Motif ID: Zbtb4

Z-value: 0.620


Transcription factors associated with Zbtb4:

Gene SymbolEntrez IDGene Name
Zbtb4 ENSMUSG00000018750.8 Zbtb4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb4mm10_v2_chr11_+_69765899_69765925-0.076.4e-01Click!


Activity profile for motif Zbtb4.

activity profile for motif Zbtb4


Sorted Z-values histogram for motif Zbtb4

Sorted Z-values for motif Zbtb4



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_103422010 4.447 ENSMUST00000182089.1
Gm26992
predicted gene, 26992
chr5_+_139543889 2.864 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx

UNC homeobox

chr6_+_47244359 2.768 ENSMUST00000060839.6
Cntnap2
contactin associated protein-like 2
chr4_+_125490688 2.166 ENSMUST00000030676.7
Grik3
glutamate receptor, ionotropic, kainate 3
chr6_-_48841373 2.075 ENSMUST00000166247.1
Tmem176b
transmembrane protein 176B
chr6_+_58831456 1.848 ENSMUST00000141600.1
ENSMUST00000122981.1
Herc3

hect domain and RLD 3

chr7_+_123982799 1.828 ENSMUST00000106437.1
Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr14_-_30626196 1.803 ENSMUST00000112210.3
ENSMUST00000112211.2
ENSMUST00000112208.1
Prkcd


protein kinase C, delta


chr6_-_48841098 1.716 ENSMUST00000101429.4
Tmem176b
transmembrane protein 176B
chr9_+_75071386 1.461 ENSMUST00000155282.2
Myo5a
myosin VA
chr19_+_41482632 1.456 ENSMUST00000067795.5
Lcor
ligand dependent nuclear receptor corepressor
chr18_-_13972617 1.422 ENSMUST00000025288.7
Zfp521
zinc finger protein 521
chr9_+_75071579 1.368 ENSMUST00000136731.1
Myo5a
myosin VA
chr6_+_58831748 1.341 ENSMUST00000126292.1
ENSMUST00000031823.5
Herc3

hect domain and RLD 3

chrX_+_164373363 1.310 ENSMUST00000033751.7
Figf
c-fos induced growth factor
chr12_-_45074112 1.308 ENSMUST00000120531.1
ENSMUST00000143376.1
Stxbp6

syntaxin binding protein 6 (amisyn)

chr5_+_65764073 1.278 ENSMUST00000138239.1
ENSMUST00000087264.3
N4bp2

NEDD4 binding protein 2

chr8_-_122678653 1.228 ENSMUST00000134045.1
Cbfa2t3
core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)
chr10_+_100015817 1.172 ENSMUST00000130190.1
ENSMUST00000020129.7
Kitl

kit ligand

chr12_-_45074457 1.160 ENSMUST00000053768.6
Stxbp6
syntaxin binding protein 6 (amisyn)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 6.0 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
1.0 3.8 GO:0051643 endoplasmic reticulum localization(GO:0051643)
0.4 2.9 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.6 2.8 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.3 2.5 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.2 2.2 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 2.2 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.1 2.0 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.4 1.8 GO:0006680 glucosylceramide catabolic process(GO:0006680)
0.2 1.8 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.1 1.8 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.2 1.6 GO:0006004 fucose metabolic process(GO:0006004)
0.0 1.4 GO:0048663 neuron fate commitment(GO:0048663)
0.1 1.3 GO:0008209 androgen metabolic process(GO:0008209)
0.2 1.2 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.2 1.2 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.0 1.2 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.2 1.1 GO:0015808 L-alanine transport(GO:0015808)
0.0 1.1 GO:0030641 regulation of cellular pH(GO:0030641)
0.3 1.0 GO:0006657 CDP-choline pathway(GO:0006657)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 3.8 GO:0042642 actomyosin, myosin complex part(GO:0042642)
0.1 2.8 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 2.5 GO:0000145 exocyst(GO:0000145)
0.1 2.2 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 1.8 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.8 GO:0016605 PML body(GO:0016605)
0.0 1.2 GO:0030175 filopodium(GO:0030175)
0.1 1.0 GO:0042587 glycogen granule(GO:0042587)
0.0 1.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.9 GO:0044447 axoneme part(GO:0044447)
0.1 0.8 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 0.8 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.8 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.8 GO:0045171 intercellular bridge(GO:0045171)
0.2 0.7 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.1 0.7 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 0.7 GO:0035748 myelin sheath abaxonal region(GO:0035748)
0.0 0.6 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 0.5 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.2 3.8 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.1 2.5 GO:0017049 GTP-Rho binding(GO:0017049)
0.4 2.2 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.1 2.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.5 1.8 GO:0070976 calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976)
0.2 1.8 GO:0046790 virion binding(GO:0046790)
0.3 1.7 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.1 1.7 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.4 1.6 GO:0042806 fucose binding(GO:0042806)
0.1 1.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 1.3 GO:0045503 dynein light chain binding(GO:0045503)
0.0 1.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 1.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 1.2 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.4 1.1 GO:0015173 hydrogen:amino acid symporter activity(GO:0005280) aromatic amino acid transmembrane transporter activity(GO:0015173)
0.3 1.0 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.2 1.0 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 1.0 GO:0097602 cullin family protein binding(GO:0097602)
0.0 1.0 GO:0030551 cyclic nucleotide binding(GO:0030551)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 2.1 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 2.0 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 2.0 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 1.3 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.9 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.9 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.8 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.4 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.2 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 2.2 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 2.0 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.8 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.8 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.3 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.1 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.0 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 0.8 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.8 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.8 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 0.7 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 0.7 REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.0 0.7 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.7 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 0.7 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.6 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER
0.0 0.6 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.5 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 0.4 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels