ISMARA results: Trp73

Motif ID: Trp73

Z-value: 0.596

Transcription factors associated with Trp73:

Gene Symbol	Entrez ID	Gene Name
Trp73	ENSMUSG00000029026.10	Trp73

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Trp73	mm10_v2_chr4_-_154097105_154097173	0.51	5.9e-05	Click!

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Showing 1 to 20 of 75 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr13_+_48261427	7.760	ENSMUST00000021810.1	Id4	inhibitor of DNA binding 4
chr7_-_116038734	5.072	ENSMUST00000166877.1	Sox6	SRY-box containing gene 6
chr1_+_153665274	4.302	ENSMUST00000152114.1 ENSMUST00000111812.1	Rgs8	regulator of G-protein signaling 8
chr12_-_45074112	3.745	ENSMUST00000120531.1 ENSMUST00000143376.1	Stxbp6	syntaxin binding protein 6 (amisyn)
chr16_-_17125106	3.688	ENSMUST00000093336.6	2610318N02Rik	RIKEN cDNA 2610318N02 gene
chrX_+_10717390	3.665	ENSMUST00000115524.1 ENSMUST00000008179.6	Mid1ip1	Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))
chr7_-_141443314	3.623	ENSMUST00000106005.2	Lrdd	leucine-rich and death domain containing
chr15_+_99055164	3.404	ENSMUST00000047104.7 ENSMUST00000024249.3	Prph	peripherin
chr1_+_72824482	3.366	ENSMUST00000047328.4	Igfbp2	insulin-like growth factor binding protein 2
chr17_+_29090969	3.345	ENSMUST00000119901.1	Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)
chr12_-_45074457	3.296	ENSMUST00000053768.6	Stxbp6	syntaxin binding protein 6 (amisyn)
chr7_-_116308241	3.175	ENSMUST00000183057.1 ENSMUST00000182487.1 ENSMUST00000181998.1	Plekha7	pleckstrin homology domain containing, family A member 7
chr1_-_5070281	3.141	ENSMUST00000147158.1 ENSMUST00000118000.1	Rgs20	regulator of G-protein signaling 20
chrX_+_10717451	3.126	ENSMUST00000156321.1	Mid1ip1	Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))
chr1_+_135729147	3.121	ENSMUST00000027677.7	Csrp1	cysteine and glycine-rich protein 1
chr3_+_159839729	2.913	ENSMUST00000068952.5	Wls	wntless homolog (Drosophila)
chr4_+_62583568	2.192	ENSMUST00000098031.3	Rgs3	regulator of G-protein signaling 3
chrX_-_109013389	1.857	ENSMUST00000033597.8	Hmgn5	high-mobility group nucleosome binding domain 5
chr4_+_101068983	1.588	ENSMUST00000038463.8 ENSMUST00000106955.1	Raver2	ribonucleoprotein, PTB-binding 2
chr2_-_164857671	1.543	ENSMUST00000059954.7	Pltp	phospholipid transfer protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Showing 1 to 20 of 44 entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.9	7.8	GO:0060741	prostate gland stromal morphogenesis(GO:0060741)
0.9	7.0	GO:0035542	regulation of SNARE complex assembly(GO:0035542)
0.4	6.8	GO:0045723	positive regulation of fatty acid biosynthetic process(GO:0045723)
0.0	5.4	GO:0007186	G-protein coupled receptor signaling pathway(GO:0007186)
0.5	5.1	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.3	4.3	GO:0007213	G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) regulation of dopamine receptor signaling pathway(GO:0060159)
0.2	3.4	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1	3.4	GO:0045104	intermediate filament cytoskeleton organization(GO:0045104)
0.4	3.3	GO:0071493	cellular response to UV-B(GO:0071493)
0.5	3.2	GO:0045218	zonula adherens maintenance(GO:0045218)
0.8	3.1	GO:0042360	vitamin E metabolic process(GO:0042360)
1.0	2.9	GO:0061357	Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.2	2.3	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.0	2.3	GO:0070527	platelet aggregation(GO:0070527)
0.0	1.9	GO:0006749	glutathione metabolic process(GO:0006749)
0.5	1.4	GO:0043456	regulation of pentose-phosphate shunt(GO:0043456)
0.4	1.4	GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.1	1.3	GO:0043248	proteasome assembly(GO:0043248)
0.1	1.3	GO:0044381	glucose import in response to insulin stimulus(GO:0044381)
0.0	1.2	GO:0042462	eye photoreceptor cell development(GO:0042462)

Gene overrepresentation in cellular_component category:

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Showing 1 to 20 of 29 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	7.0	GO:0000145	exocyst(GO:0000145)
0.0	6.1	GO:0005667	transcription factor complex(GO:0005667)
0.0	5.9	GO:0005874	microtubule(GO:0005874)
0.0	3.8	GO:0005925	focal adhesion(GO:0005925)
1.1	3.4	GO:0044299	C-fiber(GO:0044299)
1.1	3.3	GO:0070557	PCNA-p21 complex(GO:0070557)
0.3	3.2	GO:0005915	zonula adherens(GO:0005915)
0.1	3.2	GO:0032839	dendrite cytoplasm(GO:0032839)
0.1	3.1	GO:0032809	neuronal cell body membrane(GO:0032809)
0.0	3.1	GO:0005802	trans-Golgi network(GO:0005802)
0.0	2.8	GO:0016324	apical plasma membrane(GO:0016324)
0.0	2.7	GO:0043209	myelin sheath(GO:0043209)
0.3	2.3	GO:0090571	RNA polymerase II transcription repressor complex(GO:0090571)
0.1	1.3	GO:0008541	proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1	1.3	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	1.2	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.0	1.1	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.3	0.9	GO:0000811	GINS complex(GO:0000811)
0.1	0.9	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.1	0.9	GO:0061700	GATOR2 complex(GO:0061700)

Gene overrepresentation in molecular_function category:

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Showing 1 to 20 of 35 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.8	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)
0.4	7.0	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0	5.3	GO:0008022	protein C-terminus binding(GO:0008022)
0.0	5.1	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1	4.3	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.4	3.4	GO:0031995	insulin-like growth factor II binding(GO:0031995)
1.1	3.3	GO:0019912	cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.3	3.2	GO:0070097	delta-catenin binding(GO:0070097)
0.3	2.9	GO:0031852	mu-type opioid receptor binding(GO:0031852)
0.3	2.3	GO:0001226	RNA polymerase II transcription corepressor binding(GO:0001226)
0.0	1.9	GO:0031492	nucleosomal DNA binding(GO:0031492)
0.5	1.4	GO:0046538	bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1	1.4	GO:0008483	transaminase activity(GO:0008483)
0.3	1.3	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
0.0	1.3	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.2	1.2	GO:0008242	omega peptidase activity(GO:0008242)
0.1	1.1	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.0	1.1	GO:0051787	misfolded protein binding(GO:0051787)
0.1	1.0	GO:1990247	N6-methyladenosine-containing RNA binding(GO:1990247)
0.0	1.0	GO:0030971	receptor tyrosine kinase binding(GO:0030971)

Gene overrepresentation in C2:CP category:

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Showing 1 to 16 of 16 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	3.3	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1	3.2	PID_ECADHERIN_STABILIZATION_PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.1	3.1	ST_G_ALPHA_I_PATHWAY	G alpha i Pathway
0.0	2.9	NABA_ECM_GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	2.3	PID_HDAC_CLASSII_PATHWAY	Signaling events mediated by HDAC Class II
0.1	2.0	PID_EPHRINB_REV_PATHWAY	Ephrin B reverse signaling
0.0	1.4	PID_E2F_PATHWAY	E2F transcription factor network
0.1	1.3	PID_PRL_SIGNALING_EVENTS_PATHWAY	Signaling events mediated by PRL
0.0	1.3	PID_INSULIN_GLUCOSE_PATHWAY	Insulin-mediated glucose transport
0.0	0.7	PID_ANTHRAX_PATHWAY	Cellular roles of Anthrax toxin
0.0	0.7	PID_PDGFRA_PATHWAY	PDGFR-alpha signaling pathway
0.0	0.6	ST_GAQ_PATHWAY	G alpha q Pathway
0.0	0.6	PID_NEPHRIN_NEPH1_PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.0	0.5	PID_RXR_VDR_PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	0.5	PID_TELOMERASE_PATHWAY	Regulation of Telomerase
0.0	0.2	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes

Gene overrepresentation in C2:CP:REACTOME category:

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Showing 1 to 15 of 15 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.5	REACTOME_G_ALPHA_I_SIGNALLING_EVENTS	Genes involved in G alpha (i) signalling events
0.2	3.4	REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	3.3	REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.2	3.1	REACTOME_HDL_MEDIATED_LIPID_TRANSPORT	Genes involved in HDL-mediated lipid transport
0.0	2.3	REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1	1.4	REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	1.4	REACTOME_GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.1	1.3	REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.0	1.3	REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1	0.9	REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1	0.9	REACTOME_UNWINDING_OF_DNA	Genes involved in Unwinding of DNA
0.0	0.7	REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.1	0.6	REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.6	REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.0	0.4	REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1