Motif ID: Vsx1_Uncx_Prrx2_Shox2_Noto

Z-value: 1.380

Transcription factors associated with Vsx1_Uncx_Prrx2_Shox2_Noto:

Gene SymbolEntrez IDGene Name
Noto ENSMUSG00000068302.7 Noto
Prrx2 ENSMUSG00000039476.7 Prrx2
Shox2 ENSMUSG00000027833.10 Shox2
Uncx ENSMUSG00000029546.11 Uncx
Vsx1 ENSMUSG00000033080.8 Vsx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Uncxmm10_v2_chr5_+_139543889_1395439040.695.6e-09Click!
Prrx2mm10_v2_chr2_+_30834972_308349720.575.3e-06Click!
Shox2mm10_v2_chr3_-_66981279_669813180.312.1e-02Click!


Activity profile for motif Vsx1_Uncx_Prrx2_Shox2_Noto.

activity profile for motif Vsx1_Uncx_Prrx2_Shox2_Noto


Sorted Z-values histogram for motif Vsx1_Uncx_Prrx2_Shox2_Noto

Sorted Z-values for motif Vsx1_Uncx_Prrx2_Shox2_Noto



Network of associatons between targets according to the STRING database.



First level regulatory network of Vsx1_Uncx_Prrx2_Shox2_Noto

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_20737306 48.263 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr9_+_118478344 44.780 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478182 40.664 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr5_+_139543889 39.073 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr8_-_61902669 33.828 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr14_-_118052235 33.037 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr14_-_48665098 25.104 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr4_-_97778042 23.176 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chrX_-_60893430 22.642 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr2_+_25372315 22.057 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
 Sapcd2


suppressor APC domain containing 2


chr2_+_71528657 20.419 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr3_+_159839729 19.235 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr3_-_88410295 17.119 ENSMUST00000056370.7
 Pmf1
polyamine-modulated factor 1
chr17_+_34592248 17.020 ENSMUST00000038149.6
 Pbx2
pre B cell leukemia homeobox 2
chr2_-_168767136 16.951 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr7_-_49636847 16.752 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr15_+_25773985 15.576 ENSMUST00000125667.1
 Myo10
myosin X
chr2_-_168767029 14.408 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr6_+_8948608 14.193 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr2_-_72986716 13.710 ENSMUST00000112062.1
 Gm11084
predicted gene 11084

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 149 entries
Log-likelihood per target Total log-likelihoodTermDescription
28.5 85.4 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
4.4 48.7 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.4 43.4 GO:0048706 embryonic skeletal system development(GO:0048706)
4.9 39.1 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
1.8 33.8 GO:0071803 keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803)
5.5 33.0 GO:0006570 tyrosine metabolic process(GO:0006570)
1.7 31.4 GO:0001833 inner cell mass cell proliferation(GO:0001833)
6.9 27.5 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
1.6 25.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.5 25.7 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
1.1 22.6 GO:0007530 sex determination(GO:0007530)
6.8 20.4 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
6.4 19.2 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
1.5 16.8 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
1.2 16.0 GO:0021796 cerebral cortex regionalization(GO:0021796)
5.2 15.7 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 15.6 GO:0022409 positive regulation of cell-cell adhesion(GO:0022409)
2.2 13.4 GO:0003150 muscular septum morphogenesis(GO:0003150)
0.1 12.1 GO:0043488 regulation of mRNA stability(GO:0043488)
2.0 11.7 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 348.8 GO:0005634 nucleus(GO:0005634)
0.1 41.1 GO:0005667 transcription factor complex(GO:0005667)
0.8 33.8 GO:0002102 podosome(GO:0002102)
1.2 33.0 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 31.3 GO:0000792 heterochromatin(GO:0000792)
0.5 19.2 GO:0032839 dendrite cytoplasm(GO:0032839)
2.9 17.1 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.3 15.6 GO:0016459 myosin complex(GO:0016459)
0.8 11.9 GO:0042788 polysomal ribosome(GO:0042788)
2.9 11.5 GO:0060187 cell pole(GO:0060187)
0.6 9.1 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.3 8.4 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 7.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 6.9 GO:0043198 dendritic shaft(GO:0043198)
1.0 5.8 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.5 5.8 GO:0005915 zonula adherens(GO:0005915)
0.1 5.4 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 5.4 GO:0005925 focal adhesion(GO:0005925)
0.1 5.2 GO:0097440 apical dendrite(GO:0097440)
0.3 5.1 GO:0005614 interstitial matrix(GO:0005614)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 255.4 GO:0043565 sequence-specific DNA binding(GO:0043565)
1.4 87.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.3 34.5 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
2.5 33.0 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
2.2 32.6 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 30.2 GO:0003779 actin binding(GO:0003779)
2.4 23.5 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.7 22.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
2.5 17.5 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
1.4 17.1 GO:0043522 leucine zipper domain binding(GO:0043522)
2.0 15.7 GO:0050693 LBD domain binding(GO:0050693)
0.4 13.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 12.7 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.5 12.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
1.7 11.9 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.3 11.9 GO:0017091 AU-rich element binding(GO:0017091)
0.2 11.3 GO:0030507 spectrin binding(GO:0030507)
1.1 11.1 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.2 10.1 GO:0015144 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.4 9.2 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 85.4 PID_IL12_2PATHWAY IL12-mediated signaling events
1.5 50.8 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.3 29.6 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 20.4 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.4 18.6 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.5 15.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.3 14.3 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 8.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.3 8.0 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.2 8.0 PID_ARF6_PATHWAY Arf6 signaling events
0.3 6.8 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.3 6.8 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 6.7 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 5.8 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 4.7 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 4.2 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 4.1 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.2 4.0 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 3.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 3.2 PID_PLK1_PATHWAY PLK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 23.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 19.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.4 17.5 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 15.0 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 14.2 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 14.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 7.0 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 6.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 6.2 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.3 4.7 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.2 4.2 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 4.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.4 3.9 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 3.6 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 3.6 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM Genes involved in Integration of energy metabolism
0.1 3.5 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 3.0 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 2.9 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 2.8 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 2.8 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening