Motif ID: Xbp1_Creb3l1

Z-value: 0.808

Transcription factors associated with Xbp1_Creb3l1:

Gene SymbolEntrez IDGene Name
Creb3l1 ENSMUSG00000027230.9 Creb3l1
Xbp1 ENSMUSG00000020484.12 Xbp1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Xbp1mm10_v2_chr11_+_5520652_5520659-0.524.5e-05Click!
Creb3l1mm10_v2_chr2_-_92024502_920245290.123.8e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Xbp1_Creb3l1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_45092130 14.421 ENSMUST00000148175.1
Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr7_-_45092198 11.970 ENSMUST00000140449.1
ENSMUST00000117546.1
ENSMUST00000019683.3
Rcn3


reticulocalbin 3, EF-hand calcium binding domain


chr15_+_79516396 8.483 ENSMUST00000010974.7
Kdelr3
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr7_-_45091713 8.190 ENSMUST00000141576.1
Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr5_-_135251209 6.053 ENSMUST00000062572.2
Fzd9
frizzled homolog 9 (Drosophila)
chr2_-_105399286 5.414 ENSMUST00000006128.6
Rcn1
reticulocalbin 1
chr6_-_54593139 5.098 ENSMUST00000046520.6
Fkbp14
FK506 binding protein 14
chr15_-_32244632 4.464 ENSMUST00000181536.1
0610007N19Rik
RIKEN cDNA 0610007N19
chr1_-_163313661 3.344 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
Prrx1


paired related homeobox 1


chr3_+_93520473 3.110 ENSMUST00000029515.4
S100a11
S100 calcium binding protein A11 (calgizzarin)
chr1_-_55226768 2.745 ENSMUST00000027121.8
ENSMUST00000114428.2
Rftn2

raftlin family member 2

chr10_+_41519493 2.483 ENSMUST00000019962.8
Cd164
CD164 antigen
chr3_+_96697100 2.473 ENSMUST00000107077.3
Pias3
protein inhibitor of activated STAT 3
chr4_-_137796350 2.470 ENSMUST00000030551.4
Alpl
alkaline phosphatase, liver/bone/kidney
chr3_+_96697076 2.439 ENSMUST00000162778.2
ENSMUST00000064900.9
Pias3

protein inhibitor of activated STAT 3

chr10_+_128908907 2.174 ENSMUST00000105229.1
Cd63
CD63 antigen
chr3_+_88206786 2.030 ENSMUST00000181134.1
ENSMUST00000181550.1
Gm3764

predicted gene 3764

chr6_-_101377342 2.029 ENSMUST00000151175.1
Pdzrn3
PDZ domain containing RING finger 3
chr13_-_38528412 1.952 ENSMUST00000035988.8
Txndc5
thioredoxin domain containing 5
chr7_+_128523576 1.888 ENSMUST00000033136.7
Bag3
BCL2-associated athanogene 3
chr14_-_79301623 1.850 ENSMUST00000022595.7
Rgcc
regulator of cell cycle
chr3_+_88207308 1.704 ENSMUST00000180582.1
Gm3764
predicted gene 3764
chrX_+_56454871 1.701 ENSMUST00000039374.2
ENSMUST00000101553.2
Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr4_+_88094599 1.677 ENSMUST00000097992.3
Focad
focadhesin
chr10_+_91082940 1.661 ENSMUST00000020150.3
Ikbip
IKBKB interacting protein
chr10_+_91083036 1.654 ENSMUST00000020149.5
Ikbip
IKBKB interacting protein
chr2_+_80315461 1.600 ENSMUST00000028392.7
Dnajc10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr9_+_57504012 1.596 ENSMUST00000080514.7
Rpp25
ribonuclease P/MRP 25 subunit
chr12_+_88953399 1.549 ENSMUST00000057634.7
Nrxn3
neurexin III
chrX_+_136741821 1.542 ENSMUST00000089350.4
BC065397
cDNA sequence BC065397
chr11_-_69948145 1.480 ENSMUST00000179298.1
ENSMUST00000018710.6
ENSMUST00000135437.1
ENSMUST00000141837.2
ENSMUST00000142500.1
Slc2a4




solute carrier family 2 (facilitated glucose transporter), member 4




chr4_-_43562397 1.425 ENSMUST00000030187.7
Tln1
talin 1
chr2_-_157204483 1.413 ENSMUST00000029170.7
Rbl1
retinoblastoma-like 1 (p107)
chr13_-_76098606 1.339 ENSMUST00000120573.1
Arsk
arylsulfatase K
chr17_-_47833169 1.314 ENSMUST00000131971.1
ENSMUST00000129360.1
ENSMUST00000113280.1
ENSMUST00000132125.1
Mdfi



MyoD family inhibitor



chr4_-_108406676 1.241 ENSMUST00000184609.1
Gpx7
glutathione peroxidase 7
chr6_+_29348069 1.219 ENSMUST00000173216.1
ENSMUST00000031779.10
ENSMUST00000090481.7
Calu


calumenin


chr8_-_46294592 1.211 ENSMUST00000058636.7
Helt
helt bHLH transcription factor
chr17_-_47833256 1.205 ENSMUST00000152455.1
ENSMUST00000035375.7
Mdfi

MyoD family inhibitor

chr7_-_45211877 1.197 ENSMUST00000033057.7
Dkkl1
dickkopf-like 1
chr5_+_64970069 1.133 ENSMUST00000031080.8
Fam114a1
family with sequence similarity 114, member A1
chr6_-_82774448 1.131 ENSMUST00000000642.4
Hk2
hexokinase 2
chr11_-_88718078 1.112 ENSMUST00000092794.5
Msi2
musashi RNA-binding protein 2
chr17_-_51831884 1.082 ENSMUST00000124222.1
Satb1
special AT-rich sequence binding protein 1
chr11_-_116274102 1.041 ENSMUST00000106425.3
Srp68
signal recognition particle 68
chr5_-_71095765 1.031 ENSMUST00000000572.5
Gabra2
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2
chr10_+_81136534 1.023 ENSMUST00000119606.1
ENSMUST00000146895.1
ENSMUST00000121840.1
Zbtb7a


zinc finger and BTB domain containing 7a


chr17_-_25785324 1.015 ENSMUST00000150324.1
Haghl
hydroxyacylglutathione hydrolase-like
chr2_+_150786735 1.008 ENSMUST00000045441.7
Pygb
brain glycogen phosphorylase
chr1_-_13589717 1.007 ENSMUST00000027068.4
Tram1
translocating chain-associating membrane protein 1
chr11_-_116274197 0.998 ENSMUST00000021133.9
Srp68
signal recognition particle 68
chr9_-_32541589 0.959 ENSMUST00000016231.7
Fli1
Friend leukemia integration 1
chr15_-_10470490 0.956 ENSMUST00000136591.1
Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr7_-_142578139 0.940 ENSMUST00000136359.1
H19
H19 fetal liver mRNA
chr10_+_81136223 0.918 ENSMUST00000048128.8
Zbtb7a
zinc finger and BTB domain containing 7a
chr7_-_142578093 0.895 ENSMUST00000149974.1
ENSMUST00000152754.1
H19

H19 fetal liver mRNA

chr9_+_57560934 0.868 ENSMUST00000045791.9
Scamp2
secretory carrier membrane protein 2
chr7_+_24904384 0.866 ENSMUST00000117419.1
Arhgef1
Rho guanine nucleotide exchange factor (GEF) 1
chr10_-_84533884 0.836 ENSMUST00000053871.3
Ckap4
cytoskeleton-associated protein 4
chr3_-_84582616 0.823 ENSMUST00000143514.1
Arfip1
ADP-ribosylation factor interacting protein 1
chr4_-_129640959 0.809 ENSMUST00000132217.1
ENSMUST00000130017.1
ENSMUST00000154105.1
Txlna


taxilin alpha


chr16_+_36875119 0.794 ENSMUST00000135406.1
ENSMUST00000114812.1
ENSMUST00000134616.1
ENSMUST00000023534.6
Golgb1


Golgb1
golgi autoantigen, golgin subfamily b, macrogolgin 1


golgi autoantigen, golgin subfamily b, macrogolgin 1
chr3_-_84582476 0.775 ENSMUST00000107687.2
ENSMUST00000098990.3
Arfip1

ADP-ribosylation factor interacting protein 1

chr12_+_59130767 0.769 ENSMUST00000175877.1
Ctage5
CTAGE family, member 5
chr8_+_125995102 0.767 ENSMUST00000046765.8
Kcnk1
potassium channel, subfamily K, member 1
chr2_-_79428891 0.766 ENSMUST00000143974.1
Cerkl
ceramide kinase-like
chr1_+_92831614 0.747 ENSMUST00000045970.6
Gpc1
glypican 1
chr2_+_164497518 0.739 ENSMUST00000103101.4
ENSMUST00000117066.1
Pigt

phosphatidylinositol glycan anchor biosynthesis, class T

chr10_-_84533968 0.716 ENSMUST00000167671.1
Ckap4
cytoskeleton-associated protein 4
chr9_-_89705017 0.697 ENSMUST00000058488.6
Tmed3
transmembrane emp24 domain containing 3
chr7_-_118491912 0.696 ENSMUST00000178344.1
Itpripl2
inositol 1,4,5-triphosphate receptor interacting protein-like 2
chr9_+_104063376 0.664 ENSMUST00000120854.1
Acad11
acyl-Coenzyme A dehydrogenase family, member 11
chr2_-_39065505 0.663 ENSMUST00000039165.8
Golga1
golgi autoantigen, golgin subfamily a, 1
chr6_+_83115495 0.659 ENSMUST00000032114.7
Mogs
mannosyl-oligosaccharide glucosidase
chr14_-_26638183 0.655 ENSMUST00000166902.1
4930570N19Rik
RIKEN cDNA 4930570N19 gene
chr7_+_82867327 0.634 ENSMUST00000082237.5
Mex3b
mex3 homolog B (C. elegans)
chr11_+_3514861 0.628 ENSMUST00000094469.4
Selm
selenoprotein M
chr15_-_57892358 0.627 ENSMUST00000022993.5
Derl1
Der1-like domain family, member 1
chr5_-_100038869 0.603 ENSMUST00000153442.1
Hnrnpdl
heterogeneous nuclear ribonucleoprotein D-like
chr11_-_72796028 0.592 ENSMUST00000156294.1
Cyb5d2
cytochrome b5 domain containing 2
chr12_+_33957645 0.585 ENSMUST00000049089.5
Twist1
twist basic helix-loop-helix transcription factor 1
chr4_-_134000857 0.583 ENSMUST00000105887.1
ENSMUST00000012262.5
ENSMUST00000144668.1
ENSMUST00000105889.3
Dhdds



dehydrodolichyl diphosphate synthase



chr5_+_30869579 0.572 ENSMUST00000046349.7
Tmem214
transmembrane protein 214
chr3_+_144570409 0.546 ENSMUST00000082437.3
Sep15
selenoprotein
chr11_-_72795801 0.535 ENSMUST00000079681.5
Cyb5d2
cytochrome b5 domain containing 2
chr19_-_5771376 0.530 ENSMUST00000025890.8
Scyl1
SCY1-like 1 (S. cerevisiae)
chr19_+_5088534 0.528 ENSMUST00000025811.4
Yif1a
Yip1 interacting factor homolog A (S. cerevisiae)
chr5_-_72559599 0.488 ENSMUST00000074948.4
ENSMUST00000087216.5
Nfxl1

nuclear transcription factor, X-box binding-like 1

chr2_-_91070180 0.488 ENSMUST00000153367.1
ENSMUST00000079976.3
Slc39a13

solute carrier family 39 (metal ion transporter), member 13

chr4_-_129640691 0.481 ENSMUST00000084264.5
Txlna
taxilin alpha
chr4_+_47474652 0.457 ENSMUST00000065678.5
ENSMUST00000137461.1
ENSMUST00000125622.1
Sec61b


Sec61 beta subunit


chr2_+_31572775 0.453 ENSMUST00000137889.1
Fubp3
far upstream element (FUSE) binding protein 3
chr4_-_129641060 0.449 ENSMUST00000046425.9
ENSMUST00000133803.1
Txlna

taxilin alpha

chr17_-_25861456 0.428 ENSMUST00000079461.8
ENSMUST00000176923.1
Wdr90

WD repeat domain 90

chr5_-_115158169 0.428 ENSMUST00000053271.5
ENSMUST00000112121.1
Mlec

malectin

chr3_+_144570687 0.420 ENSMUST00000106211.1
Sep15
selenoprotein
chr2_-_144011202 0.409 ENSMUST00000016072.5
ENSMUST00000037875.5
Rrbp1

ribosome binding protein 1

chr19_+_8898090 0.407 ENSMUST00000096246.3
Ganab
alpha glucosidase 2 alpha neutral subunit
chr9_-_21091974 0.403 ENSMUST00000115487.1
Raver1
ribonucleoprotein, PTB-binding 1
chr9_-_103202113 0.402 ENSMUST00000035157.8
Srprb
signal recognition particle receptor, B subunit
chr4_-_155653184 0.392 ENSMUST00000030937.1
Mmp23
matrix metallopeptidase 23
chr10_+_42761483 0.391 ENSMUST00000019937.4
Sec63
SEC63-like (S. cerevisiae)
chr5_+_30869623 0.379 ENSMUST00000114716.1
Tmem214
transmembrane protein 214
chr10_+_85102627 0.371 ENSMUST00000095383.4
AI597468
expressed sequence AI597468
chr18_-_52529692 0.369 ENSMUST00000025409.7
Lox
lysyl oxidase
chr16_-_35490873 0.368 ENSMUST00000023550.7
Pdia5
protein disulfide isomerase associated 5
chr2_-_91070283 0.367 ENSMUST00000111436.2
ENSMUST00000073575.5
Slc39a13

solute carrier family 39 (metal ion transporter), member 13

chr7_+_49910112 0.359 ENSMUST00000056442.5
Slc6a5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
chr19_+_6909692 0.356 ENSMUST00000088257.7
Trmt112
tRNA methyltransferase 11-2
chr16_-_36874806 0.350 ENSMUST00000075946.5
Eaf2
ELL associated factor 2
chr3_-_65392546 0.347 ENSMUST00000119896.1
Ssr3
signal sequence receptor, gamma
chr9_-_42472198 0.344 ENSMUST00000128959.1
ENSMUST00000066148.5
ENSMUST00000138506.1
Tbcel


tubulin folding cofactor E-like


chr4_-_11386757 0.333 ENSMUST00000108313.1
ENSMUST00000108311.2
Esrp1

epithelial splicing regulatory protein 1

chr19_+_6909722 0.330 ENSMUST00000116551.3
Trmt112
tRNA methyltransferase 11-2
chr9_+_44379490 0.328 ENSMUST00000066601.6
Hyou1
hypoxia up-regulated 1
chr12_+_13269111 0.326 ENSMUST00000042953.8
Nbas
neuroblastoma amplified sequence
chr9_+_44379536 0.325 ENSMUST00000161318.1
ENSMUST00000160902.1
Hyou1

hypoxia up-regulated 1

chr5_+_124541296 0.323 ENSMUST00000124529.1
Tmed2
transmembrane emp24 domain trafficking protein 2
chr17_+_29490812 0.321 ENSMUST00000024811.6
Pim1
proviral integration site 1
chr13_+_76098734 0.316 ENSMUST00000091466.3
Ttc37
tetratricopeptide repeat domain 37
chr5_-_35679416 0.308 ENSMUST00000114233.2
Htra3
HtrA serine peptidase 3
chr1_+_92910758 0.290 ENSMUST00000027487.8
Rnpepl1
arginyl aminopeptidase (aminopeptidase B)-like 1
chr4_+_153957230 0.285 ENSMUST00000058393.2
ENSMUST00000105645.2
A430005L14Rik

RIKEN cDNA A430005L14 gene

chr1_-_172082757 0.278 ENSMUST00000003550.4
Ncstn
nicastrin
chr11_-_100970887 0.275 ENSMUST00000060792.5
Ptrf
polymerase I and transcript release factor
chr18_-_52529847 0.263 ENSMUST00000171470.1
Lox
lysyl oxidase
chrX_+_56346390 0.261 ENSMUST00000101560.3
Zfp449
zinc finger protein 449
chr1_-_75479271 0.251 ENSMUST00000079205.7
ENSMUST00000094818.2
Chpf

chondroitin polymerizing factor

chr6_-_113740675 0.243 ENSMUST00000032440.4
Sec13
SEC13 homolog (S. cerevisiae)
chr1_+_36471590 0.225 ENSMUST00000153128.1
Cnnm4
cyclin M4
chr13_-_100833369 0.224 ENSMUST00000067246.4
Slc30a5
solute carrier family 30 (zinc transporter), member 5
chr3_-_107696462 0.214 ENSMUST00000029490.8
Ahcyl1
S-adenosylhomocysteine hydrolase-like 1
chr18_+_53176345 0.202 ENSMUST00000037850.5
Snx2
sorting nexin 2
chr19_+_46761578 0.201 ENSMUST00000077666.4
ENSMUST00000099373.4
Cnnm2

cyclin M2

chr8_+_71366848 0.181 ENSMUST00000110053.2
ENSMUST00000110054.1
ENSMUST00000139541.1
Use1


unconventional SNARE in the ER 1 homolog (S. cerevisiae)


chr13_-_37994111 0.151 ENSMUST00000021864.6
Ssr1
signal sequence receptor, alpha
chr1_+_93215899 0.151 ENSMUST00000138595.1
E030010N08Rik
RIKEN cDNA E030010N08 gene
chr3_-_65392579 0.150 ENSMUST00000029414.5
Ssr3
signal sequence receptor, gamma
chr9_-_73039644 0.148 ENSMUST00000184389.1
Pigb
phosphatidylinositol glycan anchor biosynthesis, class B
chr4_+_153957247 0.148 ENSMUST00000141493.1
A430005L14Rik
RIKEN cDNA A430005L14 gene
chr14_-_62761112 0.140 ENSMUST00000053959.6
Ints6
integrator complex subunit 6
chr6_+_31574967 0.136 ENSMUST00000150540.1
Gm6117
predicted gene 6117
chr15_+_76701455 0.135 ENSMUST00000019224.7
Mfsd3
major facilitator superfamily domain containing 3
chr7_-_144939823 0.133 ENSMUST00000093962.4
Ccnd1
cyclin D1
chr5_+_124540695 0.129 ENSMUST00000060226.4
Tmed2
transmembrane emp24 domain trafficking protein 2
chr2_+_155133501 0.123 ENSMUST00000029126.8
ENSMUST00000109685.1
Itch

itchy, E3 ubiquitin protein ligase

chr17_-_34031684 0.118 ENSMUST00000169397.1
Slc39a7
solute carrier family 39 (zinc transporter), member 7
chr6_-_88518760 0.115 ENSMUST00000032168.5
Sec61a1
Sec61 alpha 1 subunit (S. cerevisiae)
chr5_+_143403819 0.103 ENSMUST00000110731.2
Kdelr2
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chr11_+_54100924 0.098 ENSMUST00000093107.5
ENSMUST00000019050.5
ENSMUST00000174616.1
ENSMUST00000129499.1
ENSMUST00000126840.1
P4ha2




procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide




chr7_+_127912510 0.096 ENSMUST00000033070.7
Kat8
K(lysine) acetyltransferase 8
chr17_+_34032071 0.092 ENSMUST00000174299.1
ENSMUST00000173554.1
Rxrb

retinoid X receptor beta

chr14_-_75754475 0.091 ENSMUST00000049168.7
Cog3
component of oligomeric golgi complex 3
chr8_+_70302761 0.089 ENSMUST00000150968.1
Cope
coatomer protein complex, subunit epsilon
chr7_-_128461168 0.087 ENSMUST00000106228.1
Tial1
Tia1 cytotoxic granule-associated RNA binding protein-like 1
chr7_-_29232478 0.086 ENSMUST00000085818.4
Kcnk6
potassium inwardly-rectifying channel, subfamily K, member 6
chr13_+_72628831 0.080 ENSMUST00000169028.1
Irx2
Iroquois related homeobox 2 (Drosophila)
chr1_-_183369529 0.060 ENSMUST00000069922.5
Mia3
melanoma inhibitory activity 3
chr7_-_126799134 0.058 ENSMUST00000087566.4
Aldoa
aldolase A, fructose-bisphosphate
chr17_-_34031644 0.056 ENSMUST00000171872.1
Slc39a7
solute carrier family 39 (zinc transporter), member 7
chr4_+_44756553 0.053 ENSMUST00000107824.2
Zcchc7
zinc finger, CCHC domain containing 7
chr3_+_58525821 0.050 ENSMUST00000029387.8
Eif2a
eukaryotic translation initiation factor 2A
chr8_+_71367210 0.050 ENSMUST00000019169.7
Use1
unconventional SNARE in the ER 1 homolog (S. cerevisiae)
chr7_-_127393604 0.049 ENSMUST00000165495.1
ENSMUST00000106303.2
ENSMUST00000074249.6
E430018J23Rik


RIKEN cDNA E430018J23 gene


chr4_+_44756609 0.048 ENSMUST00000143385.1
Zcchc7
zinc finger, CCHC domain containing 7
chr7_-_44869788 0.035 ENSMUST00000046575.9
Ptov1
prostate tumor over expressed gene 1
chr11_+_82781108 0.034 ENSMUST00000092849.5
ENSMUST00000021039.5
ENSMUST00000080461.5
ENSMUST00000173347.1
ENSMUST00000173727.1
ENSMUST00000173009.1
ENSMUST00000131537.2
ENSMUST00000173722.1
Lig3







ligase III, DNA, ATP-dependent







chr10_+_61680302 0.033 ENSMUST00000020285.8
Sar1a
SAR1 gene homolog A (S. cerevisiae)
chr7_-_121035096 0.031 ENSMUST00000065740.2
Gm9905
predicted gene 9905
chr17_-_56183887 0.023 ENSMUST00000019723.7
D17Wsu104e
DNA segment, Chr 17, Wayne State University 104, expressed
chr12_-_112671564 0.018 ENSMUST00000128300.2
Akt1
thymoma viral proto-oncogene 1
chr7_+_28741968 0.016 ENSMUST00000094632.4
Sars2
seryl-aminoacyl-tRNA synthetase 2
chr19_+_8741473 0.005 ENSMUST00000177373.1
ENSMUST00000010254.9
Stx5a

syntaxin 5A

chr13_-_55321928 0.004 ENSMUST00000035242.7
Rab24
RAB24, member RAS oncogene family

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.1 GO:1990523 bone regeneration(GO:1990523)
1.2 8.6 GO:0006621 protein retention in ER lumen(GO:0006621)
0.5 1.9 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.4 2.2 GO:2000680 regulation of rubidium ion transport(GO:2000680)
0.4 2.7 GO:0032596 protein transport into membrane raft(GO:0032596) dsRNA transport(GO:0033227)
0.3 0.6 GO:2000275 regulation of oxidative phosphorylation uncoupler activity(GO:2000275)
0.3 4.9 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.3 0.8 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.3 3.3 GO:0048664 neuron fate determination(GO:0048664)
0.2 0.7 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.2 0.7 GO:0070476 rRNA (guanine-N7)-methylation(GO:0070476)
0.2 1.1 GO:1901526 negative regulation of mitochondrial membrane permeability(GO:0035795) positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.2 0.7 GO:1903298 regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298)
0.2 1.6 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.2 1.4 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.2 1.8 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.1 1.8 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 0.9 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.1 2.5 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.1 1.6 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.1 0.7 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.1 0.4 GO:0036233 glycine import(GO:0036233)
0.1 1.9 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.1 1.0 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 0.6 GO:0072697 protein localization to cell cortex(GO:0072697)
0.1 1.2 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.1 1.5 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.1 0.6 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.3 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.1 1.1 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 1.3 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.1 2.5 GO:0046677 response to antibiotic(GO:0046677)
0.1 1.0 GO:0005980 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.1 1.5 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
0.1 4.6 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.1 0.2 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.0 0.9 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 2.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.3 GO:0070561 vitamin D receptor signaling pathway(GO:0070561)
0.0 1.5 GO:0043277 apoptotic cell clearance(GO:0043277)
0.0 0.4 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 1.0 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.1 GO:0035519 protein K29-linked ubiquitination(GO:0035519)
0.0 0.4 GO:0016093 polyprenol metabolic process(GO:0016093)
0.0 0.5 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 0.2 GO:0070166 enamel mineralization(GO:0070166)
0.0 0.7 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 1.0 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.2 GO:0042045 epithelial fluid transport(GO:0042045)
0.0 2.0 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.0 GO:0090298 negative regulation of mitochondrial DNA replication(GO:0090298)
0.0 1.9 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 0.2 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.0 0.3 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.3 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.0 0.1 GO:0072272 proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
0.0 0.3 GO:0007220 Notch receptor processing(GO:0007220)
0.0 0.4 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.1 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.0 0.7 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 0.2 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.0 0.1 GO:0097502 mannosylation(GO:0097502)
0.0 0.1 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.3 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.0 0.2 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.2 GO:0072673 lamellipodium morphogenesis(GO:0072673)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.2 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.3 1.6 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.3 5.8 GO:0031527 filopodium membrane(GO:0031527)
0.2 0.8 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.2 2.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.2 1.8 GO:0048500 signal recognition particle(GO:0048500)
0.2 0.5 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.1 2.5 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.1 0.7 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.1 0.3 GO:0070939 Dsl1p complex(GO:0070939)
0.1 0.3 GO:0055087 Ski complex(GO:0055087)
0.1 0.4 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.1 1.5 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 2.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 1.0 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 0.2 GO:0030905 retromer, tubulation complex(GO:0030905)
0.1 1.4 GO:0005801 cis-Golgi network(GO:0005801)
0.1 2.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.1 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 0.5 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.3 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 2.7 GO:0005844 polysome(GO:0005844)
0.0 2.0 GO:0031594 neuromuscular junction(GO:0031594)
0.0 46.3 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 1.5 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 1.9 GO:0030018 Z disc(GO:0030018)
0.0 1.1 GO:0005720 nuclear heterochromatin(GO:0005720)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 8.6 GO:0046923 ER retention sequence binding(GO:0046923)
0.6 2.5 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.4 2.0 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.4 1.5 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.3 1.2 GO:0004096 catalase activity(GO:0004096)
0.3 6.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.3 0.8 GO:0001729 ceramide kinase activity(GO:0001729)
0.3 1.0 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.2 0.7 GO:0070052 collagen V binding(GO:0070052)
0.2 4.6 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 1.1 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.2 0.7 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.2 1.9 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 1.0 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.2 4.9 GO:0019789 SUMO transferase activity(GO:0019789)
0.2 1.4 GO:0030274 LIM domain binding(GO:0030274)
0.2 0.6 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 1.6 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 0.7 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.1 0.5 GO:0048408 epidermal growth factor binding(GO:0048408)
0.1 1.0 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 1.6 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.1 3.3 GO:0071837 HMG box domain binding(GO:0071837)
0.1 1.3 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.1 1.1 GO:0015926 glucosidase activity(GO:0015926)
0.1 1.6 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 0.3 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.1 0.9 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.6 GO:0034046 poly(G) binding(GO:0034046)
0.1 1.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 36.1 GO:0005509 calcium ion binding(GO:0005509)
0.1 1.9 GO:0070412 R-SMAD binding(GO:0070412)
0.1 1.9 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 0.2 GO:1990460 leptin receptor binding(GO:1990460)
0.0 1.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.6 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 0.4 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 1.1 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.1 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0 0.3 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.2 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.0 0.7 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.3 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.1 GO:0005047 signal recognition particle binding(GO:0005047)
0.0 0.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.6 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 1.1 GO:0020037 heme binding(GO:0020037)
0.0 1.4 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.9 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.1 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 2.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.9 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.2 6.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.5 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 1.4 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.3 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.6 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.7 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 1.5 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.3 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 3.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.2 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.9 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 1.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.7 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 17.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 1.3 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 1.5 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 0.9 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 1.5 REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.1 6.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.0 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 1.4 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 0.7 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 1.7 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.4 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.1 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 0.5 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 1.1 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.3 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.7 REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.3 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.3 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 1.4 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.8 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 0.3 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.3 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination