Motif ID: Vdr

Z-value: 0.890


Transcription factors associated with Vdr:

Gene SymbolEntrez IDGene Name
Vdr ENSMUSG00000022479.9 Vdr



Activity profile for motif Vdr.

activity profile for motif Vdr


Sorted Z-values histogram for motif Vdr

Sorted Z-values for motif Vdr



Network of associatons between targets according to the STRING database.



First level regulatory network of Vdr

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_79716588 6.314 ENSMUST00000099513.1
ENSMUST00000020581.2
 Hcn2

hyperpolarization-activated, cyclic nucleotide-gated K+ 2

chr15_-_72546279 6.193 ENSMUST00000044624.6
 Kcnk9
potassium channel, subfamily K, member 9
chr11_+_16752203 5.726 ENSMUST00000102884.3
ENSMUST00000020329.6
 Egfr

epidermal growth factor receptor

chr7_-_19310035 5.244 ENSMUST00000003640.2
 Fosb
FBJ osteosarcoma oncogene B
chr5_+_17574268 5.153 ENSMUST00000030568.7
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr10_+_127725392 5.007 ENSMUST00000026466.3
 Tac2
tachykinin 2
chr3_-_88000350 3.858 ENSMUST00000090971.5
 Bcan
brevican
chr13_+_94173992 3.280 ENSMUST00000121618.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr13_+_105443693 3.196 ENSMUST00000022235.4
 Htr1a
5-hydroxytryptamine (serotonin) receptor 1A
chr9_-_107667375 2.839 ENSMUST00000010208.8
 Slc38a3
solute carrier family 38, member 3
chr1_-_180483410 2.773 ENSMUST00000136521.1
ENSMUST00000179826.1
 6330403A02Rik

RIKEN cDNA 6330403A02 gene

chr9_-_21248437 2.588 ENSMUST00000122088.1
 S1pr5
sphingosine-1-phosphate receptor 5
chr4_-_42034726 2.494 ENSMUST00000084677.2
 Gm21093
predicted gene, 21093
chr4_+_42459563 2.491 ENSMUST00000098119.2
 Gm3883
predicted gene 3883
chr10_+_57784914 2.423 ENSMUST00000165013.1
 Fabp7
fatty acid binding protein 7, brain
chr3_+_117575268 2.298 ENSMUST00000039564.6
 4833424O15Rik
RIKEN cDNA 4833424O15 gene
chr6_-_128143525 2.277 ENSMUST00000032503.5
ENSMUST00000112173.1
 Tspan9

tetraspanin 9

chrX_+_136590841 2.133 ENSMUST00000138047.1
ENSMUST00000145648.1
 Tceal3

transcription elongation factor A (SII)-like 3

chr10_+_57784859 2.123 ENSMUST00000020024.5
 Fabp7
fatty acid binding protein 7, brain
chr6_+_125215551 2.062 ENSMUST00000032487.7
ENSMUST00000100942.2
ENSMUST00000063588.8
 Vamp1


vesicle-associated membrane protein 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 6.3 GO:0070305 response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321)
0.6 6.2 GO:0030322 stabilization of membrane potential(GO:0030322)
1.1 5.7 GO:0070459 prolactin secretion(GO:0070459)
0.9 5.2 GO:0003350 pulmonary myocardium development(GO:0003350)
1.3 5.0 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.3 4.5 GO:0060134 prepulse inhibition(GO:0060134)
0.1 4.5 GO:0071277 cellular response to calcium ion(GO:0071277)
1.2 3.5 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.8 3.4 GO:0001920 negative regulation of receptor recycling(GO:0001920)
1.1 3.2 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.0 3.2 GO:0021766 hippocampus development(GO:0021766)
0.9 2.8 GO:0042823 pyridoxal phosphate biosynthetic process(GO:0042823)
0.7 2.8 GO:0015817 histidine transport(GO:0015817)
0.2 2.4 GO:0015802 basic amino acid transport(GO:0015802) arginine transport(GO:0015809)
0.1 2.1 GO:0035493 SNARE complex assembly(GO:0035493)
0.2 2.0 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 2.0 GO:0033327 Leydig cell differentiation(GO:0033327)
0.6 1.9 GO:1902022 L-lysine transport(GO:1902022)
0.0 1.9 GO:0007416 synapse assembly(GO:0007416)
0.1 1.8 GO:0006516 glycoprotein catabolic process(GO:0006516)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 6.3 GO:0098855 HCN channel complex(GO:0098855)
0.0 6.2 GO:0008021 synaptic vesicle(GO:0008021)
1.4 5.7 GO:0097487 vesicle lumen(GO:0031983) multivesicular body, internal vesicle(GO:0097487)
0.0 4.2 GO:0005802 trans-Golgi network(GO:0005802)
0.0 3.7 GO:0031225 anchored component of membrane(GO:0031225)
0.2 3.2 GO:0043203 axon hillock(GO:0043203)
0.6 3.1 GO:1990761 growth cone lamellipodium(GO:1990761)
0.0 3.0 GO:0032587 ruffle membrane(GO:0032587)
0.0 2.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.3 2.3 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.4 2.1 GO:0070820 tertiary granule(GO:0070820)
0.1 2.1 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 1.7 GO:0044327 dendritic spine head(GO:0044327)
0.0 1.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 1.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 1.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 1.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 1.2 GO:0044295 axonal growth cone(GO:0044295)
0.0 1.2 GO:0005581 collagen trimer(GO:0005581)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 6.3 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.6 6.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
1.9 5.7 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.4 5.2 GO:0038191 neuropilin binding(GO:0038191)
0.0 4.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 4.3 GO:0005504 fatty acid binding(GO:0005504)
0.5 4.2 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.2 3.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 3.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 3.5 GO:0005246 calcium channel regulator activity(GO:0005246)
0.4 3.4 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
1.1 3.2 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.9 2.8 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
0.9 2.8 GO:0031403 lithium ion binding(GO:0031403)
0.3 2.6 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 2.6 GO:0050699 WW domain binding(GO:0050699)
0.0 2.1 GO:0005484 SNAP receptor activity(GO:0005484)
0.5 2.0 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 2.0 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 2.0 GO:0015485 cholesterol binding(GO:0015485)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4 5.7 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 5.4 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 3.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.2 2.7 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 1.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.9 NABA_CORE_MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.1 1.4 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.2 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.8 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.7 PID_FOXO_PATHWAY FoxO family signaling
0.0 0.5 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.4 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis
0.0 0.3 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.2 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.1 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 6.3 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.9 6.2 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.2 5.7 REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING Genes involved in SHC1 events in EGFR signaling
0.3 3.9 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
1.1 3.2 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.0 2.6 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.2 2.1 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 2.1 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.8 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.6 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 1.5 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.2 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 1.1 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 0.9 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.9 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.8 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.8 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.6 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.4 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes