Motif ID: Xbp1_Creb3l1

Z-value: 0.808

Transcription factors associated with Xbp1_Creb3l1:

Gene SymbolEntrez IDGene Name
Creb3l1 ENSMUSG00000027230.9 Creb3l1
Xbp1 ENSMUSG00000020484.12 Xbp1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Xbp1mm10_v2_chr11_+_5520652_5520659-0.524.5e-05Click!
Creb3l1mm10_v2_chr2_-_92024502_920245290.123.8e-01Click!


Activity profile for motif Xbp1_Creb3l1.

activity profile for motif Xbp1_Creb3l1


Sorted Z-values histogram for motif Xbp1_Creb3l1

Sorted Z-values for motif Xbp1_Creb3l1



Network of associatons between targets according to the STRING database.



First level regulatory network of Xbp1_Creb3l1

PNG image of the network

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Top targets:


Showing 1 to 20 of 174 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_45092130 14.421 ENSMUST00000148175.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr7_-_45092198 11.970 ENSMUST00000140449.1
ENSMUST00000117546.1
ENSMUST00000019683.3
 Rcn3


reticulocalbin 3, EF-hand calcium binding domain


chr15_+_79516396 8.483 ENSMUST00000010974.7
 Kdelr3
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr7_-_45091713 8.190 ENSMUST00000141576.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr5_-_135251209 6.053 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr2_-_105399286 5.414 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr6_-_54593139 5.098 ENSMUST00000046520.6
 Fkbp14
FK506 binding protein 14
chr15_-_32244632 4.464 ENSMUST00000181536.1
 0610007N19Rik
RIKEN cDNA 0610007N19
chr1_-_163313661 3.344 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
 Prrx1


paired related homeobox 1


chr3_+_93520473 3.110 ENSMUST00000029515.4
 S100a11
S100 calcium binding protein A11 (calgizzarin)
chr1_-_55226768 2.745 ENSMUST00000027121.8
ENSMUST00000114428.2
 Rftn2

raftlin family member 2

chr10_+_41519493 2.483 ENSMUST00000019962.8
 Cd164
CD164 antigen
chr3_+_96697100 2.473 ENSMUST00000107077.3
 Pias3
protein inhibitor of activated STAT 3
chr4_-_137796350 2.470 ENSMUST00000030551.4
 Alpl
alkaline phosphatase, liver/bone/kidney
chr3_+_96697076 2.439 ENSMUST00000162778.2
ENSMUST00000064900.9
 Pias3

protein inhibitor of activated STAT 3

chr10_+_128908907 2.174 ENSMUST00000105229.1
 Cd63
CD63 antigen
chr3_+_88206786 2.030 ENSMUST00000181134.1
ENSMUST00000181550.1
 Gm3764

predicted gene 3764

chr6_-_101377342 2.029 ENSMUST00000151175.1
 Pdzrn3
PDZ domain containing RING finger 3
chr13_-_38528412 1.952 ENSMUST00000035988.8
 Txndc5
thioredoxin domain containing 5
chr7_+_128523576 1.888 ENSMUST00000033136.7
 Bag3
BCL2-associated athanogene 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 8.6 GO:0006621 protein retention in ER lumen(GO:0006621)
2.0 6.1 GO:1990523 bone regeneration(GO:1990523)
0.3 4.9 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.1 4.6 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.3 3.3 GO:0048664 neuron fate determination(GO:0048664)
0.4 2.7 GO:0032596 protein transport into membrane raft(GO:0032596) dsRNA transport(GO:0033227)
0.1 2.5 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.1 2.5 GO:0046677 response to antibiotic(GO:0046677)
0.0 2.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.4 2.2 GO:2000680 regulation of rubidium ion transport(GO:2000680)
0.0 2.0 GO:0007528 neuromuscular junction development(GO:0007528)
0.5 1.9 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.1 1.9 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.0 1.9 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.2 1.8 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.1 1.8 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.2 1.6 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 1.6 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.1 1.5 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.1 1.5 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 46.3 GO:0005783 endoplasmic reticulum(GO:0005783)
0.3 5.8 GO:0031527 filopodium membrane(GO:0031527)
0.0 2.7 GO:0005844 polysome(GO:0005844)
0.1 2.5 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.1 2.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.2 2.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.5 2.2 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.1 2.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 2.0 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.9 GO:0030018 Z disc(GO:0030018)
0.2 1.8 GO:0048500 signal recognition particle(GO:0048500)
0.3 1.6 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 1.5 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 1.5 GO:0042734 presynaptic membrane(GO:0042734)
0.1 1.4 GO:0005801 cis-Golgi network(GO:0005801)
0.0 1.1 GO:0005720 nuclear heterochromatin(GO:0005720)
0.1 1.0 GO:1902711 GABA-A receptor complex(GO:1902711)
0.2 0.8 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.1 0.7 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.2 0.5 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 36.1 GO:0005509 calcium ion binding(GO:0005509)
2.1 8.6 GO:0046923 ER retention sequence binding(GO:0046923)
0.3 6.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 4.9 GO:0019789 SUMO transferase activity(GO:0019789)
0.2 4.6 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 3.3 GO:0071837 HMG box domain binding(GO:0071837)
0.0 2.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.6 2.5 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.4 2.0 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.2 1.9 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 1.9 GO:0070412 R-SMAD binding(GO:0070412)
0.1 1.9 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 1.6 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 1.6 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.1 1.6 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.4 1.5 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.2 1.4 GO:0030274 LIM domain binding(GO:0030274)
0.0 1.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.4 GO:0019905 syntaxin binding(GO:0019905)
0.1 1.3 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.4 4.9 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.0 3.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.5 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 1.5 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.4 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 1.2 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.9 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.7 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.7 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.6 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.3 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.3 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 17.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 6.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.8 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 1.7 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 1.5 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 1.5 REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.1 1.4 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 1.4 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 1.3 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 1.1 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 1.1 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 1.0 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 0.9 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.7 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.7 REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.5 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.4 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.3 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.3 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)