Motif ID: Zbtb12

Z-value: 0.590


Transcription factors associated with Zbtb12:

Gene SymbolEntrez IDGene Name
Zbtb12 ENSMUSG00000049823.8 Zbtb12

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb12mm10_v2_chr17_+_34894515_34894573-0.302.4e-02Click!


Activity profile for motif Zbtb12.

activity profile for motif Zbtb12


Sorted Z-values histogram for motif Zbtb12

Sorted Z-values for motif Zbtb12



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb12

PNG image of the network

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Top targets:


Showing 1 to 20 of 57 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_12027958 9.026 ENSMUST00000109654.1
 Grb10
growth factor receptor bound protein 10
chr3_+_88081997 5.638 ENSMUST00000071812.5
 Iqgap3
IQ motif containing GTPase activating protein 3
chr17_-_15375969 4.640 ENSMUST00000014917.7
 Dll1
delta-like 1 (Drosophila)
chr19_+_59260878 4.243 ENSMUST00000026084.3
 Slc18a2
solute carrier family 18 (vesicular monoamine), member 2
chr6_-_124814288 4.103 ENSMUST00000172132.2
 Tpi1
triosephosphate isomerase 1
chr14_-_103844173 3.993 ENSMUST00000022718.3
 Ednrb
endothelin receptor type B
chr13_+_104229366 3.831 ENSMUST00000022227.6
 Cenpk
centromere protein K
chr11_-_88718078 3.043 ENSMUST00000092794.5
 Msi2
musashi RNA-binding protein 2
chr3_-_84155762 2.522 ENSMUST00000047368.6
 Mnd1
meiotic nuclear divisions 1 homolog (S. cerevisiae)
chr4_-_151057933 2.501 ENSMUST00000030797.3
 Vamp3
vesicle-associated membrane protein 3
chr18_-_70472429 2.475 ENSMUST00000067556.3
 4930503L19Rik
RIKEN cDNA 4930503L19 gene
chr8_-_45382198 1.948 ENSMUST00000093526.6
 Fam149a
family with sequence similarity 149, member A
chr11_+_54902917 1.928 ENSMUST00000149324.1
 Gpx3
glutathione peroxidase 3
chr7_-_25477607 1.910 ENSMUST00000098669.1
ENSMUST00000098668.1
ENSMUST00000098666.2
 Ceacam1


carcinoembryonic antigen-related cell adhesion molecule 1


chr14_+_79481164 1.867 ENSMUST00000040131.5
 Elf1
E74-like factor 1
chr11_+_54902743 1.862 ENSMUST00000082430.3
 Gpx3
glutathione peroxidase 3
chr3_+_5218546 1.790 ENSMUST00000026284.6
 Zfhx4
zinc finger homeodomain 4
chr6_+_29398920 1.654 ENSMUST00000181464.1
ENSMUST00000180829.1
 Ccdc136

coiled-coil domain containing 136

chr3_+_5218516 1.451 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr4_-_119173849 1.338 ENSMUST00000052715.4
ENSMUST00000179290.1
ENSMUST00000154226.1
 Zfp691


zinc finger protein 691



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 9.0 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.6 5.6 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
1.5 4.6 GO:0001757 somite specification(GO:0001757) arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel endothelial cell fate specification(GO:0097101)
0.7 4.2 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
1.4 4.1 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
1.3 4.0 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.2 3.8 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 2.8 GO:0048864 stem cell development(GO:0048864)
0.1 2.5 GO:0035493 SNARE complex assembly(GO:0035493)
0.1 2.5 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.7 2.2 GO:1900275 negative regulation of phospholipase C activity(GO:1900275)
0.6 1.9 GO:2001187 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.1 1.9 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 1.7 GO:0001675 acrosome assembly(GO:0001675)
0.0 1.3 GO:0030901 midbrain development(GO:0030901)
0.1 1.2 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.3 1.0 GO:0010248 B cell negative selection(GO:0002352) establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.1 1.0 GO:0043201 response to leucine(GO:0043201) cellular response to leucine(GO:0071233)
0.0 1.0 GO:0007032 endosome organization(GO:0007032)
0.0 0.8 GO:0043923 positive regulation by host of viral transcription(GO:0043923)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 4.6 GO:0016324 apical plasma membrane(GO:0016324)
0.2 4.2 GO:0031045 dense core granule(GO:0031045)
0.0 4.0 GO:0031965 nuclear membrane(GO:0031965)
0.0 3.0 GO:0005844 polysome(GO:0005844)
0.1 2.5 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 2.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 1.9 GO:0042101 T cell receptor complex(GO:0042101)
0.1 1.7 GO:0002080 acrosomal membrane(GO:0002080)
0.0 1.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 1.0 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 1.0 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 1.0 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 0.8 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.2 0.7 GO:0061702 inflammasome complex(GO:0061702)
0.1 0.7 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.7 GO:0045178 basal part of cell(GO:0045178)
0.1 0.3 GO:0055087 Ski complex(GO:0055087)
0.0 0.3 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.3 GO:0042405 nuclear inclusion body(GO:0042405)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.4 GO:0001784 phosphotyrosine binding(GO:0001784)
1.1 5.6 GO:0032027 myosin light chain binding(GO:0032027)
0.3 4.6 GO:0030957 Tat protein binding(GO:0030957)
1.4 4.2 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.4 4.1 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
1.3 4.0 GO:0004962 endothelin receptor activity(GO:0004962)
0.3 3.8 GO:0008430 selenium binding(GO:0008430)
0.1 3.0 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 2.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 2.5 GO:0003690 double-stranded DNA binding(GO:0003690)
0.3 1.9 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 1.0 GO:0051400 BH domain binding(GO:0051400)
0.1 0.8 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 0.7 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 0.7 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.7 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.7 GO:0019003 GDP binding(GO:0019003)
0.1 0.4 GO:0070736 protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.0 PID_IGF1_PATHWAY IGF1 pathway
0.1 6.5 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 5.6 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 4.6 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 2.2 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 1.9 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 1.2 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 1.0 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.0 PID_MTOR_4PATHWAY mTOR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 9.0 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.3 4.6 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.4 4.2 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 4.1 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 3.9 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 3.8 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 2.5 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.1 2.2 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.0 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.8 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 0.7 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 0.7 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.7 REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0 0.4 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.3 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants