Motif ID: Zbtb3

Z-value: 0.705


Transcription factors associated with Zbtb3:

Gene SymbolEntrez IDGene Name
Zbtb3 ENSMUSG00000071661.6 Zbtb3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb3mm10_v2_chr19_+_8802486_88025300.402.5e-03Click!


Activity profile for motif Zbtb3.

activity profile for motif Zbtb3


Sorted Z-values histogram for motif Zbtb3

Sorted Z-values for motif Zbtb3



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb3

PNG image of the network

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Top targets:


Showing 1 to 20 of 136 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_10272572 4.866 ENSMUST00000042103.8
 Myo16
myosin XVI
chr16_+_20589471 4.045 ENSMUST00000100074.3
ENSMUST00000096197.4
 Vwa5b2

von Willebrand factor A domain containing 5B2

chr7_-_63212514 2.789 ENSMUST00000032738.5
 Chrna7
cholinergic receptor, nicotinic, alpha polypeptide 7
chr15_+_98167806 2.747 ENSMUST00000031914.4
 AI836003
expressed sequence AI836003
chr9_-_40531362 2.598 ENSMUST00000119373.1
 Gramd1b
GRAM domain containing 1B
chr1_-_173367638 2.585 ENSMUST00000005470.4
ENSMUST00000111220.1
 Cadm3

cell adhesion molecule 3

chr15_-_72546279 2.456 ENSMUST00000044624.6
 Kcnk9
potassium channel, subfamily K, member 9
chr15_-_67113909 2.294 ENSMUST00000092640.5
 St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr15_-_66969616 2.022 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr11_-_3774706 1.983 ENSMUST00000155197.1
 Osbp2
oxysterol binding protein 2
chr5_+_30588078 1.782 ENSMUST00000066295.2
 Kcnk3
potassium channel, subfamily K, member 3
chr5_+_37242025 1.768 ENSMUST00000114158.2
 Crmp1
collapsin response mediator protein 1
chr16_+_11405648 1.737 ENSMUST00000096273.2
 Snx29
sorting nexin 29
chr5_+_141856692 1.735 ENSMUST00000074546.6
 Sdk1
sidekick homolog 1 (chicken)
chr11_+_87592145 1.520 ENSMUST00000103179.3
ENSMUST00000092802.5
ENSMUST00000146871.1
 Mtmr4


myotubularin related protein 4


chr2_-_172043466 1.496 ENSMUST00000087950.3
 Cbln4
cerebellin 4 precursor protein
chr11_-_54028090 1.444 ENSMUST00000020586.6
 Slc22a4
solute carrier family 22 (organic cation transporter), member 4
chr10_+_74967164 1.410 ENSMUST00000037813.4
 Gnaz
guanine nucleotide binding protein, alpha z subunit
chr14_-_19977249 1.338 ENSMUST00000160013.1
 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr18_+_34247685 1.313 ENSMUST00000066133.6
 Apc
adenomatosis polyposis coli

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.9 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.4 4.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.9 2.8 GO:0001978 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978)
0.0 2.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 2.3 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.2 2.0 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.4 1.8 GO:1904529 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
0.1 1.8 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.1 1.7 GO:0048148 behavioral response to cocaine(GO:0048148)
0.2 1.4 GO:0015879 carnitine transport(GO:0015879)
0.0 1.4 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.4 1.3 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.3 1.3 GO:2000211 regulation of glutamate metabolic process(GO:2000211)
0.1 1.3 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.4 1.2 GO:0010512 negative regulation of phosphatidylinositol biosynthetic process(GO:0010512)
0.0 1.2 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 1.2 GO:1901607 alpha-amino acid biosynthetic process(GO:1901607)
0.1 1.1 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.1 1.1 GO:2000009 negative regulation of protein localization to cell surface(GO:2000009)
0.3 0.9 GO:0060854 patterning of lymph vessels(GO:0060854)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.0 GO:0016459 myosin complex(GO:0016459)
0.0 3.4 GO:0001650 fibrillar center(GO:0001650)
0.0 3.2 GO:0008021 synaptic vesicle(GO:0008021)
0.3 2.8 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 2.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.4 GO:0036126 sperm flagellum(GO:0036126)
0.1 2.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 2.0 GO:0097440 apical dendrite(GO:0097440)
0.2 1.8 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 1.8 GO:0031941 filamentous actin(GO:0031941)
0.0 1.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.5 GO:0005581 collagen trimer(GO:0005581)
0.1 1.3 GO:0070852 cell body fiber(GO:0070852)
0.1 1.3 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 1.2 GO:0098845 postsynaptic endosome(GO:0098845)
0.0 1.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 1.0 GO:0005902 microvillus(GO:0005902)
0.0 0.9 GO:0031514 motile cilium(GO:0031514)
0.1 0.7 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.7 GO:0005844 polysome(GO:0005844)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.2 GO:0003774 motor activity(GO:0003774)
0.4 4.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 2.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.3 2.8 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 2.7 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.6 2.3 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 2.1 GO:0008013 beta-catenin binding(GO:0008013)
0.0 2.0 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 2.0 GO:0015485 cholesterol binding(GO:0015485)
0.1 1.8 GO:0031005 filamin binding(GO:0031005)
0.0 1.7 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 1.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.4 1.4 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.2 1.4 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 1.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 1.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 1.2 GO:0032051 clathrin light chain binding(GO:0032051)
0.1 1.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 1.2 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 1.1 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 3.4 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 2.0 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 1.4 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 1.3 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 1.3 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.2 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 1.0 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.7 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 0.6 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 0.6 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.4 PID_IL4_2PATHWAY IL4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 4.2 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 3.7 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.3 2.8 REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS Genes involved in Acetylcholine Binding And Downstream Events
0.2 2.3 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 1.8 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 1.6 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.2 1.4 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 1.4 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.0 1.4 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.1 1.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 1.3 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 1.1 REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.6 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.6 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.5 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.4 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.1 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport