Motif ID: Yy1_Yy2

Z-value: 3.088

Transcription factors associated with Yy1_Yy2:

Gene SymbolEntrez IDGene Name
Yy1 ENSMUSG00000021264.11 Yy1
Yy2 ENSMUSG00000091736.2 Yy2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Yy2mm10_v2_chrX_-_157598642_157598655-0.463.9e-04Click!
Yy1mm10_v2_chr12_+_108792946_1087929880.162.5e-01Click!


Activity profile for motif Yy1_Yy2.

activity profile for motif Yy1_Yy2


Sorted Z-values histogram for motif Yy1_Yy2

Sorted Z-values for motif Yy1_Yy2



Network of associatons between targets according to the STRING database.



First level regulatory network of Yy1_Yy2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_22163299 20.731 ENSMUST00000100052.4
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr16_+_30065333 19.899 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr19_+_25610533 18.413 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr10_-_42583628 15.008 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr11_+_94741782 14.076 ENSMUST00000021240.6
 Cdc34-ps
cell division cycle 34 homolog, pseudogene (S. cerevisiae)
chr17_-_23829095 13.745 ENSMUST00000069579.5
 Tceb2
transcription elongation factor B (SIII), polypeptide 2
chr11_+_117849286 12.966 ENSMUST00000093906.4
 Birc5
baculoviral IAP repeat-containing 5
chr19_-_50030735 12.735 ENSMUST00000071866.1
 Rpl13a-ps1
ribosomal protein 13A, pseudogene 1
chr3_-_90213577 12.429 ENSMUST00000170122.2
 Rps27
ribosomal protein S27
chr19_-_59170978 11.940 ENSMUST00000172821.2
 Vax1
ventral anterior homeobox containing gene 1
chr13_+_21811737 10.895 ENSMUST00000104941.2
 Hist1h4m
histone cluster 1, H4m
chr14_-_20181773 10.685 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr8_-_107263248 10.520 ENSMUST00000080443.6
 Rps18-ps3
ribosomal protein S18, pseudogene 3
chr1_-_186117251 10.498 ENSMUST00000045388.7
 Lyplal1
lysophospholipase-like 1
chr7_-_78783026 10.258 ENSMUST00000032841.5
 Mrpl46
mitochondrial ribosomal protein L46
chr14_-_54617993 10.118 ENSMUST00000022803.4
 Psmb5
proteasome (prosome, macropain) subunit, beta type 5
chr4_+_154960915 10.109 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr18_-_13972617 10.108 ENSMUST00000025288.7
 Zfp521
zinc finger protein 521
chr9_-_97018823 10.107 ENSMUST00000055433.4
 Spsb4
splA/ryanodine receptor domain and SOCS box containing 4
chr13_-_23551648 9.922 ENSMUST00000102971.1
 Hist1h4f
histone cluster 1, H4f

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 892 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.5 108.8 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.2 61.6 GO:0002181 cytoplasmic translation(GO:0002181)
0.9 50.5 GO:0032543 mitochondrial translation(GO:0032543)
2.1 48.5 GO:0000028 ribosomal small subunit assembly(GO:0000028)
1.1 48.4 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
4.9 34.6 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.4 30.1 GO:0006413 translational initiation(GO:0006413)
7.5 30.0 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
1.6 29.3 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
1.7 27.6 GO:0043248 proteasome assembly(GO:0043248)
0.2 21.9 GO:0051028 mRNA transport(GO:0051028)
0.9 21.8 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.6 21.1 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
2.1 20.8 GO:0036123 histone H3-K9 dimethylation(GO:0036123)
1.9 20.6 GO:0032825 positive regulation of natural killer cell differentiation(GO:0032825)
0.6 20.4 GO:0006270 DNA replication initiation(GO:0006270)
1.8 19.4 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
1.5 18.4 GO:0002227 innate immune response in mucosa(GO:0002227)
0.7 17.7 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.8 17.6 GO:0032467 positive regulation of cytokinesis(GO:0032467)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 366 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 142.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
2.9 96.1 GO:0000788 nuclear nucleosome(GO:0000788)
1.8 93.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
1.4 86.8 GO:0015934 large ribosomal subunit(GO:0015934)
0.2 68.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
1.4 66.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 49.0 GO:0005730 nucleolus(GO:0005730)
1.3 48.6 GO:0000786 nucleosome(GO:0000786)
1.3 40.3 GO:0015935 small ribosomal subunit(GO:0015935)
0.0 36.1 GO:0005615 extracellular space(GO:0005615)
1.5 35.6 GO:0005839 proteasome core complex(GO:0005839)
6.4 32.0 GO:0032133 chromosome passenger complex(GO:0032133)
0.4 31.2 GO:0016363 nuclear matrix(GO:0016363)
0.3 24.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
1.6 22.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 22.0 GO:0000790 nuclear chromatin(GO:0000790)
0.5 21.4 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
1.9 21.0 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.3 19.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.8 19.5 GO:0005680 anaphase-promoting complex(GO:0005680)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 535 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 321.8 GO:0003735 structural constituent of ribosome(GO:0003735)
1.6 79.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 55.7 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
0.6 36.8 GO:0003743 translation initiation factor activity(GO:0003743)
1.5 33.8 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 33.1 GO:0003723 RNA binding(GO:0003723)
1.2 32.3 GO:0008432 JUN kinase binding(GO:0008432)
1.1 31.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.3 26.6 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.6 26.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.6 23.7 GO:0008536 Ran GTPase binding(GO:0008536)
2.5 22.5 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.9 21.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.3 20.9 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.6 20.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.9 20.0 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
1.2 19.6 GO:0003680 AT DNA binding(GO:0003680)
0.1 19.3 GO:0046982 protein heterodimerization activity(GO:0046982)
1.3 18.5 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.3 18.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 72.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.9 46.7 PID_PLK1_PATHWAY PLK1 signaling events
1.0 45.3 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.5 43.4 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.5 36.8 PID_E2F_PATHWAY E2F transcription factor network
1.2 34.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.9 33.1 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.6 23.3 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.6 21.2 PID_ATR_PATHWAY ATR signaling pathway
0.7 19.9 PID_AURORA_A_PATHWAY Aurora A signaling
0.5 18.0 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.5 17.2 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 17.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 16.7 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.4 15.7 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.4 15.5 NABA_COLLAGENS Genes encoding collagen proteins
1.1 14.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.9 14.7 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.3 13.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.4 13.6 PID_ILK_PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 169 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 245.6 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
2.7 141.8 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
1.4 97.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
1.6 88.1 REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.8 68.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.5 39.0 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.8 35.4 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
1.0 33.0 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
1.8 32.5 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.4 30.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.4 29.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
1.3 27.3 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
1.0 26.1 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.6 25.2 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
1.0 24.7 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.8 22.7 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.7 20.8 REACTOME_G1_PHASE Genes involved in G1 Phase
0.4 20.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.5 19.4 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.5 19.0 REACTOME_SIGNALING_BY_NOTCH1 Genes involved in Signaling by NOTCH1