Motif ID: Vsx2_Dlx3

Z-value: 1.098

Transcription factors associated with Vsx2_Dlx3:

Gene SymbolEntrez IDGene Name
Dlx3 ENSMUSG00000001510.7 Dlx3
Vsx2 ENSMUSG00000021239.6 Vsx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Vsx2mm10_v2_chr12_+_84569762_845698400.038.1e-01Click!


Activity profile for motif Vsx2_Dlx3.

activity profile for motif Vsx2_Dlx3


Sorted Z-values histogram for motif Vsx2_Dlx3

Sorted Z-values for motif Vsx2_Dlx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Vsx2_Dlx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 121 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 58.673 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr6_-_23248264 35.200 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr2_-_168767136 12.601 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr10_+_73821857 8.507 ENSMUST00000177128.1
ENSMUST00000064562.7
ENSMUST00000129404.2
ENSMUST00000105426.3
ENSMUST00000131321.2
ENSMUST00000126920.2
ENSMUST00000147189.2
ENSMUST00000105424.3
ENSMUST00000092420.6
ENSMUST00000105429.3
ENSMUST00000131724.2
ENSMUST00000152655.2
ENSMUST00000151116.2
ENSMUST00000155701.2
ENSMUST00000152819.2
ENSMUST00000125517.2
ENSMUST00000124046.1
ENSMUST00000149977.2
ENSMUST00000146682.1
ENSMUST00000177107.1
 Pcdh15



















protocadherin 15



















chr2_-_168767029 7.869 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr17_-_70853482 7.747 ENSMUST00000118283.1
 Tgif1
TGFB-induced factor homeobox 1
chr12_+_38780284 7.644 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr7_-_49636847 7.476 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr12_+_38780817 7.339 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr3_+_159839729 7.267 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr4_+_8690399 7.148 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7
chr3_-_116253467 6.496 ENSMUST00000090473.5
 Gpr88
G-protein coupled receptor 88
chrX_-_60893430 6.299 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr3_+_55782500 6.176 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr4_+_62583568 6.033 ENSMUST00000098031.3
 Rgs3
regulator of G-protein signaling 3
chr3_-_79841729 5.803 ENSMUST00000168038.1
 Tmem144
transmembrane protein 144
chr9_-_79977782 5.416 ENSMUST00000093811.4
 Filip1
filamin A interacting protein 1
chr17_+_43952999 5.289 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2
chr10_-_6980376 4.887 ENSMUST00000105617.1
 Ipcef1
interaction protein for cytohesin exchange factors 1
chr8_-_61902669 4.755 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.3 58.7 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
6.2 37.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.1 20.5 GO:0001833 inner cell mass cell proliferation(GO:0001833)
1.7 18.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
1.1 8.5 GO:0050957 equilibrioception(GO:0050957)
0.8 8.5 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.5 8.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.4 7.5 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
2.4 7.3 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
2.4 7.1 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
1.6 6.5 GO:0061743 motor learning(GO:0061743)
0.3 6.3 GO:0007530 sex determination(GO:0007530)
0.4 5.8 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.3 4.8 GO:0071803 keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803)
1.2 4.7 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.1 4.1 GO:0050873 brown fat cell differentiation(GO:0050873)
0.2 4.0 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.1 3.8 GO:0006493 protein O-linked glycosylation(GO:0006493)
1.1 3.4 GO:0021759 globus pallidus development(GO:0021759)
1.0 3.1 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 142.0 GO:0005634 nucleus(GO:0005634)
0.1 20.5 GO:0000792 heterochromatin(GO:0000792)
0.0 10.7 GO:0005667 transcription factor complex(GO:0005667)
0.2 8.5 GO:0032420 stereocilium(GO:0032420)
0.2 7.3 GO:0032590 dendrite membrane(GO:0032590)
0.1 4.8 GO:0002102 podosome(GO:0002102)
0.8 4.7 GO:0001674 female germ cell nucleus(GO:0001674)
0.7 4.3 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.2 3.6 GO:0042788 polysomal ribosome(GO:0042788)
0.8 3.1 GO:0060187 cell pole(GO:0060187)
0.3 2.9 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 2.6 GO:0016459 myosin complex(GO:0016459)
0.2 2.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 2.2 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 2.0 GO:0035861 site of double-strand break(GO:0035861)
0.1 1.8 GO:0016460 myosin II complex(GO:0016460)
0.3 1.6 GO:0061689 paranodal junction(GO:0033010) tricellular tight junction(GO:0061689)
0.2 1.3 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0 1.1 GO:0005871 kinesin complex(GO:0005871)
0.1 0.9 GO:0031045 dense core granule(GO:0031045)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 116.1 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.2 37.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 10.2 GO:0003774 motor activity(GO:0003774)
0.1 9.1 GO:0047485 protein N-terminus binding(GO:0047485)
0.4 7.7 GO:0070410 co-SMAD binding(GO:0070410)
0.7 7.3 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.2 7.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 6.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 6.2 GO:0015144 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.0 6.2 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.4 4.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.7 4.0 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.2 3.8 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 3.6 GO:0017091 AU-rich element binding(GO:0017091)
0.3 3.4 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.3 3.0 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.5 2.9 GO:0070728 leucine binding(GO:0070728)
0.3 2.6 GO:0070700 BMP receptor binding(GO:0070700)
0.0 2.6 GO:0051015 actin filament binding(GO:0051015)
0.1 2.5 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 18.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 17.6 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 7.7 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.2 7.1 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.2 6.0 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 4.9 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 4.0 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 3.4 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 1.5 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 4.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 4.0 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 3.8 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 3.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 3.0 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 2.6 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 2.2 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 1.7 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.1 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.1 0.8 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.7 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.5 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.5 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 0.4 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins