Motif ID: Zbtb33_Chd2

Z-value: 2.128

Transcription factors associated with Zbtb33_Chd2:

Gene SymbolEntrez IDGene Name
Chd2 ENSMUSG00000078671.4 Chd2
Zbtb33 ENSMUSG00000048047.3 Zbtb33

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Chd2mm10_v2_chr7_-_73541738_735417580.632.2e-07Click!
Zbtb33mm10_v2_chrX_+_38189780_381898260.341.1e-02Click!


Activity profile for motif Zbtb33_Chd2.

activity profile for motif Zbtb33_Chd2


Sorted Z-values histogram for motif Zbtb33_Chd2

Sorted Z-values for motif Zbtb33_Chd2



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb33_Chd2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_34833631 22.325 ENSMUST00000093191.2
 Spdl1
spindle apparatus coiled-coil protein 1
chr5_+_45669907 17.082 ENSMUST00000117396.1
 Ncapg
non-SMC condensin I complex, subunit G
chr11_-_90638062 16.388 ENSMUST00000020858.7
ENSMUST00000107875.1
ENSMUST00000107872.1
ENSMUST00000143203.1
 Stxbp4



syntaxin binding protein 4



chr4_-_118437331 13.711 ENSMUST00000006565.6
 Cdc20
cell division cycle 20
chr3_+_69004711 13.158 ENSMUST00000042901.8
 Smc4
structural maintenance of chromosomes 4
chr3_+_69004969 13.100 ENSMUST00000136502.1
ENSMUST00000107803.1
 Smc4

structural maintenance of chromosomes 4

chr16_+_48994185 12.495 ENSMUST00000117994.1
ENSMUST00000048374.5
 C330027C09Rik

RIKEN cDNA C330027C09 gene

chr19_+_38931008 11.899 ENSMUST00000145051.1
 Hells
helicase, lymphoid specific
chr4_+_24496434 11.871 ENSMUST00000108222.2
ENSMUST00000138567.2
ENSMUST00000050446.6
 Mms22l


MMS22-like, DNA repair protein


chr9_-_72491939 11.307 ENSMUST00000185151.1
ENSMUST00000085358.5
ENSMUST00000184125.1
ENSMUST00000183574.1
ENSMUST00000184831.1
 Tex9




testis expressed gene 9




chr15_+_99074968 11.229 ENSMUST00000039665.6
 Troap
trophinin associated protein
chr19_+_38930909 10.931 ENSMUST00000025965.5
 Hells
helicase, lymphoid specific
chr14_-_57826128 9.675 ENSMUST00000022536.2
 Ska3
spindle and kinetochore associated complex subunit 3
chr11_+_29172890 9.357 ENSMUST00000102856.2
ENSMUST00000020755.5
 Smek2

SMEK homolog 2, suppressor of mek1 (Dictyostelium)

chr4_+_94614483 8.502 ENSMUST00000030311.4
ENSMUST00000107104.2
 Ift74

intraflagellar transport 74

chr9_+_121719172 8.285 ENSMUST00000035112.6
ENSMUST00000182311.1
 Nktr

natural killer tumor recognition sequence

chr2_-_156180135 8.272 ENSMUST00000126992.1
ENSMUST00000146288.1
ENSMUST00000029149.6
ENSMUST00000109587.2
ENSMUST00000109584.1
 Rbm39




RNA binding motif protein 39




chr12_+_9029982 8.224 ENSMUST00000085741.1
 Ttc32
tetratricopeptide repeat domain 32
chr17_+_56040350 8.067 ENSMUST00000002914.8
 Chaf1a
chromatin assembly factor 1, subunit A (p150)
chr11_+_98203059 7.428 ENSMUST00000107539.1
 Cdk12
cyclin-dependent kinase 12

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 187 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 27.6 GO:0071459 protein localization to chromosome, centromeric region(GO:0071459)
3.3 26.3 GO:0010032 meiotic chromosome condensation(GO:0010032)
3.3 22.8 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
4.1 16.4 GO:0010838 positive regulation of keratinocyte proliferation(GO:0010838)
0.2 16.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.5 16.0 GO:0045005 DNA-dependent DNA replication maintenance of fidelity(GO:0045005)
0.9 15.3 GO:0030953 astral microtubule organization(GO:0030953)
1.3 14.8 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.5 14.2 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
1.6 14.1 GO:0007076 mitotic chromosome condensation(GO:0007076)
2.0 13.7 GO:0000279 M phase(GO:0000279)
0.1 12.8 GO:0031109 microtubule polymerization or depolymerization(GO:0031109)
0.2 12.6 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.3 11.1 GO:0035329 hippo signaling(GO:0035329)
0.5 10.0 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.3 9.2 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
2.9 8.7 GO:0072554 arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel lumenization(GO:0072554) blood vessel endothelial cell fate specification(GO:0097101) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of heart induction(GO:1901321) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
1.2 8.5 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1 8.3 GO:0006986 response to unfolded protein(GO:0006986)
1.3 7.6 GO:0016584 nucleosome positioning(GO:0016584)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.1 50.7 GO:0000796 condensin complex(GO:0000796)
2.5 32.0 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.9 26.6 GO:0005721 pericentric heterochromatin(GO:0005721)
0.6 15.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.5 14.1 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 12.8 GO:0005815 microtubule organizing center(GO:0005815)
4.0 11.9 GO:0035101 FACT complex(GO:0035101)
0.4 8.8 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
1.7 8.7 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
2.7 8.1 GO:0033186 CAF-1 complex(GO:0033186)
0.1 7.7 GO:0005643 nuclear pore(GO:0005643)
2.5 7.4 GO:0002944 cyclin K-CDK12 complex(GO:0002944)
0.3 7.0 GO:0005685 U1 snRNP(GO:0005685)
0.7 6.9 GO:0016589 NURF complex(GO:0016589)
1.5 6.2 GO:0000939 condensed chromosome inner kinetochore(GO:0000939)
0.4 5.9 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 5.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.8 5.8 GO:0097422 tubular endosome(GO:0097422)
0.2 5.6 GO:0034451 centriolar satellite(GO:0034451)
0.1 5.3 GO:0031941 filamentous actin(GO:0031941)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 125 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 27.7 GO:0004386 helicase activity(GO:0004386)
0.2 25.5 GO:0003697 single-stranded DNA binding(GO:0003697)
4.5 22.3 GO:0043515 kinetochore binding(GO:0043515)
0.2 16.3 GO:0019905 syntaxin binding(GO:0019905)
0.3 14.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 14.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.3 14.2 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
2.3 13.7 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 11.0 GO:0045296 cadherin binding(GO:0045296)
1.0 10.0 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 9.0 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.2 8.7 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
1.0 8.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.3 7.4 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.2 7.3 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.2 7.2 GO:0043014 alpha-tubulin binding(GO:0043014)
2.2 6.7 GO:0030350 iron-responsive element binding(GO:0030350)
0.2 6.7 GO:0031491 nucleosome binding(GO:0031491)
0.8 5.8 GO:0034452 dynactin binding(GO:0034452)
0.4 5.5 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 53.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.9 41.2 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.4 18.1 PID_PLK1_PATHWAY PLK1 signaling events
0.4 14.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.2 10.0 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 7.8 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 7.4 PID_CMYB_PATHWAY C-MYB transcription factor network
0.2 6.5 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 6.5 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.2 6.1 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 5.5 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.0 5.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.4 PID_ATR_PATHWAY ATR signaling pathway
0.1 3.3 PID_BARD1_PATHWAY BARD1 signaling events
0.1 3.2 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 3.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 2.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 2.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.7 PID_CXCR4_PATHWAY CXCR4-mediated signaling events
0.1 1.6 PID_FANCONI_PATHWAY Fanconi anemia pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 19.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 17.9 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.8 15.0 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.4 11.1 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.5 8.7 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 5.8 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.2 5.6 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 5.6 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 5.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.3 4.8 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 4.1 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 3.5 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 3.4 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.2 3.3 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.1 3.3 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 3.2 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 3.2 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.1 3.0 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 3.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.7 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination