Motif ID: Zbtb16

Z-value: 1.411


Transcription factors associated with Zbtb16:

Gene SymbolEntrez IDGene Name
Zbtb16 ENSMUSG00000066687.4 Zbtb16

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb16mm10_v2_chr9_-_48835932_48835962-0.133.6e-01Click!


Activity profile for motif Zbtb16.

activity profile for motif Zbtb16


Sorted Z-values histogram for motif Zbtb16

Sorted Z-values for motif Zbtb16



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb16

PNG image of the network

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Top targets:


Showing 1 to 20 of 189 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_44300876 23.221 ENSMUST00000045607.5
 Melk
maternal embryonic leucine zipper kinase
chr4_-_117178726 22.751 ENSMUST00000153953.1
ENSMUST00000106436.1
 Kif2c

kinesin family member 2C

chrY_+_90785442 20.973 ENSMUST00000177591.1
ENSMUST00000177671.1
ENSMUST00000179077.1
 Erdr1


erythroid differentiation regulator 1


chrX_+_170010744 20.073 ENSMUST00000178789.1
 Gm21887
predicted gene, 21887
chr11_+_69045640 17.195 ENSMUST00000108666.1
ENSMUST00000021277.5
 Aurkb

aurora kinase B

chr14_-_65833963 12.966 ENSMUST00000022613.9
 Esco2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr19_-_30175414 12.477 ENSMUST00000025778.7
 Gldc
glycine decarboxylase
chr7_-_115846080 12.034 ENSMUST00000166207.1
 Sox6
SRY-box containing gene 6
chr6_+_137754529 10.930 ENSMUST00000087675.6
 Dera
2-deoxyribose-5-phosphate aldolase homolog (C. elegans)
chr11_+_101627942 9.860 ENSMUST00000010506.3
 Rdm1
RAD52 motif 1
chr1_+_107511416 8.633 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_107511489 8.430 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr3_-_157925056 7.661 ENSMUST00000118539.1
 Cth
cystathionase (cystathionine gamma-lyase)
chr1_+_74391479 7.254 ENSMUST00000027367.7
 Ctdsp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr9_-_79977782 7.250 ENSMUST00000093811.4
 Filip1
filamin A interacting protein 1
chr5_+_110330697 7.123 ENSMUST00000112481.1
 Pole
polymerase (DNA directed), epsilon
chrX_+_170009892 6.747 ENSMUST00000180251.1
 Gm21887
predicted gene, 21887
chr11_-_106998483 6.477 ENSMUST00000124541.1
 Kpna2
karyopherin (importin) alpha 2
chr6_+_6863269 6.458 ENSMUST00000160937.2
ENSMUST00000171311.1
 Dlx6

distal-less homeobox 6

chr4_+_80910646 6.137 ENSMUST00000055922.3
 Lurap1l
leucine rich adaptor protein 1-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 25.0 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.4 23.2 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
4.6 22.8 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
5.7 17.2 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.1 17.1 GO:0010466 negative regulation of peptidase activity(GO:0010466)
2.6 13.0 GO:0034421 post-translational protein acetylation(GO:0034421)
4.2 12.5 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
1.1 12.0 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
2.7 10.9 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.3 10.1 GO:0010960 magnesium ion homeostasis(GO:0010960)
2.6 7.7 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344)
0.1 7.3 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
2.4 7.1 GO:0045004 DNA replication proofreading(GO:0045004)
0.1 6.6 GO:0007569 cell aging(GO:0007569)
0.1 6.5 GO:0042472 inner ear morphogenesis(GO:0042472)
0.6 5.9 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
1.4 5.6 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.3 5.6 GO:0044872 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.2 5.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 5.3 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 29.0 GO:0005938 cell cortex(GO:0005938)
0.0 26.8 GO:0005730 nucleolus(GO:0005730)
0.6 22.8 GO:0035371 microtubule plus-end(GO:0035371)
3.4 17.2 GO:0032133 chromosome passenger complex(GO:0032133)
1.0 13.0 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 12.5 GO:0005615 extracellular space(GO:0005615)
0.1 11.9 GO:1990204 oxidoreductase complex(GO:1990204)
0.1 8.4 GO:0005643 nuclear pore(GO:0005643)
0.0 7.7 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
1.4 7.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 6.0 GO:0005667 transcription factor complex(GO:0005667)
0.1 5.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 5.4 GO:0043296 apical junction complex(GO:0043296)
0.7 4.5 GO:0005663 DNA replication factor C complex(GO:0005663)
1.0 4.0 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0 3.6 GO:0045177 apical part of cell(GO:0045177)
0.2 3.4 GO:0005922 connexon complex(GO:0005922)
0.5 3.2 GO:0030870 Mre11 complex(GO:0030870)
0.1 3.1 GO:0035869 ciliary transition zone(GO:0035869)
0.8 3.0 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 22.8 GO:0051010 microtubule plus-end binding(GO:0051010)
0.4 20.6 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
3.4 17.2 GO:0035174 histone serine kinase activity(GO:0035174)
0.4 17.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 16.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.0 13.2 GO:0016832 aldehyde-lyase activity(GO:0016832)
2.2 13.0 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.8 12.5 GO:0016594 glycine binding(GO:0016594)
1.3 10.1 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.3 8.9 GO:0008139 nuclear localization sequence binding(GO:0008139)
1.0 7.7 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.8 7.3 GO:0008420 CTD phosphatase activity(GO:0008420)
2.4 7.1 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.3 5.9 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 5.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
1.1 5.4 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.1 5.0 GO:0008026 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) ATP-dependent helicase activity(GO:0008026) RNA-dependent ATPase activity(GO:0008186) purine NTP-dependent helicase activity(GO:0070035)
0.0 4.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.4 4.5 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.3 4.4 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 39.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 17.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.5 13.7 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 6.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 5.3 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.1 4.9 PID_E2F_PATHWAY E2F transcription factor network
0.1 4.4 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.6 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 3.2 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.1 3.2 PID_BARD1_PATHWAY BARD1 signaling events
0.2 3.1 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 2.4 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.7 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.2 1.4 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.4 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.3 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 1.3 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 1.1 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.6 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 22.8 REACTOME_KINESINS Genes involved in Kinesins
0.2 17.0 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 14.5 REACTOME_HEMOSTASIS Genes involved in Hemostasis
0.1 8.0 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.3 7.7 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.5 7.1 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.2 3.6 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.3 3.4 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.2 3.2 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.5 3.0 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2 3.0 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 2.7 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.2 2.6 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.1 2.5 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 2.5 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 1.9 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.2 1.8 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 1.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.7 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 1.7 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction