499)
0.1 1.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 1.0 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.1 1.6 GO:0008483 transaminase activity(GO:0008483)
0.1 3.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 11.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.6 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 1.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 12.4 GO:0003779 actin binding(GO:0003779)
0.0 0.1 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.0 7.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.6 GO:0008536 Ran GTPase binding(GO:0008536)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 6.7 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 3.0 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 3.6 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 5.9 PID_IL4_2PATHWAY IL4-mediated signaling events
0.1 2.9 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 3.2 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.9 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.3 3.0 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.3 3.6 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.2 6.7 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.2 9.4 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.6 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 1.5 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 3.7 REACTOME_UNFOLDED_PROTEIN_RESPONSE Genes involved in Unfolded Protein Response