Motif ID: Zbtb14

Z-value: 1.906


Transcription factors associated with Zbtb14:

Gene SymbolEntrez IDGene Name
Zbtb14 ENSMUSG00000049672.8 Zbtb14

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb14mm10_v2_chr17_+_69383024_693830650.256.7e-02Click!


Activity profile for motif Zbtb14.

activity profile for motif Zbtb14


Sorted Z-values histogram for motif Zbtb14

Sorted Z-values for motif Zbtb14



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb14

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_7213897 18.881 ENSMUST00000020702.4
ENSMUST00000135887.2
 Igfbp3

insulin-like growth factor binding protein 3

chr11_+_7063423 16.624 ENSMUST00000020706.4
 Adcy1
adenylate cyclase 1
chr7_-_63212514 15.759 ENSMUST00000032738.5
 Chrna7
cholinergic receptor, nicotinic, alpha polypeptide 7
chr7_-_27396542 15.371 ENSMUST00000108363.1
 Sptbn4
spectrin beta, non-erythrocytic 4
chr11_+_104231573 14.865 ENSMUST00000132977.1
ENSMUST00000132245.1
ENSMUST00000100347.4
 Mapt


microtubule-associated protein tau


chr11_-_102296618 14.752 ENSMUST00000107132.2
ENSMUST00000073234.2
 Atxn7l3

ataxin 7-like 3

chr11_-_6065737 14.609 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
 Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr11_+_104231515 14.537 ENSMUST00000106993.3
 Mapt
microtubule-associated protein tau
chr10_+_13966268 14.329 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr2_-_104410334 13.805 ENSMUST00000089726.3
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr11_-_6065538 13.658 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr11_+_104231465 13.589 ENSMUST00000145227.1
 Mapt
microtubule-associated protein tau
chr11_+_104231390 13.286 ENSMUST00000106992.3
 Mapt
microtubule-associated protein tau
chr7_+_123982799 12.995 ENSMUST00000106437.1
 Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr4_+_42917234 12.227 ENSMUST00000107976.2
ENSMUST00000069184.2
 N28178

expressed sequence N28178

chr15_+_83779975 11.954 ENSMUST00000163723.1
 Mpped1
metallophosphoesterase domain containing 1
chr15_+_83779999 10.669 ENSMUST00000046168.5
 Mpped1
metallophosphoesterase domain containing 1
chr14_-_102982630 10.355 ENSMUST00000184744.1
 KCTD12
mmu-mir-5130
chr17_-_24689901 10.339 ENSMUST00000007236.4
 Syngr3
synaptogyrin 3
chr4_+_42916647 10.262 ENSMUST00000132173.1
ENSMUST00000107975.1
 N28178

expressed sequence N28178


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 439 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.2 56.0 GO:1900034 regulation of cellular response to heat(GO:1900034)
5.4 32.7 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
9.4 28.3 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
0.9 23.1 GO:0030204 chondroitin sulfate metabolic process(GO:0030204)
0.7 19.8 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.6 18.8 GO:0061098 positive regulation of protein tyrosine kinase activity(GO:0061098)
6.1 18.2 GO:1902512 positive regulation of apoptotic DNA fragmentation(GO:1902512)
1.1 17.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.4 16.8 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
5.3 15.8 GO:0001978 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978)
1.2 15.8 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
1.2 14.8 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.5 14.6 GO:0016578 histone deubiquitination(GO:0016578)
3.6 14.4 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
1.2 13.2 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.7 12.9 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
1.2 12.7 GO:0032482 Rab protein signal transduction(GO:0032482)
0.7 12.1 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
1.5 11.7 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.2 11.4 GO:0046513 ceramide biosynthetic process(GO:0046513)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 198 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 61.9 GO:0031224 intrinsic component of membrane(GO:0031224)
5.6 56.3 GO:0045298 tubulin complex(GO:0045298)
0.1 33.1 GO:0099572 postsynaptic specialization(GO:0099572)
0.5 30.9 GO:0031594 neuromuscular junction(GO:0031594)
1.5 28.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.8 27.1 GO:0051233 spindle midzone(GO:0051233)
4.2 25.3 GO:0008091 spectrin(GO:0008091)
0.2 23.7 GO:0005769 early endosome(GO:0005769)
4.7 18.9 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.5 18.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.7 17.9 GO:0033268 node of Ranvier(GO:0033268)
0.2 16.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 16.0 GO:0043025 neuronal cell body(GO:0043025)
1.4 15.8 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
1.1 14.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.9 14.8 GO:0000124 SAGA complex(GO:0000124)
0.2 14.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 14.0 GO:0000139 Golgi membrane(GO:0000139)
2.5 12.7 GO:0030314 junctional membrane complex(GO:0030314)
0.3 12.7 GO:0044295 axonal growth cone(GO:0044295)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 279 entries
Log-likelihood per target Total log-likelihoodTermDescription
8.0 56.3 GO:0099609 microtubule lateral binding(GO:0099609)
1.4 32.5 GO:0030506 ankyrin binding(GO:0030506)
1.2 31.8 GO:0043274 phospholipase binding(GO:0043274)
3.6 21.9 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
2.2 19.8 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.2 19.5 GO:0000149 SNARE binding(GO:0000149)
0.1 19.3 GO:0017137 Rab GTPase binding(GO:0017137)
3.8 18.9 GO:0072542 protein phosphatase activator activity(GO:0072542)
1.7 18.2 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.7 17.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
3.4 16.9 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.2 16.0 GO:0008013 beta-catenin binding(GO:0008013)
1.6 15.8 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.3 14.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.6 14.3 GO:0031489 myosin V binding(GO:0031489)
0.3 14.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 12.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.3 12.0 GO:0046875 ephrin receptor binding(GO:0046875)
1.9 11.7 GO:0042296 ISG15 transferase activity(GO:0042296)
0.3 11.7 GO:0005246 calcium channel regulator activity(GO:0005246)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 56.3 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
2.2 37.6 PID_LPA4_PATHWAY LPA4-mediated signaling events
1.2 28.1 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 19.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 19.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.3 18.5 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.3 17.0 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.3 14.1 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 11.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 11.3 PID_P73PATHWAY p73 transcription factor network
0.3 8.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.2 8.9 PID_INSULIN_PATHWAY Insulin Pathway
0.2 7.2 PID_REELIN_PATHWAY Reelin signaling pathway
0.4 7.1 PID_IGF1_PATHWAY IGF1 pathway
0.1 7.0 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.2 6.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.4 6.4 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.3 6.3 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.3 6.1 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.2 6.1 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 56.3 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
1.6 40.0 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
1.0 34.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
2.3 27.7 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.6 22.7 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
1.2 18.9 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.4 17.0 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
1.8 15.8 REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS Genes involved in Acetylcholine Binding And Downstream Events
0.5 15.3 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
1.2 14.8 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.4 13.2 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.6 13.0 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.4 12.3 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.5 11.7 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.6 10.6 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.4 10.4 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 9.3 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.3 9.0 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 8.9 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.3 8.6 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling