Motif ID: Wrnip1_Mta3_Rcor1

Z-value: 2.936

Transcription factors associated with Wrnip1_Mta3_Rcor1:

Gene SymbolEntrez IDGene Name
Mta3 ENSMUSG00000055817.11 Mta3
Rcor1 ENSMUSG00000037896.11 Rcor1
Wrnip1 ENSMUSG00000021400.6 Wrnip1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rcor1mm10_v2_chr12_+_111039334_111039400-0.733.6e-10Click!
Mta3mm10_v2_chr17_+_83706170_837062000.331.4e-02Click!
Wrnip1mm10_v2_chr13_+_32802007_328021520.302.5e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Wrnip1_Mta3_Rcor1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_180499893 22.579 ENSMUST00000029084.2
Ntsr1
neurotensin receptor 1
chr6_-_115994953 19.913 ENSMUST00000015511.8
Plxnd1
plexin D1
chr15_-_66948419 14.534 ENSMUST00000167817.1
Ndrg1
N-myc downstream regulated gene 1
chr7_+_36698002 14.282 ENSMUST00000021641.6
Tshz3
teashirt zinc finger family member 3
chr7_+_123982799 13.716 ENSMUST00000106437.1
Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr11_+_104132841 13.213 ENSMUST00000093925.4
Crhr1
corticotropin releasing hormone receptor 1
chr4_-_68954351 13.177 ENSMUST00000030036.5
Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chr7_-_120202104 13.097 ENSMUST00000033198.5
Crym
crystallin, mu
chr5_+_30588078 12.079 ENSMUST00000066295.2
Kcnk3
potassium channel, subfamily K, member 3
chr9_+_109931774 11.995 ENSMUST00000169851.2
Map4
microtubule-associated protein 4
chr7_+_43797567 11.958 ENSMUST00000085461.2
Klk8
kallikrein related-peptidase 8
chr4_+_138454305 11.779 ENSMUST00000050918.3
Camk2n1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr5_+_130448801 11.723 ENSMUST00000111288.2
Caln1
calneuron 1
chr4_+_104367549 11.142 ENSMUST00000106830.2
Dab1
disabled 1
chr18_-_38211957 10.697 ENSMUST00000159405.1
ENSMUST00000160721.1
Pcdh1

protocadherin 1

chr14_-_34201604 10.598 ENSMUST00000096019.2
Gprin2
G protein regulated inducer of neurite outgrowth 2
chr2_-_181156993 10.550 ENSMUST00000055990.7
Eef1a2
eukaryotic translation elongation factor 1 alpha 2
chr15_-_66969616 10.536 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
Ndrg1



N-myc downstream regulated gene 1



chr3_-_54915867 10.514 ENSMUST00000070342.3
Sertm1
serine rich and transmembrane domain containing 1
chr5_-_108549934 10.382 ENSMUST00000129040.1
ENSMUST00000046892.9
Cplx1

complexin 1


Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,413 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 37.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
1.4 36.7 GO:0090662 ATP hydrolysis coupled transmembrane transport(GO:0090662)
2.3 32.3 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
1.2 31.5 GO:0071625 vocalization behavior(GO:0071625)
0.5 31.5 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.6 28.5 GO:0006414 translational elongation(GO:0006414)
4.7 28.2 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
3.0 26.7 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.6 25.8 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.6 25.5 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
2.1 25.2 GO:1900121 negative regulation of receptor binding(GO:1900121)
2.2 24.6 GO:0031645 negative regulation of neurological system process(GO:0031645)
4.8 24.2 GO:0070327 thyroid hormone transport(GO:0070327)
1.3 23.8 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
1.3 23.8 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.5 22.3 GO:0022900 electron transport chain(GO:0022900)
1.3 22.1 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
2.4 21.8 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
1.8 21.6 GO:0002323 natural killer cell activation involved in immune response(GO:0002323)
2.3 21.1 GO:1900034 regulation of cellular response to heat(GO:1900034)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 466 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 496.3 GO:0016021 integral component of membrane(GO:0016021)
0.6 165.7 GO:0097060 synaptic membrane(GO:0097060)
0.1 77.0 GO:1903561 extracellular vesicle(GO:1903561)
1.4 68.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.8 65.2 GO:0043195 terminal bouton(GO:0043195)
0.2 64.9 GO:0005615 extracellular space(GO:0005615)
0.9 63.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
1.0 62.4 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.2 58.9 GO:0031012 extracellular matrix(GO:0031012)
1.2 50.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 49.3 GO:0000139 Golgi membrane(GO:0000139)
0.6 49.2 GO:0031225 anchored component of membrane(GO:0031225)
0.2 48.3 GO:0005768 endosome(GO:0005768)
0.7 48.2 GO:0005581 collagen trimer(GO:0005581)
0.9 44.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
1.1 41.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.4 38.0 GO:0070382 exocytic vesicle(GO:0070382)
1.1 37.1 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
1.1 37.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.8 37.0 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 748 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 155.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 68.1 GO:0003924 GTPase activity(GO:0003924)
0.8 48.1 GO:0035254 glutamate receptor binding(GO:0035254)
0.9 46.8 GO:0030276 clathrin binding(GO:0030276)
0.5 41.2 GO:0016247 channel regulator activity(GO:0016247)
1.0 40.7 GO:0043015 gamma-tubulin binding(GO:0043015)
2.6 39.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.5 38.9 GO:0004860 protein kinase inhibitor activity(GO:0004860)
1.0 37.1 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.8 36.6 GO:0048487 beta-tubulin binding(GO:0048487)
2.9 35.1 GO:0004016 adenylate cyclase activity(GO:0004016)
0.5 32.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
1.6 31.9 GO:0008188 neuropeptide receptor activity(GO:0008188)
1.3 31.3 GO:0003746 translation elongation factor activity(GO:0003746)
3.5 31.2 GO:0070324 thyroid hormone binding(GO:0070324)
5.6 28.1 GO:0097643 amylin receptor activity(GO:0097643)
1.0 27.6 GO:0017046 peptide hormone binding(GO:0017046)
1.2 26.5 GO:0031489 myosin V binding(GO:0031489)
1.8 25.9 GO:0031005 filamin binding(GO:0031005)
1.0 24.7 GO:0017075 syntaxin-1 binding(GO:0017075)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 122 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 122.6 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.7 86.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.7 45.1 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
1.0 42.9 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.4 42.6 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
2.2 37.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
1.2 36.7 PID_ARF_3PATHWAY Arf1 pathway
0.9 32.9 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.9 32.6 PID_ALK1_PATHWAY ALK1 signaling events
0.8 30.0 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.5 29.9 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.8 26.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.6 22.6 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.2 19.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.5 18.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
1.0 18.5 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.7 18.5 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
1.1 18.1 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.6 18.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.5 17.8 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 212 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 111.7 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.9 68.5 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.9 64.0 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
1.3 55.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.3 50.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
1.3 46.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.9 45.0 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.8 41.6 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
1.1 41.0 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
1.9 37.8 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
3.0 36.5 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
2.7 35.7 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.5 34.0 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
1.4 32.9 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
2.0 32.4 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.8 32.1 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
1.9 30.8 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.8 30.3 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.6 30.0 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
1.9 29.7 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation