Motif ID: Ybx1_Nfya_Nfyb_Nfyc_Cebpz

Z-value: 8.140

Transcription factors associated with Ybx1_Nfya_Nfyb_Nfyc_Cebpz:

Gene SymbolEntrez IDGene Name
Cebpz ENSMUSG00000024081.8 Cebpz
Nfya ENSMUSG00000023994.7 Nfya
Nfyb ENSMUSG00000020248.12 Nfyb
Nfyc ENSMUSG00000032897.11 Nfyc
Ybx1 ENSMUSG00000028639.8 Ybx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfybmm10_v2_chr10_-_82764088_82764144-0.402.4e-03Click!
Nfycmm10_v2_chr4_-_120815703_1208157610.341.2e-02Click!
Cebpzmm10_v2_chr17_-_78937031_78937074-0.274.6e-02Click!
Nfyamm10_v2_chr17_-_48409729_48409906-0.191.6e-01Click!
Ybx1mm10_v2_chr4_-_119294520_1192946040.191.8e-01Click!


Activity profile for motif Ybx1_Nfya_Nfyb_Nfyc_Cebpz.

activity profile for motif Ybx1_Nfya_Nfyb_Nfyc_Cebpz


Sorted Z-values histogram for motif Ybx1_Nfya_Nfyb_Nfyc_Cebpz

Sorted Z-values for motif Ybx1_Nfya_Nfyb_Nfyc_Cebpz



Network of associatons between targets according to the STRING database.



First level regulatory network of Ybx1_Nfya_Nfyb_Nfyc_Cebpz

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_99024179 138.714 ENSMUST00000068031.7
 Top2a
topoisomerase (DNA) II alpha
chr6_+_124829582 137.367 ENSMUST00000024270.7
 Cdca3
cell division cycle associated 3
chr8_+_83955507 120.244 ENSMUST00000005607.8
 Asf1b
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
chr8_+_57511833 111.707 ENSMUST00000067925.6
 Hmgb2
high mobility group box 2
chr3_-_27153861 106.167 ENSMUST00000108300.1
ENSMUST00000108298.2
 Ect2

ect2 oncogene

chr3_-_27153844 103.470 ENSMUST00000176242.2
ENSMUST00000176780.1
 Ect2

ect2 oncogene

chr14_+_46760526 103.444 ENSMUST00000067426.4
 Cdkn3
cyclin-dependent kinase inhibitor 3
chr1_+_139454747 100.787 ENSMUST00000053364.8
ENSMUST00000097554.3
 Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr11_-_87108656 100.161 ENSMUST00000051395.8
 Prr11
proline rich 11
chr3_-_27153782 96.700 ENSMUST00000175857.1
ENSMUST00000177055.1
ENSMUST00000176535.1
 Ect2


ect2 oncogene


chr14_-_67715585 96.468 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
 Cdca2


cell division cycle associated 2


chr6_+_124829540 93.325 ENSMUST00000150120.1
 Cdca3
cell division cycle associated 3
chr6_+_124830217 90.158 ENSMUST00000131847.1
ENSMUST00000151674.1
 Cdca3

cell division cycle associated 3

chr15_+_99074968 83.619 ENSMUST00000039665.6
 Troap
trophinin associated protein
chr2_+_164769892 78.718 ENSMUST00000088248.6
ENSMUST00000001439.6
 Ube2c

ubiquitin-conjugating enzyme E2C

chr7_-_48881596 71.924 ENSMUST00000119223.1
 E2f8
E2F transcription factor 8
chr9_-_70421533 70.649 ENSMUST00000034742.6
 Ccnb2
cyclin B2
chr13_+_51645232 70.321 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2
chr16_+_14163275 67.353 ENSMUST00000023359.6
ENSMUST00000117958.1
 Nde1

nuclear distribution gene E homolog 1 (A nidulans)

chr10_-_69352886 66.885 ENSMUST00000119827.1
ENSMUST00000020099.5
 Cdk1

cyclin-dependent kinase 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 614 entries
Log-likelihood per target Total log-likelihoodTermDescription
23.8 429.2 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
9.9 306.1 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
2.9 245.2 GO:0006342 chromatin silencing(GO:0006342)
15.3 199.1 GO:0071459 protein localization to chromosome, centromeric region(GO:0071459)
6.0 198.5 GO:0051310 metaphase plate congression(GO:0051310)
11.7 186.8 GO:0007100 mitotic centrosome separation(GO:0007100)
1.3 184.8 GO:0007059 chromosome segregation(GO:0007059)
27.4 164.7 GO:0009786 regulation of asymmetric cell division(GO:0009786)
11.2 156.5 GO:0022027 interkinetic nuclear migration(GO:0022027)
1.4 154.9 GO:0007050 cell cycle arrest(GO:0007050)
5.9 147.7 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
34.7 138.7 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
22.7 136.5 GO:0072049 comma-shaped body morphogenesis(GO:0072049)
3.0 135.7 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
18.9 132.1 GO:0016321 female meiosis chromosome segregation(GO:0016321)
0.4 128.4 GO:0051301 cell division(GO:0051301)
4.9 126.9 GO:0006270 DNA replication initiation(GO:0006270)
41.7 125.0 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
41.6 124.9 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
2.4 124.5 GO:0008156 negative regulation of DNA replication(GO:0008156)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 241 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 633.5 GO:0005634 nucleus(GO:0005634)
5.8 407.5 GO:0000786 nucleosome(GO:0000786)
1.2 365.5 GO:0000790 nuclear chromatin(GO:0000790)
67.8 339.0 GO:0097149 centralspindlin complex(GO:0097149)
3.1 304.4 GO:0000793 condensed chromosome(GO:0000793)
2.8 280.0 GO:0000776 kinetochore(GO:0000776)
0.8 242.0 GO:0005667 transcription factor complex(GO:0005667)
12.7 216.6 GO:0031616 spindle pole centrosome(GO:0031616)
5.0 201.2 GO:0005876 spindle microtubule(GO:0005876)
1.8 190.2 GO:0005913 cell-cell adherens junction(GO:0005913)
3.7 188.2 GO:0005657 replication fork(GO:0005657)
37.2 186.2 GO:0032133 chromosome passenger complex(GO:0032133)
22.4 157.1 GO:0005818 aster(GO:0005818)
0.6 154.3 GO:0016607 nuclear speck(GO:0016607)
3.1 151.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
1.6 148.3 GO:0005814 centriole(GO:0005814)
5.9 147.0 GO:0005680 anaphase-promoting complex(GO:0005680)
2.8 143.7 GO:0005871 kinesin complex(GO:0005871)
33.0 132.1 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.5 118.3 GO:0005694 chromosome(GO:0005694)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 366 entries
Log-likelihood per target Total log-likelihoodTermDescription
8.1 398.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
1.7 304.0 GO:0001047 core promoter binding(GO:0001047)
2.4 283.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
4.0 281.3 GO:0003777 microtubule motor activity(GO:0003777)
0.7 228.2 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
1.1 226.5 GO:0008017 microtubule binding(GO:0008017)
1.2 208.1 GO:0042393 histone binding(GO:0042393)
0.2 168.6 GO:0003677 DNA binding(GO:0003677)
41.1 164.2 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
2.6 153.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
2.0 142.3 GO:0070491 repressing transcription factor binding(GO:0070491)
35.5 142.0 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
25.9 129.5 GO:0035174 histone serine kinase activity(GO:0035174)
2.6 121.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
19.5 117.1 GO:0010997 anaphase-promoting complex binding(GO:0010997)
18.7 112.1 GO:0050786 RAGE receptor binding(GO:0050786)
25.8 103.3 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.4 98.0 GO:0003682 chromatin binding(GO:0003682)
5.9 94.1 GO:0000400 four-way junction DNA binding(GO:0000400)
2.1 93.8 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
16.3 1030.0 PID_PLK1_PATHWAY PLK1 signaling events
10.2 376.1 PID_FOXM1_PATHWAY FOXM1 transcription factor network
4.1 193.6 PID_FANCONI_PATHWAY Fanconi anemia pathway
2.9 167.4 PID_IL12_2PATHWAY IL12-mediated signaling events
5.1 167.2 PID_AURORA_A_PATHWAY Aurora A signaling
11.0 153.7 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
3.9 145.4 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
2.3 145.3 PID_TELOMERASE_PATHWAY Regulation of Telomerase
3.8 127.0 PID_AURORA_B_PATHWAY Aurora B signaling
2.1 105.4 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
1.7 98.8 PID_E2F_PATHWAY E2F transcription factor network
3.5 95.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
2.9 84.6 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.9 74.9 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.9 60.8 PID_CMYB_PATHWAY C-MYB transcription factor network
2.7 50.9 PID_MYC_PATHWAY C-MYC pathway
0.7 47.3 PID_CDC42_PATHWAY CDC42 signaling events
0.9 39.1 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.8 39.0 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
1.1 38.2 PID_RAS_PATHWAY Regulation of Ras family activation

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 122 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.1 505.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
7.8 407.6 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
18.4 312.5 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
3.3 271.3 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
8.9 239.9 REACTOME_KINESINS Genes involved in Kinesins
8.0 231.1 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
13.8 220.6 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
7.9 198.7 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
9.0 198.6 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
9.5 151.7 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
6.7 94.0 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
1.3 88.7 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
1.6 84.9 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
1.1 83.7 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
2.9 75.9 REACTOME_G1_PHASE Genes involved in G1 Phase
1.4 73.0 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
3.2 67.2 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
7.1 63.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
2.1 61.2 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
1.4 58.7 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes