Motif ID: Xbp1_Creb3l1
Z-value: 0.808
Transcription factors associated with Xbp1_Creb3l1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Creb3l1 | ENSMUSG00000027230.9 | Creb3l1 |
Xbp1 | ENSMUSG00000020484.12 | Xbp1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Xbp1 | mm10_v2_chr11_+_5520652_5520659 | -0.52 | 4.5e-05 | Click! |
Creb3l1 | mm10_v2_chr2_-_92024502_92024529 | 0.12 | 3.8e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.0 | 6.1 | GO:1990523 | bone regeneration(GO:1990523) |
1.2 | 8.6 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
0.5 | 1.9 | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
0.4 | 2.2 | GO:2000680 | regulation of rubidium ion transport(GO:2000680) |
0.4 | 2.7 | GO:0032596 | protein transport into membrane raft(GO:0032596) dsRNA transport(GO:0033227) |
0.3 | 0.6 | GO:2000275 | regulation of oxidative phosphorylation uncoupler activity(GO:2000275) |
0.3 | 4.9 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
0.3 | 0.8 | GO:0031204 | posttranslational protein targeting to membrane, translocation(GO:0031204) |
0.3 | 3.3 | GO:0048664 | neuron fate determination(GO:0048664) |
0.2 | 0.7 | GO:0030200 | heparan sulfate proteoglycan catabolic process(GO:0030200) |
0.2 | 0.7 | GO:0070476 | rRNA (guanine-N7)-methylation(GO:0070476) |
0.2 | 1.1 | GO:1901526 | negative regulation of mitochondrial membrane permeability(GO:0035795) positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925) |
0.2 | 0.7 | GO:1903298 | regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298) |
0.2 | 1.6 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
0.2 | 1.4 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
0.2 | 1.8 | GO:2000653 | regulation of genetic imprinting(GO:2000653) |
0.1 | 1.8 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
0.1 | 0.9 | GO:0060075 | regulation of resting membrane potential(GO:0060075) |
0.1 | 2.5 | GO:0060707 | trophoblast giant cell differentiation(GO:0060707) |
0.1 | 1.6 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
0.1 | 0.7 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
0.1 | 0.4 | GO:0036233 | glycine import(GO:0036233) |
0.1 | 1.9 | GO:0097201 | negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201) |
0.1 | 1.0 | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
0.1 | 0.6 | GO:0072697 | protein localization to cell cortex(GO:0072697) |
0.1 | 1.2 | GO:0097154 | GABAergic neuron differentiation(GO:0097154) |
0.1 | 1.5 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
0.1 | 0.6 | GO:0048251 | elastic fiber assembly(GO:0048251) |
0.1 | 0.3 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
0.1 | 1.1 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
0.1 | 1.3 | GO:0034315 | regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315) |
0.1 | 2.5 | GO:0046677 | response to antibiotic(GO:0046677) |
0.1 | 1.0 | GO:0005980 | polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247) |
0.1 | 1.5 | GO:0044381 | glucose import in response to insulin stimulus(GO:0044381) |
0.1 | 4.6 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
0.1 | 0.2 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
0.0 | 0.9 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
0.0 | 2.5 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
0.0 | 0.3 | GO:0070561 | vitamin D receptor signaling pathway(GO:0070561) |
0.0 | 1.5 | GO:0043277 | apoptotic cell clearance(GO:0043277) |
0.0 | 0.4 | GO:0060770 | negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) |
0.0 | 1.0 | GO:0035855 | megakaryocyte development(GO:0035855) |
0.0 | 0.1 | GO:0035519 | protein K29-linked ubiquitination(GO:0035519) |
0.0 | 0.4 | GO:0016093 | polyprenol metabolic process(GO:0016093) |
0.0 | 0.5 | GO:0032525 | somite rostral/caudal axis specification(GO:0032525) |
0.0 | 0.2 | GO:0070166 | enamel mineralization(GO:0070166) |
0.0 | 0.7 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
0.0 | 1.0 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
0.0 | 0.2 | GO:0042045 | epithelial fluid transport(GO:0042045) |
0.0 | 2.0 | GO:0007528 | neuromuscular junction development(GO:0007528) |
0.0 | 0.0 | GO:0090298 | negative regulation of mitochondrial DNA replication(GO:0090298) |
0.0 | 1.9 | GO:0045670 | regulation of osteoclast differentiation(GO:0045670) |
0.0 | 0.2 | GO:0061088 | sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088) |
0.0 | 0.3 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
0.0 | 0.3 | GO:0071712 | ER-associated misfolded protein catabolic process(GO:0071712) |
0.0 | 0.1 | GO:0072272 | proximal/distal pattern formation involved in metanephric nephron development(GO:0072272) |
0.0 | 0.3 | GO:0007220 | Notch receptor processing(GO:0007220) |
0.0 | 0.4 | GO:0006491 | N-glycan processing(GO:0006491) |
0.0 | 0.1 | GO:0000320 | re-entry into mitotic cell cycle(GO:0000320) |
0.0 | 0.7 | GO:0043550 | regulation of lipid kinase activity(GO:0043550) |
0.0 | 0.2 | GO:0071786 | endoplasmic reticulum tubular network organization(GO:0071786) |
0.0 | 0.1 | GO:0097502 | mannosylation(GO:0097502) |
0.0 | 0.1 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
0.0 | 0.3 | GO:0060445 | branching involved in salivary gland morphogenesis(GO:0060445) |
0.0 | 0.2 | GO:0015693 | magnesium ion transport(GO:0015693) |
0.0 | 0.2 | GO:0072673 | lamellipodium morphogenesis(GO:0072673) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 2.2 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
0.3 | 1.6 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
0.3 | 5.8 | GO:0031527 | filopodium membrane(GO:0031527) |
0.2 | 0.8 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
0.2 | 2.3 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
0.2 | 1.8 | GO:0048500 | signal recognition particle(GO:0048500) |
0.2 | 0.5 | GO:0031205 | endoplasmic reticulum Sec complex(GO:0031205) |
0.1 | 2.5 | GO:0065010 | extracellular membrane-bounded organelle(GO:0065010) |
0.1 | 0.7 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
0.1 | 0.3 | GO:0070939 | Dsl1p complex(GO:0070939) |
0.1 | 0.3 | GO:0055087 | Ski complex(GO:0055087) |
0.1 | 0.4 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
0.1 | 1.5 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
0.1 | 2.5 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
0.1 | 1.0 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
0.1 | 0.2 | GO:0030905 | retromer, tubulation complex(GO:0030905) |
0.1 | 1.4 | GO:0005801 | cis-Golgi network(GO:0005801) |
0.1 | 2.1 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
0.0 | 0.1 | GO:0016222 | procollagen-proline 4-dioxygenase complex(GO:0016222) |
0.0 | 0.5 | GO:0042589 | zymogen granule membrane(GO:0042589) |
0.0 | 0.3 | GO:0070765 | gamma-secretase complex(GO:0070765) |
0.0 | 2.7 | GO:0005844 | polysome(GO:0005844) |
0.0 | 2.0 | GO:0031594 | neuromuscular junction(GO:0031594) |
0.0 | 46.3 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
0.0 | 0.3 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
0.0 | 1.5 | GO:0042734 | presynaptic membrane(GO:0042734) |
0.0 | 0.1 | GO:0072487 | MSL complex(GO:0072487) |
0.0 | 1.9 | GO:0030018 | Z disc(GO:0030018) |
0.0 | 1.1 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.1 | 8.6 | GO:0046923 | ER retention sequence binding(GO:0046923) |
0.6 | 2.5 | GO:0004035 | alkaline phosphatase activity(GO:0004035) |
0.4 | 2.0 | GO:0030942 | endoplasmic reticulum signal peptide binding(GO:0030942) |
0.4 | 1.5 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
0.3 | 1.2 | GO:0004096 | catalase activity(GO:0004096) |
0.3 | 6.1 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.3 | 0.8 | GO:0001729 | ceramide kinase activity(GO:0001729) |
0.3 | 1.0 | GO:0008184 | glycogen phosphorylase activity(GO:0008184) |
0.2 | 0.7 | GO:0070052 | collagen V binding(GO:0070052) |
0.2 | 4.6 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
0.2 | 1.1 | GO:0008865 | fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
0.2 | 0.7 | GO:0017099 | very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099) |
0.2 | 1.9 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
0.2 | 1.0 | GO:0022851 | GABA-gated chloride ion channel activity(GO:0022851) |
0.2 | 4.9 | GO:0019789 | SUMO transferase activity(GO:0019789) |
0.2 | 1.4 | GO:0030274 | LIM domain binding(GO:0030274) |
0.2 | 0.6 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
0.1 | 1.6 | GO:0004526 | ribonuclease P activity(GO:0004526) |
0.1 | 0.7 | GO:0003923 | GPI-anchor transamidase activity(GO:0003923) |
0.1 | 0.5 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
0.1 | 1.0 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
0.1 | 1.6 | GO:0016671 | oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671) |
0.1 | 3.3 | GO:0071837 | HMG box domain binding(GO:0071837) |
0.1 | 1.3 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
0.1 | 1.1 | GO:0015926 | glucosidase activity(GO:0015926) |
0.1 | 1.6 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
0.1 | 0.3 | GO:0050510 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510) |
0.1 | 0.9 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
0.1 | 0.6 | GO:0034046 | poly(G) binding(GO:0034046) |
0.1 | 1.1 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
0.1 | 36.1 | GO:0005509 | calcium ion binding(GO:0005509) |
0.1 | 1.9 | GO:0070412 | R-SMAD binding(GO:0070412) |
0.1 | 1.9 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
0.1 | 0.2 | GO:1990460 | leptin receptor binding(GO:1990460) |
0.0 | 1.4 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
0.0 | 1.1 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
0.0 | 0.6 | GO:0004659 | prenyltransferase activity(GO:0004659) |
0.0 | 0.4 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
0.0 | 1.1 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
0.0 | 0.1 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798) |
0.0 | 0.3 | GO:0042288 | MHC class I protein binding(GO:0042288) |
0.0 | 0.2 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
0.0 | 0.1 | GO:0042954 | lipoprotein transporter activity(GO:0042954) |
0.0 | 0.7 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
0.0 | 0.3 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
0.0 | 0.1 | GO:0005047 | signal recognition particle binding(GO:0005047) |
0.0 | 0.4 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
0.0 | 0.6 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
0.0 | 1.1 | GO:0020037 | heme binding(GO:0020037) |
0.0 | 1.4 | GO:0019905 | syntaxin binding(GO:0019905) |
0.0 | 0.3 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
0.0 | 0.9 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
0.0 | 0.3 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
0.0 | 0.1 | GO:0043995 | histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972) |
0.0 | 0.1 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
0.0 | 2.8 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 4.9 | ST_JAK_STAT_PATHWAY | Jak-STAT Pathway |
0.2 | 6.1 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
0.0 | 1.5 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
0.0 | 1.4 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
0.0 | 0.3 | PID_IL5_PATHWAY | IL5-mediated signaling events |
0.0 | 0.6 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
0.0 | 0.7 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
0.0 | 1.5 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
0.0 | 0.3 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
0.0 | 3.0 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
0.0 | 1.2 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
0.0 | 0.9 | PID_LYSOPHOSPHOLIPID_PATHWAY | LPA receptor mediated events |
0.0 | 1.7 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.0 | 0.7 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 17.1 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
0.2 | 1.3 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
0.1 | 1.5 | REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
0.1 | 0.9 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
0.1 | 1.5 | REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle |
0.1 | 6.1 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
0.1 | 1.0 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
0.1 | 1.4 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
0.0 | 0.7 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
0.0 | 1.7 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
0.0 | 0.4 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
0.0 | 1.1 | REACTOME_GLUCOSE_TRANSPORT | Genes involved in Glucose transport |
0.0 | 0.5 | REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
0.0 | 1.1 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
0.0 | 0.3 | REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR | Genes involved in Regulated proteolysis of p75NTR |
0.0 | 0.7 | REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
0.0 | 0.3 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
0.0 | 0.3 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
0.0 | 1.4 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
0.0 | 1.8 | REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
0.0 | 0.3 | REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
0.0 | 0.3 | REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |