Motif ID: Wrnip1_Mta3_Rcor1
Z-value: 2.936



Transcription factors associated with Wrnip1_Mta3_Rcor1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Mta3 | ENSMUSG00000055817.11 | Mta3 |
Rcor1 | ENSMUSG00000037896.11 | Rcor1 |
Wrnip1 | ENSMUSG00000021400.6 | Wrnip1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Rcor1 | mm10_v2_chr12_+_111039334_111039400 | -0.73 | 3.6e-10 | Click! |
Mta3 | mm10_v2_chr17_+_83706170_83706200 | 0.33 | 1.4e-02 | Click! |
Wrnip1 | mm10_v2_chr13_+_32802007_32802152 | 0.30 | 2.5e-02 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 1,413 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.4 | 37.4 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
1.4 | 36.7 | GO:0090662 | ATP hydrolysis coupled transmembrane transport(GO:0090662) |
2.3 | 32.3 | GO:0007190 | activation of adenylate cyclase activity(GO:0007190) |
1.2 | 31.5 | GO:0071625 | vocalization behavior(GO:0071625) |
0.5 | 31.5 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
0.6 | 28.5 | GO:0006414 | translational elongation(GO:0006414) |
4.7 | 28.2 | GO:0097646 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
3.0 | 26.7 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
0.6 | 25.8 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
0.6 | 25.5 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
2.1 | 25.2 | GO:1900121 | negative regulation of receptor binding(GO:1900121) |
2.2 | 24.6 | GO:0031645 | negative regulation of neurological system process(GO:0031645) |
4.8 | 24.2 | GO:0070327 | thyroid hormone transport(GO:0070327) |
1.3 | 23.8 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
1.3 | 23.8 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
0.5 | 22.3 | GO:0022900 | electron transport chain(GO:0022900) |
1.3 | 22.1 | GO:0032287 | peripheral nervous system myelin maintenance(GO:0032287) |
2.4 | 21.8 | GO:2000467 | positive regulation of glycogen (starch) synthase activity(GO:2000467) |
1.8 | 21.6 | GO:0002323 | natural killer cell activation involved in immune response(GO:0002323) |
2.3 | 21.1 | GO:1900034 | regulation of cellular response to heat(GO:1900034) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 466 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 496.3 | GO:0016021 | integral component of membrane(GO:0016021) |
0.6 | 165.7 | GO:0097060 | synaptic membrane(GO:0097060) |
0.1 | 77.0 | GO:1903561 | extracellular vesicle(GO:1903561) |
1.4 | 68.4 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
0.8 | 65.2 | GO:0043195 | terminal bouton(GO:0043195) |
0.2 | 64.9 | GO:0005615 | extracellular space(GO:0005615) |
0.9 | 63.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
1.0 | 62.4 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
0.2 | 58.9 | GO:0031012 | extracellular matrix(GO:0031012) |
1.2 | 50.6 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
0.2 | 49.3 | GO:0000139 | Golgi membrane(GO:0000139) |
0.6 | 49.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.2 | 48.3 | GO:0005768 | endosome(GO:0005768) |
0.7 | 48.2 | GO:0005581 | collagen trimer(GO:0005581) |
0.9 | 44.1 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
1.1 | 41.2 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
0.4 | 38.0 | GO:0070382 | exocytic vesicle(GO:0070382) |
1.1 | 37.1 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
1.1 | 37.0 | GO:0055038 | recycling endosome membrane(GO:0055038) |
0.8 | 37.0 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 748 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 155.2 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
0.3 | 68.1 | GO:0003924 | GTPase activity(GO:0003924) |
0.8 | 48.1 | GO:0035254 | glutamate receptor binding(GO:0035254) |
0.9 | 46.8 | GO:0030276 | clathrin binding(GO:0030276) |
0.5 | 41.2 | GO:0016247 | channel regulator activity(GO:0016247) |
1.0 | 40.7 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
2.6 | 39.4 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
0.5 | 38.9 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
1.0 | 37.1 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
0.8 | 36.6 | GO:0048487 | beta-tubulin binding(GO:0048487) |
2.9 | 35.1 | GO:0004016 | adenylate cyclase activity(GO:0004016) |
0.5 | 32.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
1.6 | 31.9 | GO:0008188 | neuropeptide receptor activity(GO:0008188) |
1.3 | 31.3 | GO:0003746 | translation elongation factor activity(GO:0003746) |
3.5 | 31.2 | GO:0070324 | thyroid hormone binding(GO:0070324) |
5.6 | 28.1 | GO:0097643 | amylin receptor activity(GO:0097643) |
1.0 | 27.6 | GO:0017046 | peptide hormone binding(GO:0017046) |
1.2 | 26.5 | GO:0031489 | myosin V binding(GO:0031489) |
1.8 | 25.9 | GO:0031005 | filamin binding(GO:0031005) |
1.0 | 24.7 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 122 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 122.6 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
0.7 | 86.9 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.7 | 45.1 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
1.0 | 42.9 | PID_PI3K_PLC_TRK_PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
0.4 | 42.6 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
2.2 | 37.9 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
1.2 | 36.7 | PID_ARF_3PATHWAY | Arf1 pathway |
0.9 | 32.9 | PID_IL8_CXCR2_PATHWAY | IL8- and CXCR2-mediated signaling events |
0.9 | 32.6 | PID_ALK1_PATHWAY | ALK1 signaling events |
0.8 | 30.0 | PID_INTEGRIN3_PATHWAY | Beta3 integrin cell surface interactions |
0.5 | 29.9 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
0.8 | 26.9 | PID_RAS_PATHWAY | Regulation of Ras family activation |
0.6 | 22.6 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
0.2 | 19.0 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.5 | 18.8 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
1.0 | 18.5 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
0.7 | 18.5 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
1.1 | 18.1 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
0.6 | 18.0 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
0.5 | 17.8 | PID_RETINOIC_ACID_PATHWAY | Retinoic acid receptors-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 212 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.0 | 111.7 | REACTOME_PEPTIDE_CHAIN_ELONGATION | Genes involved in Peptide chain elongation |
0.9 | 68.5 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
0.9 | 64.0 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
1.3 | 55.7 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
0.3 | 50.7 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
1.3 | 46.3 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
0.9 | 45.0 | REACTOME_G_ALPHA_S_SIGNALLING_EVENTS | Genes involved in G alpha (s) signalling events |
0.8 | 41.6 | REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
1.1 | 41.0 | REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
1.9 | 37.8 | REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
3.0 | 36.5 | REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY | Genes involved in Adenylate cyclase activating pathway |
2.7 | 35.7 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
0.5 | 34.0 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
1.4 | 32.9 | REACTOME_KERATAN_SULFATE_BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
2.0 | 32.4 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
0.8 | 32.1 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
1.9 | 30.8 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
0.8 | 30.3 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
0.6 | 30.0 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
1.9 | 29.7 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |