Motif ID: Twist1

Z-value: 1.498


Transcription factors associated with Twist1:

Gene SymbolEntrez IDGene Name
Twist1 ENSMUSG00000035799.5 Twist1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Twist1mm10_v2_chr12_+_33957645_33957671-0.133.3e-01Click!


Activity profile for motif Twist1.

activity profile for motif Twist1


Sorted Z-values histogram for motif Twist1

Sorted Z-values for motif Twist1



Network of associatons between targets according to the STRING database.



First level regulatory network of Twist1

PNG image of the network

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Top targets:


Showing 1 to 20 of 118 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_119053339 26.546 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chr9_+_118478851 19.986 ENSMUST00000150633.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_60794468 17.383 ENSMUST00000050183.6
 Uaca
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr2_-_180225812 15.637 ENSMUST00000015791.5
 Lama5
laminin, alpha 5
chr7_+_45216671 13.889 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr6_-_95718800 13.419 ENSMUST00000079847.5
 Suclg2
succinate-Coenzyme A ligase, GDP-forming, beta subunit
chr19_+_25610533 12.869 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr5_+_149411749 11.077 ENSMUST00000093110.5
 Medag
mesenteric estrogen dependent adipogenesis
chr2_-_172940299 10.792 ENSMUST00000009143.7
 Bmp7
bone morphogenetic protein 7
chr7_-_127218390 10.574 ENSMUST00000142356.1
ENSMUST00000106314.1
 Sept1

septin 1

chr19_+_5740885 9.922 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr7_-_127218303 9.388 ENSMUST00000106313.1
 Sept1
septin 1
chr1_+_74791516 8.484 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr6_+_85187438 8.435 ENSMUST00000045942.8
 Emx1
empty spiracles homeobox 1
chr16_-_18811615 8.213 ENSMUST00000096990.3
 Cdc45
cell division cycle 45
chr9_-_54661870 8.182 ENSMUST00000034822.5
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr6_+_29398920 8.113 ENSMUST00000181464.1
ENSMUST00000180829.1
 Ccdc136

coiled-coil domain containing 136

chr7_+_4119556 7.606 ENSMUST00000079415.5
 Ttyh1
tweety homolog 1 (Drosophila)
chr7_+_4119525 7.472 ENSMUST00000119661.1
ENSMUST00000129423.1
 Ttyh1

tweety homolog 1 (Drosophila)

chr9_-_114844090 7.390 ENSMUST00000047013.3
 Cmtm8
CKLF-like MARVEL transmembrane domain containing 8

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.7 30.9 GO:0060032 notochord regression(GO:0060032)
2.4 21.4 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
6.7 20.0 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
5.0 20.0 GO:0051311 spindle assembly involved in female meiosis(GO:0007056) meiotic metaphase plate congression(GO:0051311)
0.6 18.9 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
1.0 17.4 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.4 14.3 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.6 13.9 GO:0048368 lateral mesoderm development(GO:0048368)
1.5 13.4 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
3.6 10.8 GO:0072076 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
2.5 10.1 GO:0070125 mitochondrial translational elongation(GO:0070125)
1.4 10.1 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
9.9 9.9 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.2 9.6 GO:1902476 chloride transmembrane transport(GO:1902476)
0.6 8.4 GO:0021796 cerebral cortex regionalization(GO:0021796)
2.7 8.2 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.6 8.1 GO:0001675 acrosome assembly(GO:0001675)
0.1 7.8 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
1.5 7.4 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 7.4 GO:0045444 fat cell differentiation(GO:0045444)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 30.9 GO:0097542 ciliary tip(GO:0097542)
2.2 20.0 GO:0072687 meiotic spindle(GO:0072687)
0.1 18.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
4.3 17.4 GO:0043293 apoptosome(GO:0043293)
0.0 16.1 GO:0005783 endoplasmic reticulum(GO:0005783)
3.9 15.6 GO:0043259 laminin-10 complex(GO:0043259)
5.0 15.1 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1 14.3 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
4.6 13.9 GO:0071149 TEAD-2-YAP complex(GO:0071149)
2.2 13.4 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0 10.6 GO:0005615 extracellular space(GO:0005615)
0.0 8.7 GO:0031012 extracellular matrix(GO:0031012)
2.7 8.2 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.4 8.1 GO:0002080 acrosomal membrane(GO:0002080)
0.0 8.0 GO:0005759 mitochondrial matrix(GO:0005759)
2.2 6.6 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0 6.6 GO:0000793 condensed chromosome(GO:0000793)
0.4 5.0 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.2 4.9 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 4.4 GO:0005884 actin filament(GO:0005884)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 25.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 20.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 20.0 GO:0005525 GTP binding(GO:0005525)
0.1 15.6 GO:0005178 integrin binding(GO:0005178)
3.8 15.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
1.3 14.3 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.7 13.9 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 13.6 GO:0043565 sequence-specific DNA binding(GO:0043565)
4.5 13.4 GO:0004774 succinate-CoA ligase activity(GO:0004774)
1.1 10.8 GO:0070700 BMP receptor binding(GO:0070700)
0.7 10.1 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.4 10.1 GO:0003746 translation elongation factor activity(GO:0003746)
0.4 9.9 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.2 8.5 GO:0005109 frizzled binding(GO:0005109)
0.6 8.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 7.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.9 7.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.8 7.4 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.9 6.8 GO:0005095 GTPase inhibitor activity(GO:0005095)
1.1 6.6 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 26.5 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.4 20.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.3 18.9 PID_IL12_2PATHWAY IL12-mediated signaling events
2.0 15.6 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 12.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.4 11.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
1.0 10.8 PID_ALK2_PATHWAY ALK2 signaling events
0.1 10.6 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.2 6.6 PID_ARF6_PATHWAY Arf6 signaling events
0.1 5.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 4.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 4.3 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 3.5 PID_IFNG_PATHWAY IFN-gamma pathway
0.1 3.3 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.1 2.2 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.2 2.1 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 2.1 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 1.9 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.4 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.8 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 14.2 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 14.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.4 13.9 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.6 13.4 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.5 8.2 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.3 6.6 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.4 5.4 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.6 5.1 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.5 5.1 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.2 5.0 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 4.4 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.5 3.7 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.3 3.5 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.1 3.3 REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION Genes involved in Nuclear Events (kinase and transcription factor activation)
0.1 3.3 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 2.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.4 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.1 2.4 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 2.2 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 2.2 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP